#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97287	uniprotkb:Q16611	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	intact:EBI-519866|ensembl:ENSP00000363591|uniprotkb:Q92533|uniprotkb:Q6I9T6|uniprotkb:C0H5Y7	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:bak_human(display_long)|uniprotkb:Apoptosis regulator BAK(gene name synonym)|uniprotkb:Bcl-2-like protein 7(gene name synonym)|uniprotkb:BAK1(gene name)|psi-mi:BAK1(display_short)|uniprotkb:BAK(gene name synonym)|uniprotkb:BCL2L7(gene name synonym)|uniprotkb:CDN1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Willis et al. (2005)	pubmed:15901672	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707284	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	refseq:NP_001179.1|ensembl:ENSG00000030110(gene)|ensembl:ENST00000374467(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009620"(response to fungus)|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010225"(response to UV-C)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051400"(BH domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026308|interpro:IPR036834|mint:Q16611|rcsb pdb:1BXL|rcsb pdb:2IMS|rcsb pdb:2IMT|rcsb pdb:2JBY|rcsb pdb:2JCN|rcsb pdb:2LP8|rcsb pdb:2M5B|rcsb pdb:2XPX|rcsb pdb:2YV6|rcsb pdb:3I1H|rcsb pdb:3QBR|rcsb pdb:4D2L|rcsb pdb:4U2U|rcsb pdb:4U2V|rcsb pdb:4UF1|rcsb pdb:5AJK|rcsb pdb:5FMI|rcsb pdb:5FMK|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX1|rcsb pdb:6ODH|rcsb pdb:6UXM|rcsb pdb:6UXN|rcsb pdb:6UXO|rcsb pdb:6UXP|rcsb pdb:6UXQ|rcsb pdb:6UXR|rcsb pdb:7K02|rcsb pdb:7OFM|rcsb pdb:7OFO|reactome:R-HSA-111452|reactome:R-HSA-111457|reactome:R-HSA-5620971|refseq:XP_011513081.1|dip:DIP-935N	-	-	-	kinetics:IC50=8nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rogid:F13a6H/g/tv/Pr90ehCDePpcSB49606	intact-crc:F63ABD31BCE2ACF0|rigid:8mCwx1xiBBOu4/93Ebxg1g0k+8g	false	-	binding-associated region:67-92(IPR000712)|mutation decreasing interaction:78-78	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16611	uniprotkb:Q07817-1	intact:EBI-519866|ensembl:ENSP00000363591|uniprotkb:Q92533|uniprotkb:Q6I9T6|uniprotkb:C0H5Y7	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:bak_human(display_long)|uniprotkb:Apoptosis regulator BAK(gene name synonym)|uniprotkb:Bcl-2-like protein 7(gene name synonym)|uniprotkb:BAK1(gene name)|psi-mi:BAK1(display_short)|uniprotkb:BAK(gene name synonym)|uniprotkb:BCL2L7(gene name synonym)|uniprotkb:CDN1(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Willis et al. (2005)	pubmed:15901672	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707303	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001179.1|ensembl:ENSG00000030110(gene)|ensembl:ENST00000374467(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009620"(response to fungus)|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010225"(response to UV-C)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051400"(BH domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026308|interpro:IPR036834|mint:Q16611|rcsb pdb:1BXL|rcsb pdb:2IMS|rcsb pdb:2IMT|rcsb pdb:2JBY|rcsb pdb:2JCN|rcsb pdb:2LP8|rcsb pdb:2M5B|rcsb pdb:2XPX|rcsb pdb:2YV6|rcsb pdb:3I1H|rcsb pdb:3QBR|rcsb pdb:4D2L|rcsb pdb:4U2U|rcsb pdb:4U2V|rcsb pdb:4UF1|rcsb pdb:5AJK|rcsb pdb:5FMI|rcsb pdb:5FMK|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX1|rcsb pdb:6ODH|rcsb pdb:6UXM|rcsb pdb:6UXN|rcsb pdb:6UXO|rcsb pdb:6UXP|rcsb pdb:6UXQ|rcsb pdb:6UXR|rcsb pdb:7K02|rcsb pdb:7OFM|rcsb pdb:7OFO|reactome:R-HSA-111452|reactome:R-HSA-111457|reactome:R-HSA-5620971|refseq:XP_011513081.1|dip:DIP-935N	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	-	-	-	kinetics:IC50=50nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:F13a6H/g/tv/Pr90ehCDePpcSB49606	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	intact-crc:4A3B35FB8D3DB63B|rigid:Vsl19lBLoL75CYE+wO3EE44R3hE	false	binding-associated region:67-92(IPR000712)|mutation decreasing interaction:78-78	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16611	uniprotkb:P97287	