#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P53867	uniprotkb:P38182	intact:EBI-29160|uniprotkb:D6W0W7|ensemblfungi:YNL223W	intact:EBI-2684|uniprotkb:D6VPS5|ensemblfungi:YBL078C	psi-mi:atg4_yeast(display_long)|uniprotkb:Autophagy-related protein 4(gene name synonym)|uniprotkb:YNL223W(locus name)|uniprotkb:N1274(orf name)|uniprotkb:APG4(gene name synonym)|uniprotkb:AUT2(gene name synonym)|uniprotkb:ATG4(gene name)|psi-mi:ATG4(display_short)	psi-mi:atg8_yeast(display_long)|uniprotkb:ATG8(gene name)|psi-mi:ATG8(display_short)|uniprotkb:APG8(gene name synonym)|uniprotkb:AUT7(gene name synonym)|uniprotkb:YBL078C(locus name)|uniprotkb:YBL0732(orf name)|uniprotkb:CVT5(gene name synonym)|uniprotkb:Autophagy-related ubiquitin-like modifier ATG8(gene name synonym)|uniprotkb:Cytoplasm to vacuole targeting protein 5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lang et al. (1998)	pubmed:9649430	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-491970	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014176.2|sgd:S000005167|reactome:R-SCE-1632852|dip:DIP-2339N|ensemblfungi:YNL223W(gene)|ensemblfungi:YNL223W_mRNA(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006508"(proteolysis)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006914"(autophagy)|go:"GO:0019786"(Atg8-specific protease activity)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0044805"(late nucleophagy)|go:"GO:0051697"(protein delipidation)|interpro:IPR005078(Peptidase C54)|interpro:IPR038765	sgd:S000000174|refseq:NP_009475.1|dip:DIP-1197N|mint:P38182|ensemblfungi:YBL078C(gene)|ensemblfungi:YBL078C_mRNA(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0016236"(macroautophagy)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031386"(protein tag)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0033110"(Cvt vesicle membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0034629"|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0044805"(late nucleophagy)|go:"GO:0061025"(membrane fusion)|go:"GO:0061709"(reticulophagy)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:0120095"(vacuole-isolation membrane contact site)|go:"GO:1905153"(regulation of membrane invagination)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|rcsb pdb:2KQ7|rcsb pdb:2KWC|rcsb pdb:2LI5|rcsb pdb:2ZPN|rcsb pdb:3RUI|rcsb pdb:3VH3|rcsb pdb:3VH4|rcsb pdb:3VXW|rcsb pdb:5YEC|rcsb pdb:6AAG|rcsb pdb:6WY6|rcsb pdb:7BRN|reactome:R-SCE-1632852|reactome:R-SCE-8854214|reactome:R-SCE-8934903	-	crc64:E68ABCA662A28C32	crc64:1246CEFF5A038819	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/02/08	2014/10/16	rogid:drOwUSIcK9X73A7/5cS0mb01AoY559292	rogid:UlmpBW3JgdYFHLkZCQeJeb7DpK4559292	intact-crc:6DB85B17AD168C23|rigid:nbnxljLWhONUq1TgapQ0A36sd54	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53867	uniprotkb:P09733	intact:EBI-29160|uniprotkb:D6W0W7|ensemblfungi:YNL223W	intact:EBI-18976|uniprotkb:D6W0J8|ensemblfungi:YML085C	psi-mi:atg4_yeast(display_long)|uniprotkb:Autophagy-related protein 4(gene name synonym)|uniprotkb:YNL223W(locus name)|uniprotkb:N1274(orf name)|uniprotkb:APG4(gene name synonym)|uniprotkb:AUT2(gene name synonym)|uniprotkb:ATG4(gene name)|psi-mi:ATG4(display_short)	psi-mi:tba1_yeast(display_long)|uniprotkb:YML085C(locus name)|uniprotkb:TUB1(gene name)|psi-mi:TUB1(display_short)	psi-mi:"MI:0018"(two hybrid)	Lang et al. (1998)	pubmed:9649430	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-491973	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014176.2|sgd:S000005167|reactome:R-SCE-1632852|dip:DIP-2339N|ensemblfungi:YNL223W(gene)|ensemblfungi:YNL223W_mRNA(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006508"(proteolysis)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006914"(autophagy)|go:"GO:0019786"(Atg8-specific protease activity)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0044805"(late nucleophagy)|go:"GO:0051697"(protein delipidation)|interpro:IPR005078(Peptidase C54)|interpro:IPR038765	ensemblfungi:YML085C(gene)|ensemblfungi:YML085C_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000280"(nuclear division)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005827"(polar microtubule)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0005874"(microtubule)|go:"GO:0005880"(nuclear microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0034399"(nuclear periphery)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045298"(tubulin complex)|go:"GO:0098863"(nuclear migration by microtubule mediated pushing forces)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|rcsb pdb:4FFB|rcsb pdb:4U3J|rcsb pdb:5W3F|rcsb pdb:5W3H|rcsb pdb:5W3J|reactome:R-SCE-114608|refseq:NP_013625.1|sgd:S000004550|dip:DIP-854N|mint:P09733	-	crc64:E68ABCA662A28C32	crc64:E263B49440F71889	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/02/08	2014/10/16	rogid:drOwUSIcK9X73A7/5cS0mb01AoY559292	rogid:SPNp3+7RZr0dO/P0VCbXlJTCOXg559292	