#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8WXG6	uniprotkb:Q16849	intact:EBI-310528|uniprotkb:O15293|intact:EBI-728168|uniprotkb:D3DQR4|uniprotkb:Q15732|uniprotkb:Q15741|uniprotkb:Q8IWD7|uniprotkb:Q8WXG3|uniprotkb:Q8WXG4|uniprotkb:Q8WXG5|uniprotkb:Q8WZ63|uniprotkb:O15065|uniprotkb:A8K8S7|uniprotkb:B5MEE5|ensembl:ENSP00000310933	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	psi-mi:madd_human(display_long)|uniprotkb:MADD(gene name)|psi-mi:MADD(display_short)|uniprotkb:DENN(gene name synonym)|uniprotkb:IG20(gene name synonym)|uniprotkb:KIAA0358(gene name synonym)|uniprotkb:Differentially expressed in normal and neoplastic cells(gene name synonym)|uniprotkb:Insulinoma glucagonoma clone 20(gene name synonym)|uniprotkb:Rab3 GDP/GTP exchange factor(gene name synonym)|uniprotkb:Rab3 GDP/GTP exchange protein(gene name synonym)	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-728164	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129415.1|refseq:NP_001129416.1|refseq:NP_003673.3|refseq:NP_569826.2|refseq:NP_569827.2|refseq:NP_569828.2|refseq:NP_569829.2|refseq:NP_569830.2|refseq:NP_569831.1|refseq:NP_569832.2|refseq:XP_005253246.1|refseq:XP_005253253.1|refseq:XP_005253258.1|refseq:XP_005253260.1|refseq:XP_005253256.1|refseq:XP_005253261.1|refseq:XP_005253262.1|ensembl:ENSP00000310933|ensembl:ENST00000349238|ensembl:ENSP00000304505|ensembl:ENST00000395336|ensembl:ENSP00000378745|ensembl:ENST00000395344|ensembl:ENSP00000378753|ensembl:ENST00000402192|ensembl:ENSP00000384287|ensembl:ENST00000402799|ensembl:ENSP00000385585|ensembl:ENST00000406482|ensembl:ENSP00000384435|ensembl:ENST00000407859|ensembl:ENSP00000384204|ensembl:ENSG00000110514(gene)|ensembl:ENST00000311027(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0032483"(regulation of Rab protein signal transduction)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001194(DENN)|interpro:IPR005112(dDENN)|interpro:IPR005113(uDENN)|interpro:IPR037516|interpro:IPR039980|interpro:IPR043153|reactome:R-HSA-5357905|reactome:R-HSA-8876198	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/11/18	2014/10/16	rogid:+YF66uj9WWG+hZ6fvrmXfelsQZs9606	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	intact-crc:4346EC2D15214310|rigid:7733bMOYrGVwYe56E21B7Zf/Oc4	false	sufficient binding region:1350-1588	sufficient binding region:602-979	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O14522	uniprotkb:Q16849	intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym)	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-728216	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/11/18	2014/10/16	rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	intact-crc:0F4DF7B29F6B4CD3|rigid:e/CgyrlNGPFL4MYeWv1VeqHMjVY	false	sufficient binding region:835-1378|myc tag:?-?	sufficient binding region:602-979|flag tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13332	uniprotkb:Q16849	intact:EBI-711536|ensembl:ENSP00000467537|uniprotkb:Q2M3R7|uniprotkb:O75255|uniprotkb:O75870|uniprotkb:Q15718|uniprotkb:Q16341|intact:EBI-1058503	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	psi-mi:ptprs_human(display_long)|uniprotkb:PTPRS(gene name)|psi-mi:PTPRS(display_short)|uniprotkb:Receptor-type tyrosine-protein phosphatase sigma(gene name synonym)	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-728224	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008201"(heparin binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021510"(spinal cord development)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099560"(synaptic membrane adhesion)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2FH7|rcsb pdb:2YD2|rcsb pdb:2YD3|rcsb pdb:2YD9|rcsb pdb:4BPC|rcsb pdb:4PBX|reactome:R-HSA-3000178|reactome:R-HSA-388844|reactome:R-HSA-8849932|reactome:R-HSA-9034015|ensembl:ENSG00000105426(gene)|ensembl:ENST00000587303(transcript)|go:"GO:0004721"(phosphoprotein phosphatase activity)|refseq:NP_002841.3|refseq:NP_570923.2|refseq:NP_570924.2|refseq:NP_570925.2|refseq:XP_005259663.1|refseq:XP_005259666.1|refseq:XP_016882554.1|refseq:XP_016882555.1|refseq:XP_016882556.1	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/11/18	2014/10/16	rogid:mD7s7/H78PNJDAPLckZ19jmdAn89606	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	intact-crc:EA83ACEF82FA68FD|rigid:imyqtNZqctWSn9RS54Cy/yr2n9I	false	sufficient binding region:1697-1948	sufficient binding region:602-979	