intact:EBI-519866|ensembl:ENSP00000363591|uniprotkb:Q92533|uniprotkb:Q6I9T6|uniprotkb:C0H5Y7	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:bak_human(display_long)|uniprotkb:Apoptosis regulator BAK(gene name synonym)|uniprotkb:Bcl-2-like protein 7(gene name synonym)|uniprotkb:BAK1(gene name)|psi-mi:BAK1(display_short)|uniprotkb:BAK(gene name synonym)|uniprotkb:BCL2L7(gene name synonym)|uniprotkb:CDN1(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Willis et al. (2005)	pubmed:15901672	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707315	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001179.1|ensembl:ENSG00000030110(gene)|ensembl:ENST00000374467(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009620"(response to fungus)|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010225"(response to UV-C)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051400"(BH domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026308|interpro:IPR036834|mint:Q16611|rcsb pdb:1BXL|rcsb pdb:2IMS|rcsb pdb:2IMT|rcsb pdb:2JBY|rcsb pdb:2JCN|rcsb pdb:2LP8|rcsb pdb:2M5B|rcsb pdb:2XPX|rcsb pdb:2YV6|rcsb pdb:3I1H|rcsb pdb:3QBR|rcsb pdb:4D2L|rcsb pdb:4U2U|rcsb pdb:4U2V|rcsb pdb:4UF1|rcsb pdb:5AJK|rcsb pdb:5FMI|rcsb pdb:5FMK|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX1|rcsb pdb:6ODH|rcsb pdb:6UXM|rcsb pdb:6UXN|rcsb pdb:6UXO|rcsb pdb:6UXP|rcsb pdb:6UXQ|rcsb pdb:6UXR|rcsb pdb:7K02|rcsb pdb:7OFM|rcsb pdb:7OFO|reactome:R-HSA-111452|reactome:R-HSA-111457|reactome:R-HSA-5620971|refseq:XP_011513081.1|dip:DIP-935N	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:F13a6H/g/tv/Pr90ehCDePpcSB49606	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	intact-crc:07406283A7248C5F|rigid:8mCwx1xiBBOu4/93Ebxg1g0k+8g	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16611	uniprotkb:Q07817-1	intact:EBI-519866|ensembl:ENSP00000363591|uniprotkb:Q92533|uniprotkb:Q6I9T6|uniprotkb:C0H5Y7	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:bak_human(display_long)|uniprotkb:Apoptosis regulator BAK(gene name synonym)|uniprotkb:Bcl-2-like protein 7(gene name synonym)|uniprotkb:BAK1(gene name)|psi-mi:BAK1(display_short)|uniprotkb:BAK(gene name synonym)|uniprotkb:BCL2L7(gene name synonym)|uniprotkb:CDN1(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Willis et al. (2005)	pubmed:15901672	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707323	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001179.1|ensembl:ENSG00000030110(gene)|ensembl:ENST00000374467(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009620"(response to fungus)|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010225"(response to UV-C)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051400"(BH domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026308|interpro:IPR036834|mint:Q16611|rcsb pdb:1BXL|rcsb pdb:2IMS|rcsb pdb:2IMT|rcsb pdb:2JBY|rcsb pdb:2JCN|rcsb pdb:2LP8|rcsb pdb:2M5B|rcsb pdb:2XPX|rcsb pdb:2YV6|rcsb pdb:3I1H|rcsb pdb:3QBR|rcsb pdb:4D2L|rcsb pdb:4U2U|rcsb pdb:4U2V|rcsb pdb:4UF1|rcsb pdb:5AJK|rcsb pdb:5FMI|rcsb pdb:5FMK|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX1|rcsb pdb:6ODH|rcsb pdb:6UXM|rcsb pdb:6UXN|rcsb pdb:6UXO|rcsb pdb:6UXP|rcsb pdb:6UXQ|rcsb pdb:6UXR|rcsb pdb:7K02|rcsb pdb:7OFM|rcsb pdb:7OFO|reactome:R-HSA-111452|reactome:R-HSA-111457|reactome:R-HSA-5620971|refseq:XP_011513081.1|dip:DIP-935N	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:F13a6H/g/tv/Pr90ehCDePpcSB49606	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	intact-crc:57AF1DBF04A553A7|rigid:Vsl19lBLoL75CYE+wO3EE44R3hE	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16611	uniprotkb:Q07820	intact:EBI-519866|ensembl:ENSP00000363591|uniprotkb:Q92533|uniprotkb:Q6I9T6|uniprotkb:C0H5Y7	intact:EBI-1003422|uniprotkb:Q9HD91|uniprotkb:Q9NRQ3|uniprotkb:Q9NRQ4|uniprotkb:Q9UHR7|uniprotkb:Q9UHR8|uniprotkb:Q9UHR9|uniprotkb:Q9UNJ1|uniprotkb:B2R6B2|uniprotkb:D3DV03|uniprotkb:D3DV04|ensembl:ENSP00000358022|ensembl:ENSP00000502859	psi-mi:bak_human(display_long)|uniprotkb:Apoptosis regulator