#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03120	uniprotkb:P17676	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-969696|intact:EBI-28973829|ensembl:ENSP00000305422|uniprotkb:Q96IH2|uniprotkb:Q9H4Z5|uniprotkb:A8K671	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpb_human(display_long)|uniprotkb:CEBPB(gene name)|psi-mi:CEBPB(display_short)|uniprotkb:TCF5(gene name synonym)|uniprotkb:PP9092(orf name)|uniprotkb:Liver activator protein(gene name synonym)|uniprotkb:Nuclear factor NF-IL6(gene name synonym)|uniprotkb:Transcription factor 5(gene name synonym)|uniprotkb:Liver-enriched inhibitory protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632590|mint:MINT-73546	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7|mint:MINT-732664(identity)	refseq:NP_001272807.1|refseq:NP_001272808.1|ensembl:ENSG00000172216(gene)|ensembl:ENST00000303004(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002432"(granuloma formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006953"(acute-phase response)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007613"(memory)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019900"(kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901329"(regulation of odontoblast differentiation)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P17676|rcsb pdb:1GTW|rcsb pdb:1GU4|rcsb pdb:1GU5|rcsb pdb:1H88|rcsb pdb:1H89|rcsb pdb:1H8A|rcsb pdb:1HJB|rcsb pdb:1IO4|rcsb pdb:2E42|rcsb pdb:2E43|rcsb pdb:6MG1|rcsb pdb:6MG2|rcsb pdb:6MG3|reactome:R-HSA-2559582|reactome:R-HSA-380994|reactome:R-HSA-381340|reactome:R-HSA-8853884|reactome:R-HSA-9616222|reactome:R-HSA-9633012|reactome:R-HSA-9648895|ensembl:ENSP00000305422|refseq:NP_005185.2|dip:DIP-35345N|mint:MINT-732671(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/13	2014/10/16	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:RZKdnZRt48VZoER/NDVHSDFzqEA9606	intact-crc:88648A18A8287B13|rigid:8n6UxqzmZrvPcc+ozv37EQNUar4	false	glutathione s tranferase tag:?-?(MINT-732665)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P03120	uniprotkb:P49715	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-1172054|uniprotkb:A7LNP2|uniprotkb:Q05CA4|uniprotkb:P78319|ensembl:ENSP00000427514	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpa_human(display_long)|uniprotkb:CEBPA(gene name)|psi-mi:CEBPA(display_short)|uniprotkb:CEBP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632605|mint:MINT-73548	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7|mint:MINT-732709(identity)	ensembl:ENSG00000245848(gene)|ensembl:ENST00000498907(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001163"(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048469"(cell maturation)|go:"GO:0048839"(inner ear development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P49715|rcsb pdb:6DC0|reactome:R-HSA-381340|reactome:R-HSA-9616222|refseq:NP_004355.2|refseq:NP_001272758.1|refseq:NP_001274353.1|refseq:NP_001274364.1|dip:DIP-37882N|mint:MINT-732716(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/13	2014/10/16	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:uo2VMV1hbdAvsRxr6yU2EVW11nY9606	intact-crc:183576C792D10CBF|rigid:IwElSIlboeNbAHyYpLw60DWnA6g	false	glutathione s tranferase tag:?-?(MINT-732710)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P06422	uniprotkb:P49715	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-1172054|uniprotkb:A7LNP2|uniprotkb:Q05CA4|uniprotkb:P78319|ensembl:ENSP00000427514	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpa_human(display_long)|uniprotkb:CEBPA(gene name)|psi-mi:CEBPA(display_short)|uniprotkb:CEBP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632620|mint:MINT-73549	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|mint:MINT-732694(identity)	ensembl:ENSG00000245848(gene)|ensembl:ENST00000498907(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001163"(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048469"(cell maturation)|go:"GO:0048839"(inner ear development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P49715|rcsb pdb:6DC0|reactome:R-HSA-381340|reactome:R-HSA-9616222|refseq:NP_004355.2|refseq:NP_001272758.1|refseq:NP_001274353.1|refseq:NP_001274364.1|dip:DIP-37882N|mint:MINT-732701(identity)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/13	2014/10/16	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:uo2VMV1hbdAvsRxr6yU2EVW11nY9606	intact-crc:5F5E27BE34FC6DC1|rigid:M5CdcQzKFp12nBFSJQ3TMXckjmU	false	glutathione s tranferase tag:?-?