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q16849	uniprotkb:Q92543	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	intact:EBI-728232|ensembl:ENSP00000265909|uniprotkb:E9PKB9|uniprotkb:Q8IV55	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:snx19_human(display_long)|uniprotkb:SNX19(gene name)|psi-mi:SNX19(display_short)|uniprotkb:KIAA0254(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-728240	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	ensembl:ENSG00000120451(gene)|ensembl:ENST00000265909(transcript)|refseq:NP_055573.2|refseq:NP_001334847.1|refseq:NP_001334848.1|refseq:NP_001334849.1|refseq:NP_001334850.1|refseq:NP_001334851.1|refseq:NP_001334852.1|refseq:NP_001334853.1|refseq:NP_001334854.1|refseq:NP_001334855.1|refseq:NP_001334856.1|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0030073"(insulin secretion)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR001683(Phox-like)|interpro:IPR003114(PX-associated)|interpro:IPR013937(Sorting nexin, C-terminal)|interpro:IPR034908|interpro:IPR036871|interpro:IPR037909	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/11/18	2014/10/16	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	rogid:K3NS39vRx+FYSZXGpylwf32l0ug9606	intact-crc:7608FFEFE03316A2|rigid:oQGjaZqASYfQ8FAKNxSKuqIGG0Y	false	sufficient binding region:602-979	sufficient binding region:258-992	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q16849	uniprotkb:P62937	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	intact:EBI-437708|uniprotkb:P05092|uniprotkb:Q3KQW3|uniprotkb:Q6IBU5|uniprotkb:Q96IX3|uniprotkb:Q9BRU4|uniprotkb:Q9BTY9|uniprotkb:Q9UC61|uniprotkb:Q567Q0|ensembl:ENSP00000419425|uniprotkb:A8K220	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:ppia_human(display_long)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:PPIA(gene name)|psi-mi:PPIA(display_short)|uniprotkb:CYPA(gene name synonym)|uniprotkb:Rotamase A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-728248	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	refseq:NP_066953.1|interpro:IPR029000|mint:P62937|rcsb pdb:1AK4|rcsb pdb:1AWQ|rcsb pdb:1AWR|rcsb pdb:1AWS|rcsb pdb:1AWT|rcsb pdb:1AWU|rcsb pdb:1AWV|rcsb pdb:1BCK|rcsb pdb:1CWA|rcsb pdb:1CWB|rcsb pdb:1CWC|rcsb pdb:1CWF|rcsb pdb:1CWH|rcsb pdb:1CWI|rcsb pdb:1CWJ|rcsb pdb:1CWK|rcsb pdb:1CWL|rcsb pdb:1CWM|interpro:IPR024936|rcsb pdb:1CWO|rcsb pdb:1FGL|rcsb pdb:2N0T|rcsb pdb:2RMA|rcsb pdb:1M63|rcsb pdb:2RMB|rcsb pdb:2X25|rcsb pdb:2X2A|rcsb pdb:2X2C|rcsb pdb:2X2D|rcsb pdb:1M9C|rcsb pdb:1M9D|rcsb pdb:1M9E|rcsb pdb:2XGY|rcsb pdb:3CYH|rcsb pdb:3CYS|rcsb pdb:3K0M|rcsb pdb:3K0N|rcsb pdb:3K0O|rcsb pdb:3K0P|rcsb pdb:3K0Q|rcsb pdb:3K0R|rcsb pdb:3ODI|rcsb pdb:3ODL|rcsb pdb:1M9F|rcsb pdb:3RDD|rcsb pdb:1M9X|rcsb pdb:1M9Y|rcsb pdb:4CYH|rcsb pdb:4IPZ|rcsb pdb:4N1M|rcsb pdb:4N1N|rcsb pdb:1MF8|rcsb pdb:4N1O|rcsb pdb:4N1P|rcsb pdb:4N1Q|rcsb pdb:1MIK|rcsb pdb:1NMK|rcsb pdb:1OCA|rcsb pdb:1RMH|rcsb pdb:1VBS|rcsb pdb:1VBT|rcsb pdb:1W8L|rcsb pdb:1W8M|rcsb pdb:1W8V|rcsb pdb:1YND|rcsb pdb:1ZKF|rcsb pdb:2ALF|rcsb pdb:2CPL|rcsb pdb:2CYH|rcsb pdb:2MS4|rcsb pdb:2MZU|rcsb pdb:4N1R|rcsb pdb:4N1S|rcsb pdb:4YUG|rcsb pdb:4YUH|refseq:NP_001287910.1|reactome:R-HSA-210991|reactome:R-HSA-6798695|reactome:R-HSA-8950505|reactome:R-HSA-2025928|ensembl:ENSG00000196262(gene)|ensembl:ENST00000468812(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046790"(virion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|go:"GO:0005178"(integrin binding)|rcsb pdb:4YUI|rcsb pdb:4YUJ|rcsb pdb:4YUK|rcsb pdb:4YUL|rcsb pdb:4YUM|rcsb pdb:4YUN|rcsb pdb:4YUO|rcsb pdb:4YUP|rcsb pdb:5CYH|rcsb pdb:5F66|rcsb pdb:5FJB|rcsb pdb:5KUL|rcsb pdb:5KUN|rcsb pdb:5KUO|rcsb pdb:5KUQ|rcsb pdb:5KUR|rcsb pdb:5KUS|rcsb pdb:5KUU|rcsb pdb:5KUV|rcsb pdb:5KUW|rcsb pdb:5KUZ|rcsb pdb:5KV0|rcsb pdb:5KV1|rcsb pdb:5KV2|rcsb pdb:5KV3|rcsb pdb:5KV4|rcsb pdb:5KV5|rcsb pdb:5KV6|rcsb pdb:5KV7|rcsb pdb:5LUD|rcsb pdb:5NOQ|rcsb pdb:5NOR|rcsb pdb:5NOT|rcsb pdb:5NOU|rcsb pdb:5NOV|rcsb pdb:5NOW|rcsb pdb:5NOX|rcsb pdb:5NOY|rcsb pdb:5NOZ|rcsb pdb:5T9U|rcsb pdb:5T9W|rcsb pdb:5T9Z|rcsb pdb:5TA2|rcsb pdb:5TA4|rcsb pdb:5WC7|rcsb pdb:6BTA|rcsb pdb:6GJI|rcsb pdb:6GJJ|rcsb pdb:6GJL|rcsb pdb:6GJM|rcsb pdb:6GJN|rcsb pdb:6GJP|rcsb pdb:6GJR|rcsb pdb:6GJY|rcsb pdb:6GS6|rcsb pdb:6I42|rcsb pdb:6U5C|rcsb pdb:6U5D|rcsb pdb:6U5E|rcsb pdb:6U5G|rcsb pdb:6X3R|rcsb pdb:6X3Y|rcsb pdb:5NOS|rcsb pdb:6X4N|rcsb pdb:6X4O|rcsb pdb:6X4P|rcsb