BAK(gene name synonym)|uniprotkb:Bcl-2-like protein 7(gene name synonym)|uniprotkb:BAK1(gene name)|psi-mi:BAK1(display_short)|uniprotkb:BAK(gene name synonym)|uniprotkb:BCL2L7(gene name synonym)|uniprotkb:CDN1(gene name synonym)	psi-mi:mcl1_human(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:mcl1/EAT(gene name synonym)|uniprotkb:MCL1(gene name)|psi-mi:MCL1(display_short)|uniprotkb:BCL2L3(gene name synonym)|uniprotkb:Bcl-2-like protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Willis et al. (2005)	pubmed:15901672	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707366	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001179.1|ensembl:ENSG00000030110(gene)|ensembl:ENST00000374467(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009620"(response to fungus)|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010225"(response to UV-C)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051400"(BH domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026308|interpro:IPR036834|mint:Q16611|rcsb pdb:1BXL|rcsb pdb:2IMS|rcsb pdb:2IMT|rcsb pdb:2JBY|rcsb pdb:2JCN|rcsb pdb:2LP8|rcsb pdb:2M5B|rcsb pdb:2XPX|rcsb pdb:2YV6|rcsb pdb:3I1H|rcsb pdb:3QBR|rcsb pdb:4D2L|rcsb pdb:4U2U|rcsb pdb:4U2V|rcsb pdb:4UF1|rcsb pdb:5AJK|rcsb pdb:5FMI|rcsb pdb:5FMK|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX1|rcsb pdb:6ODH|rcsb pdb:6UXM|rcsb pdb:6UXN|rcsb pdb:6UXO|rcsb pdb:6UXP|rcsb pdb:6UXQ|rcsb pdb:6UXR|rcsb pdb:7K02|rcsb pdb:7OFM|rcsb pdb:7OFO|reactome:R-HSA-111452|reactome:R-HSA-111457|reactome:R-HSA-5620971|refseq:XP_011513081.1|dip:DIP-935N	refseq:NP_001184249.1|refseq:NP_068779.1|refseq:NP_877495.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|ensembl:ENSG00000143384(gene)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|ensembl:ENST00000369026(transcript)|ensembl:ENST00000678770(transcript)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0001709"(cell fate determination)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|go:"GO:0005741"(mitochondrial outer membrane)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|go:"GO:0005829"(cytosol)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|rcsb pdb:6QFI|rcsb pdb:6QFM|rcsb pdb:6QFQ|interpro:IPR026298|interpro:IPR036834|rcsb pdb:6QGD|mint:Q07820|rcsb pdb:2KBW|rcsb pdb:2MHS|rcsb pdb:2NL9|rcsb pdb:2NLA|rcsb pdb:6QXJ|rcsb pdb:2PQK|rcsb pdb:6QYK|rcsb pdb:3D7V|rcsb pdb:6QYL|rcsb pdb:3IO9|rcsb pdb:6QYN|rcsb pdb:3KJ0|rcsb pdb:6QYO|rcsb pdb:3KJ1|rcsb pdb:3KJ2|rcsb pdb:6QYP|rcsb pdb:3KZ0|rcsb pdb:6QZ5|rcsb pdb:3MK8|rcsb pdb:3PK1|rcsb pdb:3TWU|rcsb pdb:3WIX|rcsb pdb:3WIY|rcsb pdb:6QZ6|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4HW2|rcsb pdb:4HW3|rcsb pdb:4HW4|rcsb pdb:4OQ5|rcsb pdb:4OQ6|rcsb pdb:4WGI|rcsb pdb:6QZ7|rcsb pdb:4WMR|rcsb pdb:4WMS|rcsb pdb:4WMT|rcsb pdb:4WMU|rcsb pdb:4WMV|rcsb pdb:4WMW|rcsb pdb:4WMX|rcsb pdb:4ZBF|rcsb pdb:4ZBI|rcsb pdb:5C3F|rcsb pdb:5C6H|rcsb pdb:5FC4|rcsb pdb:5FDO|rcsb pdb:5FDR|rcsb pdb:5IEZ|rcsb pdb:5IF4|rcsb pdb:6QZ8|rcsb pdb:5JSB|rcsb pdb:5KU9|rcsb pdb:5LOF|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5UUM|rcsb pdb:5VKC|rcsb pdb:5VX2|rcsb pdb:5W89|rcsb pdb:6QZB|rcsb pdb:5W8F|rcsb pdb:6B4L|rcsb pdb:6B4U|rcsb pdb:6STJ|rcsb pdb:6BW2|rcsb pdb:6BW8|rcsb pdb:6FS0|rcsb pdb:6FS1|rcsb pdb:6FS2|rcsb pdb:6MBD|rcsb pdb:6MBE|rcsb pdb:6NE5|rcsb pdb:6O4U|rcsb pdb:6O6F|rcsb pdb:6O6G|rcsb pdb:6OQB|rcsb pdb:6U63|rcsb pdb:6OQC|rcsb pdb:6U64|rcsb pdb:6U65|rcsb pdb:6OQD|rcsb pdb:6OQN|rcsb pdb:6OVC|rcsb pdb:6P3P|rcsb pdb:6QB3|rcsb pdb:6QB4|rcsb pdb:6QB6|rcsb pdb:6QFC|rcsb pdb:6U67|rcsb pdb:6U6F|rcsb pdb:6UA3|rcsb pdb:6UAB|rcsb pdb:6UD2|rcsb pdb:6UDI|rcsb pdb:6UDU|rcsb pdb:6UDV|rcsb pdb:6UDX|rcsb pdb:6UDY|rcsb pdb:6VBX|rcsb pdb:6YBG|rcsb pdb:6YBJ|rcsb pdb:6YBK|rcsb pdb:6YBL|rcsb pdb:6UDT|rcsb pdb:6ZIE|reactome:R-HSA-6785807|dip:DIP-231N	go:"GO:0016020"(membrane)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:F13a6H/g/tv/Pr90ehCDePpcSB49606	rogid:zHymH4IKoOVjBLtkMF1dmNmH2DU9606	intact-crc:75139E07DC7FB45B|rigid:VisuGieuWq5SpkNI4as5rU+RX5E	false	ha tag:?-?