(MINT-732695)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P06422	uniprotkb:P17676	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-969696|intact:EBI-28973829|ensembl:ENSP00000305422|uniprotkb:Q96IH2|uniprotkb:Q9H4Z5|uniprotkb:A8K671	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpb_human(display_long)|uniprotkb:CEBPB(gene name)|psi-mi:CEBPB(display_short)|uniprotkb:TCF5(gene name synonym)|uniprotkb:PP9092(orf name)|uniprotkb:Liver activator protein(gene name synonym)|uniprotkb:Nuclear factor NF-IL6(gene name synonym)|uniprotkb:Transcription factor 5(gene name synonym)|uniprotkb:Liver-enriched inhibitory protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632635|mint:MINT-73550	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|mint:MINT-732904(identity)	refseq:NP_001272807.1|refseq:NP_001272808.1|ensembl:ENSG00000172216(gene)|ensembl:ENST00000303004(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002432"(granuloma formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006953"(acute-phase response)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007613"(memory)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019900"(kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901329"(regulation of odontoblast differentiation)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P17676|rcsb pdb:1GTW|rcsb pdb:1GU4|rcsb pdb:1GU5|rcsb pdb:1H88|rcsb pdb:1H89|rcsb pdb:1H8A|rcsb pdb:1HJB|rcsb pdb:1IO4|rcsb pdb:2E42|rcsb pdb:2E43|rcsb pdb:6MG1|rcsb pdb:6MG2|rcsb pdb:6MG3|reactome:R-HSA-2559582|reactome:R-HSA-380994|reactome:R-HSA-381340|reactome:R-HSA-8853884|reactome:R-HSA-9616222|reactome:R-HSA-9633012|reactome:R-HSA-9648895|ensembl:ENSP00000305422|refseq:NP_005185.2|dip:DIP-35345N|mint:MINT-732911(identity)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/13	2014/10/16	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:RZKdnZRt48VZoER/NDVHSDFzqEA9606	intact-crc:C77AD1975C695193|rigid:QDMWjyUCM8SxmdLMVgghr88Lc2U	false	glutathione s tranferase tag:?-?(MINT-732905)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P03122	uniprotkb:P17676	intact:EBI-7028618|uniprotkb:Q9WMH0|intact:MINT-95676	intact:EBI-969696|intact:EBI-28973829|ensembl:ENSP00000305422|uniprotkb:Q96IH2|uniprotkb:Q9H4Z5|uniprotkb:A8K671	psi-mi:ve2_bpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpb_human(display_long)|uniprotkb:CEBPB(gene name)|psi-mi:CEBPB(display_short)|uniprotkb:TCF5(gene name synonym)|uniprotkb:PP9092(orf name)|uniprotkb:Liver activator protein(gene name synonym)|uniprotkb:Nuclear factor NF-IL6(gene name synonym)|uniprotkb:Transcription factor 5(gene name synonym)|uniprotkb:Liver-enriched inhibitory protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632650|mint:MINT-73552	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056740.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042504|rcsb pdb:1DBD|rcsb pdb:1JJH|rcsb pdb:2BOP|rcsb pdb:2JEU|rcsb pdb:2JEX|rcsb pdb:6BUS|interpro:IPR042503|dip:DIP-40866N|mint:MINT-732889(identity)	refseq:NP_001272807.1|refseq:NP_001272808.1|ensembl:ENSG00000172216(gene)|ensembl:ENST00000303004(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002432"(granuloma formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006953"(acute-phase response)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007613"(memory)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019900"(kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901329"(regulation of odontoblast differentiation)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P17676|rcsb pdb:1GTW|rcsb pdb:1GU4|rcsb pdb:1GU5|rcsb pdb:1H88|rcsb pdb:1H89|rcsb pdb:1H8A|rcsb pdb:1HJB|rcsb pdb:1IO4|rcsb pdb:2E42|rcsb pdb:2E43|rcsb pdb:6MG1|rcsb pdb:6MG2|rcsb pdb:6MG3|reactome:R-HSA-2559582|reactome:R-HSA-380994|reactome:R-HSA-381340|reactome:R-HSA-8853884|reactome:R-HSA-9616222|reactome:R-HSA-9633012|reactome:R-HSA-9648895|ensembl:ENSP00000305422|refseq:NP_005185.2|dip:DIP-35345N|mint:MINT-732896(identity)	-	comment:mint|function:"E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/13	2014/10/16	rogid:q+tFpuRXU8hhZnmVO8ZNtF5YS5o337052	rogid:RZKdnZRt48VZoER/NDVHSDFzqEA9606	intact-crc:7254CAC20E03FB0E|rigid:mwM1ltgno5qC3JWLwFTg9il9+yY	false	glutathione s tranferase tag:?-?(MINT-732890)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P03122	uniprotkb:P49715	intact:EBI-7028618|uniprotkb:Q9WMH0|intact:MINT-95676	intact:EBI-1172054|uniprotkb:A7LNP2|uniprotkb:Q05CA4|uniprotkb:P78319|ensembl:ENSP00000427514	psi-mi:ve2_bpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpa_human(display_long)|uniprotkb:CEBPA(gene name)|psi-mi:CEBPA(display_short)|uniprotkb:CEBP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632665|mint:MINT-73553	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056740.