#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03951	uniprotkb:P23827	intact:EBI-1041019|uniprotkb:Q4W5C2|uniprotkb:Q9Y495|uniprotkb:D3DP64|ensembl:ENSP00000384957	intact:EBI-1029159|ensemblbacteria:AAC75269|ensemblbacteria:BAA15992	psi-mi:fa11_human(display_long)|uniprotkb:F11(gene name)|psi-mi:F11(display_short)|uniprotkb:Plasma thromboplastin antecedent(gene name synonym)	psi-mi:ecot_ecoli(display_long)|uniprotkb:eco(gene name)|psi-mi:eco(display_short)|uniprotkb:eti(gene name synonym)|uniprotkb:b2209(locus name)|uniprotkb:JW2197(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Jin et al. (2005)	pubmed:15545266	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1041053|rcsb pdb:1XX9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000119.1|ensembl:ENSG00000088926(gene)|ensembl:ENST00000403665(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0016020"(membrane)|go:"GO:0031639"(plasminogen activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0051919"(positive regulation of fibrinolysis)|go:"GO:0070009"(serine-type aminopeptidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000177(Apple)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003609(Apple-like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1XX9|rcsb pdb:1XXD|rcsb pdb:1XXF|rcsb pdb:1ZHM|rcsb pdb:1ZHP|rcsb pdb:1ZHR|rcsb pdb:1ZJD|rcsb pdb:1ZLR|rcsb pdb:1ZMJ|rcsb pdb:1ZML|rcsb pdb:1ZMN|rcsb pdb:1ZOM|rcsb pdb:1ZPB|rcsb pdb:1ZPC|rcsb pdb:1ZPZ|rcsb pdb:1ZRK|rcsb pdb:1ZSJ|rcsb pdb:1ZSK|rcsb pdb:1ZSL|rcsb pdb:1ZTJ|rcsb pdb:1ZTK|rcsb pdb:1ZTL|rcsb pdb:2F83|rcsb pdb:2FDA|rcsb pdb:2J8J|rcsb pdb:2J8L|rcsb pdb:3BG8|rcsb pdb:3SOR|rcsb pdb:3SOS|rcsb pdb:4CR9|rcsb pdb:4CRA|rcsb pdb:4CRB|rcsb pdb:4CRC|rcsb pdb:4CRD|rcsb pdb:4CRE|rcsb pdb:4CRF|rcsb pdb:4CRG|rcsb pdb:4D76|rcsb pdb:4D7F|rcsb pdb:4D7G|rcsb pdb:4NA7|rcsb pdb:4NA8|rcsb pdb:4TY6|rcsb pdb:4TY7|rcsb pdb:4WXI|rcsb pdb:4X6M|rcsb pdb:4X6N|rcsb pdb:4X6O|rcsb pdb:4X6P|rcsb pdb:4Y8X|rcsb pdb:4Y8Y|rcsb pdb:4Y8Z|rcsb pdb:5E2O|rcsb pdb:5E2P|rcsb pdb:5EOD|rcsb pdb:5EOK|rcsb pdb:5EXL|rcsb pdb:5EXM|rcsb pdb:5EXN|rcsb pdb:5I25|rcsb pdb:5Q0D|rcsb pdb:5Q0E|rcsb pdb:5Q0F|rcsb pdb:5Q0G|rcsb pdb:5Q0H|rcsb pdb:4CR5|rcsb pdb:5QCK|rcsb pdb:5QCL|rcsb pdb:5QCM|rcsb pdb:5QCN|rcsb pdb:5QQO|rcsb pdb:5QQP|rcsb pdb:5QTV|rcsb pdb:5QTW|rcsb pdb:5QTY|rcsb pdb:5TKS|rcsb pdb:5TKT|rcsb pdb:5TKU|rcsb pdb:5WB6|rcsb pdb:6AOD|rcsb pdb:6C0S|rcsb pdb:6HHC|rcsb pdb:6I58|rcsb pdb:6R8X|rcsb pdb:6TS4|rcsb pdb:6TS5|rcsb pdb:6TS6|rcsb pdb:6TS7|rcsb pdb:6TWB|rcsb pdb:6USY|rcsb pdb:6VLU|rcsb pdb:6VLV|rcsb pdb:6W50|reactome:R-HSA-140837|reactome:R-HSA-9673221|rcsb pdb:5QTT|dip:DIP-29085N	refseq:NP_416713.1|interpro:IPR005658(Proteinase inhibitor I11, ecotin)|interpro:IPR023084|rcsb