#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9VCU9 uniprotkb:Q9VJY9 intact:EBI-112170|uniprotkb:Q961S7|ensemblmetazoa:FBpp0083717 intact:EBI-638074|ensemblmetazoa:FBpp0080076|uniprotkb:Q8SZ74 psi-mi:dcr1_drome(display_long)|uniprotkb:Dcr-1(gene name)|psi-mi:Dcr-1(display_short)|uniprotkb:CG4792(orf name) psi-mi:q9vjy9_drome(display_long)|uniprotkb:loqs(gene name)|psi-mi:loqs(display_short)|uniprotkb:Loqs-PD(gene name synonym)|uniprotkb:LqPD(gene name synonym)|uniprotkb:Dmel\CG6866(gene name synonym)|uniprotkb:LOQS(gene name synonym)|uniprotkb:Loqs(gene name synonym)|uniprotkb:R3D1(gene name synonym)|uniprotkb:R3D1-L(gene name synonym)|uniprotkb:R3D1-S(gene name synonym)|uniprotkb:TRBP(gene name synonym)|uniprotkb:dRax(gene name synonym)|uniprotkb:loq(gene name synonym)|uniprotkb:r3d1(gene name synonym)|uniprotkb:Dmel_CG6866(orf name)|uniprotkb:cg6866(gene name synonym)|uniprotkb:CG6866(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jiang et al. (2005) pubmed:15985611 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-638071 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524453.1|flybase:FBgn0039016|dip:DIP-23028N|ensemblmetazoa:FBgn0039016(gene)|ensemblmetazoa:FBtr0084324(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0007279"(pole cell formation)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007367"(segment polarity determination)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0016443"(bidentate ribonuclease III activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030727"(germarium-derived female germ-line cyst formation)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0033227"(dsRNA transport)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042594"(response to starvation)|go:"GO:0045448"(mitotic cell cycle, embryonic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|reactome:R-DME-203927|reactome:R-DME-426486 ensemblmetazoa:FBgn0032515(gene)|ensemblmetazoa:FBtr0080498(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007417"(central nervous system development)|go:"GO:0009047"(dosage compensation by hyperactivation of X chromosome)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035197"(siRNA binding)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|refseq:NP_609646.1|flybase:FBgn0032515|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070877"(microprocessor complex)|go:"GO:0070918"(primary sncRNA processing)|go:"GO:0070920"(regulation of production of small RNA involved in gene silencing by RNA)|go:"GO:1905172"(RISC complex binding)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|rcsb pdb:4X8W|reactome:R-DME-203927|reactome:R-DME-426486|dip:DIP-18138N - - - - taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2005/08/25 2014/10/16 rogid:qQiK00k/1UZST/JWnD/HUdltS9w7227 rogid:b4hUTrpZAKdYrKrNXyii52Zz43Y7227 intact-crc:E0B158E62495BFF9|rigid:iP7iA/wVj/Cf0Uwld5b/ri0wr0s false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9VCU9 uniprotkb:Q32KD4 intact:EBI-112170|uniprotkb:Q961S7|ensemblmetazoa:FBpp0083717 intact:EBI-105513|ensemblmetazoa:FBpp0086738|ensemblmetazoa:FBpp0086739|ensemblmetazoa:FBpp0294043 psi-mi:dcr1_drome(display_long)|uniprotkb:Dcr-1(gene name)|psi-mi:Dcr-1(display_short)|uniprotkb:CG4792(orf name) psi-mi:q32kd4_drome(display_long)|uniprotkb:AGO1(gene name)|psi-mi:AGO1(display_short)|uniprotkb:AGO1-RC(gene name synonym)|uniprotkb:Ago-1(gene name synonym)|uniprotkb:Ago1(gene name synonym)|uniprotkb:Agp1(gene name synonym)|uniprotkb:Dm Ago1(gene name synonym)|uniprotkb:DmAgo1(gene name synonym)|uniprotkb:Dmel\CG6671(gene name synonym)|uniprotkb:MRE20(gene name synonym)|uniprotkb:ago1(gene name synonym)|uniprotkb:ago1-1(gene name synonym)|uniprotkb:anon-WO0257455.29(gene name synonym)|uniprotkb:argonaute1(gene