|mutation decreasing interaction:78-78	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16611	uniprotkb:Q07812	intact:EBI-519866|ensembl:ENSP00000363591|uniprotkb:Q92533|uniprotkb:Q6I9T6|uniprotkb:C0H5Y7	intact:EBI-516580|uniprotkb:P55269|uniprotkb:Q07814|uniprotkb:Q07815|uniprotkb:Q8WZ49|uniprotkb:Q9NR76|uniprotkb:Q9UQD6|uniprotkb:Q9NYG7|uniprotkb:Q9UCZ6|uniprotkb:Q9UCZ7|uniprotkb:A8K4W1|intact:EBI-8995042|ensembl:ENSP00000263262	psi-mi:bak_human(display_long)|uniprotkb:Apoptosis regulator BAK(gene name synonym)|uniprotkb:Bcl-2-like protein 7(gene name synonym)|uniprotkb:BAK1(gene name)|psi-mi:BAK1(display_short)|uniprotkb:BAK(gene name synonym)|uniprotkb:BCL2L7(gene name synonym)|uniprotkb:CDN1(gene name synonym)	psi-mi:bax_human(display_long)|uniprotkb:BAX(gene name)|psi-mi:BAX(display_short)|uniprotkb:BCL2L4(gene name synonym)|uniprotkb:Bcl-2-like protein 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Willis et al. (2005)	pubmed:15901672	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707374	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001179.1|ensembl:ENSG00000030110(gene)|ensembl:ENST00000374467(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009620"(response to fungus)|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010225"(response to UV-C)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051400"(BH domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026308|interpro:IPR036834|mint:Q16611|rcsb pdb:1BXL|rcsb pdb:2IMS|rcsb pdb:2IMT|rcsb pdb:2JBY|rcsb pdb:2JCN|rcsb pdb:2LP8|rcsb pdb:2M5B|rcsb pdb:2XPX|rcsb pdb:2YV6|rcsb pdb:3I1H|rcsb pdb:3QBR|rcsb pdb:4D2L|rcsb pdb:4U2U|rcsb pdb:4U2V|rcsb pdb:4UF1|rcsb pdb:5AJK|rcsb pdb:5FMI|rcsb pdb:5FMK|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX1|rcsb pdb:6ODH|rcsb pdb:6UXM|rcsb pdb:6UXN|rcsb pdb:6UXO|rcsb pdb:6UXP|rcsb pdb:6UXQ|rcsb pdb:6UXR|rcsb pdb:7K02|rcsb pdb:7OFM|rcsb pdb:7OFO|reactome:R-HSA-111452|reactome:R-HSA-111457|reactome:R-HSA-5620971|refseq:XP_011513081.1|dip:DIP-935N	refseq:NP_004315.1|refseq:NP_620116.1|refseq:NP_620118.1|refseq:NP_620119.2|refseq:XP_016882566.1|refseq:NP_001278357.1|refseq:NP_001278360.1|dip:DIP-232N|ensembl:ENSG00000087088(gene)|ensembl:ENST00000345358(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001764"(neuron migration)|go:"GO:0001777"(T cell homeostatic proliferation)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001844"(protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0002358"(B cell homeostatic proliferation)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006687"(glycosphingolipid metabolic process)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009651"(response to salt stress)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032976"(release of matrix enzymes from mitochondria)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045136"(development of secondary sexual characteristics)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048087"(positive regulation of developmental pigmentation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051087"(chaperone binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097144"(BAX complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0021854"(hypothalamus development)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902445"(regulation of mitochondrial membrane permeability involved in programmed necrotic cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1990117"(B cell receptor apoptotic signaling pathway)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026304|interpro:IPR036834|mint:Q07812|rcsb pdb:1F16|rcsb pdb:2G5B|rcsb pdb:2K7W|rcsb pdb:2LR1|rcsb pdb:3PK1|rcsb pdb:3PL7|rcsb pdb:4BD2|rcsb pdb:4BD6|rcsb pdb:4BD7|rcsb pdb:4BD8|rcsb pdb:4BDU|rcsb pdb:4S0O|rcsb pdb:4S0P|rcsb pdb:4UF2|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIG|rcsb pdb:4ZIH|rcsb pdb:4ZII|rcsb pdb:5W5X|rcsb pdb:5W5Z|rcsb pdb:5W60|rcsb pdb:5W61|rcsb pdb:6EB6|rcsb pdb:6L8V|rcsb pdb:6L95|rcsb pdb:6TRR|rcsb