pdb:1AZZ|rcsb pdb:1ECY|rcsb pdb:1ECZ|rcsb pdb:1EZS|rcsb pdb:1EZU|rcsb pdb:1FI8|rcsb pdb:1ID5|rcsb pdb:1IFG|rcsb pdb:1N8O|rcsb pdb:1P0S|rcsb pdb:1SLU|rcsb pdb:1SLV|rcsb pdb:1SLW|rcsb pdb:1SLX|rcsb pdb:1XX9|rcsb pdb:1XXD|rcsb pdb:1XXF|ensemblbacteria:AAC75269(transcript)|ensemblbacteria:b2209(gene)|ensemblbacteria:BAA15992(gene)|ensemblbacteria:BAA15992(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|refseq:WP_000849209.1|interpro:IPR027438|rcsb pdb:4IW4|rcsb pdb:4NIY|interpro:IPR036198|rcsb pdb:7CBK	-	-	-	assembly:tetrameric, multimeric|3d-r-factors:working 76.500%, free 71.500%|3d-resolution:2.2A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:wWSTChOgzznzQ19l1hkxEVMun1g9606	rogid:ZzO2zrHSsO5iH2kANpN5qFp+S8w83333	intact-crc:7C7B0FB17D55D102|rigid:Y9rIN8Wwdu3ppIqMQ5WfPEw4K7M	false	sufficient binding region:388-625	sufficient binding region:21-162	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03951	uniprotkb:P23827	intact:EBI-1041019|uniprotkb:Q4W5C2|uniprotkb:Q9Y495|uniprotkb:D3DP64|ensembl:ENSP00000384957	intact:EBI-1029159|ensemblbacteria:AAC75269|ensemblbacteria:BAA15992	psi-mi:fa11_human(display_long)|uniprotkb:F11(gene name)|psi-mi:F11(display_short)|uniprotkb:Plasma thromboplastin antecedent(gene name synonym)	psi-mi:ecot_ecoli(display_long)|uniprotkb:eco(gene name)|psi-mi:eco(display_short)|uniprotkb:eti(gene name synonym)|uniprotkb:b2209(locus name)|uniprotkb:JW2197(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Jin et al. (2005)	pubmed:15545266	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1041064|rcsb pdb:1XXD	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000119.1|ensembl:ENSG00000088926(gene)|ensembl:ENST00000403665(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0016020"(membrane)|go:"GO:0031639"(plasminogen activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0051919"(positive regulation of fibrinolysis)|go:"GO:0070009"(serine-type aminopeptidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000177(Apple)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003609(Apple-like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1XX9|rcsb pdb:1XXD|rcsb pdb:1XXF|rcsb pdb:1ZHM|rcsb pdb:1ZHP|rcsb pdb:1ZHR|rcsb pdb:1ZJD|rcsb pdb:1ZLR|rcsb pdb:1ZMJ|rcsb pdb:1ZML|rcsb pdb:1ZMN|rcsb pdb:1ZOM|rcsb pdb:1ZPB|rcsb pdb:1ZPC|rcsb pdb:1ZPZ|rcsb pdb:1ZRK|rcsb pdb:1ZSJ|rcsb pdb:1ZSK|rcsb pdb:1ZSL|rcsb pdb:1ZTJ|rcsb pdb:1ZTK|rcsb pdb:1ZTL|rcsb pdb:2F83|rcsb pdb:2FDA|rcsb pdb:2J8J|rcsb pdb:2J8L|rcsb pdb:3BG8|rcsb pdb:3SOR|rcsb pdb:3SOS|rcsb pdb:4CR9|rcsb pdb:4CRA|rcsb pdb:4CRB|rcsb pdb:4CRC|rcsb pdb:4CRD|rcsb pdb:4CRE|rcsb pdb:4CRF|rcsb pdb:4CRG|rcsb pdb:4D76|rcsb pdb:4D7F|rcsb pdb:4D7G|rcsb