#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q29983 uniprotkb:P26718 intact:EBI-1031130|uniprotkb:Q9TQK8|uniprotkb:Q9TQK9|uniprotkb:Q9TQL0|uniprotkb:Q9TQL1|uniprotkb:Q9TQL2|uniprotkb:Q9TQL3|uniprotkb:Q9TQL4|uniprotkb:Q9UE04|uniprotkb:Q9UE05|uniprotkb:Q9UE06|uniprotkb:Q9UE11|uniprotkb:Q5XM81|uniprotkb:Q70I48|uniprotkb:Q70I49|uniprotkb:Q7JFH9|uniprotkb:Q7JFI0|uniprotkb:Q7JFI1|uniprotkb:Q7JFI2|uniprotkb:Q7YQ98|uniprotkb:Q861I1|uniprotkb:Q95464|uniprotkb:Q95HA2|uniprotkb:Q95HD6|uniprotkb:Q95HN4|uniprotkb:Q95HN6|uniprotkb:Q95IB2|uniprotkb:Q95IY7|uniprotkb:Q95HN5|uniprotkb:Q9TQ92|uniprotkb:O97992|uniprotkb:P79507|uniprotkb:P79508|uniprotkb:P79509|uniprotkb:O97993|uniprotkb:O97994|uniprotkb:O97995|uniprotkb:O98234|uniprotkb:O98235|uniprotkb:O98236|uniprotkb:O98237|uniprotkb:O98238|uniprotkb:P79506|uniprotkb:A8KQR0|uniprotkb:Q99692|uniprotkb:Q9BCR3|uniprotkb:Q9BCR4|uniprotkb:Q9BCR5|uniprotkb:Q9BCS4|uniprotkb:Q9BD20|uniprotkb:Q9GIZ1|uniprotkb:Q9GIZ2|uniprotkb:Q9BCR6|uniprotkb:Q9BCR7|uniprotkb:Q9BCR8|uniprotkb:Q9BCR9|uniprotkb:Q9BCS0|uniprotkb:Q9BCS1|uniprotkb:Q9BCS2|uniprotkb:Q9BCS3|uniprotkb:A9LRW5|uniprotkb:A9QVE0|uniprotkb:B1VJF1|uniprotkb:O60917|uniprotkb:O60918|uniprotkb:O60919|uniprotkb:O60920|uniprotkb:O60933|uniprotkb:O77956|uniprotkb:O78150|uniprotkb:O78151|uniprotkb:O78152|uniprotkb:O78153|uniprotkb:O97987|uniprotkb:O97988|uniprotkb:O97989|uniprotkb:O97990|uniprotkb:O97991|uniprotkb:P79510|uniprotkb:Q9GJ08|uniprotkb:Q9GIZ3|uniprotkb:Q9GIZ4|uniprotkb:Q9GIZ5|uniprotkb:Q9GIZ6|uniprotkb:Q9GJ01|uniprotkb:Q9GJ02|uniprotkb:Q9GJ03|uniprotkb:Q9GJ04|uniprotkb:Q9GJ05|uniprotkb:Q9GJ06|uniprotkb:Q9GJ07|uniprotkb:P79511|uniprotkb:P79512|uniprotkb:P79513|uniprotkb:P79514|uniprotkb:P79515|uniprotkb:P79516|uniprotkb:P79517|uniprotkb:P79518|uniprotkb:P79519|uniprotkb:P79520|uniprotkb:Q5C9P8|uniprotkb:P79521|uniprotkb:Q9GJ09|uniprotkb:Q9MY21|uniprotkb:Q9TQ86|uniprotkb:Q9TQ87|uniprotkb:Q9TQ88|uniprotkb:Q9TQ89|uniprotkb:Q9TQ93|uniprotkb:Q9TQ94|uniprotkb:Q9TQ95|uniprotkb:Q9TQ96|uniprotkb:Q9TQ97|uniprotkb:Q9TQ98|uniprotkb:Q9TQ99|uniprotkb:Q9TQA0|uniprotkb:Q9TQA1|uniprotkb:Q9TQA2|uniprotkb:Q9TQA3|uniprotkb:Q9TQA4|uniprotkb:Q9TQI9|uniprotkb:Q9TQJ0|uniprotkb:Q9TQJ1|uniprotkb:Q9TQJ9|uniprotkb:Q9TQK0|uniprotkb:Q9TQK1|uniprotkb:Q9TQK2|ensembl:ENSP00000383179|ensembl:ENSP00000402134|ensembl:ENSP00000446963 intact:EBI-458344|ensembl:ENSP00000240618|ensembl:ENSP00000446003|uniprotkb:Q9NR41|uniprotkb:A8K7K5|uniprotkb:A8K7P4 psi-mi:mica_human(display_long)|uniprotkb:MICA(gene name)|psi-mi:MICA(display_short)|uniprotkb:PERB11.1(gene name synonym) psi-mi:nkg2d_human(display_long)|uniprotkb:KLRK1(gene name)|psi-mi:KLRK1(display_short)|uniprotkb:NKG2D(gene name synonym)|uniprotkb:NKG2-D-activating NK receptor(gene name synonym)|uniprotkb:NK cell receptor D(gene name synonym)|uniprotkb:Killer cell lectin-like receptor subfamily K member 1(gene name synonym)|uniprotkb:D12S2489E(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Li et al. (2001) pubmed:11323699 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1031146|rcsb pdb:1HYR - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000238.1|ensembl:ENSG00000183214(gene)|ensembl:ENSG00000235233(gene)|ensembl:ENST00000400325(transcript)|ensembl:ENST00000418465(transcript)|ensembl:ENST00000547609(transcript)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009408"(response to heat)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019835"(cytolysis)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|rcsb pdb:1B3J|rcsb pdb:1HYR|reactome:R-HSA-198933|dip:DIP-29681N reactome:R-HSA-2424491|reactome:R-HSA-2172127|ensembl:ENSG00000213809(gene)|ensembl:ENST00000540818(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|interpro:IPR042169|rcsb pdb:1HYR|rcsb pdb:1KCG|rcsb pdb:1MPU|rcsb pdb:4PDC|rcsb pdb:4S0U|ensembl:ENST00000240618(transcript)|reactome:R-HSA-198933|refseq:NP_001186734.1|refseq:NP_031386.2|dip:DIP-31100N - - - assembly:dodecameric, multimeric|3d-r-factors:working 77.300%, free 71.800%|3d-resolution:2.7A|dataset:PDBe - Data obtained from the Protein Data Bank Europe taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/09/20 2014/10/16 rogid:rBIu0nHHyVgNhLmPsQ4pTFy0Xj89606 rogid:KAqdqIVvc4LUwx7y0KRMc87FsUM9606 intact-crc:8DD39BB2886209C8|rigid:HkiOh+RYj3XHqwdCornuT/P0fTA false sufficient binding region:25-297 sufficient binding region:80-216 1 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)