#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P09527 uniprotkb:P37727 intact:EBI-916225|uniprotkb:Q4AEF6|ensembl:ENSRNOP00000016432 intact:EBI-1039231 psi-mi:rab7a_rat(display_long)|uniprotkb:Rab7a(gene name)|psi-mi:Rab7a(display_short)|uniprotkb:Ras-related protein p23(gene name synonym)|uniprotkb:Ras-related protein BRL-RAS(gene name synonym)|uniprotkb:Rab7(gene name synonym) psi-mi:rae1_rat(display_long)|uniprotkb:Chm(gene name)|psi-mi:Chm(display_short)|uniprotkb:Rep1(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:Choroideremia protein homolog(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Rak et al. (2004) pubmed:15186776 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1039245|rcsb pdb:1VG0 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:61908|refseq:NP_076440.1|ensembl:ENSRNOG00000012247(gene)|ensembl:ENSRNOT00000016432(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007174"(epidermal growth factor catabolic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019003"(GDP binding)|go:"GO:0019076"(viral release from host cell)|go:"GO:0022615"(protein to membrane docking)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032419"(extrinsic component of lysosome membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043195"(terminal bouton)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045453"(bone resorption)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0061724"(lipophagy)|go:"GO:0090383"(phagosome acidification)|go:"GO:0090385"(phagosome-lysosome fusion)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0099638"(endosome to plasma membrane protein transport)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1905394"(retromer complex binding)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P09527|rcsb pdb:1VG0|rcsb pdb:1VG1|rcsb pdb:1VG8|rcsb pdb:1VG9|reactome:R-RNO-2132295|reactome:R-RNO-6798695|reactome:R-RNO-8854214|reactome:R-RNO-8873719|reactome:R-RNO-8876198|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013405|reactome:R-RNO-9013406|reactome:R-RNO-9013407|reactome:R-RNO-9013408|reactome:R-RNO-9013423|reactome:R-RNO-9035034|refseq:XP_006236911.1 rgd:2340|refseq:NP_058763.1|interpro:IPR018203|interpro:IPR001738("Rab escort (choroideraemia) protein")|rcsb pdb:1LTX|rcsb pdb:1VG0|rcsb pdb:1VG9|go:"GO:0031267"(small GTPase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0001568"(blood vessel development)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0018344"(protein geranylgeranylation)|interpro:IPR036188|reactome:R-RNO-6803205|reactome:R-RNO-8873719|reactome:R-RNO-8876198 - - - assembly:dimeric, multimeric|3d-r-factors:working 81.200%, free 76.700%|3d-resolution:2.2A|dataset:PDBe - Data obtained from the Protein Data Bank Europe taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/09/20 2014/10/16 rogid:lppyS2rWzk4Iax3nOHVdHiA0ceg10116 rogid:GOfi8UJB/2hh/tw6rYSzWQ2qAyQ10116 intact-crc:842B6135A0EC8A40|rigid:8zhpE5cZylne2y12RABZF34UsnI false sufficient binding region:1-207 sufficient binding region:1-650 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P09527 uniprotkb:P37727 intact:EBI-916225|uniprotkb:Q4AEF6|ensembl:ENSRNOP00000016432 intact:EBI-1039231 psi-mi:rab7a_rat(display_long)|uniprotkb:Rab7a(gene name)|psi-mi:Rab7a(display_short)|uniprotkb:Ras-related protein p23(gene name synonym)|uniprotkb:Ras-related protein BRL-RAS(gene name synonym)|uniprotkb:Rab7(gene name synonym) psi-mi:rae1_rat(display_long)|uniprotkb:Chm(gene name)|psi-mi:Chm(display_short)|uniprotkb:Rep1(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:Choroideremia protein homolog(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Rak et al. (2004) pubmed:15186776 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1039256|rcsb pdb:1VG9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:61908|refseq:NP_076440.1|ensembl:ENSRNOG00000012247(gene)|ensembl:ENSRNOT00000016432(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007174"(epidermal growth factor catabolic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019003"(GDP binding)|go:"GO:0019076"(viral release from host cell)|go:"GO:0022615"(protein to membrane docking)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032419"(extrinsic component of lysosome membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043195"(terminal bouton)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045453"(bone resorption)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0061724"(lipophagy)|go:"GO:0090383"(phagosome acidification)|go:"GO:0090385"(phagosome-lysosome fusion)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0099638"(endosome to plasma membrane protein transport)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1905394"(retromer complex binding)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P09527|rcsb pdb:1VG0|rcsb pdb:1VG1|rcsb pdb:1VG8|rcsb pdb:1VG9|reactome:R-RNO-2132295|reactome:R-RNO-6798695|reactome:R-RNO-8854214|reactome:R-RNO-8873719|reactome:R-RNO-8876198|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013405|reactome:R-RNO-9013406|reactome:R-RNO-9013407|reactome:R-RNO-9013408|reactome:R-RNO-9013423|reactome:R-RNO-9035034|refseq:XP_006236911.1 rgd:2340|refseq:NP_058763.1|interpro:IPR018203|interpro:IPR001738("Rab escort (choroideraemia) protein")|rcsb pdb:1LTX|rcsb pdb:1VG0|rcsb pdb:1VG9|go:"GO:0031267"(small GTPase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0001568"(blood vessel development)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0018344"(protein geranylgeranylation)|interpro:IPR036188|reactome:R-RNO-6803205|reactome:R-RNO-8873719|reactome:R-RNO-8876198 - - - assembly:tetrameric, multimeric|3d-r-factors:working 79.400%, free 75.00%|3d-resolution:2.5A|dataset:PDBe - Data obtained from the Protein Data Bank Europe taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/09/20 2014/10/16 rogid:lppyS2rWzk4Iax3nOHVdHiA0ceg10116 rogid:GOfi8UJB/2hh/tw6rYSzWQ2qAyQ10116 intact-crc:00A8EDEF38AA8A57|rigid:8zhpE5cZylne2y12RABZF34UsnI false sufficient binding region:1-185 sufficient binding region:1-650 4 4 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)