#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P49927 uniprotkb:P02554 intact:EBI-768761|ensembl:ENSSSCP00000065581|ensembl:ENSSSCP00015018718|ensembl:ENSSSCP00015018759|ensembl:ENSSSCP00025021495|ensembl:ENSSSCP00025021501|ensembl:ENSSSCP00030016409|ensembl:ENSSSCP00035023953|ensembl:ENSSSCP00035023962|ensembl:ENSSSCP00040033828|ensembl:ENSSSCP00045021264|ensembl:ENSSSCP00045021303|ensembl:ENSSSCP00050033444|ensembl:ENSSSCP00050033447|ensembl:ENSSSCP00055042278|ensembl:ENSSSCP00055042335|ensembl:ENSSSCP00070027105|ensembl:ENSSSCP00070027111 intact:EBI-768768 psi-mi:prio_pig(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym) psi-mi:tbb_pig(display_long)|uniprotkb:Beta-tubulin(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Nieznanski et al. (2005) pubmed:16004966 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-779483 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005672726.1|refseq:XP_013840478.1|refseq:XP_013840479.1|refseq:NP_001008687.1|go:"GO:0045121"(membrane raft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|rcsb pdb:1XYQ|reactome:R-SSC-9609523|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSSSCG00000007039(gene)|ensembl:ENSSSCG00015035652(gene)|ensembl:ENSSSCG00025037000(gene)|ensembl:ENSSSCG00030025735(gene)|ensembl:ENSSSCG00035044839(gene)|ensembl:ENSSSCG00040057844(gene)|ensembl:ENSSSCG00045018026(gene)|ensembl:ENSSSCG00050057010(gene)|ensembl:ENSSSCG00055026808(gene)|ensembl:ENSSSCG00070016484(gene)|ensembl:ENSSSCT00000074204(transcript)|ensembl:ENSSSCT00015047326(transcript)|ensembl:ENSSSCT00015047394(transcript)|ensembl:ENSSSCT00025050350(transcript)|ensembl:ENSSSCT00025050363(transcript)|ensembl:ENSSSCT00030035933(transcript)|ensembl:ENSSSCT00035059569(transcript)|ensembl:ENSSSCT00035059581(transcript)|ensembl:ENSSSCT00040078436(transcript)|ensembl:ENSSSCT00045030673(transcript)|ensembl:ENSSSCT00045030724(transcript)|ensembl:ENSSSCT00050077719(transcript)|ensembl:ENSSSCT00050077722(transcript)|ensembl:ENSSSCT00055052966(transcript)|ensembl:ENSSSCT00055053039(transcript)|ensembl:ENSSSCT00070032471(transcript)|ensembl:ENSSSCT00070032479(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization) rcsb pdb:3JAK|rcsb pdb:3JAL|rcsb pdb:3JAR|rcsb pdb:3JAS|rcsb pdb:3JAT|rcsb pdb:3JAW|rcsb pdb:3J6H|rcsb pdb:5OAM|rcsb pdb:5OCU|rcsb pdb:5OGC|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR002453(Beta tubulin)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR000217(Tubulin)|interpro:IPR018316|interpro:IPR017975|interpro:IPR003008(Tubulin/FtsZ, GTPase)|rcsb pdb:1FFX|rcsb pdb:1IA0|rcsb pdb:1JFF|rcsb pdb:1TUB|rcsb pdb:2HXF|rcsb pdb:2HXH|rcsb pdb:3J7I|rcsb pdb:3J6P|rcsb pdb:5XKE|rcsb pdb:5XKH|rcsb pdb:6BR1|rcsb pdb:6BRF|rcsb pdb:6BRY|rcsb pdb:6BS2|rcsb pdb:6MZE|rcsb pdb:6MZG|rcsb pdb:6D88|rcsb pdb:6MLQ|rcsb pdb:6MLR|rcsb pdb:6O2Q|rcsb pdb:6O2R|rcsb pdb:6O2S|rcsb pdb:6O2T|rcsb pdb:6MZF|rcsb pdb:6ZPI|rcsb pdb:4ABO|rcsb pdb:5SYC|rcsb pdb:5SYE|rcsb pdb:5SYF|rcsb pdb:5SYG|rcsb pdb:6KPP|rcsb pdb:6PC4|rcsb pdb:5FNV|rcsb pdb:5JQG|rcsb pdb:6LS4|rcsb pdb:3J6E|rcsb pdb:3J6F|rcsb pdb:3J6G|rcsb pdb:6CVJ|rcsb pdb:6CVN|rcsb pdb:4ZHQ|rcsb pdb:4ZI7|rcsb pdb:4ZOL|rcsb pdb:5BMV|rcsb pdb:5KMG|interpro:IPR036525|interpro:IPR037103|interpro:IPR023123|rcsb pdb:5JCB|rcsb pdb:5XP3|rcsb pdb:6BJC|rcsb pdb:5MM7|rcsb pdb:6EVX|rcsb pdb:5MM4|rcsb pdb:6DPU|rcsb pdb:6DPV|rcsb pdb:6DPW|rcsb pdb:6EVW|rcsb pdb:6EVY|rcsb pdb:6EVZ|rcsb pdb:6EW0|rcsb pdb:5XIW|rcsb pdb:5XKF|rcsb pdb:5XKG|rcsb pdb:5XXT|rcsb pdb:5XXV|rcsb pdb:5XXW|rcsb pdb:5XXX|rcsb pdb:5YL2|rcsb pdb:5YLJ|rcsb pdb:5YLS|rcsb pdb:6B0C|rcsb pdb:6B0I|rcsb pdb:6B0L|rcsb pdb:6RZA|rcsb pdb:6RZB|rcsb pdb:6TA3|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|rcsb pdb:6NNG|rcsb pdb:6O5M|rcsb pdb:6O5N|rcsb pdb:6O61|rcsb pdb:6KIO|rcsb pdb:6KIQ|rcsb pdb:6TA4|rcsb pdb:6TIW|rcsb pdb:6VPO|rcsb pdb:6VPP|rcsb pdb:6Y4M|rcsb pdb:6Y4N|rcsb pdb:7CBZ - - - - taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/16 2014/10/16 rogid:V3dI5ePh4SjSOezVBp9joeZ1yGw9823 rogid:Jkf0jKi5PcZwpsMsC3Et91s930g9823 intact-crc:817828A37767D63B|rigid:CLg14AmAU4kC4LQyjyupw+zZg4Y false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P49927 uniprotkb:P02550 intact:EBI-768761|ensembl:ENSSSCP00000065581|ensembl:ENSSSCP00015018718|ensembl:ENSSSCP00015018759|ensembl:ENSSSCP00025021495|ensembl:ENSSSCP00025021501|ensembl:ENSSSCP00030016409|ensembl:ENSSSCP00035023953|ensembl:ENSSSCP00035023962|ensembl:ENSSSCP00040033828|ensembl:ENSSSCP00045021264|ensembl:ENSSSCP00045021303|ensembl:ENSSSCP00050033444|ensembl:ENSSSCP00050033447|ensembl:ENSSSCP00055042278|ensembl:ENSSSCP00055042335|ensembl:ENSSSCP00070027105|ensembl:ENSSSCP00070027111 intact:EBI-768776 