pdb:6X4Q|rcsb pdb:6Y9V|rcsb pdb:6Y9W|rcsb pdb:6Y9X|rcsb pdb:6Y9Y|rcsb pdb:6Y9Z|rcsb pdb:6ZDJ|rcsb pdb:7ABT|reactome:R-HSA-114608|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-173107|rcsb pdb:6X4M|reactome:R-HSA-175474|reactome:R-HSA-180689|dip:DIP-6080N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/11/18	2014/10/16	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	rogid:dr4EVxcO+sqTPBqsQcydRn+rHoo9606	intact-crc:703955C74BDC3C94|rigid:rrCqv3yEXrB3x5KOpQEkvvVr6Ak	false	sufficient binding region:602-979	sufficient binding region:2-165	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q16849	uniprotkb:Q8WXG6	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	intact:EBI-310528|uniprotkb:O15293|intact:EBI-728168|uniprotkb:D3DQR4|uniprotkb:Q15732|uniprotkb:Q15741|uniprotkb:Q8IWD7|uniprotkb:Q8WXG3|uniprotkb:Q8WXG4|uniprotkb:Q8WXG5|uniprotkb:Q8WZ63|uniprotkb:O15065|uniprotkb:A8K8S7|uniprotkb:B5MEE5|ensembl:ENSP00000310933	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:madd_human(display_long)|uniprotkb:MADD(gene name)|psi-mi:MADD(display_short)|uniprotkb:DENN(gene name synonym)|uniprotkb:IG20(gene name synonym)|uniprotkb:KIAA0358(gene name synonym)|uniprotkb:Differentially expressed in normal and neoplastic cells(gene name synonym)|uniprotkb:Insulinoma glucagonoma clone 20(gene name synonym)|uniprotkb:Rab3 GDP/GTP exchange factor(gene name synonym)|uniprotkb:Rab3 GDP/GTP exchange protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-728261	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	refseq:NP_001129415.1|refseq:NP_001129416.1|refseq:NP_003673.3|refseq:NP_569826.2|refseq:NP_569827.2|refseq:NP_569828.2|refseq:NP_569829.2|refseq:NP_569830.2|refseq:NP_569831.1|refseq:NP_569832.2|refseq:XP_005253246.1|refseq:XP_005253253.1|refseq:XP_005253258.1|refseq:XP_005253260.1|refseq:XP_005253256.1|refseq:XP_005253261.1|refseq:XP_005253262.1|ensembl:ENSP00000310933|ensembl:ENST00000349238|ensembl:ENSP00000304505|ensembl:ENST00000395336|ensembl:ENSP00000378745|ensembl:ENST00000395344|ensembl:ENSP00000378753|ensembl:ENST00000402192|ensembl:ENSP00000384287|ensembl:ENST00000402799|ensembl:ENSP00000385585|ensembl:ENST00000406482|ensembl:ENSP00000384435|ensembl:ENST00000407859|ensembl:ENSP00000384204|ensembl:ENSG00000110514(gene)|ensembl:ENST00000311027(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0032483"(regulation of Rab protein signal transduction)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001194(DENN)|interpro:IPR005112(dDENN)|interpro:IPR005113(uDENN)|interpro:IPR037516|interpro:IPR039980|interpro:IPR043153|reactome:R-HSA-5357905|reactome:R-HSA-8876198	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/11/18	2014/10/16	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	rogid:+YF66uj9WWG+hZ6fvrmXfelsQZs9606	intact-crc:0EEF87B53959074F|rigid:7733bMOYrGVwYe56E21B7Zf/Oc4	false	sufficient binding region:744-979|necessary binding region:?-?	sufficient binding region:1356-1588	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92543	uniprotkb:Q16849	intact:EBI-728232|ensembl:ENSP00000265909|uniprotkb:E9PKB9|uniprotkb:Q8IV55	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	psi-mi:snx19_human(display_long)|uniprotkb:SNX19(gene name)|psi-mi:SNX19(display_short)|uniprotkb:KIAA0254(gene name synonym)	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-728270	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000120451(gene)|ensembl:ENST00000265909(transcript)|refseq:NP_055573.2|refseq:NP_001334847.1|refseq:NP_001334848.1|refseq:NP_001334849.1|refseq:NP_001334850.1|refseq:NP_001334851.1|refseq:NP_001334852.1|refseq:NP_001334853.1|refseq:NP_001334854.1|refseq:NP_001334855.1|refseq:NP_001334856.1|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0030073"(insulin secretion)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR001683(Phox-like)|interpro:IPR003114(PX-associated)|interpro:IPR013937(Sorting nexin, C-terminal)|interpro:IPR034908|interpro:IPR036871|interpro:IPR037909	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/11/18	2014/10/16	rogid:K3NS39vRx+FYSZXGpylwf32l0ug9606	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	intact-crc:85234AA5B5E1815E|rigid:oQGjaZqASYfQ8FAKNxSKuqIGG0Y	false	sufficient binding region:494-992(IPR001683)	sufficient binding region:744-979|necessary binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14522	uniprotkb:Q16849	intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym)	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-728280	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/11/18	2014/10/16	rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	intact-crc:569F93BF7E9A5592|rigid:e/CgyrlNGPFL4MYeWv1VeqHMjVY	false	sufficient binding region:835-1378	sufficient binding region:693-917|necessary binding region:693-743	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16849	uniprotkb:Q13332	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	intact:EBI-711536|ensembl:ENSP00000467537|uniprotkb:Q2M3R7|uniprotkb:O75255|uniprotkb:O75870|uniprotkb:Q15718|uniprotkb:Q16341|intact:EBI-1058503	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:ptprs_human(display_long)|uniprotkb:PTPRS(gene name)|psi-mi:PTPRS(display_short)|uniprotkb:Receptor-type tyrosine-protein phosphatase sigma(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-728291	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008201"(heparin binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021510"(spinal cord development)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099560"(synaptic membrane adhesion)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2FH7|rcsb pdb:2YD2|rcsb pdb:2YD3|rcsb pdb:2YD9|rcsb pdb:4BPC|rcsb pdb:4PBX|reactome:R-HSA-3000178|reactome:R-HSA-388844|reactome:R-HSA-8849932|reactome:R-HSA-9034015|ensembl:ENSG00000105426(gene)|ensembl:ENST00000587303(transcript)|go:"GO:0004721"(phosphoprotein phosphatase activity)|refseq:NP_002841.3|refseq:NP_570923.2|refseq:NP_570924.2|refseq:NP_570925.2|refseq:XP_005259663.1|refseq:XP_005259666.1|refseq:XP_016882554.1|refseq:XP_016882555.1|refseq:XP_016882556.1	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/11/18	2014/10/16	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	rogid:mD7s7/H78PNJDAPLckZ19jmdAn89606	intact-crc:36BCECE1361BCA7F|rigid:imyqtNZqctWSn9RS54Cy/yr2n9I	false	necessary binding region:693-743|sufficient binding region:693-917	sufficient binding region:1697-1948	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16849	uniprotkb:Q8WXG6	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	intact:EBI-310528|uniprotkb:O15293|intact:EBI-728168|uniprotkb:D3DQR4|uniprotkb:Q15732|uniprotkb:Q15741|uniprotkb:Q8IWD7|uniprotkb:Q8WXG3|uniprotkb:Q8WXG4|uniprotkb:Q8WXG5|uniprotkb:Q8WZ63|uniprotkb:O15065|uniprotkb:A8K8S7|uniprotkb:B5MEE5|ensembl:ENSP00000310933	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:madd_human(display_long)|uniprotkb:MADD(gene name)|psi-mi:MADD(display_short)|uniprotkb:DENN(gene name synonym)|uniprotkb:IG20(gene name synonym)|uniprotkb:KIAA0358(gene name synonym)|uniprotkb:Differentially expressed in normal and neoplastic cells(gene name synonym)|uniprotkb:Insulinoma glucagonoma clone 20(gene name synonym)|uniprotkb:Rab3 GDP/GTP exchange factor(gene name synonym)|uniprotkb:Rab3 GDP/GTP exchange protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-728305	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	refseq:NP_001129415.1|refseq:NP_001129416.1|refseq:NP_003673.3|refseq:NP_569826.2|refseq:NP_569827.2|refseq:NP_569828.2|refseq:NP_569829.2|refseq:NP_569830.2|refseq:NP_569831.1|refseq:NP_569832.2|refseq:XP_005253246.1|refseq:XP_005253253.1|refseq:XP_005253258.1|refseq:XP_005253260.1|refseq:XP_005253256.1|refseq:XP_005253261.1|refseq:XP_005253262.1|ensembl:ENSP00000310933|ensembl:ENST00000349238|ensembl:ENSP00000304505|ensembl:ENST00000395336|ensembl:ENSP00000378745|ensembl:ENST00000395344|ensembl:ENSP00000378753|ensembl:ENST00000402192|ensembl:ENSP00000384287|ensembl:ENST00000402799|ensembl:ENSP00000385585|ensembl:ENST00000406482|ensembl:ENSP00000384435|ensembl:ENST00000407859|ensembl:ENSP00000384204|ensembl:ENSG00000110514(gene)|ensembl:ENST00000311027(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0032483"(regulation of Rab protein signal transduction)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001194(DENN)|interpro:IPR005112(dDENN)|interpro:IPR005113(uDENN)|interpro:IPR037516|interpro:IPR039980|interpro:IPR043153|reactome:R-HSA-5357905|reactome:R-HSA-8876198	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/11/18	2014/10/16	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	rogid:+YF66uj9WWG+hZ6fvrmXfelsQZs9606	intact-crc:68D49FC2FC203762|rigid:7733bMOYrGVwYe56E21B7Zf/Oc4	false	sufficient binding region:602-979|myc tag:?-?	