pdb:4NA7|rcsb pdb:4NA8|rcsb pdb:4TY6|rcsb pdb:4TY7|rcsb pdb:4WXI|rcsb pdb:4X6M|rcsb pdb:4X6N|rcsb pdb:4X6O|rcsb pdb:4X6P|rcsb pdb:4Y8X|rcsb pdb:4Y8Y|rcsb pdb:4Y8Z|rcsb pdb:5E2O|rcsb pdb:5E2P|rcsb pdb:5EOD|rcsb pdb:5EOK|rcsb pdb:5EXL|rcsb pdb:5EXM|rcsb pdb:5EXN|rcsb pdb:5I25|rcsb pdb:5Q0D|rcsb pdb:5Q0E|rcsb pdb:5Q0F|rcsb pdb:5Q0G|rcsb pdb:5Q0H|rcsb pdb:4CR5|rcsb pdb:5QCK|rcsb pdb:5QCL|rcsb pdb:5QCM|rcsb pdb:5QCN|rcsb pdb:5QQO|rcsb pdb:5QQP|rcsb pdb:5QTV|rcsb pdb:5QTW|rcsb pdb:5QTY|rcsb pdb:5TKS|rcsb pdb:5TKT|rcsb pdb:5TKU|rcsb pdb:5WB6|rcsb pdb:6AOD|rcsb pdb:6C0S|rcsb pdb:6HHC|rcsb pdb:6I58|rcsb pdb:6R8X|rcsb pdb:6TS4|rcsb pdb:6TS5|rcsb pdb:6TS6|rcsb pdb:6TS7|rcsb pdb:6TWB|rcsb pdb:6USY|rcsb pdb:6VLU|rcsb pdb:6VLV|rcsb pdb:6W50|reactome:R-HSA-140837|reactome:R-HSA-9673221|rcsb pdb:5QTT|dip:DIP-29085N	refseq:NP_416713.1|interpro:IPR005658(Proteinase inhibitor I11, ecotin)|interpro:IPR023084|rcsb pdb:1AZZ|rcsb pdb:1ECY|rcsb pdb:1ECZ|rcsb pdb:1EZS|rcsb pdb:1EZU|rcsb pdb:1FI8|rcsb pdb:1ID5|rcsb pdb:1IFG|rcsb pdb:1N8O|rcsb pdb:1P0S|rcsb pdb:1SLU|rcsb pdb:1SLV|rcsb pdb:1SLW|rcsb pdb:1SLX|rcsb pdb:1XX9|rcsb pdb:1XXD|rcsb pdb:1XXF|ensemblbacteria:AAC75269(transcript)|ensemblbacteria:b2209(gene)|ensemblbacteria:BAA15992(gene)|ensemblbacteria:BAA15992(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|refseq:WP_000849209.1|interpro:IPR027438|rcsb pdb:4IW4|rcsb pdb:4NIY|interpro:IPR036198|rcsb pdb:7CBK	-	-	-	assembly:tetrameric, multimeric|3d-r-factors:working 77.00%, free 71.800%|3d-resolution:2.91A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:wWSTChOgzznzQ19l1hkxEVMun1g9606	rogid:ZzO2zrHSsO5iH2kANpN5qFp+S8w83333	intact-crc:CCA846BC55912486|rigid:Y9rIN8Wwdu3ppIqMQ5WfPEw4K7M	false	sufficient binding region:388-625	sufficient binding region:21-162	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23827	uniprotkb:P03951	intact:EBI-1029159|ensemblbacteria:AAC75269|ensemblbacteria:BAA15992	intact:EBI-1041019|uniprotkb:Q4W5C2|uniprotkb:Q9Y495|uniprotkb:D3DP64|ensembl:ENSP00000384957	psi-mi:ecot_ecoli(display_long)|uniprotkb:eco(gene name)|psi-mi:eco(display_short)|uniprotkb:eti(gene name synonym)|uniprotkb:b2209(locus name)|uniprotkb:JW2197(locus name)	psi-mi:fa11_human(display_long)|uniprotkb:F11(gene name)|psi-mi:F11(display_short)|uniprotkb:Plasma thromboplastin antecedent(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Jin et al. (2005)	pubmed:15545266	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1041075|rcsb pdb:1XXF	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416713.1|interpro:IPR005658(Proteinase inhibitor I11, ecotin)|interpro:IPR023084|rcsb pdb:1AZZ|rcsb pdb:1ECY|rcsb pdb:1ECZ|rcsb pdb:1EZS|rcsb pdb:1EZU|rcsb pdb:1FI8|rcsb pdb:1ID5|rcsb