pdb:6XY6|reactome:R-HSA-111457|reactome:R-HSA-114294|reactome:R-HSA-5620971|reactome:R-HSA-6803204|reactome:R-HSA-6804114|reactome:R-HSA-8878166|reactome:R-HSA-9603505|go:"GO:0097193"(intrinsic apoptotic signaling pathway)	go:"GO:0016020"(membrane)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:F13a6H/g/tv/Pr90ehCDePpcSB49606	rogid:+Fz2No3HFxN4vZ+KGhDcgPQhpLo9606	intact-crc:AF016BF7B756AFD9|rigid:byMfvIo+lT15VXggrnv165/gHH4	false	mutation decreasing interaction:78-78|ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16611	uniprotkb:Q16611	intact:EBI-519866|ensembl:ENSP00000363591|uniprotkb:Q92533|uniprotkb:Q6I9T6|uniprotkb:C0H5Y7	intact:EBI-519866|ensembl:ENSP00000363591|uniprotkb:Q92533|uniprotkb:Q6I9T6|uniprotkb:C0H5Y7	psi-mi:bak_human(display_long)|uniprotkb:Apoptosis regulator BAK(gene name synonym)|uniprotkb:Bcl-2-like protein 7(gene name synonym)|uniprotkb:BAK1(gene name)|psi-mi:BAK1(display_short)|uniprotkb:BAK(gene name synonym)|uniprotkb:BCL2L7(gene name synonym)|uniprotkb:CDN1(gene name synonym)	psi-mi:bak_human(display_long)|uniprotkb:Apoptosis regulator BAK(gene name synonym)|uniprotkb:Bcl-2-like protein 7(gene name synonym)|uniprotkb:BAK1(gene name)|psi-mi:BAK1(display_short)|uniprotkb:BAK(gene name synonym)|uniprotkb:BCL2L7(gene name synonym)|uniprotkb:CDN1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Willis et al. (2005)	pubmed:15901672	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707383	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001179.1|ensembl:ENSG00000030110(gene)|ensembl:ENST00000374467(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009620"(response to fungus)|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010225"(response to UV-C)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051400"(BH domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026308|interpro:IPR036834|mint:Q16611|rcsb pdb:1BXL|rcsb pdb:2IMS|rcsb pdb:2IMT|rcsb pdb:2JBY|rcsb pdb:2JCN|rcsb pdb:2LP8|rcsb pdb:2M5B|rcsb pdb:2XPX|rcsb pdb:2YV6|rcsb pdb:3I1H|rcsb pdb:3QBR|rcsb pdb:4D2L|rcsb pdb:4U2U|rcsb pdb:4U2V|rcsb pdb:4UF1|rcsb pdb:5AJK|rcsb pdb:5FMI|rcsb pdb:5FMK|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX1|rcsb pdb:6ODH|rcsb pdb:6UXM|rcsb pdb:6UXN|rcsb pdb:6UXO|rcsb pdb:6UXP|rcsb pdb:6UXQ|rcsb pdb:6UXR|rcsb pdb:7K02|rcsb pdb:7OFM|rcsb pdb:7OFO|reactome:R-HSA-111452|reactome:R-HSA-111457|reactome:R-HSA-5620971|refseq:XP_011513081.1|dip:DIP-935N	refseq:NP_001179.1|ensembl:ENSG00000030110(gene)|ensembl:ENST00000374467(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009620"(response to fungus)|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010225"(response to UV-C)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051400"(BH domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026308|interpro:IPR036834|mint:Q16611|rcsb pdb:1BXL|rcsb pdb:2IMS|rcsb pdb:2IMT|rcsb pdb:2JBY|rcsb pdb:2JCN|rcsb pdb:2LP8|rcsb pdb:2M5B|rcsb pdb:2XPX|rcsb pdb:2YV6|rcsb pdb:3I1H|rcsb pdb:3QBR|rcsb pdb:4D2L|rcsb pdb:4U2U|rcsb pdb:4U2V|rcsb pdb:4UF1|rcsb pdb:5AJK|rcsb pdb:5FMI|rcsb pdb:5FMK|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX1|rcsb pdb:6ODH|rcsb pdb:6UXM|rcsb pdb:6UXN|rcsb pdb:6UXO|rcsb pdb:6UXP|rcsb pdb:6UXQ|rcsb pdb:6UXR|rcsb pdb:7K02|rcsb pdb:7OFM|rcsb pdb:7OFO|reactome:R-HSA-111452|reactome:R-HSA-111457|reactome:R-HSA-5620971|refseq:XP_011513081.1|dip:DIP-935N	go:"GO:0042803"(protein homodimerization activity)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:F13a6H/g/tv/Pr90ehCDePpcSB49606	rogid:F13a6H/g/tv/Pr90ehCDePpcSB49606	intact-crc:D49A2DDC5A4B6D1F|rigid:BDEG3z9fKDZAXFWl94t1Id8KFJI	false	-	ha tag:?-?