#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8VHY0 uniprotkb:Q925T6 intact:EBI-8327479|uniprotkb:Q8BPI8|uniprotkb:G5E892|intact:MINT-1787512|uniprotkb:Q5DTG1|uniprotkb:Q8CE79|ensembl:ENSMUSP00000038909 intact:EBI-537752|uniprotkb:Q8BLQ3|uniprotkb:Q8C0T3|uniprotkb:Q925T5|uniprotkb:Q925T7|ensembl:ENSMUSP00000123234 psi-mi:cspg4_mouse(display_long)|uniprotkb:Cspg4(gene name)|psi-mi:Cspg4(display_short)|uniprotkb:An2(gene name synonym)|uniprotkb:Kiaa4232(gene name synonym)|uniprotkb:Ng2(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan NG2(gene name synonym)|uniprotkb:Proteoglycan AN2(gene name synonym) psi-mi:grip1_mouse(display_long)|uniprotkb:Grip1(gene name)|psi-mi:Grip1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Stegmüller et al. (2003) mint:MINT-5215950|pubmed:12458226 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8567018|mint:MINT-1787720 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_620570.2|ensembl:ENSMUSG00000032911(gene)|ensembl:ENSMUST00000035661(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005518"(collagen binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097178"(ruffle assembly)|interpro:IPR001791(Laminin G)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR039005|mint:Q8VHY0|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|mint:MINT-1787732(identity) refseq:NP_001264224.1|refseq:NP_083012.1|refseq:NP_570961.1|refseq:NP_597699.1|refseq:NP_001264221.1|refseq:NP_001264223.1|ensembl:ENSMUSG00000034813(gene)|ensembl:ENSMUST00000138410(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030026|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|mint:Q925T6|rcsb pdb:1V5Q|reactome:R-MMU-416993|mint:MINT-1787721(identity) - comment:mint|function:"Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3C|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2006/03/20 2014/10/16 rogid:n54yGf7CRd/tmSmXWRBTfg/CML410090 rogid:nQDCS/yQb0DlZs+60Vf3Q3hbECk10090 intact-crc:36437910D6B66D42|rigid:5RlQSCEu67K4z9jml0l9wFdjMJc false - myc tag:?-?(MINT-1787730)|binding-associated region:926-1127(MINT-1787722) 1 1 psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8VHY0 uniprotkb:Q925T6 intact:EBI-8327479|uniprotkb:Q8BPI8|uniprotkb:G5E892|intact:MINT-1787512|uniprotkb:Q5DTG1|uniprotkb:Q8CE79|ensembl:ENSMUSP00000038909 intact:EBI-537752|uniprotkb:Q8BLQ3|uniprotkb:Q8C0T3|uniprotkb:Q925T5|uniprotkb:Q925T7|ensembl:ENSMUSP00000123234 psi-mi:cspg4_mouse(display_long)|uniprotkb:Cspg4(gene name)|psi-mi:Cspg4(display_short)|uniprotkb:An2(gene name synonym)|uniprotkb:Kiaa4232(gene name synonym)|uniprotkb:Ng2(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan NG2(gene name synonym)|uniprotkb:Proteoglycan AN2(gene name synonym) psi-mi:grip1_mouse(display_long)|uniprotkb:Grip1(gene name)|psi-mi:Grip1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Stegmüller et al. (2003) mint:MINT-5215950|pubmed:12458226 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8567085|mint:MINT-1787913 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_620570.2|ensembl:ENSMUSG00000032911(gene)|ensembl:ENSMUST00000035661(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005518"(collagen binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097178"(ruffle assembly)|interpro:IPR001791(Laminin G)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR039005|mint:Q8VHY0|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|mint:MINT-1787914(identity) refseq:NP_001264224.1|refseq:NP_083012.1|refseq:NP_570961.1|refseq:NP_597699.1|refseq:NP_001264221.1|refseq:NP_001264223.1|ensembl:ENSMUSG00000034813(gene)|ensembl:ENSMUST00000138410(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030026|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|mint:Q925T6|rcsb pdb:1V5Q|reactome:R-MMU-416993|mint:MINT-1787920(identity) - comment:mint|function:"Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F6B|comment:Only with co-overexpression of