pdb:1IFG|rcsb pdb:1N8O|rcsb pdb:1P0S|rcsb pdb:1SLU|rcsb pdb:1SLV|rcsb pdb:1SLW|rcsb pdb:1SLX|rcsb pdb:1XX9|rcsb pdb:1XXD|rcsb pdb:1XXF|ensemblbacteria:AAC75269(transcript)|ensemblbacteria:b2209(gene)|ensemblbacteria:BAA15992(gene)|ensemblbacteria:BAA15992(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|refseq:WP_000849209.1|interpro:IPR027438|rcsb pdb:4IW4|rcsb pdb:4NIY|interpro:IPR036198|rcsb pdb:7CBK	refseq:NP_000119.1|ensembl:ENSG00000088926(gene)|ensembl:ENST00000403665(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0016020"(membrane)|go:"GO:0031639"(plasminogen activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0051919"(positive regulation of fibrinolysis)|go:"GO:0070009"(serine-type aminopeptidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000177(Apple)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003609(Apple-like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1XX9|rcsb pdb:1XXD|rcsb pdb:1XXF|rcsb pdb:1ZHM|rcsb pdb:1ZHP|rcsb pdb:1ZHR|rcsb pdb:1ZJD|rcsb pdb:1ZLR|rcsb pdb:1ZMJ|rcsb pdb:1ZML|rcsb pdb:1ZMN|rcsb pdb:1ZOM|rcsb pdb:1ZPB|rcsb pdb:1ZPC|rcsb pdb:1ZPZ|rcsb pdb:1ZRK|rcsb pdb:1ZSJ|rcsb pdb:1ZSK|rcsb pdb:1ZSL|rcsb pdb:1ZTJ|rcsb pdb:1ZTK|rcsb pdb:1ZTL|rcsb pdb:2F83|rcsb pdb:2FDA|rcsb pdb:2J8J|rcsb pdb:2J8L|rcsb pdb:3BG8|rcsb pdb:3SOR|rcsb pdb:3SOS|rcsb pdb:4CR9|rcsb pdb:4CRA|rcsb pdb:4CRB|rcsb pdb:4CRC|rcsb pdb:4CRD|rcsb pdb:4CRE|rcsb pdb:4CRF|rcsb pdb:4CRG|rcsb pdb:4D76|rcsb pdb:4D7F|rcsb pdb:4D7G|rcsb pdb:4NA7|rcsb pdb:4NA8|rcsb pdb:4TY6|rcsb pdb:4TY7|rcsb pdb:4WXI|rcsb pdb:4X6M|rcsb pdb:4X6N|rcsb pdb:4X6O|rcsb pdb:4X6P|rcsb pdb:4Y8X|rcsb pdb:4Y8Y|rcsb pdb:4Y8Z|rcsb pdb:5E2O|rcsb pdb:5E2P|rcsb pdb:5EOD|rcsb pdb:5EOK|rcsb pdb:5EXL|rcsb pdb:5EXM|rcsb pdb:5EXN|rcsb pdb:5I25|rcsb pdb:5Q0D|rcsb pdb:5Q0E|rcsb pdb:5Q0F|rcsb pdb:5Q0G|rcsb pdb:5Q0H|rcsb pdb:4CR5|rcsb pdb:5QCK|rcsb pdb:5QCL|rcsb pdb:5QCM|rcsb pdb:5QCN|rcsb pdb:5QQO|rcsb pdb:5QQP|rcsb pdb:5QTV|rcsb pdb:5QTW|rcsb pdb:5QTY|rcsb pdb:5TKS|rcsb pdb:5TKT|rcsb pdb:5TKU|rcsb pdb:5WB6|rcsb pdb:6AOD|rcsb pdb:6C0S|rcsb pdb:6HHC|rcsb pdb:6I58|rcsb pdb:6R8X|rcsb pdb:6TS4|rcsb pdb:6TS5|rcsb pdb:6TS6|rcsb pdb:6TS7|rcsb pdb:6TWB|rcsb pdb:6USY|rcsb pdb:6VLU|rcsb pdb:6VLV|rcsb pdb:6W50|reactome:R-HSA-140837|reactome:R-HSA-9673221|rcsb pdb:5QTT|dip:DIP-29085N	-	-	-	assembly:tetrameric, multimeric|3d-r-factors:working 77.500%, free 71.600%|3d-resolution:2.6A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:ZzO2zrHSsO5iH2kANpN5qFp+S8w83333	rogid:wWSTChOgzznzQ19l1hkxEVMun1g9606	intact-crc:1E109FB17D55D2C2|rigid:Y9rIN8Wwdu3ppIqMQ5WfPEw4K7M	false	sufficient binding region:21-162	sufficient binding region:388-625	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)