sufficient binding region:1288-1588|ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8WXG6	uniprotkb:Q16849	intact:EBI-310528|uniprotkb:O15293|intact:EBI-728168|uniprotkb:D3DQR4|uniprotkb:Q15732|uniprotkb:Q15741|uniprotkb:Q8IWD7|uniprotkb:Q8WXG3|uniprotkb:Q8WXG4|uniprotkb:Q8WXG5|uniprotkb:Q8WZ63|uniprotkb:O15065|uniprotkb:A8K8S7|uniprotkb:B5MEE5|ensembl:ENSP00000310933	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	psi-mi:madd_human(display_long)|uniprotkb:MADD(gene name)|psi-mi:MADD(display_short)|uniprotkb:DENN(gene name synonym)|uniprotkb:IG20(gene name synonym)|uniprotkb:KIAA0358(gene name synonym)|uniprotkb:Differentially expressed in normal and neoplastic cells(gene name synonym)|uniprotkb:Insulinoma glucagonoma clone 20(gene name synonym)|uniprotkb:Rab3 GDP/GTP exchange factor(gene name synonym)|uniprotkb:Rab3 GDP/GTP exchange protein(gene name synonym)	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-728316	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129415.1|refseq:NP_001129416.1|refseq:NP_003673.3|refseq:NP_569826.2|refseq:NP_569827.2|refseq:NP_569828.2|refseq:NP_569829.2|refseq:NP_569830.2|refseq:NP_569831.1|refseq:NP_569832.2|refseq:XP_005253246.1|refseq:XP_005253253.1|refseq:XP_005253258.1|refseq:XP_005253260.1|refseq:XP_005253256.1|refseq:XP_005253261.1|refseq:XP_005253262.1|ensembl:ENSP00000310933|ensembl:ENST00000349238|ensembl:ENSP00000304505|ensembl:ENST00000395336|ensembl:ENSP00000378745|ensembl:ENST00000395344|ensembl:ENSP00000378753|ensembl:ENST00000402192|ensembl:ENSP00000384287|ensembl:ENST00000402799|ensembl:ENSP00000385585|ensembl:ENST00000406482|ensembl:ENSP00000384435|ensembl:ENST00000407859|ensembl:ENSP00000384204|ensembl:ENSG00000110514(gene)|ensembl:ENST00000311027(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0032483"(regulation of Rab protein signal transduction)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001194(DENN)|interpro:IPR005112(dDENN)|interpro:IPR005113(uDENN)|interpro:IPR037516|interpro:IPR039980|interpro:IPR043153|reactome:R-HSA-5357905|reactome:R-HSA-8876198	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/11/18	2014/10/16	rogid:+YF66uj9WWG+hZ6fvrmXfelsQZs9606	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	intact-crc:33E588DB6CDBD15C|rigid:7733bMOYrGVwYe56E21B7Zf/Oc4	false	ha tag:?-?|sufficient binding region:1288-1588	sufficient binding region:602-979|myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16849	uniprotkb:O14522	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-728331	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/11/18	2014/10/16	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606	intact-crc:5254AABC402B5FC6|rigid:e/CgyrlNGPFL4MYeWv1VeqHMjVY	false	flag tag:?-?|sufficient binding region:602-979	sufficient binding region:835-1378|myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16849	uniprotkb:Q13332	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	intact:EBI-711536|ensembl:ENSP00000467537|uniprotkb:Q2M3R7|uniprotkb:O75255|uniprotkb:O75870|uniprotkb:Q15718|uniprotkb:Q16341|intact:EBI-1058503	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:ptprs_human(display_long)|uniprotkb:PTPRS(gene name)|psi-mi:PTPRS(display_short)|uniprotkb:Receptor-type tyrosine-protein phosphatase sigma(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-728342	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008201"(heparin binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021510"(spinal cord development)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099560"(synaptic membrane adhesion)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2FH7|rcsb pdb:2YD2|rcsb pdb:2YD3|rcsb pdb:2YD9|rcsb pdb:4BPC|rcsb pdb:4PBX|reactome:R-HSA-3000178|reactome:R-HSA-388844|reactome:R-HSA-8849932|reactome:R-HSA-9034015|ensembl:ENSG00000105426(gene)|ensembl:ENST00000587303(transcript)|go:"GO:0004721"(phosphoprotein phosphatase activity)|refseq:NP_002841.3|refseq:NP_570923.2|refseq:NP_570924.2|refseq:NP_570925.2|refseq:XP_005259663.1|refseq:XP_005259666.1|refseq:XP_016882554.1|refseq:XP_016882555.1|refseq:XP_016882556.1	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/11/18	2014/10/16	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	rogid:mD7s7/H78PNJDAPLckZ19jmdAn89606	intact-crc:081FFB92F78D28E8|rigid:imyqtNZqctWSn9RS54Cy/yr2n9I	false	sufficient binding region:602-979|flag tag:?-?	