#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q28619	uniprotkb:O70293-1	intact:EBI-7073613|intact:MINT-148118	intact:EBI-7073604|ensembl:ENSMUSP00000152968|intact:MINT-1793125	psi-mi:nhrf1_rabit(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:o70293-1(display_long)|uniprotkb:Grk6(gene name)|psi-mi:Grk6(display_short)|uniprotkb:G protein-coupled receptor kinase GRK6(gene name synonym)|uniprotkb:Gprk6(gene name synonym)	psi-mi:"MI:0440"(saturation binding)	Hall et al. (1999)	pubmed:10446210|mint:MINT-5211743	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7073599|mint:MINT-1793234	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR031199|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0030175"(filopodium)|go:"GO:0031528"(microvillus membrane)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070293"(renal absorption)|go:"GO:0071944"(cell periphery)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:2000146"(negative regulation of cell motility)|refseq:NP_001075814.1|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:MINT-1793235(identity)	ensembl:ENSMUSG00000074886(gene)|ensembl:ENSMUST00000224118(transcript)|intact:EBI-8376435(grk6_mouse)|mint:MINT-1793243(identity)	-	function:Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F2D|kinetics:kd 31 nanomolar|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/30	2014/10/16	rogid:Whyx53K9mx3z81+1fNi++cEigDc9986	rogid:L/P0QqiVMCARRg+JIDwiL6TL0bw10090	intact-crc:A11F3459C55DDF72|rigid:Q0KHBXXpkBqAG+qxtWjYdhOyLDE	false	binding-associated region:1-151(MINT-1793236)	binding-associated region:559-576(MINT-1793244)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q28619	uniprotkb:O70293-1	intact:EBI-7073613|intact:MINT-148118	intact:EBI-7073604|ensembl:ENSMUSP00000152968|intact:MINT-1793125	psi-mi:nhrf1_rabit(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:o70293-1(display_long)|uniprotkb:Grk6(gene name)|psi-mi:Grk6(display_short)|uniprotkb:G protein-coupled receptor kinase GRK6(gene name synonym)|uniprotkb:Gprk6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hall et al. (1999)	pubmed:10446210|mint:MINT-5211743	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7073728|mint:MINT-1793261	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR031199|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0030175"(filopodium)|go:"GO:0031528"(microvillus membrane)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070293"(renal absorption)|go:"GO:0071944"(cell periphery)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:2000146"(negative regulation of cell motility)|refseq:NP_001075814.1|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:MINT-1793262(identity)	ensembl:ENSMUSG00000074886(gene)|ensembl:ENSMUST00000224118(transcript)|intact:EBI-8376435(grk6_mouse)|mint:MINT-1793270(identity)	-	function:Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F2E|comment:mint	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/03/30	2014/10/16	rogid:Whyx53K9mx3z81+1fNi++cEigDc9986	rogid:L/P0QqiVMCARRg+JIDwiL6TL0bw10090	intact-crc:70A2FB507BA1B98E|rigid:Q0KHBXXpkBqAG+qxtWjYdhOyLDE	false	ha tag:?-?(MINT-1793283)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70293-1	uniprotkb:Q28619	intact:EBI-7073604|ensembl:ENSMUSP00000152968|intact:MINT-1793125	intact:EBI-7073613|intact:MINT-148118	psi-mi:o70293-1(display_long)|uniprotkb:Grk6(gene name)|psi-mi:Grk6(display_short)|uniprotkb:G protein-coupled receptor kinase GRK6(gene name synonym)|uniprotkb:Gprk6(gene name synonym)	psi-mi:nhrf1_rabit(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Hall et al. (1999)	pubmed:10446210|mint:MINT-5211743	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7073749|mint:MINT-1793135	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000074886(gene)|ensembl:ENSMUST00000224118(transcript)|intact:EBI-8376435(grk6_mouse)|mint:MINT-1793137(identity)	interpro:IPR031199|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0030175"(filopodium)|go:"GO:0031528"(microvillus membrane)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070293"(renal absorption)|go:"GO:0071944"(cell periphery)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:2000146"(negative regulation of cell motility)|refseq:NP_001075814.1|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:MINT-1793136(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	function:Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F2B|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/30	2014/10/16	rogid:L/P0QqiVMCARRg+JIDwiL6TL0bw10090	rogid:Whyx53K9mx3z81+1fNi++cEigDc9986	intact-crc:0F13C8EFA879F7F8|rigid:Q0KHBXXpkBqAG+qxtWjYdhOyLDE	false	glutathione s tranferase tag:?-?(MINT-1793142)	binding-associated region:1-151(MINT-1795020)|tag:?-?