|mutation decreasing interaction:78-78	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13794	uniprotkb:Q07820	intact:EBI-707392|uniprotkb:B2R4T7|uniprotkb:Q8N589|ensembl:ENSP00000326119	intact:EBI-1003422|uniprotkb:Q9HD91|uniprotkb:Q9NRQ3|uniprotkb:Q9NRQ4|uniprotkb:Q9UHR7|uniprotkb:Q9UHR8|uniprotkb:Q9UHR9|uniprotkb:Q9UNJ1|uniprotkb:B2R6B2|uniprotkb:D3DV03|uniprotkb:D3DV04|ensembl:ENSP00000358022|ensembl:ENSP00000502859	psi-mi:apr_human(display_long)|uniprotkb:NOXA(gene name synonym)|uniprotkb:Immediate-early-response protein APR(gene name synonym)|uniprotkb:PMAIP1(gene name)|psi-mi:PMAIP1(display_short)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:mcl1_human(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:mcl1/EAT(gene name synonym)|uniprotkb:MCL1(gene name)|psi-mi:MCL1(display_short)|uniprotkb:BCL2L3(gene name synonym)|uniprotkb:Bcl-2-like protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Willis et al. (2005)	pubmed:15901672	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707397	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066950.1|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051607"(defense response to virus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR024140|mint:Q13794|rcsb pdb:3MQP|reactome:R-HSA-111448|reactome:R-HSA-111453|reactome:R-HSA-6803204|ensembl:ENSG00000141682(gene)|ensembl:ENST00000316660(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043331"(response to dsRNA)	refseq:NP_001184249.1|refseq:NP_068779.1|refseq:NP_877495.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|ensembl:ENSG00000143384(gene)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|ensembl:ENST00000369026(transcript)|ensembl:ENST00000678770(transcript)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0001709"(cell fate determination)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|go:"GO:0005741"(mitochondrial outer membrane)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|go:"GO:0005829"(cytosol)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|rcsb pdb:6QFI|rcsb pdb:6QFM|rcsb pdb:6QFQ|interpro:IPR026298|interpro:IPR036834|rcsb pdb:6QGD|mint:Q07820|rcsb pdb:2KBW|rcsb pdb:2MHS|rcsb pdb:2NL9|rcsb pdb:2NLA|rcsb pdb:6QXJ|rcsb pdb:2PQK|rcsb pdb:6QYK|rcsb pdb:3D7V|rcsb pdb:6QYL|rcsb pdb:3IO9|rcsb pdb:6QYN|rcsb pdb:3KJ0|rcsb pdb:6QYO|rcsb pdb:3KJ1|rcsb pdb:3KJ2|rcsb pdb:6QYP|rcsb pdb:3KZ0|rcsb pdb:6QZ5|rcsb pdb:3MK8|rcsb pdb:3PK1|rcsb pdb:3TWU|rcsb pdb:3WIX|rcsb pdb:3WIY|rcsb pdb:6QZ6|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4HW2|rcsb pdb:4HW3|rcsb pdb:4HW4|rcsb pdb:4OQ5|rcsb pdb:4OQ6|rcsb pdb:4WGI|rcsb pdb:6QZ7|rcsb pdb:4WMR|rcsb pdb:4WMS|rcsb pdb:4WMT|rcsb pdb:4WMU|rcsb pdb:4WMV|rcsb pdb:4WMW|rcsb pdb:4WMX|rcsb pdb:4ZBF|rcsb pdb:4ZBI|rcsb pdb:5C3F|rcsb pdb:5C6H|rcsb pdb:5FC4|rcsb pdb:5FDO|rcsb pdb:5FDR|rcsb pdb:5IEZ|rcsb pdb:5IF4|rcsb pdb:6QZ8|rcsb pdb:5JSB|rcsb pdb:5KU9|rcsb pdb:5LOF|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5UUM|rcsb pdb:5VKC|rcsb pdb:5VX2|rcsb pdb:5W89|rcsb pdb:6QZB|rcsb pdb:5W8F|rcsb pdb:6B4L|rcsb pdb:6B4U|rcsb pdb:6STJ|rcsb pdb:6BW2|rcsb pdb:6BW8|rcsb pdb:6FS0|rcsb pdb:6FS1|rcsb pdb:6FS2|rcsb pdb:6MBD|rcsb pdb:6MBE|rcsb pdb:6NE5|rcsb pdb:6O4U|rcsb pdb:6O6F|rcsb pdb:6O6G|rcsb pdb:6OQB|rcsb pdb:6U63|rcsb pdb:6OQC|rcsb pdb:6U64|rcsb pdb:6U65|rcsb pdb:6OQD|rcsb pdb:6OQN|rcsb pdb:6OVC|rcsb pdb:6P3P|rcsb pdb:6QB3|rcsb pdb:6QB4|rcsb pdb:6QB6|rcsb pdb:6QFC|rcsb pdb:6U67|rcsb pdb:6U6F|rcsb pdb:6UA3|rcsb pdb:6UAB|rcsb pdb:6UD2|rcsb pdb:6UDI|rcsb pdb:6UDU|rcsb pdb:6UDV|rcsb pdb:6UDX|rcsb pdb:6UDY|rcsb pdb:6VBX|rcsb pdb:6YBG|rcsb pdb:6YBJ|rcsb pdb:6YBK|rcsb pdb:6YBL|rcsb pdb:6UDT|rcsb pdb:6ZIE|reactome:R-HSA-6785807|dip:DIP-231N	go:"GO:0016020"(membrane)	-	-	comment:Appears to bind to MCL1 in competition with BAK|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:IDaNRhZNKHvwyF0oqi9mPw+mBnc9606	rogid:zHymH4IKoOVjBLtkMF1dmNmH2DU9606	intact-crc:8564C1B60FF9B28C|rigid:qTB/l1tWrQOlDFLo7aUl+wpJf8Q	false	ha tag:n-n|mutation decreasing interaction:36-36|mutation decreasing interaction:32-32|mutation decreasing interaction:29-29	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16611	uniprotkb:Q07820	intact:EBI-519866|ensembl:ENSP00000363591|uniprotkb:Q92533|uniprotkb:Q6I9T6|uniprotkb:C0H5Y7	intact:EBI-1003422|uniprotkb:Q9HD91|uniprotkb:Q9NRQ3|uniprotkb:Q9NRQ4|uniprotkb:Q9UHR7|uniprotkb:Q9UHR8|uniprotkb:Q9UHR9|uniprotkb:Q9UNJ1|uniprotkb:B2R6B2|uniprotkb:D3DV03|uniprotkb:D3DV04|ensembl:ENSP00000358022|ensembl:ENSP00000502859	