#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P81122	uniprotkb:P09405	intact:EBI-1369862|uniprotkb:B9EJW3|ensembl:ENSMUSP00000038514	intact:EBI-641864|uniprotkb:Q548M9|uniprotkb:Q61991|uniprotkb:Q8BQD8|uniprotkb:Q99K50|ensembl:ENSMUSP00000027438	psi-mi:irs2_mouse(display_long)|uniprotkb:Irs2(gene name)|psi-mi:Irs2(display_short)|uniprotkb:4PS(gene name synonym)	psi-mi:nucl_mouse(display_long)|uniprotkb:Protein C23(gene name synonym)|uniprotkb:Ncl(gene name)|psi-mi:Ncl(display_short)|uniprotkb:Nuc(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Burks et al. (1998)	pubmed:9813005|mint:MINT-6548329	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8655642|mint:MINT-58475	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074681.1|dip:DIP-39500N|ensembl:ENSMUSG00000038894(gene)|ensembl:ENSMUST00000040514(transcript)|go:"GO:0009749"(response to glucose)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-109704|mint:MINT-1540794(identity)	refseq:NP_035010.3|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990631"(ErbB-4 class receptor binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P09405|reactome:R-MMU-6791226|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000026234(gene)|ensembl:ENSMUST00000027438(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|mint:MINT-1540801(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2|comment:"CHO are actually CHO/IR (overexpressing insulin receptor)"|comment:homomint|comment:mint	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2005/06/06	2014/10/16	rogid:9Yx/YcJZfeRjy4g3peDD5t2pynk10090	rogid:NkPifysnX6CafgtN+Ko/p4aBqGE10090	intact-crc:AA34D1393BD9742A|rigid:oYEZmQ8K+jz/ZhyoSEv4h2X9nhg	false	binding-associated region:31-143(MINT-1540795)	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P09405	uniprotkb:P35569	intact:EBI-641864|uniprotkb:Q548M9|uniprotkb:Q61991|uniprotkb:Q8BQD8|uniprotkb:Q99K50|ensembl:ENSMUSP00000027438	intact:EBI-400825	psi-mi:nucl_mouse(display_long)|uniprotkb:Protein C23(gene name synonym)|uniprotkb:Ncl(gene name)|psi-mi:Ncl(display_short)|uniprotkb:Nuc(gene name synonym)	psi-mi:irs1_mouse(display_long)|uniprotkb:Irs1(gene name)|psi-mi:Irs1(display_short)|uniprotkb:Irs-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Burks et al. (1998)	pubmed:9813005|mint:MINT-6548329	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8655659|mint:MINT-58557	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035010.3|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990631"(ErbB-4 class receptor binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P09405|reactome:R-MMU-6791226|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000026234(gene)|ensembl:ENSMUST00000027438(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|mint:MINT-1540709(identity)	refseq:NP_034700.2|mint:P35569|dip:DIP-32456N|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031000"(response to caffeine)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070094"(positive regulation of glucagon secretion)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0090275"(negative regulation of somatostatin secretion)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:1AYB|rcsb pdb:5AXI|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|mint:MINT-1540702(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2|comment:"CHO are actually CHO/IR (overexpressing insulin receptor)"|comment:mint	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2005/06/06	2014/10/16	rogid:NkPifysnX6CafgtN+Ko/p4aBqGE10090	rogid:S9ooRqBQ2LriTIe+f2hSyxU8oP010090	intact-crc:90B6023711F5AAB6|rigid:1ETVLdB8X0/nnp7DF8lwvkReyHs	false	-	binding-associated region:13-114(MINT-1540703)	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P81122	uniprotkb:P09405	intact:EBI-1369862|uniprotkb:B9EJW3|ensembl:ENSMUSP00000038514	intact:EBI-641864|uniprotkb:Q548M9|uniprotkb:Q61991|uniprotkb:Q8BQD8|uniprotkb:Q99K50|ensembl:ENSMUSP00000027438	psi-mi:irs2_mouse(display_long)|uniprotkb:Irs2(gene name)|psi-mi:Irs2(display_short)|uniprotkb:4PS(gene name synonym)	psi-mi:nucl_mouse(display_long)|uniprotkb:Protein C23(gene name synonym)|uniprotkb:Ncl(gene name)|psi-mi:Ncl(display_short)|uniprotkb:Nuc(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Burks