GluRb|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2006/03/20 2014/10/16 rogid:n54yGf7CRd/tmSmXWRBTfg/CML410090 rogid:nQDCS/yQb0DlZs+60Vf3Q3hbECk10090 intact-crc:C0A2D00AED5A7B91|rigid:5RlQSCEu67K4z9jml0l9wFdjMJc false - myc tag:n-n(MINT-1787926)|binding-associated region:577-1127(MINT-1787967) 1 1 psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8VHY0 uniprotkb:Q9WTW1 intact:EBI-8327479|uniprotkb:Q8BPI8|uniprotkb:G5E892|intact:MINT-1787512|uniprotkb:Q5DTG1|uniprotkb:Q8CE79|ensembl:ENSMUSP00000038909 intact:EBI-936045|uniprotkb:O88961|uniprotkb:Q9WU36|ensembl:ENSRNOP00000041016 psi-mi:cspg4_mouse(display_long)|uniprotkb:Cspg4(gene name)|psi-mi:Cspg4(display_short)|uniprotkb:An2(gene name synonym)|uniprotkb:Kiaa4232(gene name synonym)|uniprotkb:Ng2(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan NG2(gene name synonym)|uniprotkb:Proteoglycan AN2(gene name synonym) psi-mi:grip2_rat(display_long)|uniprotkb:Grip2(gene name)|psi-mi:Grip2(display_short)|uniprotkb:AMPA receptor-interacting protein GRIP2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Stegmüller et al. (2003) mint:MINT-5215950|pubmed:12458226 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8567052|mint:MINT-1787773 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_620570.2|ensembl:ENSMUSG00000032911(gene)|ensembl:ENSMUST00000035661(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005518"(collagen binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097178"(ruffle assembly)|interpro:IPR001791(Laminin G)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR039005|mint:Q8VHY0|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|mint:MINT-1787774(identity) refseq:NP_612544.2|rgd:621668|refseq:XP_006236957.1|ensembl:ENSRNOG00000009726(gene)|ensembl:ENSRNOT00000049657(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030029|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|reactome:R-RNO-416993|mint:MINT-1787780(identity) - comment:mint|function:"Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3C|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2006/03/20 2014/10/16 rogid:n54yGf7CRd/tmSmXWRBTfg/CML410090 rogid:g2rwY1rc9xxRnZblXFwGv4SQfZg10116 intact-crc:107F714F6FA43B90|rigid:+6EK1FzLCmuo2C4RWntv/BATN0k false - binding-associated region:917-1043(MINT-1787781)|myc tag:n-n(MINT-1787789) 1 1 psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q925T6 uniprotkb:P23819 intact:EBI-537752|uniprotkb:Q8BLQ3|uniprotkb:Q8C0T3|uniprotkb:Q925T5|uniprotkb:Q925T7|ensembl:ENSMUSP00000123234 intact:EBI-77538|uniprotkb:Q61604|uniprotkb:Q61605|uniprotkb:Q8BG69|uniprotkb:Q8BXU3|uniprotkb:Q9D6D3 psi-mi:grip1_mouse(display_long)|uniprotkb:Grip1(gene name)|psi-mi:Grip1(display_short) psi-mi:gria2_mouse(display_long)|uniprotkb:Gria2(gene name)|psi-mi:Gria2(display_short)|uniprotkb:Glur2(gene name synonym)|uniprotkb:GluR-B(gene name synonym)|uniprotkb:GluR-K2(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 2(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Stegmüller et al. (2003) mint:MINT-5215950|pubmed:12458226 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8567104|mint:MINT-1787929 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001264224.1|refseq:NP_083012.1|refseq:NP_570961.1|refseq:NP_597699.1|refseq:NP_001264221.1|refseq:NP_001264223.1|ensembl:ENSMUSG00000034813(gene)|ensembl:ENSMUST00000138410(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030026|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|mint:Q925T6|rcsb pdb:1V5Q|reactome:R-MMU-416993|mint:MINT-1787930(identity) go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051117"(ATPase binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|reactome:R-MMU-399710|reactome:R-MMU-416993|reactome:R-MMU-438066|go:"GO:0000149"(SNARE binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR028082|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|mint:P23819|mint:MINT-1787938(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F6B|comment:Only