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042504|rcsb pdb:1DBD|rcsb pdb:1JJH|rcsb pdb:2BOP|rcsb pdb:2JEU|rcsb pdb:2JEX|rcsb pdb:6BUS|interpro:IPR042503|dip:DIP-40866N|mint:MINT-732679(identity)	ensembl:ENSG00000245848(gene)|ensembl:ENST00000498907(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001163"(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048469"(cell maturation)|go:"GO:0048839"(inner ear development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P49715|rcsb pdb:6DC0|reactome:R-HSA-381340|reactome:R-HSA-9616222|refseq:NP_004355.2|refseq:NP_001272758.1|refseq:NP_001274353.1|refseq:NP_001274364.1|dip:DIP-37882N|mint:MINT-732686(identity)	-	comment:mint|function:"E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/13	2014/10/16	rogid:q+tFpuRXU8hhZnmVO8ZNtF5YS5o337052	rogid:uo2VMV1hbdAvsRxr6yU2EVW11nY9606	intact-crc:8F351AE0C7E87EBE|rigid:hdQCPfOSGru0KJHBeLLXTPIDgk4	false	glutathione s tranferase tag:?-?(MINT-732680)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P06790	uniprotkb:P17676	intact:EBI-7010629|intact:MINT-95532	intact:EBI-969696|intact:EBI-28973829|ensembl:ENSP00000305422|uniprotkb:Q96IH2|uniprotkb:Q9H4Z5|uniprotkb:A8K671	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpb_human(display_long)|uniprotkb:CEBPB(gene name)|psi-mi:CEBPB(display_short)|uniprotkb:TCF5(gene name synonym)|uniprotkb:PP9092(orf name)|uniprotkb:Liver activator protein(gene name synonym)|uniprotkb:Nuclear factor NF-IL6(gene name synonym)|uniprotkb:Transcription factor 5(gene name synonym)|uniprotkb:Liver-enriched inhibitory protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632701|mint:MINT-73556	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-732787(identity)	refseq:NP_001272807.1|refseq:NP_001272808.1|ensembl:ENSG00000172216(gene)|ensembl:ENST00000303004(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002432"(granuloma formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006953"(acute-phase response)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007613"(memory)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019900"(kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901329"(regulation of odontoblast differentiation)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P17676|rcsb pdb:1GTW|rcsb pdb:1GU4|rcsb pdb:1GU5|rcsb pdb:1H88|rcsb pdb:1H89|rcsb pdb:1H8A|rcsb pdb:1HJB|rcsb pdb:1IO4|rcsb pdb:2E42|rcsb pdb:2E43|rcsb pdb:6MG1|rcsb pdb:6MG2|rcsb pdb:6MG3|reactome:R-HSA-2559582|reactome:R-HSA-380994|reactome:R-HSA-381340|reactome:R-HSA-8853884|reactome:R-HSA-9616222|reactome:R-HSA-9633012|reactome:R-HSA-9648895|ensembl:ENSP00000305422|refseq:NP_005185.2|dip:DIP-35345N|mint:MINT-732794(identity)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/13	2014/10/16	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:RZKdnZRt48VZoER/NDVHSDFzqEA9606	intact-crc:13261A6AF7D5B292|rigid:5maS7iHfSKKI3dn+5wFCW4psoEE	false	glutathione s tranferase tag:?-?(MINT-732788)	binding-associated region:199-345(MINT-732795)|his tag:?-?(MINT-732797)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P03120	uniprotkb:P17676	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-969696|intact:EBI-28973829|ensembl:ENSP00000305422|uniprotkb:Q96IH2|uniprotkb:Q9H4Z5|uniprotkb:A8K671	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpb_human(display_long)|uniprotkb:CEBPB(gene name)|psi-mi:CEBPB(display_short)|uniprotkb:TCF5(gene name synonym)|uniprotkb:PP9092(orf name)|uniprotkb:Liver activator protein(gene name synonym)|uniprotkb:Nuclear factor NF-IL6(gene name synonym)|uniprotkb:Transcription factor 5(gene name synonym)|uniprotkb:Liver-enriched inhibitory protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632722|mint:MINT-73557	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7|mint:MINT-732825(identity)	refseq:NP_001272807.1|refseq:NP_001272808.1|ensembl:ENSG00000172216(gene)|ensembl:ENST00000303004(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002432"(granuloma formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006953"(acute-phase response)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007613"(memory)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019900"(kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901329"(regulation of odontoblast differentiation)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P17676|rcsb pdb:1GTW|rcsb pdb:1GU4|rcsb pdb:1GU5|rcsb pdb:1H88|rcsb pdb:1H89|rcsb pdb:1H8A|rcsb pdb:1HJB|rcsb pdb:1IO4|rcsb pdb:2E42|rcsb pdb:2E43|rcsb pdb:6MG1|rcsb pdb:6MG2|rcsb pdb:6MG3|reactome:R-HSA-2559582|reactome:R-HSA-380994|reactome:R-HSA-381340|reactome:R-HSA-8853884|reactome:R-HSA-9616222|reactome:R-HSA-9633012|reactome:R-HSA-9648895|ensembl:ENSP00000305422|refseq:NP_005185.2|dip:DIP-35345N|mint:MINT-732832(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/13	2014/10/16	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:RZKdnZRt48VZoER/NDVHSDFzqEA9606	intact-crc:56D784CAC912F7F9|rigid:8n6UxqzmZrvPcc+ozv37EQNUar4	false	glutathione s tranferase tag:?-?(MINT-732826)	binding-associated region:199-345(MINT-732833)|his tag:?-?