name synonym)|uniprotkb:dAGO1(gene name synonym)|uniprotkb:dAgo1(gene name synonym)|uniprotkb:"l(2)04845"(gene name synonym)|uniprotkb:AGO-1(gene name synonym)|uniprotkb:Ago(gene name synonym)|uniprotkb:"l(2)4845"(gene name synonym)|uniprotkb:"l(2)k00208"(gene name synonym)|uniprotkb:CG6671(orf name)|uniprotkb:Dmel_CG6671(orf name)|uniprotkb:"l(2)k08121"(gene name synonym)|uniprotkb:dmAgo1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jiang et al. (2005) pubmed:15985611 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-638071 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524453.1|flybase:FBgn0039016|dip:DIP-23028N|ensemblmetazoa:FBgn0039016(gene)|ensemblmetazoa:FBtr0084324(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0007279"(pole cell formation)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007367"(segment polarity determination)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0016443"(bidentate ribonuclease III activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030727"(germarium-derived female germ-line cyst formation)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0033227"(dsRNA transport)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042594"(response to starvation)|go:"GO:0045448"(mitotic cell cycle, embryonic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|reactome:R-DME-203927|reactome:R-DME-426486 refseq:NP_725341.1|refseq:NP_725342.1|flybase:FBgn0262739|refseq:NP_001246314.1|dip:DIP-59685N|ensemblmetazoa:FBgn0262739(gene)|ensemblmetazoa:FBtr0087612(transcript)|ensemblmetazoa:FBtr0087613(transcript)|ensemblmetazoa:FBtr0305592(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006342"|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007367"(segment polarity determination)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030727"(germarium-derived female germ-line cyst formation)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0046959"(habituation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0090328"(regulation of olfactory learning)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q32KD4|rcsb pdb:1R4K|reactome:R-DME-203927|reactome:R-DME-426486|reactome:R-DME-426496|reactome:R-DME-5578749 - - - - taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2005/08/25 2014/10/16 rogid:qQiK00k/1UZST/JWnD/HUdltS9w7227 rogid:YFcWf96n43RSnrWBGXlQpgi4Yvs7227 intact-crc:E0B158E62495BFF9|rigid:iP7iA/wVj/Cf0Uwld5b/ri0wr0s false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9VJY9 uniprotkb:Q32KD4 intact:EBI-638074|ensemblmetazoa:FBpp0080076|uniprotkb:Q8SZ74 intact:EBI-105513|ensemblmetazoa:FBpp0086738|ensemblmetazoa:FBpp0086739|ensemblmetazoa:FBpp0294043 psi-mi:q9vjy9_drome(display_long)|uniprotkb:loqs(gene name)|psi-mi:loqs(display_short)|uniprotkb:Loqs-PD(gene name synonym)|uniprotkb:LqPD(gene name synonym)|uniprotkb:Dmel\CG6866(gene name synonym)|uniprotkb:LOQS(gene name synonym)|uniprotkb:Loqs(gene name synonym)|uniprotkb:R3D1(gene name synonym)|uniprotkb:R3D1-L(gene name synonym)|uniprotkb:R3D1-S(gene name synonym)|uniprotkb:TRBP(gene name synonym)|uniprotkb:dRax(gene name synonym)|uniprotkb:loq(gene name synonym)|uniprotkb:r3d1(gene name synonym)|uniprotkb:Dmel_CG6866(orf name)|uniprotkb:cg6866(gene name synonym)|uniprotkb:CG6866(orf name) psi-mi:q32kd4_drome(display_long)|uniprotkb:AGO1(gene name)|psi-mi:AGO1(display_short)|uniprotkb:AGO1-RC(gene name synonym)|uniprotkb:Ago-1(gene name synonym)|uniprotkb:Ago1(gene name synonym)|uniprotkb:Agp1(gene name synonym)|uniprotkb:Dm Ago1(gene name synonym)|uniprotkb:DmAgo1(gene name synonym)|uniprotkb:Dmel\CG6671(gene name synonym)|uniprotkb:MRE20(gene name synonym)|uniprotkb:ago1(gene name synonym)|uniprotkb:ago1-1(gene name synonym)|uniprotkb:anon-WO0257455.29(gene