with co-overexpression of NG2|comment:homomint|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2006/03/20 2014/10/16 rogid:nQDCS/yQb0DlZs+60Vf3Q3hbECk10090 rogid:v71xzThz9kadLOPBasVAc1y/FXs10090 intact-crc:5C0EF20E152E6E74|rigid:sRoWVc/FXCQpyU8MWty3PtXmF38 false myc tag:n-n(MINT-1787936)|binding-associated region:577-1127(MINT-1787945) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q8VHY0 uniprotkb:Q925T6 intact:EBI-8327479|uniprotkb:Q8BPI8|uniprotkb:G5E892|intact:MINT-1787512|uniprotkb:Q5DTG1|uniprotkb:Q8CE79|ensembl:ENSMUSP00000038909 intact:EBI-537752|uniprotkb:Q8BLQ3|uniprotkb:Q8C0T3|uniprotkb:Q925T5|uniprotkb:Q925T7|ensembl:ENSMUSP00000123234 psi-mi:cspg4_mouse(display_long)|uniprotkb:Cspg4(gene name)|psi-mi:Cspg4(display_short)|uniprotkb:An2(gene name synonym)|uniprotkb:Kiaa4232(gene name synonym)|uniprotkb:Ng2(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan NG2(gene name synonym)|uniprotkb:Proteoglycan AN2(gene name synonym) psi-mi:grip1_mouse(display_long)|uniprotkb:Grip1(gene name)|psi-mi:Grip1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Stegmüller et al. (2003) mint:MINT-5215950|pubmed:12458226 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8567132|mint:MINT-1787836 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_620570.2|ensembl:ENSMUSG00000032911(gene)|ensembl:ENSMUST00000035661(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005518"(collagen binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097178"(ruffle assembly)|interpro:IPR001791(Laminin G)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR039005|mint:Q8VHY0|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|mint:MINT-1787837(identity) refseq:NP_001264224.1|refseq:NP_083012.1|refseq:NP_570961.1|refseq:NP_597699.1|refseq:NP_001264221.1|refseq:NP_001264223.1|ensembl:ENSMUSG00000034813(gene)|ensembl:ENSMUST00000138410(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030026|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|mint:Q925T6|rcsb pdb:1V5Q|reactome:R-MMU-416993|mint:MINT-1787843(identity) - comment:mint|function:"Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F6C|comment:mint taxid:10090(mouse-oligodendrocyt)|taxid:10090(Mus musculus) - 2006/03/20 2014/10/16 rogid:n54yGf7CRd/tmSmXWRBTfg/CML410090 rogid:nQDCS/yQb0DlZs+60Vf3Q3hbECk10090 intact-crc:056EDBCEB54B7E97|rigid:5RlQSCEu67K4z9jml0l9wFdjMJc false - - 1 1 psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:Q925T6 uniprotkb:P23819 intact:EBI-537752|uniprotkb:Q8BLQ3|uniprotkb:Q8C0T3|uniprotkb:Q925T5|uniprotkb:Q925T7|ensembl:ENSMUSP00000123234 intact:EBI-77538|uniprotkb:Q61604|uniprotkb:Q61605|uniprotkb:Q8BG69|uniprotkb:Q8BXU3|uniprotkb:Q9D6D3 psi-mi:grip1_mouse(display_long)|uniprotkb:Grip1(gene name)|psi-mi:Grip1(display_short) psi-mi:gria2_mouse(display_long)|uniprotkb:Gria2(gene name)|psi-mi:Gria2(display_short)|uniprotkb:Glur2(gene name synonym)|uniprotkb:GluR-B(gene name synonym)|uniprotkb:GluR-K2(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 2(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Stegmüller et al. (2003) mint:MINT-5215950|pubmed:12458226 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8567142|mint:MINT-1787859 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001264224.1|refseq:NP_083012.1|refseq:NP_570961.1|refseq:NP_597699.1|refseq:NP_001264221.1|refseq:NP_001264223.1|ensembl:ENSMUSG00000034813(gene)|ensembl:ENSMUST00000138410(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030026|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|mint:Q925T6|rcsb pdb:1V5Q|reactome:R-MMU-416993|mint:MINT-1787866(identity) go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051117"(ATPase binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|reactome:R-MMU-399710|reactome:R-MMU-416993|reactome:R-MMU-438066|go:"GO:0000149"(SNARE binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR028082|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|mint:P23819|mint:MINT-1787860(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F6C|comment:homomint|comment:mint