psi-mi:prio_pig(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym) psi-mi:tba1a_pig(display_long)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)|uniprotkb:TUBA1A(gene name)|psi-mi:TUBA1A(display_short) psi-mi:"MI:0030"(cross-linking study) Nieznanski et al. (2005) pubmed:16004966 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-779483 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005672726.1|refseq:XP_013840478.1|refseq:XP_013840479.1|refseq:NP_001008687.1|go:"GO:0045121"(membrane raft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|rcsb pdb:1XYQ|reactome:R-SSC-9609523|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSSSCG00000007039(gene)|ensembl:ENSSSCG00015035652(gene)|ensembl:ENSSSCG00025037000(gene)|ensembl:ENSSSCG00030025735(gene)|ensembl:ENSSSCG00035044839(gene)|ensembl:ENSSSCG00040057844(gene)|ensembl:ENSSSCG00045018026(gene)|ensembl:ENSSSCG00050057010(gene)|ensembl:ENSSSCG00055026808(gene)|ensembl:ENSSSCG00070016484(gene)|ensembl:ENSSSCT00000074204(transcript)|ensembl:ENSSSCT00015047326(transcript)|ensembl:ENSSSCT00015047394(transcript)|ensembl:ENSSSCT00025050350(transcript)|ensembl:ENSSSCT00025050363(transcript)|ensembl:ENSSSCT00030035933(transcript)|ensembl:ENSSSCT00035059569(transcript)|ensembl:ENSSSCT00035059581(transcript)|ensembl:ENSSSCT00040078436(transcript)|ensembl:ENSSSCT00045030673(transcript)|ensembl:ENSSSCT00045030724(transcript)|ensembl:ENSSSCT00050077719(transcript)|ensembl:ENSSSCT00050077722(transcript)|ensembl:ENSSSCT00055052966(transcript)|ensembl:ENSSSCT00055053039(transcript)|ensembl:ENSSSCT00070032471(transcript)|ensembl:ENSSSCT00070032479(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization) interpro:IPR002452(Alpha tubulin)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR000217(Tubulin)|interpro:IPR018316|interpro:IPR017975|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR036525|interpro:IPR037103|interpro:IPR023123|mint:P02550|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|rcsb pdb:1FFX|rcsb pdb:1IA0|rcsb pdb:1TUB|rcsb pdb:2HXF|rcsb pdb:2HXH|rcsb pdb:2P4N|rcsb pdb:3J6E|rcsb pdb:3J6F|rcsb pdb:3J6G|rcsb pdb:3J6H|rcsb pdb:3J6P|rcsb pdb:3J7I|rcsb pdb:4ABO|rcsb pdb:5MM4|rcsb pdb:5MM7|rcsb pdb:5XXT|rcsb pdb:5XXV|rcsb pdb:5XXW|rcsb pdb:5XXX|rcsb pdb:6KIO|rcsb pdb:6KIQ|rcsb pdb:6MLQ|rcsb pdb:6MLR|rcsb pdb:6MZE|rcsb pdb:6MZF|rcsb pdb:6MZG|rcsb pdb:6VPO|rcsb pdb:6VPP - - - - taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/16 2014/10/16 rogid:V3dI5ePh4SjSOezVBp9joeZ1yGw9823 rogid:OAdzBQZcB6dORgmQehwT+Jq64H09823 intact-crc:817828A37767D63B|rigid:CLg14AmAU4kC4LQyjyupw+zZg4Y false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P49927 uniprotkb:P02550 intact:EBI-768761|ensembl:ENSSSCP00000065581|ensembl:ENSSSCP00015018718|ensembl:ENSSSCP00015018759|ensembl:ENSSSCP00025021495|ensembl:ENSSSCP00025021501|ensembl:ENSSSCP00030016409|ensembl:ENSSSCP00035023953|ensembl:ENSSSCP00035023962|ensembl:ENSSSCP00040033828|ensembl:ENSSSCP00045021264|ensembl:ENSSSCP00045021303|ensembl:ENSSSCP00050033444|ensembl:ENSSSCP00050033447|ensembl:ENSSSCP00055042278|ensembl:ENSSSCP00055042335|ensembl:ENSSSCP00070027105|ensembl:ENSSSCP00070027111 intact:EBI-768776 psi-mi:prio_pig(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym) psi-mi:tba1a_pig(display_long)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)|uniprotkb:TUBA1A(gene name)|psi-mi:TUBA1A(display_short) psi-mi:"MI:0030"(cross-linking study) Nieznanski et al. (2005) pubmed:16004966 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-779514 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005672726.1|refseq:XP_013840478.1|refseq:XP_013840479.1|refseq:NP_001008687.1|go:"GO:0045121"(membrane raft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|rcsb pdb:1XYQ|reactome:R-SSC-9609523|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSSSCG00000007039(gene)|ensembl:ENSSSCG00015035652(gene)|ensembl:ENSSSCG00025037000(gene)|ensembl:ENSSSCG00030025735(gene)|ensembl:ENSSSCG00035044839(gene)|ensembl:ENSSSCG00040057844(gene)|ensembl:ENSSSCG00045018026(gene)|ensembl:ENSSSCG00050057010(gene)|ensembl:ENSSSCG00055026808(gene)|ensembl:ENSSSCG00070016484(gene)|ensembl:ENSSSCT00000074204(transcript)|ensembl:ENSSSCT00015047326(transcript)|ensembl:ENSSSCT00015047394(transcript)|ensembl:ENSSSCT00025050350(transcript)|ensembl:ENSSSCT00025050363(transcript)|ensembl:ENSSSCT00030035933(transcript)|ensembl:ENSSSCT00035059569(transcript)|ensembl:ENSSSCT00035059581(transcript)|ensembl:ENSSSCT00040078436(transcript)|ensembl:ENSSSCT00045030673(transcript)|ensembl:ENSSSCT00045030724(transcript)|ensembl:ENSSSCT00050077719(transcript)|ensembl:ENSSSCT00050077722(transcript)|ensembl:ENSSSCT00055052966(transcript)|ensembl:ENSSSCT00055053039(transcript)|ensembl:ENSSSCT00070032471(transcript)|ensembl:ENSSSCT00070032479(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization) interpro:IPR002452(Alpha