name synonym)|uniprotkb:argonaute1(gene name synonym)|uniprotkb:dAGO1(gene name synonym)|uniprotkb:dAgo1(gene name synonym)|uniprotkb:"l(2)04845"(gene name synonym)|uniprotkb:AGO-1(gene name synonym)|uniprotkb:Ago(gene name synonym)|uniprotkb:"l(2)4845"(gene name synonym)|uniprotkb:"l(2)k00208"(gene name synonym)|uniprotkb:CG6671(orf name)|uniprotkb:Dmel_CG6671(orf name)|uniprotkb:"l(2)k08121"(gene name synonym)|uniprotkb:dmAgo1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jiang et al. (2005) pubmed:15985611 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-638086 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0032515(gene)|ensemblmetazoa:FBtr0080498(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007417"(central nervous system development)|go:"GO:0009047"(dosage compensation by hyperactivation of X chromosome)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035197"(siRNA binding)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|refseq:NP_609646.1|flybase:FBgn0032515|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070877"(microprocessor complex)|go:"GO:0070918"(primary sncRNA processing)|go:"GO:0070920"(regulation of production of small RNA involved in gene silencing by RNA)|go:"GO:1905172"(RISC complex binding)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|rcsb pdb:4X8W|reactome:R-DME-203927|reactome:R-DME-426486|dip:DIP-18138N refseq:NP_725341.1|refseq:NP_725342.1|flybase:FBgn0262739|refseq:NP_001246314.1|dip:DIP-59685N|ensemblmetazoa:FBgn0262739(gene)|ensemblmetazoa:FBtr0087612(transcript)|ensemblmetazoa:FBtr0087613(transcript)|ensemblmetazoa:FBtr0305592(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006342"|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007367"(segment polarity determination)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030727"(germarium-derived female germ-line cyst formation)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0046959"(habituation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0090328"(regulation of olfactory learning)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q32KD4|rcsb pdb:1R4K|reactome:R-DME-203927|reactome:R-DME-426486|reactome:R-DME-426496|reactome:R-DME-5578749 - - - - taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2005/08/25 2014/10/16 rogid:b4hUTrpZAKdYrKrNXyii52Zz43Y7227 rogid:YFcWf96n43RSnrWBGXlQpgi4Yvs7227 intact-crc:A0FD6E56F342FA19|rigid:iP7iA/wVj/Cf0Uwld5b/ri0wr0s false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9VJY9 uniprotkb:Q9VCU9 intact:EBI-638074|ensemblmetazoa:FBpp0080076|uniprotkb:Q8SZ74 intact:EBI-112170|uniprotkb:Q961S7|ensemblmetazoa:FBpp0083717 psi-mi:q9vjy9_drome(display_long)|uniprotkb:loqs(gene name)|psi-mi:loqs(display_short)|uniprotkb:Loqs-PD(gene name synonym)|uniprotkb:LqPD(gene name synonym)|uniprotkb:Dmel\CG6866(gene name synonym)|uniprotkb:LOQS(gene name synonym)|uniprotkb:Loqs(gene name synonym)|uniprotkb:R3D1(gene name synonym)|uniprotkb:R3D1-L(gene name synonym)|uniprotkb:R3D1-S(gene name synonym)|uniprotkb:TRBP(gene name synonym)|uniprotkb:dRax(gene name synonym)|uniprotkb:loq(gene name synonym)|uniprotkb:r3d1(gene name synonym)|uniprotkb:Dmel_CG6866(orf name)|uniprotkb:cg6866(gene name synonym)|uniprotkb:CG6866(orf name) psi-mi:dcr1_drome(display_long)|uniprotkb:Dcr-1(gene name)|psi-mi:Dcr-1(display_short)|uniprotkb:CG4792(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jiang et al. (2005) pubmed:15985611 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-638086 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0032515(gene)|ensemblmetazoa:FBtr0080498(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007417"(central nervous system development)|go:"GO:0009047"(dosage compensation by hyperactivation