#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P04224 uniprotkb:P02089 intact:EBI-1031313 intact:EBI-494213|uniprotkb:Q5D0E8 psi-mi:ha22_mouse(display_long) psi-mi:hbb2_mouse(display_long)|uniprotkb:Hemoglobin beta-2 chain(gene name synonym)|uniprotkb:Beta-2-globin(gene name synonym)|uniprotkb:Hemoglobin beta-minor chain(gene name synonym)|uniprotkb:Hbb-b2(gene name)|psi-mi:Hbb-b2(display_short) psi-mi:"MI:0114"(x-ray crystallography) Wilson et al. (2001) pubmed:11371354 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1031334|rcsb pdb:1I3R - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4P2O|rcsb pdb:4P2Q|rcsb pdb:4P2R|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|rcsb pdb:1FNE|rcsb pdb:1FNG|rcsb pdb:1I3R|rcsb pdb:1R5V|rcsb pdb:1R5W|rcsb pdb:3QIB|rcsb pdb:3QIU|rcsb pdb:3QIW|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042613"(MHC class II protein complex)|interpro:IPR036179|rcsb pdb:6BGA|refseq:NP_034511.2 interpro:IPR009050(Globin-like)|interpro:IPR000971(Globin, subset)|interpro:IPR002337(Haemoglobin, beta)|refseq:NP_058652.1|interpro:IPR012292(Globin)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0031721"(hemoglobin alpha binding)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048821"(erythrocyte development)|go:"GO:0098869"(cellular oxidant detoxification)|rcsb pdb:1FNE|rcsb pdb:1FNG|rcsb pdb:1I3R|mint:P02089 - - - assembly:tetrameric, multimeric|3d-r-factors:working 77.100%, free 73.00%|3d-resolution:2.4A|dataset:PDBe - Data obtained from the Protein Data Bank Europe taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/09/20 2014/10/16 rogid:jPLVAknqPfAzUbGMRs94/KDiXlU10090 rogid:5t7MUKklDto4E5kgtOvSP8i82vU10090 intact-crc:DC95A2E008CB8C7A|rigid:N/3pt5+rLhafyUR20nUGXZmxpzo false sufficient binding region:26-217 sufficient binding region:2-7 4 4 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)