tubulin)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR000217(Tubulin)|interpro:IPR018316|interpro:IPR017975|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR036525|interpro:IPR037103|interpro:IPR023123|mint:P02550|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|rcsb pdb:1FFX|rcsb pdb:1IA0|rcsb pdb:1TUB|rcsb pdb:2HXF|rcsb pdb:2HXH|rcsb pdb:2P4N|rcsb pdb:3J6E|rcsb pdb:3J6F|rcsb pdb:3J6G|rcsb pdb:3J6H|rcsb pdb:3J6P|rcsb pdb:3J7I|rcsb pdb:4ABO|rcsb pdb:5MM4|rcsb pdb:5MM7|rcsb pdb:5XXT|rcsb pdb:5XXV|rcsb pdb:5XXW|rcsb pdb:5XXX|rcsb pdb:6KIO|rcsb pdb:6KIQ|rcsb pdb:6MLQ|rcsb pdb:6MLR|rcsb pdb:6MZE|rcsb pdb:6MZF|rcsb pdb:6MZG|rcsb pdb:6VPO|rcsb pdb:6VPP - - - - taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") - 2005/12/16 2014/10/16 rogid:V3dI5ePh4SjSOezVBp9joeZ1yGw9823 rogid:OAdzBQZcB6dORgmQehwT+Jq64H09823 intact-crc:8616E16A17089902|rigid:CLg14AmAU4kC4LQyjyupw+zZg4Y false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P49927 uniprotkb:P02554 intact:EBI-768761|ensembl:ENSSSCP00000065581|ensembl:ENSSSCP00015018718|ensembl:ENSSSCP00015018759|ensembl:ENSSSCP00025021495|ensembl:ENSSSCP00025021501|ensembl:ENSSSCP00030016409|ensembl:ENSSSCP00035023953|ensembl:ENSSSCP00035023962|ensembl:ENSSSCP00040033828|ensembl:ENSSSCP00045021264|ensembl:ENSSSCP00045021303|ensembl:ENSSSCP00050033444|ensembl:ENSSSCP00050033447|ensembl:ENSSSCP00055042278|ensembl:ENSSSCP00055042335|ensembl:ENSSSCP00070027105|ensembl:ENSSSCP00070027111 intact:EBI-768768 psi-mi:prio_pig(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym) psi-mi:tbb_pig(display_long)|uniprotkb:Beta-tubulin(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Nieznanski et al. (2005) pubmed:16004966 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-779514 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005672726.1|refseq:XP_013840478.1|refseq:XP_013840479.1|refseq:NP_001008687.1|go:"GO:0045121"(membrane raft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|rcsb pdb:1XYQ|reactome:R-SSC-9609523|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSSSCG00000007039(gene)|ensembl:ENSSSCG00015035652(gene)|ensembl:ENSSSCG00025037000(gene)|ensembl:ENSSSCG00030025735(gene)|ensembl:ENSSSCG00035044839(gene)|ensembl:ENSSSCG00040057844(gene)|ensembl:ENSSSCG00045018026(gene)|ensembl:ENSSSCG00050057010(gene)|ensembl:ENSSSCG00055026808(gene)|ensembl:ENSSSCG00070016484(gene)|ensembl:ENSSSCT00000074204(transcript)|ensembl:ENSSSCT00015047326(transcript)|ensembl:ENSSSCT00015047394(transcript)|ensembl:ENSSSCT00025050350(transcript)|ensembl:ENSSSCT00025050363(transcript)|ensembl:ENSSSCT00030035933(transcript)|ensembl:ENSSSCT00035059569(transcript)|ensembl:ENSSSCT00035059581(transcript)|ensembl:ENSSSCT00040078436(transcript)|ensembl:ENSSSCT00045030673(transcript)|ensembl:ENSSSCT00045030724(transcript)|ensembl:ENSSSCT00050077719(transcript)|ensembl:ENSSSCT00050077722(transcript)|ensembl:ENSSSCT00055052966(transcript)|ensembl:ENSSSCT00055053039(transcript)|ensembl:ENSSSCT00070032471(transcript)|ensembl:ENSSSCT00070032479(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization) rcsb pdb:3JAK|rcsb pdb:3JAL|rcsb pdb:3JAR|rcsb pdb:3JAS|rcsb pdb:3JAT|rcsb pdb:3JAW|rcsb pdb:3J6H|rcsb pdb:5OAM|rcsb pdb:5OCU|rcsb pdb:5OGC|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR002453(Beta tubulin)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR000217(Tubulin)|interpro:IPR018316|interpro:IPR017975|interpro:IPR003008(Tubulin/FtsZ, GTPase)|rcsb pdb:1FFX|rcsb pdb:1IA0|rcsb pdb:1JFF|rcsb pdb:1TUB|rcsb pdb:2HXF|rcsb pdb:2HXH|rcsb pdb:3J7I|rcsb pdb:3J6P|rcsb pdb:5XKE|rcsb pdb:5XKH|rcsb pdb:6BR1|rcsb pdb:6BRF|rcsb pdb:6BRY|rcsb pdb:6BS2|rcsb pdb:6MZE|rcsb pdb:6MZG|rcsb pdb:6D88|rcsb pdb:6MLQ|rcsb pdb:6MLR|rcsb pdb:6O2Q|rcsb pdb:6O2R|rcsb pdb:6O2S|rcsb pdb:6O2T|rcsb pdb:6MZF|rcsb pdb:6ZPI|rcsb pdb:4ABO|rcsb pdb:5SYC|rcsb pdb:5SYE|rcsb pdb:5SYF|rcsb pdb:5SYG|rcsb pdb:6KPP|rcsb pdb:6PC4|rcsb pdb:5FNV|rcsb pdb:5JQG|rcsb pdb:6LS4|rcsb pdb:3J6E|rcsb pdb:3J6F|rcsb pdb:3J6G|rcsb pdb:6CVJ|rcsb pdb:6CVN|rcsb pdb:4ZHQ|rcsb pdb:4ZI7|rcsb pdb:4ZOL|rcsb pdb:5BMV|rcsb pdb:5KMG|interpro:IPR036525|interpro:IPR037103|interpro:IPR023123|rcsb pdb:5JCB|rcsb pdb:5XP3|rcsb pdb:6BJC|rcsb pdb:5MM7|rcsb pdb:6EVX|rcsb pdb:5MM4|rcsb pdb:6DPU|rcsb pdb:6DPV|rcsb pdb:6DPW|rcsb pdb:6EVW|rcsb pdb:6EVY|rcsb pdb:6EVZ|rcsb pdb:6EW0|rcsb pdb:5XIW|rcsb pdb:5XKF|rcsb pdb:5XKG|rcsb pdb:5XXT|rcsb pdb:5XXV|rcsb pdb:5XXW|rcsb pdb:5XXX|rcsb pdb:5YL2|rcsb pdb:5YLJ|rcsb pdb:5YLS|rcsb pdb:6B0C|rcsb pdb:6B0I|rcsb pdb:6B0L|rcsb pdb:6RZA|rcsb pdb:6RZB|rcsb pdb:6TA3|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|rcsb