sufficient binding region:1697-1948|myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16849	uniprotkb:Q13332	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	intact:EBI-711536|ensembl:ENSP00000467537|uniprotkb:Q2M3R7|uniprotkb:O75255|uniprotkb:O75870|uniprotkb:Q15718|uniprotkb:Q16341|intact:EBI-1058503	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:ptprs_human(display_long)|uniprotkb:PTPRS(gene name)|psi-mi:PTPRS(display_short)|uniprotkb:Receptor-type tyrosine-protein phosphatase sigma(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-728353	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008201"(heparin binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021510"(spinal cord development)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099560"(synaptic membrane adhesion)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2FH7|rcsb pdb:2YD2|rcsb pdb:2YD3|rcsb pdb:2YD9|rcsb pdb:4BPC|rcsb pdb:4PBX|reactome:R-HSA-3000178|reactome:R-HSA-388844|reactome:R-HSA-8849932|reactome:R-HSA-9034015|ensembl:ENSG00000105426(gene)|ensembl:ENST00000587303(transcript)|go:"GO:0004721"(phosphoprotein phosphatase activity)|refseq:NP_002841.3|refseq:NP_570923.2|refseq:NP_570924.2|refseq:NP_570925.2|refseq:XP_005259663.1|refseq:XP_005259666.1|refseq:XP_016882554.1|refseq:XP_016882555.1|refseq:XP_016882556.1	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/11/18	2014/10/16	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	rogid:mD7s7/H78PNJDAPLckZ19jmdAn89606	intact-crc:2243515A38EDFB8D|rigid:imyqtNZqctWSn9RS54Cy/yr2n9I	false	flag tag:?-?|sufficient binding region:602-979	sufficient binding region:1697-1948|myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92543	uniprotkb:Q16849	intact:EBI-728232|ensembl:ENSP00000265909|uniprotkb:E9PKB9|uniprotkb:Q8IV55	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	psi-mi:snx19_human(display_long)|uniprotkb:SNX19(gene name)|psi-mi:SNX19(display_short)|uniprotkb:KIAA0254(gene name synonym)	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-728364	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000120451(gene)|ensembl:ENST00000265909(transcript)|refseq:NP_055573.2|refseq:NP_001334847.1|refseq:NP_001334848.1|refseq:NP_001334849.1|refseq:NP_001334850.1|refseq:NP_001334851.1|refseq:NP_001334852.1|refseq:NP_001334853.1|refseq:NP_001334854.1|refseq:NP_001334855.1|refseq:NP_001334856.1|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0030073"(insulin secretion)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR001683(Phox-like)|interpro:IPR003114(PX-associated)|interpro:IPR013937(Sorting nexin, C-terminal)|interpro:IPR034908|interpro:IPR036871|interpro:IPR037909	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/11/18	2014/10/16	rogid:K3NS39vRx+FYSZXGpylwf32l0ug9606	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	intact-crc:44B96F9A05EEAB2A|rigid:oQGjaZqASYfQ8FAKNxSKuqIGG0Y	false	sufficient binding region:258-992|myc tag:?-?	sufficient binding region:602-979|flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16849	uniprotkb:Q92543	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	intact:EBI-728232|ensembl:ENSP00000265909|uniprotkb:E9PKB9|uniprotkb:Q8IV55	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:snx19_human(display_long)|uniprotkb:SNX19(gene name)|psi-mi:SNX19(display_short)|uniprotkb:KIAA0254(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-728375	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	ensembl:ENSG00000120451(gene)|ensembl:ENST00000265909(transcript)|refseq:NP_055573.2|refseq:NP_001334847.1|refseq:NP_001334848.1|refseq:NP_001334849.1|refseq:NP_001334850.1|refseq:NP_001334851.1|refseq:NP_001334852.1|refseq:NP_001334853.1|refseq:NP_001334854.1|refseq:NP_001334855.1|refseq:NP_001334856.1|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0030073"(insulin secretion)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR001683(Phox-like)|interpro:IPR003114(PX-associated)|interpro:IPR013937(Sorting nexin, C-terminal)|interpro:IPR034908|interpro:IPR036871|interpro:IPR037909	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/11/18	2014/10/16	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	rogid:K3NS39vRx+FYSZXGpylwf32l0ug9606	intact-crc:044289A4640CFB39|rigid:oQGjaZqASYfQ8FAKNxSKuqIGG0Y	false	flag tag:?-?