psi-mi:bak_human(display_long)|uniprotkb:Apoptosis regulator BAK(gene name synonym)|uniprotkb:Bcl-2-like protein 7(gene name synonym)|uniprotkb:BAK1(gene name)|psi-mi:BAK1(display_short)|uniprotkb:BAK(gene name synonym)|uniprotkb:BCL2L7(gene name synonym)|uniprotkb:CDN1(gene name synonym)	psi-mi:mcl1_human(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:mcl1/EAT(gene name synonym)|uniprotkb:MCL1(gene name)|psi-mi:MCL1(display_short)|uniprotkb:BCL2L3(gene name synonym)|uniprotkb:Bcl-2-like protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Willis et al. (2005)	pubmed:15901672	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707350	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001179.1|ensembl:ENSG00000030110(gene)|ensembl:ENST00000374467(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009620"(response to fungus)|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010225"(response to UV-C)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051400"(BH domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026308|interpro:IPR036834|mint:Q16611|rcsb pdb:1BXL|rcsb pdb:2IMS|rcsb pdb:2IMT|rcsb pdb:2JBY|rcsb pdb:2JCN|rcsb pdb:2LP8|rcsb pdb:2M5B|rcsb pdb:2XPX|rcsb pdb:2YV6|rcsb pdb:3I1H|rcsb pdb:3QBR|rcsb pdb:4D2L|rcsb pdb:4U2U|rcsb pdb:4U2V|rcsb pdb:4UF1|rcsb pdb:5AJK|rcsb pdb:5FMI|rcsb pdb:5FMK|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX1|rcsb pdb:6ODH|rcsb pdb:6UXM|rcsb pdb:6UXN|rcsb pdb:6UXO|rcsb pdb:6UXP|rcsb pdb:6UXQ|rcsb pdb:6UXR|rcsb pdb:7K02|rcsb pdb:7OFM|rcsb pdb:7OFO|reactome:R-HSA-111452|reactome:R-HSA-111457|reactome:R-HSA-5620971|refseq:XP_011513081.1|dip:DIP-935N	refseq:NP_001184249.1|refseq:NP_068779.1|refseq:NP_877495.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|ensembl:ENSG00000143384(gene)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|ensembl:ENST00000369026(transcript)|ensembl:ENST00000678770(transcript)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0001709"(cell fate determination)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|go:"GO:0005741"(mitochondrial outer membrane)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|go:"GO:0005829"(cytosol)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|rcsb pdb:6QFI|rcsb pdb:6QFM|rcsb pdb:6QFQ|interpro:IPR026298|interpro:IPR036834|rcsb pdb:6QGD|mint:Q07820|rcsb pdb:2KBW|rcsb pdb:2MHS|rcsb pdb:2NL9|rcsb pdb:2NLA|rcsb pdb:6QXJ|rcsb pdb:2PQK|rcsb pdb:6QYK|rcsb pdb:3D7V|rcsb pdb:6QYL|rcsb pdb:3IO9|rcsb pdb:6QYN|rcsb pdb:3KJ0|rcsb pdb:6QYO|rcsb pdb:3KJ1|rcsb pdb:3KJ2|rcsb pdb:6QYP|rcsb pdb:3KZ0|rcsb pdb:6QZ5|rcsb pdb:3MK8|rcsb pdb:3PK1|rcsb pdb:3TWU|rcsb pdb:3WIX|rcsb pdb:3WIY|rcsb pdb:6QZ6|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4HW2|rcsb pdb:4HW3|rcsb pdb:4HW4|rcsb pdb:4OQ5|rcsb pdb:4OQ6|rcsb pdb:4WGI|rcsb pdb:6QZ7|rcsb pdb:4WMR|rcsb pdb:4WMS|rcsb pdb:4WMT|rcsb pdb:4WMU|rcsb pdb:4WMV|rcsb pdb:4WMW|rcsb pdb:4WMX|rcsb pdb:4ZBF|rcsb pdb:4ZBI|rcsb pdb:5C3F|rcsb pdb:5C6H|rcsb pdb:5FC4|rcsb pdb:5FDO|rcsb pdb:5FDR|rcsb pdb:5IEZ|rcsb pdb:5IF4|rcsb pdb:6QZ8|rcsb pdb:5JSB|rcsb pdb:5KU9|rcsb pdb:5LOF|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5UUM|rcsb pdb:5VKC|rcsb pdb:5VX2|rcsb pdb:5W89|rcsb pdb:6QZB|rcsb pdb:5W8F|rcsb pdb:6B4L|rcsb pdb:6B4U|rcsb pdb:6STJ|rcsb pdb:6BW2|rcsb pdb:6BW8|rcsb pdb:6FS0|rcsb pdb:6FS1|rcsb pdb:6FS2|rcsb pdb:6MBD|rcsb pdb:6MBE|rcsb pdb:6NE5|rcsb pdb:6O4U|rcsb pdb:6O6F|rcsb pdb:6O6G|rcsb pdb:6OQB|rcsb pdb:6U63|rcsb pdb:6OQC|rcsb pdb:6U64|rcsb pdb:6U65|rcsb pdb:6OQD|rcsb pdb:6OQN|rcsb pdb:6OVC|rcsb pdb:6P3P|rcsb pdb:6QB3|rcsb pdb:6QB4|rcsb pdb:6QB6|rcsb pdb:6QFC|rcsb pdb:6U67|rcsb pdb:6U6F|rcsb pdb:6UA3|rcsb pdb:6UAB|rcsb pdb:6UD2|rcsb pdb:6UDI|rcsb pdb:6UDU|rcsb pdb:6UDV|rcsb pdb:6UDX|rcsb pdb:6UDY|rcsb pdb:6VBX|rcsb pdb:6YBG|rcsb pdb:6YBJ|rcsb pdb:6YBK|rcsb pdb:6YBL|rcsb pdb:6UDT|rcsb pdb:6ZIE|reactome:R-HSA-6785807|dip:DIP-231N	go:"GO:0016020"(membrane)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2005/11/09	2014/10/16	rogid:F13a6H/g/tv/Pr90ehCDePpcSB49606	