taxid:10090(mouse-oligodendrocyt)|taxid:10090(Mus musculus) - 2006/03/20 2014/10/16 rogid:nQDCS/yQb0DlZs+60Vf3Q3hbECk10090 rogid:v71xzThz9kadLOPBasVAc1y/FXs10090 intact-crc:0C2CF74EA050494B|rigid:sRoWVc/FXCQpyU8MWty3PtXmF38 false - - 1 1 psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q8VHY0 uniprotkb:Q925T6 intact:EBI-8327479|uniprotkb:Q8BPI8|uniprotkb:G5E892|intact:MINT-1787512|uniprotkb:Q5DTG1|uniprotkb:Q8CE79|ensembl:ENSMUSP00000038909 intact:EBI-537752|uniprotkb:Q8BLQ3|uniprotkb:Q8C0T3|uniprotkb:Q925T5|uniprotkb:Q925T7|ensembl:ENSMUSP00000123234 psi-mi:cspg4_mouse(display_long)|uniprotkb:Cspg4(gene name)|psi-mi:Cspg4(display_short)|uniprotkb:An2(gene name synonym)|uniprotkb:Kiaa4232(gene name synonym)|uniprotkb:Ng2(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan NG2(gene name synonym)|uniprotkb:Proteoglycan AN2(gene name synonym) psi-mi:grip1_mouse(display_long)|uniprotkb:Grip1(gene name)|psi-mi:Grip1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Stegmüller et al. (2003) mint:MINT-5215950|pubmed:12458226 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8567161|mint:MINT-1787812 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_620570.2|ensembl:ENSMUSG00000032911(gene)|ensembl:ENSMUST00000035661(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005518"(collagen binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097178"(ruffle assembly)|interpro:IPR001791(Laminin G)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR039005|mint:Q8VHY0|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|mint:MINT-1787813(identity) refseq:NP_001264224.1|refseq:NP_083012.1|refseq:NP_570961.1|refseq:NP_597699.1|refseq:NP_001264221.1|refseq:NP_001264223.1|ensembl:ENSMUSG00000034813(gene)|ensembl:ENSMUST00000138410(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030026|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|mint:Q925T6|rcsb pdb:1V5Q|reactome:R-MMU-416993|mint:MINT-1787819(identity) - comment:mint|function:"Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3D|comment:mint taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2006/03/20 2014/10/16 rogid:n54yGf7CRd/tmSmXWRBTfg/CML410090 rogid:nQDCS/yQb0DlZs+60Vf3Q3hbECk10090 intact-crc:D304E1CD0E6A4B33|rigid:5RlQSCEu67K4z9jml0l9wFdjMJc false - - 1 1 psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:Q8VHY0 uniprotkb:Q925T6 intact:EBI-8327479|uniprotkb:Q8BPI8|uniprotkb:G5E892|intact:MINT-1787512|uniprotkb:Q5DTG1|uniprotkb:Q8CE79|ensembl:ENSMUSP00000038909 intact:EBI-537752|uniprotkb:Q8BLQ3|uniprotkb:Q8C0T3|uniprotkb:Q925T5|uniprotkb:Q925T7|ensembl:ENSMUSP00000123234 psi-mi:cspg4_mouse(display_long)|uniprotkb:Cspg4(gene name)|psi-mi:Cspg4(display_short)|uniprotkb:An2(gene name synonym)|uniprotkb:Kiaa4232(gene name synonym)|uniprotkb:Ng2(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan NG2(gene name synonym)|uniprotkb:Proteoglycan AN2(gene name synonym) psi-mi:grip1_mouse(display_long)|uniprotkb:Grip1(gene name)|psi-mi:Grip1(display_short) psi-mi:"MI:0398"(two hybrid pooling approach) Stegmüller et al. (2003) mint:MINT-5215950|pubmed:12458226 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8567179|mint:MINT-1787603 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_620570.2|ensembl:ENSMUSG00000032911(gene)|ensembl:ENSMUST00000035661(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005518"(collagen binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097178"(ruffle assembly)|interpro:IPR001791(Laminin G)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR039005|mint:Q8VHY0|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|mint:MINT-1787604(identity) refseq:NP_001264224.1|refseq:NP_083012.1|refseq:NP_570961.1|refseq:NP_597699.1|refseq:NP_001264221.1|refseq:NP_001264223.1|ensembl:ENSMUSG00000034813(gene)|ensembl:ENSMUST00000138410(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030026|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|mint:Q925T6|rcsb pdb:1V5Q|reactome:R-MMU-416993|mint:MINT-1787605(identity) - comment:mint|function:"Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2|figure legend:F1|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/03/20 2014/10/16 rogid:n54yGf7CRd/tmSmXWRBTfg/CML410090 rogid:nQDCS/yQb0DlZs+60Vf3Q3hbECk10090 intact-crc:E8AA2017DCD1B48B|rigid:5RlQSCEu67K4z9jml0l9wFdjMJc false tag:?