|sufficient binding region:602-979	sufficient binding region:258-992|myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62937	uniprotkb:Q16849	intact:EBI-437708|uniprotkb:P05092|uniprotkb:Q3KQW3|uniprotkb:Q6IBU5|uniprotkb:Q96IX3|uniprotkb:Q9BRU4|uniprotkb:Q9BTY9|uniprotkb:Q9UC61|uniprotkb:Q567Q0|ensembl:ENSP00000419425|uniprotkb:A8K220	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	psi-mi:ppia_human(display_long)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:PPIA(gene name)|psi-mi:PPIA(display_short)|uniprotkb:CYPA(gene name synonym)|uniprotkb:Rotamase A(gene name synonym)	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-728386	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066953.1|interpro:IPR029000|mint:P62937|rcsb pdb:1AK4|rcsb pdb:1AWQ|rcsb pdb:1AWR|rcsb pdb:1AWS|rcsb pdb:1AWT|rcsb pdb:1AWU|rcsb pdb:1AWV|rcsb pdb:1BCK|rcsb pdb:1CWA|rcsb pdb:1CWB|rcsb pdb:1CWC|rcsb pdb:1CWF|rcsb pdb:1CWH|rcsb pdb:1CWI|rcsb pdb:1CWJ|rcsb pdb:1CWK|rcsb pdb:1CWL|rcsb pdb:1CWM|interpro:IPR024936|rcsb pdb:1CWO|rcsb pdb:1FGL|rcsb pdb:2N0T|rcsb pdb:2RMA|rcsb pdb:1M63|rcsb pdb:2RMB|rcsb pdb:2X25|rcsb pdb:2X2A|rcsb pdb:2X2C|rcsb pdb:2X2D|rcsb pdb:1M9C|rcsb pdb:1M9D|rcsb pdb:1M9E|rcsb pdb:2XGY|rcsb pdb:3CYH|rcsb pdb:3CYS|rcsb pdb:3K0M|rcsb pdb:3K0N|rcsb pdb:3K0O|rcsb pdb:3K0P|rcsb pdb:3K0Q|rcsb pdb:3K0R|rcsb pdb:3ODI|rcsb pdb:3ODL|rcsb pdb:1M9F|rcsb pdb:3RDD|rcsb pdb:1M9X|rcsb pdb:1M9Y|rcsb pdb:4CYH|rcsb pdb:4IPZ|rcsb pdb:4N1M|rcsb pdb:4N1N|rcsb pdb:1MF8|rcsb pdb:4N1O|rcsb pdb:4N1P|rcsb pdb:4N1Q|rcsb pdb:1MIK|rcsb pdb:1NMK|rcsb pdb:1OCA|rcsb pdb:1RMH|rcsb pdb:1VBS|rcsb pdb:1VBT|rcsb pdb:1W8L|rcsb pdb:1W8M|rcsb pdb:1W8V|rcsb pdb:1YND|rcsb pdb:1ZKF|rcsb pdb:2ALF|rcsb pdb:2CPL|rcsb pdb:2CYH|rcsb pdb:2MS4|rcsb pdb:2MZU|rcsb pdb:4N1R|rcsb pdb:4N1S|rcsb pdb:4YUG|rcsb pdb:4YUH|refseq:NP_001287910.1|reactome:R-HSA-210991|reactome:R-HSA-6798695|reactome:R-HSA-8950505|reactome:R-HSA-2025928|ensembl:ENSG00000196262(gene)|ensembl:ENST00000468812(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046790"(virion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|go:"GO:0005178"(integrin binding)|rcsb pdb:4YUI|rcsb pdb:4YUJ|rcsb pdb:4YUK|rcsb pdb:4YUL|rcsb pdb:4YUM|rcsb pdb:4YUN|rcsb pdb:4YUO|rcsb pdb:4YUP|rcsb pdb:5CYH|rcsb pdb:5F66|rcsb pdb:5FJB|rcsb pdb:5KUL|rcsb pdb:5KUN|rcsb pdb:5KUO|rcsb pdb:5KUQ|rcsb pdb:5KUR|rcsb pdb:5KUS|rcsb pdb:5KUU|rcsb pdb:5KUV|rcsb pdb:5KUW|rcsb pdb:5KUZ|rcsb pdb:5KV0|rcsb pdb:5KV1|rcsb pdb:5KV2|rcsb pdb:5KV3|rcsb pdb:5KV4|rcsb pdb:5KV5|rcsb pdb:5KV6|rcsb pdb:5KV7|rcsb pdb:5LUD|rcsb pdb:5NOQ|rcsb pdb:5NOR|rcsb pdb:5NOT|rcsb pdb:5NOU|rcsb pdb:5NOV|rcsb pdb:5NOW|rcsb pdb:5NOX|rcsb pdb:5NOY|rcsb pdb:5NOZ|rcsb pdb:5T9U|rcsb pdb:5T9W|rcsb pdb:5T9Z|rcsb pdb:5TA2|rcsb pdb:5TA4|rcsb pdb:5WC7|rcsb pdb:6BTA|rcsb pdb:6GJI|rcsb pdb:6GJJ|rcsb pdb:6GJL|rcsb pdb:6GJM|rcsb pdb:6GJN|rcsb pdb:6GJP|rcsb pdb:6GJR|rcsb pdb:6GJY|rcsb pdb:6GS6|rcsb pdb:6I42|rcsb pdb:6U5C|rcsb pdb:6U5D|rcsb pdb:6U5E|rcsb pdb:6U5G|rcsb pdb:6X3R|rcsb pdb:6X3Y|rcsb pdb:5NOS|rcsb pdb:6X4N|rcsb pdb:6X4O|rcsb pdb:6X4P|rcsb pdb:6X4Q|rcsb pdb:6Y9V|rcsb pdb:6Y9W|rcsb pdb:6Y9X|rcsb pdb:6Y9Y|rcsb pdb:6Y9Z|rcsb pdb:6ZDJ|rcsb pdb:7ABT|reactome:R-HSA-114608|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-173107|rcsb pdb:6X4M|reactome:R-HSA-175474|reactome:R-HSA-180689|dip:DIP-6080N	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/11/18	2014/10/16	rogid:dr4EVxcO+sqTPBqsQcydRn+rHoo9606	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	intact-crc:D4FF8A4CBCD649C8|rigid:rrCqv3yEXrB3x5KOpQEkvvVr6Ak	false	his tag:?-?	sufficient binding region:602-979|myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16849	uniprotkb:P62937	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	intact:EBI-437708|uniprotkb:P05092|uniprotkb:Q3KQW3|uniprotkb:Q6IBU5|uniprotkb:Q96IX3|uniprotkb:Q9BRU4|uniprotkb:Q9BTY9|uniprotkb:Q9UC61|uniprotkb:Q567Q0|ensembl:ENSP00000419425|uniprotkb:A8K220	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:ppia_human(display_long)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:PPIA(gene name)|psi-mi:PPIA(display_short)|uniprotkb:CYPA(gene name synonym)|uniprotkb:Rotamase A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-728395	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	refseq:NP_066953.1|interpro:IPR029000|mint:P62937|rcsb pdb:1AK4|rcsb pdb:1AWQ|rcsb pdb:1AWR|rcsb pdb:1AWS|rcsb pdb:1AWT|rcsb pdb:1AWU|rcsb pdb:1AWV|rcsb pdb:1BCK|rcsb pdb:1CWA|rcsb pdb:1CWB|rcsb pdb:1CWC|rcsb pdb:1CWF|rcsb pdb:1CWH|rcsb