pdb:6NNG|rcsb pdb:6O5M|rcsb pdb:6O5N|rcsb pdb:6O61|rcsb pdb:6KIO|rcsb pdb:6KIQ|rcsb pdb:6TA4|rcsb pdb:6TIW|rcsb pdb:6VPO|rcsb pdb:6VPP|rcsb pdb:6Y4M|rcsb pdb:6Y4N|rcsb pdb:7CBZ - - - - taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") - 2005/12/16 2014/10/16 rogid:V3dI5ePh4SjSOezVBp9joeZ1yGw9823 rogid:Jkf0jKi5PcZwpsMsC3Et91s930g9823 intact-crc:8616E16A17089902|rigid:CLg14AmAU4kC4LQyjyupw+zZg4Y false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P49927 uniprotkb:P02550 intact:EBI-768761|ensembl:ENSSSCP00000065581|ensembl:ENSSSCP00015018718|ensembl:ENSSSCP00015018759|ensembl:ENSSSCP00025021495|ensembl:ENSSSCP00025021501|ensembl:ENSSSCP00030016409|ensembl:ENSSSCP00035023953|ensembl:ENSSSCP00035023962|ensembl:ENSSSCP00040033828|ensembl:ENSSSCP00045021264|ensembl:ENSSSCP00045021303|ensembl:ENSSSCP00050033444|ensembl:ENSSSCP00050033447|ensembl:ENSSSCP00055042278|ensembl:ENSSSCP00055042335|ensembl:ENSSSCP00070027105|ensembl:ENSSSCP00070027111 intact:EBI-768776 psi-mi:prio_pig(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym) psi-mi:tba1a_pig(display_long)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)|uniprotkb:TUBA1A(gene name)|psi-mi:TUBA1A(display_short) psi-mi:"MI:0030"(cross-linking study) Nieznanski et al. (2005) pubmed:16004966 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-781679 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005672726.1|refseq:XP_013840478.1|refseq:XP_013840479.1|refseq:NP_001008687.1|go:"GO:0045121"(membrane raft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|rcsb pdb:1XYQ|reactome:R-SSC-9609523|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSSSCG00000007039(gene)|ensembl:ENSSSCG00015035652(gene)|ensembl:ENSSSCG00025037000(gene)|ensembl:ENSSSCG00030025735(gene)|ensembl:ENSSSCG00035044839(gene)|ensembl:ENSSSCG00040057844(gene)|ensembl:ENSSSCG00045018026(gene)|ensembl:ENSSSCG00050057010(gene)|ensembl:ENSSSCG00055026808(gene)|ensembl:ENSSSCG00070016484(gene)|ensembl:ENSSSCT00000074204(transcript)|ensembl:ENSSSCT00015047326(transcript)|ensembl:ENSSSCT00015047394(transcript)|ensembl:ENSSSCT00025050350(transcript)|ensembl:ENSSSCT00025050363(transcript)|ensembl:ENSSSCT00030035933(transcript)|ensembl:ENSSSCT00035059569(transcript)|ensembl:ENSSSCT00035059581(transcript)|ensembl:ENSSSCT00040078436(transcript)|ensembl:ENSSSCT00045030673(transcript)|ensembl:ENSSSCT00045030724(transcript)|ensembl:ENSSSCT00050077719(transcript)|ensembl:ENSSSCT00050077722(transcript)|ensembl:ENSSSCT00055052966(transcript)|ensembl:ENSSSCT00055053039(transcript)|ensembl:ENSSSCT00070032471(transcript)|ensembl:ENSSSCT00070032479(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization) interpro:IPR002452(Alpha tubulin)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR000217(Tubulin)|interpro:IPR018316|interpro:IPR017975|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR036525|interpro:IPR037103|interpro:IPR023123|mint:P02550|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|rcsb pdb:1FFX|rcsb pdb:1IA0|rcsb pdb:1TUB|rcsb pdb:2HXF|rcsb pdb:2HXH|rcsb pdb:2P4N|rcsb pdb:3J6E|rcsb pdb:3J6F|rcsb pdb:3J6G|rcsb pdb:3J6H|rcsb pdb:3J6P|rcsb pdb:3J7I|rcsb pdb:4ABO|rcsb pdb:5MM4|rcsb pdb:5MM7|rcsb pdb:5XXT|rcsb pdb:5XXV|rcsb pdb:5XXW|rcsb pdb:5XXX|rcsb pdb:6KIO|rcsb pdb:6KIQ|rcsb pdb:6MLQ|rcsb pdb:6MLR|rcsb pdb:6MZE|rcsb pdb:6MZF|rcsb pdb:6MZG|rcsb pdb:6VPO|rcsb pdb:6VPP - - - comment:"The interaction results imply that the tubulin binding site on PRPc may be localized at the N-terminal half (23-110/111)." taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/16 2014/10/16 rogid:V3dI5ePh4SjSOezVBp9joeZ1yGw9823 rogid:OAdzBQZcB6dORgmQehwT+Jq64H09823 intact-crc:39BA4B84C678A8C4|rigid:CLg14AmAU4kC4LQyjyupw+zZg4Y false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P49927 uniprotkb:P02554 intact:EBI-768761|ensembl:ENSSSCP00000065581|ensembl:ENSSSCP00015018718|ensembl:ENSSSCP00015018759|ensembl:ENSSSCP00025021495|ensembl:ENSSSCP00025021501|ensembl:ENSSSCP00030016409|ensembl:ENSSSCP00035023953|ensembl:ENSSSCP00035023962|ensembl:ENSSSCP00040033828|ensembl:ENSSSCP00045021264|ensembl:ENSSSCP00045021303|ensembl:ENSSSCP00050033444|ensembl:ENSSSCP00050033447|ensembl:ENSSSCP00055042278|ensembl:ENSSSCP00055042335|ensembl:ENSSSCP00070027105|ensembl:ENSSSCP00070027111 intact:EBI-768768 psi-mi:prio_pig(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym) psi-mi:tbb_pig(display_long)|uniprotkb:Beta-tubulin(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Nieznanski et al. (2005) pubmed:16004966 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-781679 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005672726.1|refseq:XP_013840478.1|refseq:XP_013840479.1|refseq:NP_001008687.1|go:"GO:0045121"(membrane