-?(MINT-1787610)|mutation disrupting interaction:2327-2327(MINT-1792380)|binding-associated region:2252-2327(MINT-1787617)|mutation disrupting interaction:2325-2325(MINT-1792385)|mutation disrupting interaction:2326-2326(MINT-1792383) tag:?-?(MINT-1787621)|binding-associated region:926-1127(MINT-1787628) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8VHY0 uniprotkb:Q9WTW1 intact:EBI-8327479|uniprotkb:Q8BPI8|uniprotkb:G5E892|intact:MINT-1787512|uniprotkb:Q5DTG1|uniprotkb:Q8CE79|ensembl:ENSMUSP00000038909 intact:EBI-936045|uniprotkb:O88961|uniprotkb:Q9WU36|ensembl:ENSRNOP00000041016 psi-mi:cspg4_mouse(display_long)|uniprotkb:Cspg4(gene name)|psi-mi:Cspg4(display_short)|uniprotkb:An2(gene name synonym)|uniprotkb:Kiaa4232(gene name synonym)|uniprotkb:Ng2(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan NG2(gene name synonym)|uniprotkb:Proteoglycan AN2(gene name synonym) psi-mi:grip2_rat(display_long)|uniprotkb:Grip2(gene name)|psi-mi:Grip2(display_short)|uniprotkb:AMPA receptor-interacting protein GRIP2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Stegmüller et al. (2003) mint:MINT-5215950|pubmed:12458226 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8567228|mint:MINT-1787632 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_620570.2|ensembl:ENSMUSG00000032911(gene)|ensembl:ENSMUST00000035661(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005518"(collagen binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097178"(ruffle assembly)|interpro:IPR001791(Laminin G)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR039005|mint:Q8VHY0|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|mint:MINT-1787644(identity) refseq:NP_612544.2|rgd:621668|refseq:XP_006236957.1|ensembl:ENSRNOG00000009726(gene)|ensembl:ENSRNOT00000049657(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030029|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|reactome:R-RNO-416993|mint:MINT-1787633(identity) - comment:mint|function:"Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1F2|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/03/20 2014/10/16 rogid:n54yGf7CRd/tmSmXWRBTfg/CML410090 rogid:g2rwY1rc9xxRnZblXFwGv4SQfZg10116 intact-crc:5302F97FB5E42C05|rigid:+6EK1FzLCmuo2C4RWntv/BATN0k false mutation disrupting interaction:2326-2326(MINT-1792393)|mutation disrupting interaction:2327-2327(MINT-1792391)|mutation disrupting interaction:2325-2325(MINT-1792395)|binding-associated region:2252-2327(MINT-1787645)|tag:n-n(MINT-1787652) tag:?-?(MINT-1787642)|binding-associated region:917-1043(MINT-1787634) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8VHY0 uniprotkb:P97879 intact:EBI-8327479|uniprotkb:Q8BPI8|uniprotkb:G5E892|intact:MINT-1787512|uniprotkb:Q5DTG1|uniprotkb:Q8CE79|ensembl:ENSMUSP00000038909 intact:EBI-936113 psi-mi:cspg4_mouse(display_long)|uniprotkb:Cspg4(gene name)|psi-mi:Cspg4(display_short)|uniprotkb:An2(gene name synonym)|uniprotkb:Kiaa4232(gene name synonym)|uniprotkb:Ng2(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan NG2(gene name synonym)|uniprotkb:Proteoglycan AN2(gene name synonym) psi-mi:grip1_rat(display_long)|uniprotkb:Grip1(gene name)|psi-mi:Grip1(display_short)|uniprotkb:AMPA receptor-interacting protein GRIP1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Stegmüller et al. (2003) mint:MINT-5215950|pubmed:12458226 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8567268|mint:MINT-1792439 