(MINT-732835)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P03122	uniprotkb:P17676	intact:EBI-7028618|uniprotkb:Q9WMH0|intact:MINT-95676	intact:EBI-969696|intact:EBI-28973829|ensembl:ENSP00000305422|uniprotkb:Q96IH2|uniprotkb:Q9H4Z5|uniprotkb:A8K671	psi-mi:ve2_bpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpb_human(display_long)|uniprotkb:CEBPB(gene name)|psi-mi:CEBPB(display_short)|uniprotkb:TCF5(gene name synonym)|uniprotkb:PP9092(orf name)|uniprotkb:Liver activator protein(gene name synonym)|uniprotkb:Nuclear factor NF-IL6(gene name synonym)|uniprotkb:Transcription factor 5(gene name synonym)|uniprotkb:Liver-enriched inhibitory protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632680|mint:MINT-73554	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056740.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042504|rcsb pdb:1DBD|rcsb pdb:1JJH|rcsb pdb:2BOP|rcsb pdb:2JEU|rcsb pdb:2JEX|rcsb pdb:6BUS|interpro:IPR042503|dip:DIP-40866N|mint:MINT-732806(identity)	refseq:NP_001272807.1|refseq:NP_001272808.1|ensembl:ENSG00000172216(gene)|ensembl:ENST00000303004(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002432"(granuloma formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006953"(acute-phase response)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007613"(memory)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019900"(kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901329"(regulation of odontoblast differentiation)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P17676|rcsb pdb:1GTW|rcsb pdb:1GU4|rcsb pdb:1GU5|rcsb pdb:1H88|rcsb pdb:1H89|rcsb pdb:1H8A|rcsb pdb:1HJB|rcsb pdb:1IO4|rcsb pdb:2E42|rcsb pdb:2E43|rcsb pdb:6MG1|rcsb pdb:6MG2|rcsb pdb:6MG3|reactome:R-HSA-2559582|reactome:R-HSA-380994|reactome:R-HSA-381340|reactome:R-HSA-8853884|reactome:R-HSA-9616222|reactome:R-HSA-9633012|reactome:R-HSA-9648895|ensembl:ENSP00000305422|refseq:NP_005185.2|dip:DIP-35345N|mint:MINT-732813(identity)	-	comment:mint|function:"E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/13	2014/10/16	rogid:q+tFpuRXU8hhZnmVO8ZNtF5YS5o337052	rogid:RZKdnZRt48VZoER/NDVHSDFzqEA9606	intact-crc:C1D7E8ED9C2B85F8|rigid:mwM1ltgno5qC3JWLwFTg9il9+yY	false	glutathione s tranferase tag:?-?(MINT-732807)	his tag:?-?(MINT-732816)|binding-associated region:199-345(MINT-732814)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P06790	uniprotkb:P17676	intact:EBI-7010629|intact:MINT-95532	intact:EBI-969696|intact:EBI-28973829|ensembl:ENSP00000305422|uniprotkb:Q96IH2|uniprotkb:Q9H4Z5|uniprotkb:A8K671	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpb_human(display_long)|uniprotkb:CEBPB(gene name)|psi-mi:CEBPB(display_short)|uniprotkb:TCF5(gene name synonym)|uniprotkb:PP9092(orf name)|uniprotkb:Liver activator protein(gene name synonym)|uniprotkb:Nuclear factor NF-IL6(gene name synonym)|uniprotkb:Transcription factor 5(gene name synonym)|uniprotkb:Liver-enriched inhibitory protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632764|mint:MINT-73560	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-732739(identity)	refseq:NP_001272807.1|refseq:NP_001272808.1|ensembl:ENSG00000172216(gene)|ensembl:ENST00000303004(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002432"(granuloma formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006953"(acute-phase response)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007613"(memory)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019900"(kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901329"(regulation of odontoblast differentiation)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P17676|rcsb pdb:1GTW|rcsb pdb:1GU4|rcsb pdb:1GU5|rcsb pdb:1H88|rcsb pdb:1H89|rcsb pdb:1H8A|rcsb pdb:1HJB|rcsb pdb:1IO4|rcsb pdb:2E42|rcsb pdb:2E43|rcsb pdb:6MG1|rcsb pdb:6MG2|rcsb pdb:6MG3|reactome:R-HSA-2559582|reactome:R-HSA-380994|reactome:R-HSA-381340|reactome:R-HSA-8853884|reactome:R-HSA-9616222|reactome:R-HSA-9633012|reactome:R-HSA-9648895|ensembl:ENSP00000305422|refseq:NP_005185.2|dip:DIP-35345N|mint:MINT-732746(identity)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:NFA|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/13	2014/10/16	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:RZKdnZRt48VZoER/NDVHSDFzqEA9606	intact-crc:EC2DAB247C2E1D1E|rigid:5maS7iHfSKKI3dn+5wFCW4psoEE	false	his tag:?-?(MINT-732740)	glutathione s tranferase tag:?-?