intact-crc:AE201005CB4084D1|rigid:452jPVpY9tznJ7+yUR+Boi4IjZE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02557	uniprotkb:P53867	intact:EBI-18986|uniprotkb:D6VTJ3|ensemblfungi:YFL037W	intact:EBI-29160|uniprotkb:D6W0W7|ensemblfungi:YNL223W	psi-mi:tbb_yeast(display_long)|uniprotkb:YFL037W(locus name)|uniprotkb:TUB2(gene name)|psi-mi:TUB2(display_short)|uniprotkb:Beta-tubulin(gene name synonym)	psi-mi:atg4_yeast(display_long)|uniprotkb:Autophagy-related protein 4(gene name synonym)|uniprotkb:YNL223W(locus name)|uniprotkb:N1274(orf name)|uniprotkb:APG4(gene name synonym)|uniprotkb:AUT2(gene name synonym)|uniprotkb:ATG4(gene name)|psi-mi:ATG4(display_short)	psi-mi:"MI:0018"(two hybrid)	Lang et al. (1998)	pubmed:9649430	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-491978	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YFL037W(gene)|ensemblfungi:YFL037W_mRNA(transcript)|go:"GO:0000022"(mitotic spindle elongation)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0005874"(microtubule)|go:"GO:0005880"(nuclear microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007017"(microtubule-based process)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045298"(tubulin complex)|go:"GO:0046677"(response to antibiotic)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|rcsb pdb:4FFB|rcsb pdb:4U3J|rcsb pdb:5W3F|rcsb pdb:5W3H|rcsb pdb:5W3J|refseq:NP_116616.1|sgd:S000001857|dip:DIP-2340N|mint:P02557	refseq:NP_014176.2|sgd:S000005167|reactome:R-SCE-1632852|dip:DIP-2339N|ensemblfungi:YNL223W(gene)|ensemblfungi:YNL223W_mRNA(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006508"(proteolysis)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006914"(autophagy)|go:"GO:0019786"(Atg8-specific protease activity)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0044805"(late nucleophagy)|go:"GO:0051697"(protein delipidation)|interpro:IPR005078(Peptidase C54)|interpro:IPR038765	-	crc64:68EBEA7D7A5B8EA1	crc64:E68ABCA662A28C32	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/02/08	2014/10/16	rogid:kU3SKvNkJFLYaNy5pgPJGTYx2kc559292	rogid:drOwUSIcK9X73A7/5cS0mb01AoY559292	intact-crc:CD120824FE945444|rigid:AjZBAz8UOM7/3nE/CrOs9qEfrE0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38182	uniprotkb:P53867	intact:EBI-2684|uniprotkb:D6VPS5|ensemblfungi:YBL078C	intact:EBI-29160|uniprotkb:D6W0W7|ensemblfungi:YNL223W	psi-mi:atg8_yeast(display_long)|uniprotkb:ATG8(gene name)|psi-mi:ATG8(display_short)|uniprotkb:APG8(gene name synonym)|uniprotkb:AUT7(gene name synonym)|uniprotkb:YBL078C(locus name)|uniprotkb:YBL0732(orf name)|uniprotkb:CVT5(gene name synonym)|uniprotkb:Autophagy-related ubiquitin-like modifier ATG8(gene name synonym)|uniprotkb:Cytoplasm to vacuole targeting protein 5(gene name synonym)	psi-mi:atg4_yeast(display_long)|uniprotkb:Autophagy-related protein 4(gene name synonym)|uniprotkb:YNL223W(locus name)|uniprotkb:N1274(orf name)|uniprotkb:APG4(gene name synonym)|uniprotkb:AUT2(gene name synonym)|uniprotkb:ATG4(gene name)|psi-mi:ATG4(display_short)	psi-mi:"MI:0096"(pull down)	Lang et al. (1998)	pubmed:9649430	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-491985	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000174|refseq:NP_009475.1|dip:DIP-1197N|mint:P38182|ensemblfungi:YBL078C(gene)|ensemblfungi:YBL078C_mRNA(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0016236"(macroautophagy)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031386"(protein tag)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0033110"(Cvt vesicle membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0034629"|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0044805"(late nucleophagy)|go:"GO:0061025"(membrane fusion)|go:"GO:0061709"(reticulophagy)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:0120095"(vacuole-isolation membrane contact site)|go:"GO:1905153"(regulation of membrane invagination)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|rcsb pdb:2KQ7|rcsb pdb:2KWC|rcsb pdb:2LI5|rcsb pdb:2ZPN|rcsb pdb:3RUI|rcsb pdb:3VH3|rcsb pdb:3VH4|rcsb pdb:3VXW|rcsb pdb:5YEC|rcsb pdb:6AAG|rcsb pdb:6WY6|rcsb pdb:7BRN|reactome:R-SCE-1632852|reactome:R-SCE-8854214|reactome:R-SCE-8934903	refseq:NP_014176.2|sgd:S000005167|reactome:R-SCE-1632852|dip:DIP-2339N|ensemblfungi:YNL223W(gene)|ensemblfungi:YNL223W_mRNA(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006508"(proteolysis)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006914"(autophagy)|go:"GO:0019786"(Atg8-specific protease activity)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0044805"(late nucleophagy)|go:"GO:0051697"(protein delipidation)|interpro:IPR005078(Peptidase C54)|interpro:IPR038765	-	crc64:1246CEFF5A038819	crc64:E68ABCA662A28C32	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/02/08	2014/10/16	rogid:UlmpBW3JgdYFHLkZCQeJeb7DpK4559292	rogid:drOwUSIcK9X73A7/5cS0mb01AoY559292	intact-crc:3AD5BD9387D40D0A|rigid:nbnxljLWhONUq1TgapQ0A36sd54	false	tag:117-117	glutathione s tranferase tag:1-1	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)