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_620570.2|ensembl:ENSMUSG00000032911(gene)|ensembl:ENSMUST00000035661(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005518"(collagen binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097178"(ruffle assembly)|interpro:IPR001791(Laminin G)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR039005|mint:Q8VHY0|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|mint:MINT-1792440(identity) rgd:621667|refseq:NP_114458.1|dip:DIP-37486N|reactome:R-RNO-416993|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030026|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|rcsb pdb:1M5Z|rcsb pdb:1N7E|rcsb pdb:1N7F|rcsb pdb:1P1D|rcsb pdb:1P1E|rcsb pdb:2QT5|mint:MINT-1792456(identity) - comment:mint|function:"Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/03/20 2014/10/16 rogid:n54yGf7CRd/tmSmXWRBTfg/CML410090 rogid:/maXdOoLsS4jIhMXA3kFkixeJ7M10116 intact-crc:3CB0894B228B1249|rigid:6QNqw2JH2Eq+8tURRE+kD6YF7Ns false tag:n-n(MINT-1792454)|binding-associated region:2252-2327(MINT-1792447) tag:?-?(MINT-1792465)|binding-associated region:666-1112(MINT-1792457) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8VHY0 uniprotkb:Q925T6 intact:EBI-8327479|uniprotkb:Q8BPI8|uniprotkb:G5E892|intact:MINT-1787512|uniprotkb:Q5DTG1|uniprotkb:Q8CE79|ensembl:ENSMUSP00000038909 intact:EBI-537752|uniprotkb:Q8BLQ3|uniprotkb:Q8C0T3|uniprotkb:Q925T5|uniprotkb:Q925T7|ensembl:ENSMUSP00000123234 psi-mi:cspg4_mouse(display_long)|uniprotkb:Cspg4(gene name)|psi-mi:Cspg4(display_short)|uniprotkb:An2(gene name synonym)|uniprotkb:Kiaa4232(gene name synonym)|uniprotkb:Ng2(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan NG2(gene name synonym)|uniprotkb:Proteoglycan AN2(gene name synonym) psi-mi:grip1_mouse(display_long)|uniprotkb:Grip1(gene name)|psi-mi:Grip1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Stegmüller et al. (2003) mint:MINT-5215950|pubmed:12458226 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8567330|mint:MINT-1787949 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_620570.2|ensembl:ENSMUSG00000032911(gene)|ensembl:ENSMUST00000035661(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005518"(collagen binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097178"(ruffle assembly)|interpro:IPR001791(Laminin G)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR039005|mint:Q8VHY0|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|mint:MINT-1787961(identity) refseq:NP_001264224.1|refseq:NP_083012.1|refseq:NP_570961.1|refseq:NP_597699.1|refseq:NP_001264221.1|refseq:NP_001264223.1|ensembl:ENSMUSG00000034813(gene)|ensembl:ENSMUST00000138410(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030026|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|mint:Q925T6|rcsb pdb:1V5Q|reactome:R-MMU-416993|mint:MINT-1787950(identity) - comment:mint|function:"Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F6B|comment:Only with co-overexpression of GluRB|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2006/03/20 2014/10/16 rogid:n54yGf7CRd/tmSmXWRBTfg/CML410090 rogid:nQDCS/yQb0DlZs+60Vf3Q3hbECk10090 intact-crc:5D10D1911EEA7329|rigid:5RlQSCEu67K4z9jml0l9wFdjMJc false - binding-associated region:577-1127(MINT-1787951)|myc tag:n-n(MINT-1787959) 1 1 psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8VHY0 uniprotkb:P23819 intact:EBI-8327479|uniprotkb:Q8BPI8|uniprotkb:G5E892|intact:MINT-1787512|uniprotkb:Q5DTG1|uniprotkb:Q8CE79|ensembl:ENSMUSP00000038909 intact:EBI-77538|uniprotkb:Q61604|uniprotkb:Q61605|uniprotkb:Q8BG69|uniprotkb:Q8BXU3|uniprotkb:Q9D6D3 psi-mi:cspg4_mouse(display_long)|uniprotkb:Cspg4(gene name)|psi-mi:Cspg4(display_short)|uniprotkb:An2(gene name synonym)|uniprotkb:Kiaa4232(gene name synonym)|uniprotkb:Ng2(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan NG2(gene name synonym)|uniprotkb:Proteoglycan AN2(gene name synonym) psi-mi:gria2_mouse(display_long)|uniprotkb:Gria2(gene name)|psi-mi:Gria2(display_short)|uniprotkb:Glur2(gene name synonym)|uniprotkb:GluR-B(gene