of X chromosome)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035197"(siRNA binding)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|refseq:NP_609646.1|flybase:FBgn0032515|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070877"(microprocessor complex)|go:"GO:0070918"(primary sncRNA processing)|go:"GO:0070920"(regulation of production of small RNA involved in gene silencing by RNA)|go:"GO:1905172"(RISC complex binding)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|rcsb pdb:4X8W|reactome:R-DME-203927|reactome:R-DME-426486|dip:DIP-18138N refseq:NP_524453.1|flybase:FBgn0039016|dip:DIP-23028N|ensemblmetazoa:FBgn0039016(gene)|ensemblmetazoa:FBtr0084324(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0007279"(pole cell formation)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007367"(segment polarity determination)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0016443"(bidentate ribonuclease III activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030727"(germarium-derived female germ-line cyst formation)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0033227"(dsRNA transport)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042594"(response to starvation)|go:"GO:0045448"(mitotic cell cycle, embryonic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|reactome:R-DME-203927|reactome:R-DME-426486 - - - - taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2005/08/25 2014/10/16 rogid:b4hUTrpZAKdYrKrNXyii52Zz43Y7227 rogid:qQiK00k/1UZST/JWnD/HUdltS9w7227 intact-crc:A0FD6E56F342FA19|rigid:iP7iA/wVj/Cf0Uwld5b/ri0wr0s false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9VLW8 uniprotkb:A1ZAW0 intact:EBI-156415|ensemblmetazoa:FBpp0079112|ensemblmetazoa:FBpp0290544|ensemblmetazoa:FBpp0310061 intact:EBI-84244|ensemblmetazoa:FBpp0086061|intact:EBI-2409754 psi-mi:q9vlw8_drome(display_long)|uniprotkb:r2d2(gene name)|psi-mi:r2d2(display_short)|uniprotkb:Dmel\CG7138(gene name synonym)|uniprotkb:R2D2(gene name synonym)|uniprotkb:R2d2(gene name synonym)|uniprotkb:cg7138(gene name synonym)|uniprotkb:CG7138(orf name)|uniprotkb:Dmel_CG7138(orf name) psi-mi:a1zaw0_drome(display_long)|uniprotkb:Dcr-2(gene name)|psi-mi:Dcr-2(display_short)|uniprotkb:Dcr-2-RA(gene name synonym)|uniprotkb:DCR-2(gene name synonym)|uniprotkb:DCR2(gene name synonym)|uniprotkb:DICER(gene name synonym)|uniprotkb:Dcr(gene name synonym)|uniprotkb:Dcr2(gene name synonym)|uniprotkb:Dicer(gene name synonym)|uniprotkb:Dicer2(gene name synonym)|uniprotkb:Dmel\CG6493(gene name synonym)|uniprotkb:cg6493(gene name synonym)|uniprotkb:dDcr2(gene name synonym)|uniprotkb:dcr(gene name synonym)|uniprotkb:dcr-2(gene name synonym)|uniprotkb:dcr2(gene name synonym)|uniprotkb:dic2(gene name synonym)|uniprotkb:dicer(gene name synonym)|uniprotkb:dicer-2(gene name synonym)|uniprotkb:dicer2(gene name synonym)|uniprotkb:dmDcr-2(gene name synonym)|uniprotkb:CG6493(orf name)|uniprotkb:Dmel_CG6493(orf name)|uniprotkb:DICER-2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jiang et al. (2005) pubmed:15985611 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-638090 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001162903.1|refseq:NP_609152.1|flybase:FBgn0031951|refseq:NP_001285720.1|dip:DIP-34805N|ensemblmetazoa:FBgn0031951(gene)|ensemblmetazoa:FBtr0079489(transcript)|ensemblmetazoa:FBtr0301329(transcript)|ensemblmetazoa:FBtr0343415(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030713"(ovarian follicle cell stalk formation)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035197"(siRNA binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:0070918"(primary sncRNA processing)|go:"GO:0070920"(regulation of production of small RNA involved in gene silencing by RNA)|interpro:IPR014720(Double-stranded