(MINT-1795016)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q28619	uniprotkb:P18762	intact:EBI-7073613|intact:MINT-148118	intact:EBI-491143|uniprotkb:Q8BH38|ensembl:ENSMUSP00000062256	psi-mi:nhrf1_rabit(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:adrb2_mouse(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:Adrb2(gene name)|psi-mi:Adrb2(display_short)|uniprotkb:Adrb2r(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Hall et al. (1999)	pubmed:10446210|mint:MINT-5211743	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7073786|mint:MINT-1793184	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR031199|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0030175"(filopodium)|go:"GO:0031528"(microvillus membrane)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070293"(renal absorption)|go:"GO:0071944"(cell periphery)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:2000146"(negative regulation of cell motility)|refseq:NP_001075814.1|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:MINT-1793185(identity)	go:"GO:0005901"(caveola)|refseq:NP_031446.2|ensembl:ENSMUSG00000045730(gene)|ensembl:ENSMUST00000053640(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001993"(regulation of systemic arterial blood pressure by norepinephrine-epinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002086"(diaphragm contraction)|go:"GO:0003059"(positive regulation of the force of heart contraction by epinephrine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009409"(response to cold)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019899"(enzyme binding)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031649"(heat generation)|go:"GO:0031713"(B2 bradykinin receptor binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P18762|reactome:R-MMU-390696|reactome:R-MMU-418555|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|dip:DIP-59568N|mint:MINT-1793193(identity)	-	function:Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli|comment:mint|comment:"Stoichiometry: 1.0"	caution:This sequence has been withdrawn from Uniprot.|comment:"Stoichiometry: 1.0"	figure legend:F2C|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/30	2014/10/16	rogid:Whyx53K9mx3z81+1fNi++cEigDc9986	rogid:qkANf2gIbjO7PaPMabhawKJORWI10090	intact-crc:20803D93FC3714BA|rigid:VWn37VmIx52CJkeb19RzLYLL16I	false	binding-associated region:1-151(MINT-1793186)	binding-associated region:401-418(MINT-1793194)|glutathione s tranferase tag:?-?(MINT-1793200)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q28619	uniprotkb:O70293-1	intact:EBI-7073613|intact:MINT-148118	intact:EBI-7073604|ensembl:ENSMUSP00000152968|intact:MINT-1793125	psi-mi:nhrf1_rabit(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:o70293-1(display_long)|uniprotkb:Grk6(gene name)|psi-mi:Grk6(display_short)|uniprotkb:G protein-coupled receptor kinase GRK6(gene name synonym)|uniprotkb:Gprk6(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Hall et al. (1999)	pubmed:10446210|mint:MINT-5211743	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7073808|mint:MINT-1793351	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR031199|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0030175"(filopodium)|go:"GO:0031528"(microvillus membrane)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070293"(renal absorption)|go:"GO:0071944"(cell periphery)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:2000146"(negative regulation of cell motility)|refseq:NP_001075814.1|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:MINT-1793352(identity)	ensembl:ENSMUSG00000074886(gene)|ensembl:ENSMUST00000224118(transcript)|intact:EBI-8376435(grk6_mouse)|mint:MINT-1793360(identity)	-	function:Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F4A|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/30	2014/10/16	rogid:Whyx53K9mx3z81+1fNi++cEigDc9986	rogid:L/P0QqiVMCARRg+JIDwiL6TL0bw10090	intact-crc:4A9F3D5DDD424E7B|rigid:Q0KHBXXpkBqAG+qxtWjYdhOyLDE	false	mutation decreasing interaction:159-159(MINT-1793374)|binding-associated region:152-357(MINT-1793353)|mutation decreasing interaction:158-158(MINT-1793376)	glutathione s tranferase tag:?-?(MINT-1793369)|binding-associated region:559-576(MINT-1793371)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P15409	uniprotkb:O70293-1	intact:EBI-7073880|ensembl:ENSMUSP00000032471|intact:MINT-1795197|uniprotkb:Q8K0D8|uniprotkb:Q96DZ2	intact:EBI-7073604|ensembl:ENSMUSP00000152968|intact:MINT-1793125	psi-mi:opsd_mouse(display_long)|uniprotkb:Rho(gene name)|psi-mi:Rho(display_short)	psi-mi:o70293-1(display_long)|uniprotkb:Grk6(gene name)|psi-mi:Grk6(display_short)|uniprotkb:G protein-coupled receptor kinase GRK6(gene name synonym)|uniprotkb:Gprk6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Hall et al. (1999)	pubmed:10446210|mint:MINT-5211743	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7073875|mint:MINT-1795176	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000030324(gene)|ensembl:ENSMUST00000032471(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005502"(11-cis retinal binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0008020"(G protein-coupled photoreceptor activity)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009583"(detection of light stimulus)|go:"GO:0009585"(red, far-red light phototransduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016038"(absorption of visible light)|go:"GO:0016056"(rhodopsin mediated signaling pathway)|go:"GO:0016918"(retinal binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0030507"(spectrin binding)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043052"(thermotaxis)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0046872"(metal ion binding)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050960"(detection of temperature stimulus involved in thermoception)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060342"(photoreceptor inner segment membrane)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097381"(photoreceptor disc membrane)|go:"GO:1990913"(sperm head plasma membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000732(Rhodopsin)|interpro:IPR001760(Opsin)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR019477|interpro:IPR027430|reactome:R-MMU-2453902|reactome:R-MMU-2485179|reactome:R-MMU-2514859|reactome:R-MMU-418594|reactome:R-MMU-419771|reactome:R-MMU-5620916|refseq:NP_663358.1|mint:MINT-1795177(identity)	