name synonym)|uniprotkb:GluR-K2(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 2(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Stegmüller et al. (2003) mint:MINT-5215950|pubmed:12458226 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8567319|mint:MINT-1787895 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_620570.2|ensembl:ENSMUSG00000032911(gene)|ensembl:ENSMUST00000035661(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005518"(collagen binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097178"(ruffle assembly)|interpro:IPR001791(Laminin G)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR039005|mint:Q8VHY0|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|mint:MINT-1787896(identity) go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051117"(ATPase binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|reactome:R-MMU-399710|reactome:R-MMU-416993|reactome:R-MMU-438066|go:"GO:0000149"(SNARE binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR028082|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|mint:P23819|mint:MINT-1787902(identity) - comment:mint|function:"Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F6B|comment:Only with co-overexpression of Grip1|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2006/03/20 2014/10/16 rogid:n54yGf7CRd/tmSmXWRBTfg/CML410090 rogid:v71xzThz9kadLOPBasVAc1y/FXs10090 intact-crc:0E302B0906C70DEC|rigid:48EBrheBj/P3r3KjyTsvOD6k1O8 false - - 1 1 psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q8VHY0 uniprotkb:Q925T6 intact:EBI-8327479|uniprotkb:Q8BPI8|uniprotkb:G5E892|intact:MINT-1787512|uniprotkb:Q5DTG1|uniprotkb:Q8CE79|ensembl:ENSMUSP00000038909 intact:EBI-537752|uniprotkb:Q8BLQ3|uniprotkb:Q8C0T3|uniprotkb:Q925T5|uniprotkb:Q925T7|ensembl:ENSMUSP00000123234 psi-mi:cspg4_mouse(display_long)|uniprotkb:Cspg4(gene name)|psi-mi:Cspg4(display_short)|uniprotkb:An2(gene name synonym)|uniprotkb:Kiaa4232(gene name synonym)|uniprotkb:Ng2(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan NG2(gene name synonym)|uniprotkb:Proteoglycan AN2(gene name synonym) psi-mi:grip1_mouse(display_long)|uniprotkb:Grip1(gene name)|psi-mi:Grip1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Stegmüller et al. (2003) mint:MINT-5215950|pubmed:12458226 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8567301|mint:MINT-1787753 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_620570.2|ensembl:ENSMUSG00000032911(gene)|ensembl:ENSMUST00000035661(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005518"(collagen binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097178"(ruffle assembly)|interpro:IPR001791(Laminin G)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR039005|mint:Q8VHY0|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|mint:MINT-1787765(identity) refseq:NP_001264224.1|refseq:NP_083012.1|refseq:NP_570961.1|refseq:NP_597699.1|refseq:NP_001264221.1|refseq:NP_001264223.1|ensembl:ENSMUSG00000034813(gene)|ensembl:ENSMUST00000138410(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030026|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|mint:Q925T6|rcsb pdb:1V5Q|reactome:R-MMU-416993|mint:MINT-1787754(identity) - comment:mint|function:"Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3C|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2006/03/20 2014/10/16 rogid:n54yGf7CRd/tmSmXWRBTfg/CML410090 rogid:nQDCS/yQb0DlZs+60Vf3Q3hbECk10090 intact-crc:6D5DF2739BF8D968|rigid:5RlQSCEu67K4z9jml0l9wFdjMJc false - binding-associated region:926-1127(MINT-1787755)|myc tag:?-?