#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P13500 uniprotkb:O41925 intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831 intact:EBI-1034728 psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym) psi-mi:o41925_mhv68(display_long)|uniprotkb:GAMMAHV.M3(gene name)|psi-mi:GAMMAHV.M3(display_short)|uniprotkb:M3(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Alexander et al. (2002) pubmed:12419245 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:33708(mhv68)|taxid:33708("Murid herpesvirus 4 (MuHV-4)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1034763|rcsb pdb:1ML0 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N refseq:NP_044843.1|go:"GO:0019956"(chemokine binding)|interpro:IPR015296(Chemokine-binding M3, viral)|interpro:IPR015950(Chemokine-binding M3, subdomain 1, viral)|interpro:IPR015951(Chemokine-binding M3, subdomain 2, viral)|interpro:IPR036323|rcsb pdb:1MKF|rcsb pdb:1ML0|rcsb pdb:2NYZ|rcsb pdb:2NZ1|dip:DIP-45330N|mint:O41925 - - - assembly:dodecameric, multimeric|3d-r-factors:working 79.900%, free 71.800%|3d-resolution:2.8A|dataset:PDBe - Data obtained from the Protein Data Bank Europe taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/09/20 2014/10/16 rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606 rogid:8F0nh3pu9djSYZYkH2kClzjTLMQ33708 intact-crc:46B7914E5A302723|rigid:Svavt5KhyMLk1c9DugDlNns7nm8 false sufficient binding region:24-99 sufficient binding region:25-406 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)