#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P42573	uniprotkb:P30429	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Wu et al. (1997)	pubmed:9261161|mint:MINT-5221609	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-494537	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	pubmed:9261161	-	-	comment:The ced-4 protein used in this experiment is a C-terminal truncated loss of function mutant.|comment:"Because wild type CED-3 induces apotosis in mammalian cells a catalytically inactive mutant of CED-3 (CED-3-Flag-G360S) was used in this experiment."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/02/23	2014/10/16	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	intact-crc:9F731207C5740620|rigid:MV1ialotG+xu+GKbv7P/X0J/oAo	false	flag tag:?-?|mutation:360-360	binding-associated region:1-328|myc tag:?-?	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P30429	uniprotkb:P42573	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Wu et al. (1997)	pubmed:9261161|mint:MINT-5221609	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-494574	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	-	-	-	comment:"Because wild type CED-3 induces apotosis in mammalian cells a catalytically inactive mutant of CED-3 (CED-3-Flag-G360S) was used in this experiment."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/02/23	2014/10/16	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	intact-crc:63AEBDFE368D5A2D|rigid:MV1ialotG+xu+GKbv7P/X0J/oAo	false	myc tag:?-?	flag tag:?-?|binding-associated region:1-220|mutation:360-360	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P41958	uniprotkb:P30429	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Wu et al. (1997)	pubmed:9261161|mint:MINT-5221609	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-494610	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	-	-	-	comment:The authors note that binding of C-terminal truncated CED-4 to CED-9 was reduced when compared to wild type CED-4.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/02/23	2014/10/16	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	intact-crc:14F10685EC65CD43|rigid:IkyWahKhsCIdno2wk72lKUjK5kQ	false	ha tag:?-?	myc tag:?-?|binding-associated region:1-328	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P42573	uniprotkb:P41958	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Wu et al. (1997)	pubmed:9261161|mint:MINT-5221609	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-494631	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	-	-	-	comment:The interaction between the ced-3 protein and ced-4 protein only occurs when the ced-9 protein is present.|comment:"Because wild type CED-3 induces apotosis in mammalian cells a catalytically inactive mutant of CED-3 (CED-3-Flag-G360S) was used in this experiment."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/02/23	2014/10/16	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	intact-crc:BF7B929700AB2EA4|rigid:qhCVIlSlSoydkfP09kkqONycDtE	false	myc tag:?-?|mutation:360-360	ha tag:?-?	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P42573	uniprotkb:P30429	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Wu et al. (1997)	pubmed:9261161|mint:MINT-5221609	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-494684	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/02/23	2014/10/16	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	intact-crc:D74A0089501D3053|rigid:MV1ialotG+xu+GKbv7P/X0J/oAo	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P41958	uniprotkb:P30429	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Wu et al. (1997)	pubmed:9261161|mint:MINT-5221609	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-494721	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/02/23	2014/10/16	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	intact-crc:71F3BB58692E9249|rigid:IkyWahKhsCIdno2wk72lKUjK5kQ	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P42573	uniprotkb:P41958	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Wu et al. (1997)	pubmed:9261161|mint:MINT-5221609	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-494943	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	-	-	-	comment:"Because wild type CED-3 induces apotosis in mammalian cells a catalytically inactive mutant of CED-3 (CED-3-Flag-G360S) was used in this experiment."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/02/23	2014/10/16	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	intact-crc:4D628B8DD85AB2D8|rigid:qhCVIlSlSoydkfP09kkqONycDtE	false	myc tag:?-?|mutation:360-360	ha tag:?-?	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P30429	uniprotkb:P42573	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Wu et al. (1997)	pubmed:9261161|mint:MINT-5221609	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-495051	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	-	-	-	comment:"Because wild type CED-3 induces apotosis in mammalian cells a catalytically inactive mutant of CED-3 (CED-3-Flag-G360S) was used in this experiment."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/02/23	2014/10/16	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	intact-crc:14267B41FA7285ED|rigid:MV1ialotG+xu+GKbv7P/X0J/oAo	false	myc tag:?-?	flag tag:?-?|mutation:360-360	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)