raft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|rcsb pdb:1XYQ|reactome:R-SSC-9609523|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSSSCG00000007039(gene)|ensembl:ENSSSCG00015035652(gene)|ensembl:ENSSSCG00025037000(gene)|ensembl:ENSSSCG00030025735(gene)|ensembl:ENSSSCG00035044839(gene)|ensembl:ENSSSCG00040057844(gene)|ensembl:ENSSSCG00045018026(gene)|ensembl:ENSSSCG00050057010(gene)|ensembl:ENSSSCG00055026808(gene)|ensembl:ENSSSCG00070016484(gene)|ensembl:ENSSSCT00000074204(transcript)|ensembl:ENSSSCT00015047326(transcript)|ensembl:ENSSSCT00015047394(transcript)|ensembl:ENSSSCT00025050350(transcript)|ensembl:ENSSSCT00025050363(transcript)|ensembl:ENSSSCT00030035933(transcript)|ensembl:ENSSSCT00035059569(transcript)|ensembl:ENSSSCT00035059581(transcript)|ensembl:ENSSSCT00040078436(transcript)|ensembl:ENSSSCT00045030673(transcript)|ensembl:ENSSSCT00045030724(transcript)|ensembl:ENSSSCT00050077719(transcript)|ensembl:ENSSSCT00050077722(transcript)|ensembl:ENSSSCT00055052966(transcript)|ensembl:ENSSSCT00055053039(transcript)|ensembl:ENSSSCT00070032471(transcript)|ensembl:ENSSSCT00070032479(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization) rcsb pdb:3JAK|rcsb pdb:3JAL|rcsb pdb:3JAR|rcsb pdb:3JAS|rcsb pdb:3JAT|rcsb pdb:3JAW|rcsb pdb:3J6H|rcsb pdb:5OAM|rcsb pdb:5OCU|rcsb pdb:5OGC|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR002453(Beta tubulin)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR000217(Tubulin)|interpro:IPR018316|interpro:IPR017975|interpro:IPR003008(Tubulin/FtsZ, GTPase)|rcsb pdb:1FFX|rcsb pdb:1IA0|rcsb pdb:1JFF|rcsb pdb:1TUB|rcsb pdb:2HXF|rcsb pdb:2HXH|rcsb pdb:3J7I|rcsb pdb:3J6P|rcsb pdb:5XKE|rcsb pdb:5XKH|rcsb pdb:6BR1|rcsb pdb:6BRF|rcsb pdb:6BRY|rcsb pdb:6BS2|rcsb pdb:6MZE|rcsb pdb:6MZG|rcsb pdb:6D88|rcsb pdb:6MLQ|rcsb pdb:6MLR|rcsb pdb:6O2Q|rcsb pdb:6O2R|rcsb pdb:6O2S|rcsb pdb:6O2T|rcsb pdb:6MZF|rcsb pdb:6ZPI|rcsb pdb:4ABO|rcsb pdb:5SYC|rcsb pdb:5SYE|rcsb pdb:5SYF|rcsb pdb:5SYG|rcsb pdb:6KPP|rcsb pdb:6PC4|rcsb pdb:5FNV|rcsb pdb:5JQG|rcsb pdb:6LS4|rcsb pdb:3J6E|rcsb pdb:3J6F|rcsb pdb:3J6G|rcsb pdb:6CVJ|rcsb pdb:6CVN|rcsb pdb:4ZHQ|rcsb pdb:4ZI7|rcsb pdb:4ZOL|rcsb pdb:5BMV|rcsb pdb:5KMG|interpro:IPR036525|interpro:IPR037103|interpro:IPR023123|rcsb pdb:5JCB|rcsb pdb:5XP3|rcsb pdb:6BJC|rcsb pdb:5MM7|rcsb pdb:6EVX|rcsb pdb:5MM4|rcsb pdb:6DPU|rcsb pdb:6DPV|rcsb pdb:6DPW|rcsb pdb:6EVW|rcsb pdb:6EVY|rcsb pdb:6EVZ|rcsb pdb:6EW0|rcsb pdb:5XIW|rcsb pdb:5XKF|rcsb pdb:5XKG|rcsb pdb:5XXT|rcsb pdb:5XXV|rcsb pdb:5XXW|rcsb pdb:5XXX|rcsb pdb:5YL2|rcsb pdb:5YLJ|rcsb pdb:5YLS|rcsb pdb:6B0C|rcsb pdb:6B0I|rcsb pdb:6B0L|rcsb pdb:6RZA|rcsb pdb:6RZB|rcsb pdb:6TA3|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|rcsb pdb:6NNG|rcsb pdb:6O5M|rcsb pdb:6O5N|rcsb pdb:6O61|rcsb pdb:6KIO|rcsb pdb:6KIQ|rcsb pdb:6TA4|rcsb pdb:6TIW|rcsb pdb:6VPO|rcsb pdb:6VPP|rcsb pdb:6Y4M|rcsb pdb:6Y4N|rcsb pdb:7CBZ - - - comment:"The interaction results imply that the tubulin binding site on PRPc may be localized at the N-terminal half (23-110/111)." taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/16 2014/10/16 rogid:V3dI5ePh4SjSOezVBp9joeZ1yGw9823 rogid:Jkf0jKi5PcZwpsMsC3Et91s930g9823 intact-crc:39BA4B84C678A8C4|rigid:CLg14AmAU4kC4LQyjyupw+zZg4Y false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P04156 uniprotkb:P02554 intact:EBI-977302|ensembl:ENSP00000368752|ensembl:ENSP00000399376|ensembl:ENSP00000411599|ensembl:ENSP00000415284|uniprotkb:O60489|uniprotkb:P78446|uniprotkb:Q15216|uniprotkb:Q15221|uniprotkb:Q27H91|uniprotkb:Q8TBG0|uniprotkb:Q96E70|uniprotkb:Q9UP19|uniprotkb:Q5QPB4 intact:EBI-768768 psi-mi:prio_human(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ALTPRP(gene name synonym) psi-mi:tbb_pig(display_long)|uniprotkb:Beta-tubulin(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Nieznanski et al. (2005) pubmed:16004966 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-781703 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000171867(gene)|ensembl:ENST00000379440(transcript)|ensembl:ENST00000424424(transcript)|ensembl:ENST00000430350(transcript)|ensembl:ENST00000457586(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009986"(cell surface)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098794"(postsynapse)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:0045121"(membrane raft)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR025860|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR036924|mint:P04156|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|rcsb pdb:1E1G|rcsb pdb:1E1J|rcsb pdb:1E1P|rcsb pdb:1E1S|rcsb pdb:1E1U|rcsb pdb:1E1W|rcsb pdb:1FKC|rcsb pdb:1FO7|rcsb pdb:1H0L|rcsb pdb:1HJM|rcsb pdb:1HJN|rcsb pdb:1I4M|rcsb pdb:1OEH|rcsb