#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P46676	uniprotkb:P53685	intact:EBI-18547|ensemblfungi:YDR310C|uniprotkb:D6VST9	intact:EBI-8691|ensemblfungi:YOL068C|uniprotkb:D6W1Z9	psi-mi:sum1_yeast(display_long)|uniprotkb:SUM1(gene name)|psi-mi:SUM1(display_short)|uniprotkb:D9740.19(orf name)|uniprotkb:YDR310C(locus name)	psi-mi:hst1_yeast(display_long)|uniprotkb:HST1(gene name)|psi-mi:HST1(display_short)|uniprotkb:Homologous to SIR2 protein 1(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym)|uniprotkb:YOL068C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	McCord et al. (2003)	pubmed:12612074|imex:IM-19441	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-974931|imex:IM-19441-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YDR310C(gene)|ensemblfungi:YDR310C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0110029"(negative regulation of meiosis I)|refseq:NP_010596.1|sgd:S000002718|dip:DIP-6438N|mint:P46676	ensemblfungi:YOL068C(gene)|ensemblfungi:YOL068C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016740"(transferase activity)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034967"(Set3 complex)|go:"GO:0045129"(NAD-independent histone deacetylase activity)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0046872"(metal ion binding)|go:"GO:0046970"("NAD-dependent histone deacetylase activity (H4-K16 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070623"(regulation of thiamine biosynthetic process)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR007654(Protein of unknown function DUF592)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|refseq:NP_014573.1|sgd:S000005429|mint:P53685|dip:DIP-6757N	go:"GO:0000118"(histone deacetylase complex)	crc64:08A43263CCCFC1C8	-	figure legend:7A|comment:The interaction needs the presence of the RFM1 protein|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/07/24	2014/10/16	rogid:lAnZogeAb+D8ZYMJkMK+nbEFChg559292	rogid:KPRr7a9MSyJPJH9Nh4Is0pcUm4Q559292	intact-crc:2EBEF6C2E62090A2|rigid:MxpCpXOPqZRfLA20vxWuNUSfQqE	false	myc tag:c-c	v5 tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P53685	uniprotkb:Q12192	intact:EBI-8691|ensemblfungi:YOL068C|uniprotkb:D6W1Z9	intact:EBI-15023|uniprotkb:D6W2X8|ensemblfungi:YOR279C	psi-mi:hst1_yeast(display_long)|uniprotkb:HST1(gene name)|psi-mi:HST1(display_short)|uniprotkb:Homologous to SIR2 protein 1(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym)|uniprotkb:YOL068C(locus name)	psi-mi:rfm1_yeast(display_long)|uniprotkb:RFM1(gene name)|psi-mi:RFM1(display_short)|uniprotkb:YOR279C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	McCord et al. (2003)	pubmed:12612074|imex:IM-19441	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-974943|imex:IM-19441-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YOL068C(gene)|ensemblfungi:YOL068C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016740"(transferase activity)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034967"(Set3 complex)|go:"GO:0045129"(NAD-independent histone deacetylase activity)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0046872"(metal ion binding)|go:"GO:0046970"("NAD-dependent histone deacetylase activity (H4-K16 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070623"(regulation of thiamine biosynthetic process)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR007654(Protein of unknown function DUF592)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|refseq:NP_014573.1|sgd:S000005429|mint:P53685|dip:DIP-6757N	sgd:S000005805|refseq:NP_014922.3|ensemblfungi:YOR279C(gene)|ensemblfungi:YOR279C_mRNA(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|dip:DIP-4430N|mint:Q12192	go:"GO:0000118"(histone deacetylase complex)	-	-	figure legend:7B|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/07/24	2014/10/16	rogid:KPRr7a9MSyJPJH9Nh4Is0pcUm4Q559292	rogid:mM9jPExNCEs4dCtJ+Zy9dswWB6Y559292	intact-crc:86D66436232CE5F2|rigid:TC55oSJ6GvKDx6HD0WMhh8Ic8UM	false	v5 tag:c-c	ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P46676	uniprotkb:Q12192	intact:EBI-18547|ensemblfungi:YDR310C|uniprotkb:D6VST9	intact:EBI-15023|uniprotkb:D6W2X8|ensemblfungi:YOR279C	psi-mi:sum1_yeast(display_long)|uniprotkb:SUM1(gene name)|psi-mi:SUM1(display_short)|uniprotkb:D9740.19(orf name)|uniprotkb:YDR310C(locus name)	psi-mi:rfm1_yeast(display_long)|uniprotkb:RFM1(gene name)|psi-mi:RFM1(display_short)|uniprotkb:YOR279C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	McCord et al. (2003)	pubmed:12612074|imex:IM-19441	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-974966|imex:IM-19441-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YDR310C(gene)|ensemblfungi:YDR310C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0110029"(negative regulation of meiosis I)|refseq:NP_010596.1|sgd:S000002718|dip:DIP-6438N|mint:P46676	sgd:S000005805|refseq:NP_014922.3|ensemblfungi:YOR279C(gene)|ensemblfungi:YOR279C_mRNA(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|dip:DIP-4430N|mint:Q12192	go:"GO:0000118"(histone deacetylase complex)	crc64:08A43263CCCFC1C8	-	figure legend:7C|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/07/24	2014/10/16	rogid:lAnZogeAb+D8ZYMJkMK+nbEFChg559292	rogid:mM9jPExNCEs4dCtJ+Zy9dswWB6Y559292	intact-crc:E3359D6450111312|rigid:vzdfCpFFtNnLBcKbjWlF/u6/RVo	false	myc tag:c-c	ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)