(MINT-1787763) 1 1 psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8VHY0 uniprotkb:P23819 intact:EBI-8327479|uniprotkb:Q8BPI8|uniprotkb:G5E892|intact:MINT-1787512|uniprotkb:Q5DTG1|uniprotkb:Q8CE79|ensembl:ENSMUSP00000038909 intact:EBI-77538|uniprotkb:Q61604|uniprotkb:Q61605|uniprotkb:Q8BG69|uniprotkb:Q8BXU3|uniprotkb:Q9D6D3 psi-mi:cspg4_mouse(display_long)|uniprotkb:Cspg4(gene name)|psi-mi:Cspg4(display_short)|uniprotkb:An2(gene name synonym)|uniprotkb:Kiaa4232(gene name synonym)|uniprotkb:Ng2(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan NG2(gene name synonym)|uniprotkb:Proteoglycan AN2(gene name synonym) psi-mi:gria2_mouse(display_long)|uniprotkb:Gria2(gene name)|psi-mi:Gria2(display_short)|uniprotkb:Glur2(gene name synonym)|uniprotkb:GluR-B(gene name synonym)|uniprotkb:GluR-K2(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 2(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Stegmüller et al. (2003) mint:MINT-5215950|pubmed:12458226 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8567349|mint:MINT-1787972 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_620570.2|ensembl:ENSMUSG00000032911(gene)|ensembl:ENSMUST00000035661(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005518"(collagen binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097178"(ruffle assembly)|interpro:IPR001791(Laminin G)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR039005|mint:Q8VHY0|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|mint:MINT-1787984(identity) go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051117"(ATPase binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|reactome:R-MMU-399710|reactome:R-MMU-416993|reactome:R-MMU-438066|go:"GO:0000149"(SNARE binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR028082|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|mint:P23819|mint:MINT-1787973(identity) - comment:mint|function:"Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F6B|comment:Only with co-overexpression of GrIP1|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2006/03/20 2014/10/16 rogid:n54yGf7CRd/tmSmXWRBTfg/CML410090 rogid:v71xzThz9kadLOPBasVAc1y/FXs10090 intact-crc:610F6B0F1D9EE744|rigid:48EBrheBj/P3r3KjyTsvOD6k1O8 false - - 1 1 psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:P23819 uniprotkb:Q925T6 intact:EBI-77538|uniprotkb:Q61604|uniprotkb:Q61605|uniprotkb:Q8BG69|uniprotkb:Q8BXU3|uniprotkb:Q9D6D3 intact:EBI-537752|uniprotkb:Q8BLQ3|uniprotkb:Q8C0T3|uniprotkb:Q925T5|uniprotkb:Q925T7|ensembl:ENSMUSP00000123234 psi-mi:gria2_mouse(display_long)|uniprotkb:Gria2(gene name)|psi-mi:Gria2(display_short)|uniprotkb:Glur2(gene name synonym)|uniprotkb:GluR-B(gene name synonym)|uniprotkb:GluR-K2(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 2(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 2(gene name synonym) psi-mi:grip1_mouse(display_long)|uniprotkb:Grip1(gene name)|psi-mi:Grip1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Stegmüller et al. (2003) mint:MINT-5215950|pubmed:12458226 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8567360|mint:MINT-1792720 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051117"(ATPase binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|reactome:R-MMU-399710|reactome:R-MMU-416993|reactome:R-MMU-438066|go:"GO:0000149"(SNARE binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR028082|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|mint:P23819|mint:MINT-1792721(identity) refseq:NP_001264224.1|refseq:NP_083012.1|refseq:NP_570961.1|refseq:NP_597699.1|refseq:NP_001264221.1|refseq:NP_001264223.1|ensembl:ENSMUSG00000034813(gene)|ensembl:ENSMUST00000138410(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030026|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|mint:Q925T6|rcsb pdb:1V5Q|reactome:R-MMU-416993|mint:MINT-1792727(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F6B|comment:Only with co-overexpression of NG2|comment:homomint|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2006/03/20 2014/10/16 rogid:v71xzThz9kadLOPBasVAc1y/FXs10090 rogid:nQDCS/yQb0DlZs+60Vf3Q3hbECk10090 intact-crc:59F508F57454D2E5|rigid:sRoWVc/FXCQpyU8MWty3PtXmF38 false - binding-associated region:577-1127(MINT-1792740)|myc tag:n-n(MINT-1792738) 1 1 psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0078"(nucleotide sequence identification)