pdb:1OEI|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1QLX|rcsb pdb:1QLZ|rcsb pdb:1QM0|rcsb pdb:1QM1|rcsb pdb:1QM2|rcsb pdb:1QM3|rcsb pdb:2IV4|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|rcsb pdb:2IV5|rcsb pdb:2IV6|rcsb pdb:2K1D|rcsb pdb:2KUN|rcsb pdb:2LBG|rcsb pdb:2LEJ|rcsb pdb:2LFT|rcsb pdb:2LSB|rcsb pdb:2LV1|rcsb pdb:2M8T|rcsb pdb:2OL9|rcsb pdb:2W9E|rcsb pdb:3HAF|rcsb pdb:3HAK|rcsb pdb:3HEQ|rcsb pdb:3HER|rcsb pdb:3HES|rcsb pdb:3HJ5|rcsb pdb:3HJX|rcsb pdb:3MD4|rcsb pdb:3MD5|rcsb pdb:3NHC|rcsb pdb:3NHD|rcsb pdb:3NVF|rcsb pdb:4DGI|rcsb pdb:4E1H|rcsb pdb:4E1I|rcsb pdb:4KML|rcsb pdb:4N9O|rcsb pdb:5L6R|rcsb pdb:5YJ4|rcsb pdb:5YJ5|rcsb pdb:6DU9|rcsb pdb:6LNI|rcsb pdb:6PQ5|rcsb pdb:6PQA|rcsb pdb:6SUZ|rcsb pdb:6SV2|rcsb pdb:6UUR|reactome:R-HSA-419037|reactome:R-HSA-9609523|refseq:NP_000302.1|refseq:NP_001073590.1|refseq:NP_001073591.1|refseq:NP_001073592.1|refseq:NP_898902.1|refseq:NP_001258490.1|dip:DIP-29933N rcsb pdb:3JAK|rcsb pdb:3JAL|rcsb pdb:3JAR|rcsb pdb:3JAS|rcsb pdb:3JAT|rcsb pdb:3JAW|rcsb pdb:3J6H|rcsb pdb:5OAM|rcsb pdb:5OCU|rcsb pdb:5OGC|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR002453(Beta tubulin)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR000217(Tubulin)|interpro:IPR018316|interpro:IPR017975|interpro:IPR003008(Tubulin/FtsZ, GTPase)|rcsb pdb:1FFX|rcsb pdb:1IA0|rcsb pdb:1JFF|rcsb pdb:1TUB|rcsb pdb:2HXF|rcsb pdb:2HXH|rcsb pdb:3J7I|rcsb pdb:3J6P|rcsb pdb:5XKE|rcsb pdb:5XKH|rcsb pdb:6BR1|rcsb pdb:6BRF|rcsb pdb:6BRY|rcsb pdb:6BS2|rcsb pdb:6MZE|rcsb pdb:6MZG|rcsb pdb:6D88|rcsb pdb:6MLQ|rcsb pdb:6MLR|rcsb pdb:6O2Q|rcsb pdb:6O2R|rcsb pdb:6O2S|rcsb pdb:6O2T|rcsb pdb:6MZF|rcsb pdb:6ZPI|rcsb pdb:4ABO|rcsb pdb:5SYC|rcsb pdb:5SYE|rcsb pdb:5SYF|rcsb pdb:5SYG|rcsb pdb:6KPP|rcsb pdb:6PC4|rcsb pdb:5FNV|rcsb pdb:5JQG|rcsb pdb:6LS4|rcsb pdb:3J6E|rcsb pdb:3J6F|rcsb pdb:3J6G|rcsb pdb:6CVJ|rcsb pdb:6CVN|rcsb pdb:4ZHQ|rcsb pdb:4ZI7|rcsb pdb:4ZOL|rcsb pdb:5BMV|rcsb pdb:5KMG|interpro:IPR036525|interpro:IPR037103|interpro:IPR023123|rcsb pdb:5JCB|rcsb pdb:5XP3|rcsb pdb:6BJC|rcsb pdb:5MM7|rcsb pdb:6EVX|rcsb pdb:5MM4|rcsb pdb:6DPU|rcsb pdb:6DPV|rcsb pdb:6DPW|rcsb pdb:6EVW|rcsb pdb:6EVY|rcsb pdb:6EVZ|rcsb pdb:6EW0|rcsb pdb:5XIW|rcsb pdb:5XKF|rcsb pdb:5XKG|rcsb pdb:5XXT|rcsb pdb:5XXV|rcsb pdb:5XXW|rcsb pdb:5XXX|rcsb pdb:5YL2|rcsb pdb:5YLJ|rcsb pdb:5YLS|rcsb pdb:6B0C|rcsb pdb:6B0I|rcsb pdb:6B0L|rcsb pdb:6RZA|rcsb pdb:6RZB|rcsb pdb:6TA3|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|rcsb pdb:6NNG|rcsb pdb:6O5M|rcsb pdb:6O5N|rcsb pdb:6O61|rcsb pdb:6KIO|rcsb pdb:6KIQ|rcsb pdb:6TA4|rcsb pdb:6TIW|rcsb pdb:6VPO|rcsb pdb:6VPP|rcsb pdb:6Y4M|rcsb pdb:6Y4N|rcsb pdb:7CBZ - - - - taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/16 2014/10/16 rogid:O9dYBDKthE5DdgePny2xsDYzb989606 rogid:Jkf0jKi5PcZwpsMsC3Et91s930g9823 intact-crc:828D56BE5A73275F|rigid:JI0PL+BxhDlrFSxby3SSlmsdLFk false binding-associated region:23-231|his tag:?-?,n-n - - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:P04156 uniprotkb:P02550 intact:EBI-977302|ensembl:ENSP00000368752|ensembl:ENSP00000399376|ensembl:ENSP00000411599|ensembl:ENSP00000415284|uniprotkb:O60489|uniprotkb:P78446|uniprotkb:Q15216|uniprotkb:Q15221|uniprotkb:Q27H91|uniprotkb:Q8TBG0|uniprotkb:Q96E70|uniprotkb:Q9UP19|uniprotkb:Q5QPB4 intact:EBI-768776 psi-mi:prio_human(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ALTPRP(gene name synonym) psi-mi:tba1a_pig(display_long)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)|uniprotkb:TUBA1A(gene name)|psi-mi:TUBA1A(display_short) psi-mi:"MI:0030"(cross-linking study) Nieznanski et al. (2005) pubmed:16004966 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-781703 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000171867(gene)|ensembl:ENST00000379440(transcript)|ensembl:ENST00000424424(transcript)|ensembl:ENST00000430350(transcript)|ensembl:ENST00000457586(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009986"(cell surface)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098794"(postsynapse)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:0045121"(membrane raft)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR025860|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR036924|mint:P04156|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|rcsb pdb:1E1G|rcsb pdb:1E1J|rcsb pdb:1E1P|rcsb pdb:1E1S|rcsb pdb:1E1U|rcsb pdb:1E1W|rcsb pdb:1FKC|rcsb pdb:1FO7|rcsb pdb:1H0L|rcsb pdb:1HJM|rcsb pdb:1HJN|rcsb pdb:1I4M|rcsb pdb:1OEH|rcsb pdb:1OEI|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1QLX|rcsb pdb:1QLZ|rcsb pdb:1QM0|rcsb pdb:1QM1|rcsb pdb:1QM2|rcsb pdb:1QM3|rcsb pdb:2IV4|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|rcsb pdb:2IV5|rcsb pdb:2IV6|rcsb pdb:2K1D|rcsb pdb:2KUN|rcsb pdb:2LBG|rcsb pdb:2LEJ|rcsb