et al. (1998)	pubmed:9813005|mint:MINT-6548329	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8655708|mint:MINT-58556	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074681.1|dip:DIP-39500N|ensembl:ENSMUSG00000038894(gene)|ensembl:ENSMUST00000040514(transcript)|go:"GO:0009749"(response to glucose)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-109704|mint:MINT-1540830(identity)	refseq:NP_035010.3|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990631"(ErbB-4 class receptor binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P09405|reactome:R-MMU-6791226|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000026234(gene)|ensembl:ENSMUST00000027438(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|mint:MINT-1540839(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T1|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/06/06	2014/10/16	rogid:9Yx/YcJZfeRjy4g3peDD5t2pynk10090	rogid:NkPifysnX6CafgtN+Ko/p4aBqGE10090	intact-crc:5181113328CBD5D7|rigid:oYEZmQ8K+jz/ZhyoSEv4h2X9nhg	false	tag:?-?(MINT-1540834)|binding-associated region:31-143(MINT-1540831)	binding-associated region:239-341(MINT-1540840)|tag:?-?(MINT-1540842)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P09405	uniprotkb:P35569	intact:EBI-641864|uniprotkb:Q548M9|uniprotkb:Q61991|uniprotkb:Q8BQD8|uniprotkb:Q99K50|ensembl:ENSMUSP00000027438	intact:EBI-400825	psi-mi:nucl_mouse(display_long)|uniprotkb:Protein C23(gene name synonym)|uniprotkb:Ncl(gene name)|psi-mi:Ncl(display_short)|uniprotkb:Nuc(gene name synonym)	psi-mi:irs1_mouse(display_long)|uniprotkb:Irs1(gene name)|psi-mi:Irs1(display_short)|uniprotkb:Irs-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Burks et al. (1998)	pubmed:9813005|mint:MINT-6548329	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8655683|mint:MINT-58476	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035010.3|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990631"(ErbB-4 class receptor binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P09405|reactome:R-MMU-6791226|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000026234(gene)|ensembl:ENSMUST00000027438(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|mint:MINT-1540783(identity)	refseq:NP_034700.2|mint:P35569|dip:DIP-32456N|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031000"(response to caffeine)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070094"(positive regulation of glucagon secretion)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0090275"(negative regulation of somatostatin secretion)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:1AYB|rcsb pdb:5AXI|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|mint:MINT-1540774(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T1|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/06/06	2014/10/16	rogid:NkPifysnX6CafgtN+Ko/p4aBqGE10090	rogid:S9ooRqBQ2LriTIe+f2hSyxU8oP010090	intact-crc:EE2D39A86036BA78|rigid:1ETVLdB8X0/nnp7DF8lwvkReyHs	false	binding-associated region:239-341(MINT-1540784)|tag:?-?(MINT-1540786)	tag:?-?(MINT-1540778)|binding-associated region:13-114(MINT-1540775)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P81122	uniprotkb:Q8BHZ4	intact:EBI-1369862|uniprotkb:B9EJW3|ensembl:ENSMUSP00000038514	intact:EBI-6261115|ensembl:ENSMUSP00000102976|uniprotkb:Q80XM1	psi-mi:irs2_mouse(display_long)|uniprotkb:Irs2(gene name)|psi-mi:Irs2(display_short)|uniprotkb:4PS(gene name synonym)	psi-mi:zn592_mouse(display_long)|uniprotkb:Kiaa0211(gene name synonym)|uniprotkb:Zfp592(gene name synonym)|uniprotkb:Znf592(gene name)|psi-mi:Znf592(display_short)	psi-mi:"MI:0018"(two hybrid)	Burks et al. (1998)	pubmed:9813005|mint:MINT-6548329	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8655756|mint:MINT-58572	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074681.1|dip:DIP-39500N|ensembl:ENSMUSG00000038894(gene)|ensembl:ENSMUST00000040514(transcript)|go:"GO:0009749"(response to glucose)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-109704|mint:MINT-1540733(identity)	ensembl:ENSMUSG00000005621(gene)|ensembl:ENSMUST00000107353(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041697|mint:Q8BHZ4|refseq:NP_848822.2|mint:MINT-1540742(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T1|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/06/06	2014/10/16	rogid:9Yx/YcJZfeRjy4g3peDD5t2pynk10090	rogid:eTnikXtxcsynfo8/ZrEWL3NKL8g10090	intact-crc:AF7EC938DD3CCAB6|rigid:kg/9prFQdQQXDnWpPWH3FqPMO2Y	false	tag:?