#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P14434 uniprotkb:P14483 intact:EBI-1033666|uniprotkb:O78195|ensembl:ENSMUSP00000046105 intact:EBI-1033643|ensembl:ENSMUSP00000041008 psi-mi:ha2b_mouse(display_long)|uniprotkb:H2-Aa(gene name)|psi-mi:H2-Aa(display_short) psi-mi:hb2a_mouse(display_long)|uniprotkb:H2-Ab1(gene name)|psi-mi:H2-Ab1(display_short)|uniprotkb:H2-iabeta(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Liu et al. (2002) pubmed:12084926 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1033691|rcsb pdb:1LNU - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000036594(gene)|ensembl:ENSMUST00000040655(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0048002"(antigen processing and presentation of peptide antigen)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1LNU|rcsb pdb:1MUJ|rcsb pdb:3C5Z|rcsb pdb:3C60|rcsb pdb:3C6L|rcsb pdb:3RDT|rcsb pdb:4P23|rcsb pdb:4P46|rcsb pdb:4P5T|rcsb pdb:6MKD|rcsb pdb:6MKR|rcsb pdb:6MNG|rcsb pdb:6MNM|rcsb pdb:6MNN|rcsb pdb:6MNO|go:"GO:0002250"(adaptive immune response)|refseq:NP_034508.2 ensembl:ENSMUSG00000073421(gene)|ensembl:ENSMUST00000040828(transcript)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002579"(positive regulation of antigen processing and presentation)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046635"(positive regulation of alpha-beta T cell activation)|go:"GO:0048002"(antigen processing and presentation of peptide antigen)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1990405"(protein antigen binding)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1LNU|rcsb pdb:1MUJ|rcsb pdb:3C5Z|rcsb pdb:3C60|rcsb pdb:3C6L|rcsb pdb:3RDT|rcsb pdb:4P23|rcsb pdb:4P46|rcsb pdb:4P5T|rcsb pdb:6MKD|rcsb pdb:6MKR|rcsb pdb:6MNG|rcsb pdb:6MNM|rcsb pdb:6MNN|rcsb pdb:6MNO|refseq:NP_996988.2 - - - assembly:, tetrameric, multimeric, dimeric, multimeric|3d-r-factors:working 78.900%, free 75.500%|3d-resolution:2.5A|dataset:PDBe - Data obtained from the Protein Data Bank Europe taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/09/20 2014/10/16 rogid:cZiC1+07/rRKdHbL3SAI7g9qE9810090 rogid:xz/RDbS0pQBAjP2JplfMmJ4XhJg10090 intact-crc:43657BC3A2E04F95|rigid:G0riY7cOCAv+q1ygoc3/b4bbL+I false sufficient binding region:27-208 sufficient binding region:27-218 4 4 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)