pdb:2LFT|rcsb pdb:2LSB|rcsb pdb:2LV1|rcsb pdb:2M8T|rcsb pdb:2OL9|rcsb pdb:2W9E|rcsb pdb:3HAF|rcsb pdb:3HAK|rcsb pdb:3HEQ|rcsb pdb:3HER|rcsb pdb:3HES|rcsb pdb:3HJ5|rcsb pdb:3HJX|rcsb pdb:3MD4|rcsb pdb:3MD5|rcsb pdb:3NHC|rcsb pdb:3NHD|rcsb pdb:3NVF|rcsb pdb:4DGI|rcsb pdb:4E1H|rcsb pdb:4E1I|rcsb pdb:4KML|rcsb pdb:4N9O|rcsb pdb:5L6R|rcsb pdb:5YJ4|rcsb pdb:5YJ5|rcsb pdb:6DU9|rcsb pdb:6LNI|rcsb pdb:6PQ5|rcsb pdb:6PQA|rcsb pdb:6SUZ|rcsb pdb:6SV2|rcsb pdb:6UUR|reactome:R-HSA-419037|reactome:R-HSA-9609523|refseq:NP_000302.1|refseq:NP_001073590.1|refseq:NP_001073591.1|refseq:NP_001073592.1|refseq:NP_898902.1|refseq:NP_001258490.1|dip:DIP-29933N interpro:IPR002452(Alpha tubulin)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR000217(Tubulin)|interpro:IPR018316|interpro:IPR017975|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR036525|interpro:IPR037103|interpro:IPR023123|mint:P02550|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|rcsb pdb:1FFX|rcsb pdb:1IA0|rcsb pdb:1TUB|rcsb pdb:2HXF|rcsb pdb:2HXH|rcsb pdb:2P4N|rcsb pdb:3J6E|rcsb pdb:3J6F|rcsb pdb:3J6G|rcsb pdb:3J6H|rcsb pdb:3J6P|rcsb pdb:3J7I|rcsb pdb:4ABO|rcsb pdb:5MM4|rcsb pdb:5MM7|rcsb pdb:5XXT|rcsb pdb:5XXV|rcsb pdb:5XXW|rcsb pdb:5XXX|rcsb pdb:6KIO|rcsb pdb:6KIQ|rcsb pdb:6MLQ|rcsb pdb:6MLR|rcsb pdb:6MZE|rcsb pdb:6MZF|rcsb pdb:6MZG|rcsb pdb:6VPO|rcsb pdb:6VPP - - - - taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/16 2014/10/16 rogid:O9dYBDKthE5DdgePny2xsDYzb989606 rogid:OAdzBQZcB6dORgmQehwT+Jq64H09823 intact-crc:828D56BE5A73275F|rigid:JI0PL+BxhDlrFSxby3SSlmsdLFk false binding-associated region:23-231|his tag:?-?,n-n - - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:P04156 uniprotkb:P02550 intact:EBI-977302|ensembl:ENSP00000368752|ensembl:ENSP00000399376|ensembl:ENSP00000411599|ensembl:ENSP00000415284|uniprotkb:O60489|uniprotkb:P78446|uniprotkb:Q15216|uniprotkb:Q15221|uniprotkb:Q27H91|uniprotkb:Q8TBG0|uniprotkb:Q96E70|uniprotkb:Q9UP19|uniprotkb:Q5QPB4 intact:EBI-768776 psi-mi:prio_human(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ALTPRP(gene name synonym) psi-mi:tba1a_pig(display_long)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)|uniprotkb:TUBA1A(gene name)|psi-mi:TUBA1A(display_short) psi-mi:"MI:0030"(cross-linking study) Nieznanski et al. (2005) pubmed:16004966 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-781736 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000171867(gene)|ensembl:ENST00000379440(transcript)|ensembl:ENST00000424424(transcript)|ensembl:ENST00000430350(transcript)|ensembl:ENST00000457586(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009986"(cell surface)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098794"(postsynapse)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:0045121"(membrane raft)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR025860|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR036924|mint:P04156|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|rcsb pdb:1E1G|rcsb pdb:1E1J|rcsb pdb:1E1P|rcsb pdb:1E1S|rcsb pdb:1E1U|rcsb pdb:1E1W|rcsb pdb:1FKC|rcsb pdb:1FO7|rcsb pdb:1H0L|rcsb pdb:1HJM|rcsb pdb:1HJN|rcsb pdb:1I4M|rcsb pdb:1OEH|rcsb pdb:1OEI|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1QLX|rcsb pdb:1QLZ|rcsb pdb:1QM0|rcsb pdb:1QM1|rcsb pdb:1QM2|rcsb pdb:1QM3|rcsb pdb:2IV4|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|rcsb pdb:2IV5|rcsb pdb:2IV6|rcsb pdb:2K1D|rcsb pdb:2KUN|rcsb pdb:2LBG|rcsb pdb:2LEJ|rcsb pdb:2LFT|rcsb pdb:2LSB|rcsb pdb:2LV1|rcsb pdb:2M8T|rcsb pdb:2OL9|rcsb pdb:2W9E|rcsb pdb:3HAF|rcsb pdb:3HAK|rcsb pdb:3HEQ|rcsb pdb:3HER|rcsb pdb:3HES|rcsb pdb:3HJ5|rcsb pdb:3HJX|rcsb pdb:3MD4|rcsb pdb:3MD5|rcsb pdb:3NHC|rcsb pdb:3NHD|rcsb pdb:3NVF|rcsb pdb:4DGI|rcsb pdb:4E1H|rcsb pdb:4E1I|rcsb pdb:4KML|rcsb pdb:4N9O|rcsb pdb:5L6R|rcsb pdb:5YJ4|rcsb pdb:5YJ5|rcsb pdb:6DU9|rcsb pdb:6LNI|rcsb pdb:6PQ5|rcsb pdb:6PQA|rcsb pdb:6SUZ|rcsb pdb:6SV2|rcsb pdb:6UUR|reactome:R-HSA-419037|reactome:R-HSA-9609523|refseq:NP_000302.1|refseq:NP_001073590.1|refseq:NP_001073591.1|refseq:NP_001073592.1|refseq:NP_898902.1|refseq:NP_001258490.1|dip:DIP-29933N interpro:IPR002452(Alpha tubulin)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR000217(Tubulin)|interpro:IPR018316|interpro:IPR017975|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR036525|interpro:IPR037103|interpro:IPR023123|mint:P02550|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|rcsb pdb:1FFX|rcsb pdb:1IA0|rcsb pdb:1TUB|rcsb pdb:2HXF|rcsb pdb:2HXH|rcsb pdb:2P4N|rcsb pdb:3J6E|rcsb pdb:3J6F|rcsb pdb:3J6G|rcsb pdb:3J6H|rcsb pdb:3J6P|rcsb pdb:3J7I|rcsb pdb:4ABO|rcsb pdb:5MM4|rcsb pdb:5MM7|rcsb pdb:5XXT|rcsb pdb:5XXV|rcsb pdb:5XXW|rcsb pdb:5XXX|rcsb pdb:6KIO|rcsb pdb:6KIQ|rcsb pdb:6MLQ|rcsb pdb:6MLR|rcsb