RNA-binding-like)|reactome:R-DME-203927|reactome:R-DME-426486 refseq:NP_523778.2|flybase:FBgn0034246|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006342"|go:"GO:0007626"(locomotory behavior)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0009047"(dosage compensation by hyperactivation of X chromosome)|go:"GO:0009597"(detection of virus)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0016443"(bidentate ribonuclease III activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0033227"(dsRNA transport)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035197"(siRNA binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045752"(positive regulation of Toll signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|ensemblmetazoa:FBgn0034246(gene)|ensemblmetazoa:FBtr0086904(transcript)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036389|interpro:IPR038248|rcsb pdb:6BU9|rcsb pdb:6BUA|dip:DIP-54444N - - - - taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2005/08/25 2014/10/16 rogid:xnR+vKJN0j+r0G/bo3UdrnNAjIU7227 rogid:Ti1bBqs1sFBecB2FZwqHM2VcSRY7227 intact-crc:12E6050C1201F3AE|rigid:vL1RiWvHtCfRjNbh4ppZwHaVq2A false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9VJY9 uniprotkb:Q9VCU9 intact:EBI-638074|ensemblmetazoa:FBpp0080076|uniprotkb:Q8SZ74 intact:EBI-112170|uniprotkb:Q961S7|ensemblmetazoa:FBpp0083717 psi-mi:q9vjy9_drome(display_long)|uniprotkb:loqs(gene name)|psi-mi:loqs(display_short)|uniprotkb:Loqs-PD(gene name synonym)|uniprotkb:LqPD(gene name synonym)|uniprotkb:Dmel\CG6866(gene name synonym)|uniprotkb:LOQS(gene name synonym)|uniprotkb:Loqs(gene name synonym)|uniprotkb:R3D1(gene name synonym)|uniprotkb:R3D1-L(gene name synonym)|uniprotkb:R3D1-S(gene name synonym)|uniprotkb:TRBP(gene name synonym)|uniprotkb:dRax(gene name synonym)|uniprotkb:loq(gene name synonym)|uniprotkb:r3d1(gene name synonym)|uniprotkb:Dmel_CG6866(orf name)|uniprotkb:cg6866(gene name synonym)|uniprotkb:CG6866(orf name) psi-mi:dcr1_drome(display_long)|uniprotkb:Dcr-1(gene name)|psi-mi:Dcr-1(display_short)|uniprotkb:CG4792(orf name) psi-mi:"MI:0226"(ion exchange chromatography) Jiang et al. (2005) pubmed:15985611 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-638109 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0032515(gene)|ensemblmetazoa:FBtr0080498(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007417"(central nervous system development)|go:"GO:0009047"(dosage compensation by hyperactivation of X chromosome)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035197"(siRNA binding)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|refseq:NP_609646.1|flybase:FBgn0032515|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070877"(microprocessor complex)|go:"GO:0070918"(primary sncRNA processing)|go:"GO:0070920"(regulation of production of small RNA involved in gene silencing by RNA)|go:"GO:1905172"(RISC complex binding)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|rcsb pdb:4X8W|reactome:R-DME-203927|reactome:R-DME-426486|dip:DIP-18138N refseq:NP_524453.1|flybase:FBgn0039016|dip:DIP-23028N|ensemblmetazoa:FBgn0039016(gene)|ensemblmetazoa:FBtr0084324(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0007279"(pole cell formation)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007367"(segment polarity determination)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0016443"(bidentate ribonuclease III activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030727"(germarium-derived female germ-line cyst formation)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0033227"(dsRNA transport)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042594"(response to starvation)|go:"GO:0045448"(mitotic cell