(MINT-732747)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P06422	uniprotkb:P17676	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-969696|intact:EBI-28973829|ensembl:ENSP00000305422|uniprotkb:Q96IH2|uniprotkb:Q9H4Z5|uniprotkb:A8K671	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpb_human(display_long)|uniprotkb:CEBPB(gene name)|psi-mi:CEBPB(display_short)|uniprotkb:TCF5(gene name synonym)|uniprotkb:PP9092(orf name)|uniprotkb:Liver activator protein(gene name synonym)|uniprotkb:Nuclear factor NF-IL6(gene name synonym)|uniprotkb:Transcription factor 5(gene name synonym)|uniprotkb:Liver-enriched inhibitory protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632743|mint:MINT-73558	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|mint:MINT-732919(identity)	refseq:NP_001272807.1|refseq:NP_001272808.1|ensembl:ENSG00000172216(gene)|ensembl:ENST00000303004(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002432"(granuloma formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006953"(acute-phase response)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007613"(memory)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019900"(kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901329"(regulation of odontoblast differentiation)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P17676|rcsb pdb:1GTW|rcsb pdb:1GU4|rcsb pdb:1GU5|rcsb pdb:1H88|rcsb pdb:1H89|rcsb pdb:1H8A|rcsb pdb:1HJB|rcsb pdb:1IO4|rcsb pdb:2E42|rcsb pdb:2E43|rcsb pdb:6MG1|rcsb pdb:6MG2|rcsb pdb:6MG3|reactome:R-HSA-2559582|reactome:R-HSA-380994|reactome:R-HSA-381340|reactome:R-HSA-8853884|reactome:R-HSA-9616222|reactome:R-HSA-9633012|reactome:R-HSA-9648895|ensembl:ENSP00000305422|refseq:NP_005185.2|dip:DIP-35345N|mint:MINT-732928(identity)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3B F5B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/13	2014/10/16	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:RZKdnZRt48VZoER/NDVHSDFzqEA9606	intact-crc:A4A6427BBF720223|rigid:QDMWjyUCM8SxmdLMVgghr88Lc2U	false	glutathione s tranferase tag:?-?(MINT-732922)|binding-associated region:410-498(MINT-732920)	binding-associated region:199-345(MINT-732929)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P06422	uniprotkb:P17676	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-969696|intact:EBI-28973829|ensembl:ENSP00000305422|uniprotkb:Q96IH2|uniprotkb:Q9H4Z5|uniprotkb:A8K671	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpb_human(display_long)|uniprotkb:CEBPB(gene name)|psi-mi:CEBPB(display_short)|uniprotkb:TCF5(gene name synonym)|uniprotkb:PP9092(orf name)|uniprotkb:Liver activator protein(gene name synonym)|uniprotkb:Nuclear factor NF-IL6(gene name synonym)|uniprotkb:Transcription factor 5(gene name synonym)|uniprotkb:Liver-enriched inhibitory protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632805|mint:MINT-73563	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|mint:MINT-732624(identity)	refseq:NP_001272807.1|refseq:NP_001272808.1|ensembl:ENSG00000172216(gene)|ensembl:ENST00000303004(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002432"(granuloma formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006953"(acute-phase response)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007613"(memory)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019900"(kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901329"(regulation of odontoblast differentiation)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P17676|rcsb pdb:1GTW|rcsb pdb:1GU4|rcsb pdb:1GU5|rcsb pdb:1H88|rcsb pdb:1H89|rcsb pdb:1H8A|rcsb pdb:1HJB|rcsb pdb:1IO4|rcsb pdb:2E42|rcsb pdb:2E43|rcsb pdb:6MG1|rcsb pdb:6MG2|rcsb pdb:6MG3|reactome:R-HSA-2559582|reactome:R-HSA-380994|reactome:R-HSA-381340|reactome:R-HSA-8853884|reactome:R-HSA-9616222|reactome:R-HSA-9633012|reactome:R-HSA-9648895|ensembl:ENSP00000305422|refseq:NP_005185.2|dip:DIP-35345N|mint:MINT-732629(identity)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/13	2014/10/16	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:RZKdnZRt48VZoER/NDVHSDFzqEA9606	intact-crc:908DE26BBAC44DF3|rigid:QDMWjyUCM8SxmdLMVgghr88Lc2U	false	-	glutathione s tranferase tag:?-?(MINT-732635)|binding-associated region:261-302(MINT-732630)|mutation decreasing interaction:200-260,303-345(MINT-732632)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P06790	uniprotkb:P17676	intact:EBI-7010629|intact:MINT-95532	intact:EBI-969696|intact:EBI-28973829|ensembl:ENSP00000305422|uniprotkb:Q96IH2|uniprotkb:Q9H4Z5|uniprotkb:A8K671	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpb_human(display_long)|uniprotkb:CEBPB(gene name)|psi-mi:CEBPB(display_short)|uniprotkb:TCF5(gene name synonym)|uniprotkb:PP9092(orf name)|uniprotkb:Liver activator protein(gene name synonym)|uniprotkb:Nuclear factor NF-IL6(gene name synonym)|uniprotkb:Transcription factor 5(gene name synonym)|uniprotkb:Liver-enriched inhibitory protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632783|mint:MINT-73562	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-732644(identity)	refseq:NP_001272807.1|refseq:NP_001272808.1|ensembl:ENSG00000172216(gene)|ensembl:ENST00000303004(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002432"(granuloma formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006953"(acute-phase response)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007613"(memory)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019900"(kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901329"(regulation of odontoblast differentiation)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P17676|rcsb pdb:1GTW|rcsb pdb:1GU4|rcsb pdb:1GU5|rcsb pdb:1H88|rcsb pdb:1H89|rcsb pdb:1H8A|rcsb pdb:1HJB|rcsb pdb:1IO4|rcsb pdb:2E42|rcsb pdb:2E43|rcsb pdb:6MG1|rcsb pdb:6MG2|rcsb pdb:6MG3|reactome:R-HSA-2559582|reactome:R-HSA-380994|reactome:R-HSA-381340|reactome:R-HSA-8853884|reactome:R-HSA-9616222|reactome:R-HSA-9633012|reactome:R-HSA-9648895|ensembl:ENSP00000305422|refseq:NP_005185.2|dip:DIP-35345N|mint:MINT-732649(identity)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/13	2014/10/16	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:RZKdnZRt48VZoER/NDVHSDFzqEA9606	intact-crc:76F68CE8E886E77A|rigid:5maS7iHfSKKI3dn+5wFCW4psoEE	false	-	mutation decreasing interaction:303-345,200-260(MINT-732652)|binding-associated region:261-302(MINT-732650)|glutathione s tranferase tag:?-?(MINT-732655)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P03122	uniprotkb:P17676	intact:EBI-7028618|uniprotkb:Q9WMH0|intact:MINT-95676	intact:EBI-969696|intact:EBI-28973829|ensembl:ENSP00000305422|uniprotkb:Q96IH2|uniprotkb:Q9H4Z5|uniprotkb:A8K671	psi-mi:ve2_bpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpb_human(display_long)|uniprotkb:CEBPB(gene name)|psi-mi:CEBPB(display_short)|uniprotkb:TCF5(gene name synonym)|uniprotkb:PP9092(orf name)|uniprotkb:Liver activator protein(gene name synonym)|uniprotkb:Nuclear factor NF-IL6(gene name synonym)|uniprotkb:Transcription factor 5(gene name synonym)|uniprotkb:Liver-enriched inhibitory protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632827|mint:MINT-73564	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056740.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042504|rcsb pdb:1DBD|rcsb pdb:1JJH|rcsb pdb:2BOP|rcsb pdb:2JEU|rcsb pdb:2JEX|rcsb pdb:6BUS|interpro:IPR042503|dip:DIP-40866N|mint:MINT-732604(identity)	refseq:NP_001272807.1|refseq:NP_001272808.1|ensembl:ENSG00000172216(gene)|ensembl:ENST00000303004(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002432"(granuloma formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006953"(acute-phase response)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007613"(memory)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019900"(kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901329"(regulation of odontoblast differentiation)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P17676|rcsb pdb:1GTW|rcsb pdb:1GU4|rcsb pdb:1GU5|rcsb pdb:1H88|rcsb pdb:1H89|rcsb pdb:1H8A|rcsb pdb:1HJB|rcsb pdb:1IO4|rcsb pdb:2E42|rcsb pdb:2E43|rcsb pdb:6MG1|rcsb pdb:6MG2|rcsb pdb:6MG3|reactome:R-HSA-2559582|reactome:R-HSA-380994|reactome:R-HSA-381340|reactome:R-HSA-8853884|reactome:R-HSA-9616222|reactome:R-HSA-9633012|reactome:R-HSA-9648895|ensembl:ENSP00000305422|refseq:NP_005185.2|dip:DIP-35345N|mint:MINT-732609(identity)	-	comment:mint|function:"E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/13	2014/10/16	rogid:q+tFpuRXU8hhZnmVO8ZNtF5YS5o337052	rogid:RZKdnZRt48VZoER/NDVHSDFzqEA9606	intact-crc:43F5BC2E5166451F|rigid:mwM1ltgno5qC3JWLwFTg9il9+yY	false	-	glutathione s tranferase tag:?-?(MINT-732615)|mutation decreasing interaction:303-345,200-260(MINT-732612)|binding-associated region:261-302(MINT-732610)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P03122	uniprotkb:P49715	intact:EBI-7028618|uniprotkb:Q9WMH0|intact:MINT-95676	intact:EBI-1172054|uniprotkb:A7LNP2|uniprotkb:Q05CA4|uniprotkb:P78319|ensembl:ENSP00000427514	psi-mi:ve2_bpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpa_human(display_long)|uniprotkb:CEBPA(gene name)|psi-mi:CEBPA(display_short)|uniprotkb:CEBP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632849|mint:MINT-73565	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056740.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042504|rcsb pdb:1DBD|rcsb pdb:1JJH|rcsb pdb:2BOP|rcsb pdb:2JEU|rcsb pdb:2JEX|rcsb pdb:6BUS|interpro:IPR042503|dip:DIP-40866N|mint:MINT-732874(identity)	ensembl:ENSG00000245848(gene)|ensembl:ENST00000498907(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001163"(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048469"(cell maturation)|go:"GO:0048839"(inner ear development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P49715|rcsb pdb:6DC0|reactome:R-HSA-381340|reactome:R-HSA-9616222|refseq:NP_004355.2|refseq:NP_001272758.1|refseq:NP_001274353.1|refseq:NP_001274364.1|dip:DIP-37882N|mint:MINT-732879(identity)	-	comment:mint|function:"E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/13	2014/10/16	rogid:q+tFpuRXU8hhZnmVO8ZNtF5YS5o337052	rogid:uo2VMV1hbdAvsRxr6yU2EVW11nY9606	intact-crc:32E6E516902C6554|rigid:hdQCPfOSGru0KJHBeLLXTPIDgk4	false	-	glutathione s tranferase tag:?