-?(MINT-1540737)|binding-associated region:31-143(MINT-1540734)	binding-associated region:1065-1185(MINT-1540743)|tag:?-?(MINT-1540745)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P81122	uniprotkb:Q8CGK3	intact:EBI-1369862|uniprotkb:B9EJW3|ensembl:ENSMUSP00000038514	intact:EBI-911958|ensembl:ENSMUSP00000041814|uniprotkb:Q3TSK9|uniprotkb:Q3TVL2|uniprotkb:Q3TXE4|uniprotkb:Q3TZW3|uniprotkb:Q9DBP9	psi-mi:irs2_mouse(display_long)|uniprotkb:Irs2(gene name)|psi-mi:Irs2(display_short)|uniprotkb:4PS(gene name synonym)	psi-mi:lonm_mouse(display_long)|uniprotkb:Lon protease-like protein(gene name synonym)|uniprotkb:Mitochondrial ATP-dependent protease Lon(gene name synonym)|uniprotkb:Serine protease 15(gene name synonym)|uniprotkb:Lonp1(gene name)|psi-mi:Lonp1(display_short)|uniprotkb:Prss15(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Burks et al. (1998)	pubmed:9813005|mint:MINT-6548329	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8655734|mint:MINT-58571	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074681.1|dip:DIP-39500N|ensembl:ENSMUSG00000038894(gene)|ensembl:ENSMUST00000040514(transcript)|go:"GO:0009749"(response to glucose)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-109704|mint:MINT-1540867(identity)	interpro:IPR027065|interpro:IPR027417|interpro:IPR027503|mint:Q8CGK3|interpro:IPR020568|ensembl:ENSMUSG00000041168(gene)|ensembl:ENSMUST00000047226(transcript)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0009725"(response to hormone)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034622"|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070407"(oxidation-dependent protein catabolic process)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004815(Peptidase S16, ATP-dependent protease La)|interpro:IPR008268(Peptidase S16, active site)|interpro:IPR008269(Peptidase S16, lon C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015947(PUA-like)|refseq:NP_083058.2|mint:MINT-1540876(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:NFA|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/06/06	2014/10/16	rogid:9Yx/YcJZfeRjy4g3peDD5t2pynk10090	rogid:v1wc76SqQNtKne3El7ypY6H1pQI10090	intact-crc:008B264D1FB3F637|rigid:gB3h61EFyCR13h/0anKsYaUhUVg	false	binding-associated region:31-143(MINT-1540868)|tag:?-?(MINT-1540871)	tag:?-?(MINT-1540877)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P09405	uniprotkb:P35569	intact:EBI-641864|uniprotkb:Q548M9|uniprotkb:Q61991|uniprotkb:Q8BQD8|uniprotkb:Q99K50|ensembl:ENSMUSP00000027438	intact:EBI-400825	psi-mi:nucl_mouse(display_long)|uniprotkb:Protein C23(gene name synonym)|uniprotkb:Ncl(gene name)|psi-mi:Ncl(display_short)|uniprotkb:Nuc(gene name synonym)	psi-mi:irs1_mouse(display_long)|uniprotkb:Irs1(gene name)|psi-mi:Irs1(display_short)|uniprotkb:Irs-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Burks et al. (1998)	pubmed:9813005|mint:MINT-6548329	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8655807|mint:MINT-58558	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035010.3|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990631"(ErbB-4 class receptor binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P09405|reactome:R-MMU-6791226|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000026234(gene)|ensembl:ENSMUST00000027438(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|mint:MINT-1540762(identity)	refseq:NP_034700.2|mint:P35569|dip:DIP-32456N|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031000"(response to caffeine)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070094"(positive regulation of glucagon secretion)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0090275"(negative regulation of somatostatin secretion)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:1AYB|rcsb pdb:5AXI|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|mint:MINT-1540755(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3|comment:"CHO are CHO/IR (overexpressing insulin receptor)"|comment:mint	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2005/06/06	2014/10/16	rogid:NkPifysnX6CafgtN+Ko/p4aBqGE10090	rogid:S9ooRqBQ2LriTIe+f2hSyxU8oP010090	intact-crc:D2AB28174EF64F0B|rigid:1ETVLdB8X0/nnp7DF8lwvkReyHs	false	binding-associated region:239-290(MINT-1540763)|tag:?