ensembl:ENSMUSG00000074886(gene)|ensembl:ENSMUST00000224118(transcript)|intact:EBI-8376435(grk6_mouse)|mint:MINT-1795185(identity)	-	function:Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/30	2014/10/16	rogid:4T34og8GWsItKsjUopZZP+XtFqU10090	rogid:L/P0QqiVMCARRg+JIDwiL6TL0bw10090	intact-crc:BFBBBBB93D866012|rigid:PsDemP5vAlSNqr2wCKQ5mJmlTJU	false	-	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q28619	uniprotkb:O70293-1	intact:EBI-7073613|intact:MINT-148118	intact:EBI-7073604|ensembl:ENSMUSP00000152968|intact:MINT-1793125	psi-mi:nhrf1_rabit(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:o70293-1(display_long)|uniprotkb:Grk6(gene name)|psi-mi:Grk6(display_short)|uniprotkb:G protein-coupled receptor kinase GRK6(gene name synonym)|uniprotkb:Gprk6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Hall et al. (1999)	pubmed:10446210|mint:MINT-5211743	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7073848|mint:MINT-1793308	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR031199|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0030175"(filopodium)|go:"GO:0031528"(microvillus membrane)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070293"(renal absorption)|go:"GO:0071944"(cell periphery)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:2000146"(negative regulation of cell motility)|refseq:NP_001075814.1|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:MINT-1793309(identity)	ensembl:ENSMUSG00000074886(gene)|ensembl:ENSMUST00000224118(transcript)|intact:EBI-8376435(grk6_mouse)|mint:MINT-1793314(identity)	-	function:Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F3A|figure legend:F3C|figure legend:F3D|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/30	2014/10/16	rogid:Whyx53K9mx3z81+1fNi++cEigDc9986	rogid:L/P0QqiVMCARRg+JIDwiL6TL0bw10090	intact-crc:6C977C183903234A|rigid:Q0KHBXXpkBqAG+qxtWjYdhOyLDE	false	his tag:?-?(MINT-1793323)|binding-associated region:152-357(MINT-1795155)|mutation disrupting interaction:289-289(MINT-1793325)	ha tag:?-?(MINT-1795152)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P15409	uniprotkb:Q09639	intact:EBI-7073880|ensembl:ENSMUSP00000032471|intact:MINT-1795197|uniprotkb:Q8K0D8|uniprotkb:Q96DZ2	intact:EBI-7073923|ensemblmetazoa:W02B3.2.1|intact:MINT-1795241	psi-mi:opsd_mouse(display_long)|uniprotkb:Rho(gene name)|psi-mi:Rho(display_short)	psi-mi:grk2_caeel(display_long)|uniprotkb:grk-2(gene name)|psi-mi:grk-2(display_short)|uniprotkb:W02B3.2(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Hall et al. (1999)	pubmed:10446210|mint:MINT-5211743	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7073954|mint:MINT-1795217	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000030324(gene)|ensembl:ENSMUST00000032471(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005502"(11-cis retinal binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0008020"(G protein-coupled photoreceptor activity)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009583"(detection of light stimulus)|go:"GO:0009585"(red, far-red light phototransduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016038"(absorption of visible light)|go:"GO:0016056"(rhodopsin mediated signaling pathway)|go:"GO:0016918"(retinal binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0030507"(spectrin binding)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043052"(thermotaxis)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0046872"(metal ion binding)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050960"(detection of temperature stimulus involved in thermoception)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060342"(photoreceptor inner segment membrane)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097381"(photoreceptor disc membrane)|go:"GO:1990913"(sperm head plasma membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000732(Rhodopsin)|interpro:IPR001760(Opsin)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR019477|interpro:IPR027430|reactome:R-MMU-2453902|reactome:R-MMU-2485179|reactome:R-MMU-2514859|reactome:R-MMU-418594|reactome:R-MMU-419771|reactome:R-MMU-5620916|refseq:NP_663358.1|mint:MINT-1795223(identity)	ensemblmetazoa:W02B3.2.1(transcript)|ensemblmetazoa:WBGene00001709(gene)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0032501"(multicellular organismal process)|go:"GO:0040010"(positive regulation of growth rate)|go:"GO:0040017"(positive regulation of locomotion)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042429"(serotonin catabolic process)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0060160"(negative regulation of dopamine receptor signaling pathway)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902074"(response to salt)|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-CEL-111933|reactome:R-CEL-416476|refseq:NP_497235.2|interpro:IPR011993(Pleckstrin homology-type)|wormbase:W02B3.2|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036305|mint:MINT-1795218(identity)	-	function:Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:Specifically phosphorylates the activated forms of G protein-coupled receptors|comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/30	2014/10/16	rogid:4T34og8GWsItKsjUopZZP+XtFqU10090	rogid:2yKJksh2fCgNkZjjslFlgmICa7g6239	intact-crc:6DFF60BF89D57DD4|rigid:0I4CFVaciBNyFL6uUtMMu7Of+QU	false	-	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)