cycle, embryonic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|reactome:R-DME-203927|reactome:R-DME-426486 go:"GO:0016442"(RISC complex) - - - taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2005/08/25 2014/10/16 rogid:b4hUTrpZAKdYrKrNXyii52Zz43Y7227 rogid:qQiK00k/1UZST/JWnD/HUdltS9w7227 intact-crc:6ECDE5D132146054|rigid:DKU5emuACycx/C4Gj4aiayOiBu8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A1ZAW0 uniprotkb:Q9VLW8 intact:EBI-84244|ensemblmetazoa:FBpp0086061|intact:EBI-2409754 intact:EBI-156415|ensemblmetazoa:FBpp0079112|ensemblmetazoa:FBpp0290544|ensemblmetazoa:FBpp0310061 psi-mi:a1zaw0_drome(display_long)|uniprotkb:Dcr-2(gene name)|psi-mi:Dcr-2(display_short)|uniprotkb:Dcr-2-RA(gene name synonym)|uniprotkb:DCR-2(gene name synonym)|uniprotkb:DCR2(gene name synonym)|uniprotkb:DICER(gene name synonym)|uniprotkb:Dcr(gene name synonym)|uniprotkb:Dcr2(gene name synonym)|uniprotkb:Dicer(gene name synonym)|uniprotkb:Dicer2(gene name synonym)|uniprotkb:Dmel\CG6493(gene name synonym)|uniprotkb:cg6493(gene name synonym)|uniprotkb:dDcr2(gene name synonym)|uniprotkb:dcr(gene name synonym)|uniprotkb:dcr-2(gene name synonym)|uniprotkb:dcr2(gene name synonym)|uniprotkb:dic2(gene name synonym)|uniprotkb:dicer(gene name synonym)|uniprotkb:dicer-2(gene name synonym)|uniprotkb:dicer2(gene name synonym)|uniprotkb:dmDcr-2(gene name synonym)|uniprotkb:CG6493(orf name)|uniprotkb:Dmel_CG6493(orf name)|uniprotkb:DICER-2(gene name synonym) psi-mi:q9vlw8_drome(display_long)|uniprotkb:r2d2(gene name)|psi-mi:r2d2(display_short)|uniprotkb:Dmel\CG7138(gene name synonym)|uniprotkb:R2D2(gene name synonym)|uniprotkb:R2d2(gene name synonym)|uniprotkb:cg7138(gene name synonym)|uniprotkb:CG7138(orf name)|uniprotkb:Dmel_CG7138(orf name) psi-mi:"MI:0226"(ion exchange chromatography) Jiang et al. (2005) pubmed:15985611 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-638116 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_523778.2|flybase:FBgn0034246|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006342"|go:"GO:0007626"(locomotory behavior)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0009047"(dosage compensation by hyperactivation of X chromosome)|go:"GO:0009597"(detection of virus)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0016443"(bidentate ribonuclease III activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0033227"(dsRNA transport)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035197"(siRNA binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045752"(positive regulation of Toll signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|ensemblmetazoa:FBgn0034246(gene)|ensemblmetazoa:FBtr0086904(transcript)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036389|interpro:IPR038248|rcsb pdb:6BU9|rcsb pdb:6BUA|dip:DIP-54444N refseq:NP_001162903.1|refseq:NP_609152.1|flybase:FBgn0031951|refseq:NP_001285720.1|dip:DIP-34805N|ensemblmetazoa:FBgn0031951(gene)|ensemblmetazoa:FBtr0079489(transcript)|ensemblmetazoa:FBtr0301329(transcript)|ensemblmetazoa:FBtr0343415(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030713"(ovarian follicle cell stalk formation)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035197"(siRNA binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:0070918"(primary sncRNA processing)|go:"GO:0070920"(regulation of production of small RNA involved in gene silencing by RNA)|interpro:IPR014720(Double-stranded RNA-binding-like)|reactome:R-DME-203927|reactome:R-DME-426486 go:"GO:0016442"(RISC complex) - - - taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2005/08/25 2014/10/16 rogid:Ti1bBqs1sFBecB2FZwqHM2VcSRY7227 rogid:xnR+vKJN0j+r0G/bo3UdrnNAjIU7227 intact-crc:6448EFDBFA70572C|rigid:vL1RiWvHtCfRjNbh4ppZwHaVq2A false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)