-?(MINT-1540765)	binding-associated region:13-114(MINT-1540756)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P81122	uniprotkb:Q8CGK3	intact:EBI-1369862|uniprotkb:B9EJW3|ensembl:ENSMUSP00000038514	intact:EBI-911958|ensembl:ENSMUSP00000041814|uniprotkb:Q3TSK9|uniprotkb:Q3TVL2|uniprotkb:Q3TXE4|uniprotkb:Q3TZW3|uniprotkb:Q9DBP9	psi-mi:irs2_mouse(display_long)|uniprotkb:Irs2(gene name)|psi-mi:Irs2(display_short)|uniprotkb:4PS(gene name synonym)	psi-mi:lonm_mouse(display_long)|uniprotkb:Lon protease-like protein(gene name synonym)|uniprotkb:Mitochondrial ATP-dependent protease Lon(gene name synonym)|uniprotkb:Serine protease 15(gene name synonym)|uniprotkb:Lonp1(gene name)|psi-mi:Lonp1(display_short)|uniprotkb:Prss15(gene name synonym)	psi-mi:"MI:0096"(pull down)	Burks et al. (1998)	pubmed:9813005|mint:MINT-6548329	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8655838|mint:MINT-58580	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074681.1|dip:DIP-39500N|ensembl:ENSMUSG00000038894(gene)|ensembl:ENSMUST00000040514(transcript)|go:"GO:0009749"(response to glucose)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-109704|mint:MINT-1540885(identity)	interpro:IPR027065|interpro:IPR027417|interpro:IPR027503|mint:Q8CGK3|interpro:IPR020568|ensembl:ENSMUSG00000041168(gene)|ensembl:ENSMUST00000047226(transcript)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0009725"(response to hormone)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034622"|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070407"(oxidation-dependent protein catabolic process)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004815(Peptidase S16, ATP-dependent protease La)|interpro:IPR008268(Peptidase S16, active site)|interpro:IPR008269(Peptidase S16, lon C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015947(PUA-like)|refseq:NP_083058.2|mint:MINT-1540892(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B|comment:pull down from murine 32D cells|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/06	2014/10/16	rogid:9Yx/YcJZfeRjy4g3peDD5t2pynk10090	rogid:v1wc76SqQNtKne3El7ypY6H1pQI10090	intact-crc:36F5E7424C16322C|rigid:gB3h61EFyCR13h/0anKsYaUhUVg	false	binding-associated region:31-143(MINT-1540886)	binding-associated region:685-775(MINT-1540893)|tag:?-?(MINT-1540895)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P81122	uniprotkb:Q8BHZ4	intact:EBI-1369862|uniprotkb:B9EJW3|ensembl:ENSMUSP00000038514	intact:EBI-6261115|ensembl:ENSMUSP00000102976|uniprotkb:Q80XM1	psi-mi:irs2_mouse(display_long)|uniprotkb:Irs2(gene name)|psi-mi:Irs2(display_short)|uniprotkb:4PS(gene name synonym)	psi-mi:zn592_mouse(display_long)|uniprotkb:Kiaa0211(gene name synonym)|uniprotkb:Zfp592(gene name synonym)|uniprotkb:Znf592(gene name)|psi-mi:Znf592(display_short)	psi-mi:"MI:0096"(pull down)	Burks et al. (1998)	pubmed:9813005|mint:MINT-6548329	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8655862|mint:MINT-58581	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074681.1|dip:DIP-39500N|ensembl:ENSMUSG00000038894(gene)|ensembl:ENSMUST00000040514(transcript)|go:"GO:0009749"(response to glucose)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-109704|mint:MINT-1540811(identity)	ensembl:ENSMUSG00000005621(gene)|ensembl:ENSMUST00000107353(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041697|mint:Q8BHZ4|refseq:NP_848822.2|mint:MINT-1540818(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1A|comment:pull down from murine 32D cells|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/06	2014/10/16	rogid:9Yx/YcJZfeRjy4g3peDD5t2pynk10090	rogid:eTnikXtxcsynfo8/ZrEWL3NKL8g10090	intact-crc:7382442910765734|rigid:kg/9prFQdQQXDnWpPWH3FqPMO2Y	false	binding-associated region:31-143(MINT-1540812)	binding-associated region:1065-1185(MINT-1540819)|tag:?-?(MINT-1540821)	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)