-?(MINT-732880)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P06790	uniprotkb:P49715	intact:EBI-7010629|intact:MINT-95532	intact:EBI-1172054|uniprotkb:A7LNP2|uniprotkb:Q05CA4|uniprotkb:P78319|ensembl:ENSP00000427514	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpa_human(display_long)|uniprotkb:CEBPA(gene name)|psi-mi:CEBPA(display_short)|uniprotkb:CEBP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632864|mint:MINT-73566	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-732859(identity)	ensembl:ENSG00000245848(gene)|ensembl:ENST00000498907(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001163"(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048469"(cell maturation)|go:"GO:0048839"(inner ear development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P49715|rcsb pdb:6DC0|reactome:R-HSA-381340|reactome:R-HSA-9616222|refseq:NP_004355.2|refseq:NP_001272758.1|refseq:NP_001274353.1|refseq:NP_001274364.1|dip:DIP-37882N|mint:MINT-732864(identity)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/13	2014/10/16	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:uo2VMV1hbdAvsRxr6yU2EVW11nY9606	intact-crc:07E5D5D029CCC731|rigid:iOrxQejbes8gTVOPfJzxYFBsEkk	false	-	glutathione s tranferase tag:?-?(MINT-732865)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P06422	uniprotkb:P49715	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-1172054|uniprotkb:A7LNP2|uniprotkb:Q05CA4|uniprotkb:P78319|ensembl:ENSP00000427514	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpa_human(display_long)|uniprotkb:CEBPA(gene name)|psi-mi:CEBPA(display_short)|uniprotkb:CEBP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632879|mint:MINT-73567	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|mint:MINT-732844(identity)	ensembl:ENSG00000245848(gene)|ensembl:ENST00000498907(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001163"(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048469"(cell maturation)|go:"GO:0048839"(inner ear development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P49715|rcsb pdb:6DC0|reactome:R-HSA-381340|reactome:R-HSA-9616222|refseq:NP_004355.2|refseq:NP_001272758.1|refseq:NP_001274353.1|refseq:NP_001274364.1|dip:DIP-37882N|mint:MINT-732849(identity)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/13	2014/10/16	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:uo2VMV1hbdAvsRxr6yU2EVW11nY9606	intact-crc:F6B7B661CDA0570E|rigid:M5CdcQzKFp12nBFSJQ3TMXckjmU	false	-	glutathione s tranferase tag:?-?(MINT-732850)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P06422	uniprotkb:P49715	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-1172054|uniprotkb:A7LNP2|uniprotkb:Q05CA4|uniprotkb:P78319|ensembl:ENSP00000427514	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpa_human(display_long)|uniprotkb:CEBPA(gene name)|psi-mi:CEBPA(display_short)|uniprotkb:CEBP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632894|mint:MINT-73568	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|mint:MINT-732585(identity)	ensembl:ENSG00000245848(gene)|ensembl:ENST00000498907(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001163"(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048469"(cell maturation)|go:"GO:0048839"(inner ear development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P49715|rcsb pdb:6DC0|reactome:R-HSA-381340|reactome:R-HSA-9616222|refseq:NP_004355.2|refseq:NP_001272758.1|refseq:NP_001274353.1|refseq:NP_001274364.1|dip:DIP-37882N|mint:MINT-732596(identity)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/13	2014/10/16	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:uo2VMV1hbdAvsRxr6yU2EVW11nY9606	intact-crc:B55C3A395EEDBEEA|rigid:M5CdcQzKFp12nBFSJQ3TMXckjmU	false	mutation decreasing interaction:1-409(MINT-732588)|binding-associated region:410-498(MINT-732586)|glutathione s tranferase tag:?-?(MINT-732590)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P06422	uniprotkb:P17676	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-969696|intact:EBI-28973829|ensembl:ENSP00000305422|uniprotkb:Q96IH2|uniprotkb:Q9H4Z5|uniprotkb:A8K671	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpb_human(display_long)|uniprotkb:CEBPB(gene name)|psi-mi:CEBPB(display_short)|uniprotkb:TCF5(gene name synonym)|uniprotkb:PP9092(orf name)|uniprotkb:Liver activator protein(gene name synonym)|uniprotkb:Nuclear factor NF-IL6(gene name synonym)|uniprotkb:Transcription factor 5(gene name synonym)|uniprotkb:Liver-enriched inhibitory protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632938|mint:MINT-73570	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|mint:MINT-732726(identity)	