pdb:6MZE|rcsb pdb:6MZF|rcsb pdb:6MZG|rcsb pdb:6VPO|rcsb pdb:6VPP - - - - taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/16 2014/10/16 rogid:O9dYBDKthE5DdgePny2xsDYzb989606 rogid:OAdzBQZcB6dORgmQehwT+Jq64H09823 intact-crc:C6197D6D89E1CA8F|rigid:JI0PL+BxhDlrFSxby3SSlmsdLFk false binding-associated region:23-231 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P04156 uniprotkb:P02554 intact:EBI-977302|ensembl:ENSP00000368752|ensembl:ENSP00000399376|ensembl:ENSP00000411599|ensembl:ENSP00000415284|uniprotkb:O60489|uniprotkb:P78446|uniprotkb:Q15216|uniprotkb:Q15221|uniprotkb:Q27H91|uniprotkb:Q8TBG0|uniprotkb:Q96E70|uniprotkb:Q9UP19|uniprotkb:Q5QPB4 intact:EBI-768768 psi-mi:prio_human(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ALTPRP(gene name synonym) psi-mi:tbb_pig(display_long)|uniprotkb:Beta-tubulin(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Nieznanski et al. (2005) pubmed:16004966 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-781736 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000171867(gene)|ensembl:ENST00000379440(transcript)|ensembl:ENST00000424424(transcript)|ensembl:ENST00000430350(transcript)|ensembl:ENST00000457586(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009986"(cell surface)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098794"(postsynapse)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:0045121"(membrane raft)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR025860|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR036924|mint:P04156|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|rcsb pdb:1E1G|rcsb pdb:1E1J|rcsb pdb:1E1P|rcsb pdb:1E1S|rcsb pdb:1E1U|rcsb pdb:1E1W|rcsb pdb:1FKC|rcsb pdb:1FO7|rcsb pdb:1H0L|rcsb pdb:1HJM|rcsb pdb:1HJN|rcsb pdb:1I4M|rcsb pdb:1OEH|rcsb pdb:1OEI|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1QLX|rcsb pdb:1QLZ|rcsb pdb:1QM0|rcsb pdb:1QM1|rcsb pdb:1QM2|rcsb pdb:1QM3|rcsb pdb:2IV4|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|rcsb pdb:2IV5|rcsb pdb:2IV6|rcsb pdb:2K1D|rcsb pdb:2KUN|rcsb pdb:2LBG|rcsb pdb:2LEJ|rcsb pdb:2LFT|rcsb pdb:2LSB|rcsb pdb:2LV1|rcsb pdb:2M8T|rcsb pdb:2OL9|rcsb pdb:2W9E|rcsb pdb:3HAF|rcsb pdb:3HAK|rcsb pdb:3HEQ|rcsb pdb:3HER|rcsb pdb:3HES|rcsb pdb:3HJ5|rcsb pdb:3HJX|rcsb pdb:3MD4|rcsb pdb:3MD5|rcsb pdb:3NHC|rcsb pdb:3NHD|rcsb pdb:3NVF|rcsb pdb:4DGI|rcsb pdb:4E1H|rcsb pdb:4E1I|rcsb pdb:4KML|rcsb pdb:4N9O|rcsb pdb:5L6R|rcsb pdb:5YJ4|rcsb pdb:5YJ5|rcsb pdb:6DU9|rcsb pdb:6LNI|rcsb pdb:6PQ5|rcsb pdb:6PQA|rcsb pdb:6SUZ|rcsb pdb:6SV2|rcsb pdb:6UUR|reactome:R-HSA-419037|reactome:R-HSA-9609523|refseq:NP_000302.1|refseq:NP_001073590.1|refseq:NP_001073591.1|refseq:NP_001073592.1|refseq:NP_898902.1|refseq:NP_001258490.1|dip:DIP-29933N rcsb pdb:3JAK|rcsb pdb:3JAL|rcsb pdb:3JAR|rcsb pdb:3JAS|rcsb pdb:3JAT|rcsb pdb:3JAW|rcsb pdb:3J6H|rcsb pdb:5OAM|rcsb pdb:5OCU|rcsb pdb:5OGC|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR002453(Beta tubulin)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR000217(Tubulin)|interpro:IPR018316|interpro:IPR017975|interpro:IPR003008(Tubulin/FtsZ, GTPase)|rcsb pdb:1FFX|rcsb pdb:1IA0|rcsb pdb:1JFF|rcsb pdb:1TUB|rcsb pdb:2HXF|rcsb pdb:2HXH|rcsb pdb:3J7I|rcsb pdb:3J6P|rcsb pdb:5XKE|rcsb pdb:5XKH|rcsb pdb:6BR1|rcsb pdb:6BRF|rcsb pdb:6BRY|rcsb pdb:6BS2|rcsb pdb:6MZE|rcsb pdb:6MZG|rcsb pdb:6D88|rcsb pdb:6MLQ|rcsb pdb:6MLR|rcsb pdb:6O2Q|rcsb pdb:6O2R|rcsb pdb:6O2S|rcsb pdb:6O2T|rcsb pdb:6MZF|rcsb pdb:6ZPI|rcsb pdb:4ABO|rcsb pdb:5SYC|rcsb pdb:5SYE|rcsb pdb:5SYF|rcsb pdb:5SYG|rcsb pdb:6KPP|rcsb pdb:6PC4|rcsb pdb:5FNV|rcsb pdb:5JQG|rcsb pdb:6LS4|rcsb pdb:3J6E|rcsb pdb:3J6F|rcsb pdb:3J6G|rcsb pdb:6CVJ|rcsb pdb:6CVN|rcsb pdb:4ZHQ|rcsb pdb:4ZI7|rcsb pdb:4ZOL|rcsb pdb:5BMV|rcsb pdb:5KMG|interpro:IPR036525|interpro:IPR037103|interpro:IPR023123|rcsb pdb:5JCB|rcsb pdb:5XP3|rcsb pdb:6BJC|rcsb pdb:5MM7|rcsb pdb:6EVX|rcsb pdb:5MM4|rcsb pdb:6DPU|rcsb pdb:6DPV|rcsb pdb:6DPW|rcsb pdb:6EVW|rcsb pdb:6EVY|rcsb pdb:6EVZ|rcsb pdb:6EW0|rcsb pdb:5XIW|rcsb pdb:5XKF|rcsb pdb:5XKG|rcsb pdb:5XXT|rcsb pdb:5XXV|rcsb pdb:5XXW|rcsb pdb:5XXX|rcsb pdb:5YL2|rcsb pdb:5YLJ|rcsb pdb:5YLS|rcsb pdb:6B0C|rcsb pdb:6B0I|rcsb pdb:6B0L|rcsb pdb:6RZA|rcsb pdb:6RZB|rcsb pdb:6TA3|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|rcsb pdb:6NNG|rcsb pdb:6O5M|rcsb pdb:6O5N|rcsb pdb:6O61|rcsb pdb:6KIO|rcsb pdb:6KIQ|rcsb pdb:6TA4|rcsb pdb:6TIW|rcsb pdb:6VPO|rcsb pdb:6VPP|rcsb pdb:6Y4M|rcsb pdb:6Y4N|rcsb pdb:7CBZ - - - - taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/16 2014/10/16 rogid:O9dYBDKthE5DdgePny2xsDYzb989606 rogid:Jkf0jKi5PcZwpsMsC3Et91s930g9823 intact-crc:C6197D6D89E1CA8F|rigid:JI0PL+BxhDlrFSxby3SSlmsdLFk false binding-associated region:23-231 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)