pdb:1CWI|rcsb pdb:1CWJ|rcsb pdb:1CWK|rcsb pdb:1CWL|rcsb pdb:1CWM|interpro:IPR024936|rcsb pdb:1CWO|rcsb pdb:1FGL|rcsb pdb:2N0T|rcsb pdb:2RMA|rcsb pdb:1M63|rcsb pdb:2RMB|rcsb pdb:2X25|rcsb pdb:2X2A|rcsb pdb:2X2C|rcsb pdb:2X2D|rcsb pdb:1M9C|rcsb pdb:1M9D|rcsb pdb:1M9E|rcsb pdb:2XGY|rcsb pdb:3CYH|rcsb pdb:3CYS|rcsb pdb:3K0M|rcsb pdb:3K0N|rcsb pdb:3K0O|rcsb pdb:3K0P|rcsb pdb:3K0Q|rcsb pdb:3K0R|rcsb pdb:3ODI|rcsb pdb:3ODL|rcsb pdb:1M9F|rcsb pdb:3RDD|rcsb pdb:1M9X|rcsb pdb:1M9Y|rcsb pdb:4CYH|rcsb pdb:4IPZ|rcsb pdb:4N1M|rcsb pdb:4N1N|rcsb pdb:1MF8|rcsb pdb:4N1O|rcsb pdb:4N1P|rcsb pdb:4N1Q|rcsb pdb:1MIK|rcsb pdb:1NMK|rcsb pdb:1OCA|rcsb pdb:1RMH|rcsb pdb:1VBS|rcsb pdb:1VBT|rcsb pdb:1W8L|rcsb pdb:1W8M|rcsb pdb:1W8V|rcsb pdb:1YND|rcsb pdb:1ZKF|rcsb pdb:2ALF|rcsb pdb:2CPL|rcsb pdb:2CYH|rcsb pdb:2MS4|rcsb pdb:2MZU|rcsb pdb:4N1R|rcsb pdb:4N1S|rcsb pdb:4YUG|rcsb pdb:4YUH|refseq:NP_001287910.1|reactome:R-HSA-210991|reactome:R-HSA-6798695|reactome:R-HSA-8950505|reactome:R-HSA-2025928|ensembl:ENSG00000196262(gene)|ensembl:ENST00000468812(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046790"(virion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|go:"GO:0005178"(integrin binding)|rcsb pdb:4YUI|rcsb pdb:4YUJ|rcsb pdb:4YUK|rcsb pdb:4YUL|rcsb pdb:4YUM|rcsb pdb:4YUN|rcsb pdb:4YUO|rcsb pdb:4YUP|rcsb pdb:5CYH|rcsb pdb:5F66|rcsb pdb:5FJB|rcsb pdb:5KUL|rcsb pdb:5KUN|rcsb pdb:5KUO|rcsb pdb:5KUQ|rcsb pdb:5KUR|rcsb pdb:5KUS|rcsb pdb:5KUU|rcsb pdb:5KUV|rcsb pdb:5KUW|rcsb pdb:5KUZ|rcsb pdb:5KV0|rcsb pdb:5KV1|rcsb pdb:5KV2|rcsb pdb:5KV3|rcsb pdb:5KV4|rcsb pdb:5KV5|rcsb pdb:5KV6|rcsb pdb:5KV7|rcsb pdb:5LUD|rcsb pdb:5NOQ|rcsb pdb:5NOR|rcsb pdb:5NOT|rcsb pdb:5NOU|rcsb pdb:5NOV|rcsb pdb:5NOW|rcsb pdb:5NOX|rcsb pdb:5NOY|rcsb pdb:5NOZ|rcsb pdb:5T9U|rcsb pdb:5T9W|rcsb pdb:5T9Z|rcsb pdb:5TA2|rcsb pdb:5TA4|rcsb pdb:5WC7|rcsb pdb:6BTA|rcsb pdb:6GJI|rcsb pdb:6GJJ|rcsb pdb:6GJL|rcsb pdb:6GJM|rcsb pdb:6GJN|rcsb pdb:6GJP|rcsb pdb:6GJR|rcsb pdb:6GJY|rcsb pdb:6GS6|rcsb pdb:6I42|rcsb pdb:6U5C|rcsb pdb:6U5D|rcsb pdb:6U5E|rcsb pdb:6U5G|rcsb pdb:6X3R|rcsb pdb:6X3Y|rcsb pdb:5NOS|rcsb pdb:6X4N|rcsb pdb:6X4O|rcsb pdb:6X4P|rcsb pdb:6X4Q|rcsb pdb:6Y9V|rcsb pdb:6Y9W|rcsb pdb:6Y9X|rcsb pdb:6Y9Y|rcsb pdb:6Y9Z|rcsb pdb:6ZDJ|rcsb pdb:7ABT|reactome:R-HSA-114608|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-173107|rcsb pdb:6X4M|reactome:R-HSA-175474|reactome:R-HSA-180689|dip:DIP-6080N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/11/18	2014/10/16	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	rogid:dr4EVxcO+sqTPBqsQcydRn+rHoo9606	intact-crc:A9247841A0DFB239|rigid:rrCqv3yEXrB3x5KOpQEkvvVr6Ak	false	myc tag:?-?|sufficient binding region:602-979	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16849	uniprotkb:Q13332	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	intact:EBI-711536|ensembl:ENSP00000467537|uniprotkb:Q2M3R7|uniprotkb:O75255|uniprotkb:O75870|uniprotkb:Q15718|uniprotkb:Q16341|intact:EBI-1058503	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:ptprs_human(display_long)|uniprotkb:PTPRS(gene name)|psi-mi:PTPRS(display_short)|uniprotkb:Receptor-type tyrosine-protein phosphatase sigma(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2005)	pubmed:16273344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-761845	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008201"(heparin binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021510"(spinal cord development)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099560"(synaptic membrane adhesion)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2FH7|rcsb pdb:2YD2|rcsb pdb:2YD3|rcsb pdb:2YD9|rcsb pdb:4BPC|rcsb pdb:4PBX|reactome:R-HSA-3000178|reactome:R-HSA-388844|reactome:R-HSA-8849932|reactome:R-HSA-9034015|ensembl:ENSG00000105426(gene)|ensembl:ENST00000587303(transcript)|go:"GO:0004721"(phosphoprotein phosphatase activity)|refseq:NP_002841.3|refseq:NP_570923.2|refseq:NP_570924.2|refseq:NP_570925.2|refseq:XP_005259663.1|refseq:XP_005259666.1|refseq:XP_016882554.1|refseq:XP_016882555.1|refseq:XP_016882556.1	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/11/18	2014/10/16	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	rogid:mD7s7/H78PNJDAPLckZ19jmdAn89606	intact-crc:2243515A38EDFB8D|rigid:imyqtNZqctWSn9RS54Cy/yr2n9I	false	flag tag:?-?|sufficient binding region:602-979	sufficient binding region:1697-1948|myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)