refseq:NP_001272807.1|refseq:NP_001272808.1|ensembl:ENSG00000172216(gene)|ensembl:ENST00000303004(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002432"(granuloma formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006953"(acute-phase response)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007613"(memory)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019900"(kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901329"(regulation of odontoblast differentiation)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P17676|rcsb pdb:1GTW|rcsb pdb:1GU4|rcsb pdb:1GU5|rcsb pdb:1H88|rcsb pdb:1H89|rcsb pdb:1H8A|rcsb pdb:1HJB|rcsb pdb:1IO4|rcsb pdb:2E42|rcsb pdb:2E43|rcsb pdb:6MG1|rcsb pdb:6MG2|rcsb pdb:6MG3|reactome:R-HSA-2559582|reactome:R-HSA-380994|reactome:R-HSA-381340|reactome:R-HSA-8853884|reactome:R-HSA-9616222|reactome:R-HSA-9633012|reactome:R-HSA-9648895|ensembl:ENSP00000305422|refseq:NP_005185.2|dip:DIP-35345N|mint:MINT-732731(identity)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F6A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/01/13	2014/10/16	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:RZKdnZRt48VZoER/NDVHSDFzqEA9606	intact-crc:DAABA458B69CEC6F|rigid:QDMWjyUCM8SxmdLMVgghr88Lc2U	false	-	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06422	uniprotkb:P49715	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-1172054|uniprotkb:A7LNP2|uniprotkb:Q05CA4|uniprotkb:P78319|ensembl:ENSP00000427514	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpa_human(display_long)|uniprotkb:CEBPA(gene name)|psi-mi:CEBPA(display_short)|uniprotkb:CEBP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632923|mint:MINT-73569	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|mint:MINT-732772(identity)	ensembl:ENSG00000245848(gene)|ensembl:ENST00000498907(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001163"(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048469"(cell maturation)|go:"GO:0048839"(inner ear development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P49715|rcsb pdb:6DC0|reactome:R-HSA-381340|reactome:R-HSA-9616222|refseq:NP_004355.2|refseq:NP_001272758.1|refseq:NP_001274353.1|refseq:NP_001274364.1|dip:DIP-37882N|mint:MINT-732779(identity)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F6B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/01/13	2014/10/16	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:uo2VMV1hbdAvsRxr6yU2EVW11nY9606	intact-crc:90204FFFAC5970DD|rigid:M5CdcQzKFp12nBFSJQ3TMXckjmU	false	tag:?-?(MINT-732773)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06790	uniprotkb:P17676	intact:EBI-7010629|intact:MINT-95532	intact:EBI-969696|intact:EBI-28973829|ensembl:ENSP00000305422|uniprotkb:Q96IH2|uniprotkb:Q9H4Z5|uniprotkb:A8K671	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cebpb_human(display_long)|uniprotkb:CEBPB(gene name)|psi-mi:CEBPB(display_short)|uniprotkb:TCF5(gene name synonym)|uniprotkb:PP9092(orf name)|uniprotkb:Liver activator protein(gene name synonym)|uniprotkb:Nuclear factor NF-IL6(gene name synonym)|uniprotkb:Transcription factor 5(gene name synonym)|uniprotkb:Liver-enriched inhibitory protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hadaschik et al. (2003)	mint:MINT-5216320|pubmed:12692227|doi:10.1128/JVI.77.9.5253-5265.2003	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8632950|mint:MINT-73571	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-732757(identity)	refseq:NP_001272807.1|refseq:NP_001272808.1|ensembl:ENSG00000172216(gene)|ensembl:ENST00000303004(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002432"(granuloma formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006953"(acute-phase response)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007613"(memory)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019900"(kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901329"(regulation of odontoblast differentiation)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P17676|rcsb pdb:1GTW|rcsb pdb:1GU4|rcsb pdb:1GU5|rcsb pdb:1H88|rcsb pdb:1H89|rcsb pdb:1H8A|rcsb pdb:1HJB|rcsb pdb:1IO4|rcsb pdb:2E42|rcsb pdb:2E43|rcsb pdb:6MG1|rcsb pdb:6MG2|rcsb pdb:6MG3|reactome:R-HSA-2559582|reactome:R-HSA-380994|reactome:R-HSA-381340|reactome:R-HSA-8853884|reactome:R-HSA-9616222|reactome:R-HSA-9633012|reactome:R-HSA-9648895|ensembl:ENSP00000305422|refseq:NP_005185.2|dip:DIP-35345N|mint:MINT-732764(identity)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F6C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/01/13	2014/10/16	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:RZKdnZRt48VZoER/NDVHSDFzqEA9606	intact-crc:BAE9E523DF174880|rigid:5maS7iHfSKKI3dn+5wFCW4psoEE	false	tag:?-?(MINT-732758)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0113"(western blot)