rogid:zHymH4IKoOVjBLtkMF1dmNmH2DU9606	intact-crc:6108617EBBA34674|rigid:VisuGieuWq5SpkNI4as5rU+RX5E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q07817-1	uniprotkb:Q16611	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	intact:EBI-519866|ensembl:ENSP00000363591|uniprotkb:Q92533|uniprotkb:Q6I9T6|uniprotkb:C0H5Y7	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:bak_human(display_long)|uniprotkb:Apoptosis regulator BAK(gene name synonym)|uniprotkb:Bcl-2-like protein 7(gene name synonym)|uniprotkb:BAK1(gene name)|psi-mi:BAK1(display_short)|uniprotkb:BAK(gene name synonym)|uniprotkb:BCL2L7(gene name synonym)|uniprotkb:CDN1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Willis et al. (2005)	pubmed:15901672	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707356	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	refseq:NP_001179.1|ensembl:ENSG00000030110(gene)|ensembl:ENST00000374467(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009620"(response to fungus)|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010225"(response to UV-C)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051400"(BH domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026308|interpro:IPR036834|mint:Q16611|rcsb pdb:1BXL|rcsb pdb:2IMS|rcsb pdb:2IMT|rcsb pdb:2JBY|rcsb pdb:2JCN|rcsb pdb:2LP8|rcsb pdb:2M5B|rcsb pdb:2XPX|rcsb pdb:2YV6|rcsb pdb:3I1H|rcsb pdb:3QBR|rcsb pdb:4D2L|rcsb pdb:4U2U|rcsb pdb:4U2V|rcsb pdb:4UF1|rcsb pdb:5AJK|rcsb pdb:5FMI|rcsb pdb:5FMK|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX1|rcsb pdb:6ODH|rcsb pdb:6UXM|rcsb pdb:6UXN|rcsb pdb:6UXO|rcsb pdb:6UXP|rcsb pdb:6UXQ|rcsb pdb:6UXR|rcsb pdb:7K02|rcsb pdb:7OFM|rcsb pdb:7OFO|reactome:R-HSA-111452|reactome:R-HSA-111457|reactome:R-HSA-5620971|refseq:XP_011513081.1|dip:DIP-935N	go:"GO:0016020"(membrane)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2005/11/09	2014/10/16	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rogid:F13a6H/g/tv/Pr90ehCDePpcSB49606	intact-crc:3BE5E3B77A832D22|rigid:Vsl19lBLoL75CYE+wO3EE44R3hE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16611	uniprotkb:P97287	intact:EBI-519866|ensembl:ENSP00000363591|uniprotkb:Q92533|uniprotkb:Q6I9T6|uniprotkb:C0H5Y7	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:bak_human(display_long)|uniprotkb:Apoptosis regulator BAK(gene name synonym)|uniprotkb:Bcl-2-like protein 7(gene name synonym)|uniprotkb:BAK1(gene name)|psi-mi:BAK1(display_short)|uniprotkb:BAK(gene name synonym)|uniprotkb:BCL2L7(gene name synonym)|uniprotkb:CDN1(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0096"(pull down)	Willis et al. (2005)	pubmed:15901672	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707414	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001179.1|ensembl:ENSG00000030110(gene)|ensembl:ENST00000374467(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009620"(response to fungus)|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010225"(response to UV-C)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051400"(BH domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026308|interpro:IPR036834|mint:Q16611|rcsb pdb:1BXL|rcsb pdb:2IMS|rcsb pdb:2IMT|rcsb pdb:2JBY|rcsb pdb:2JCN|rcsb pdb:2LP8|rcsb pdb:2M5B|rcsb pdb:2XPX|rcsb pdb:2YV6|rcsb pdb:3I1H|rcsb pdb:3QBR|rcsb pdb:4D2L|rcsb pdb:4U2U|rcsb pdb:4U2V|rcsb pdb:4UF1|rcsb pdb:5AJK|rcsb pdb:5FMI|rcsb pdb:5FMK|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX1|rcsb pdb:6ODH|rcsb pdb:6UXM|rcsb pdb:6UXN|rcsb pdb:6UXO|rcsb pdb:6UXP|rcsb pdb:6UXQ|rcsb pdb:6UXR|rcsb pdb:7K02|rcsb pdb:7OFM|rcsb pdb:7OFO|reactome:R-HSA-111452|reactome:R-HSA-111457|reactome:R-HSA-5620971|refseq:XP_011513081.1|dip:DIP-935N	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	-	-	-	inhibition:"By PMAIP1 (Q13794) - a BH3 domain peptide compete for binding to MCL-1 with BAK"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:F13a6H/g/tv/Pr90ehCDePpcSB49606	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	intact-crc:19E7C16D9F1B9EAB|rigid:8mCwx1xiBBOu4/93Ebxg1g0k+8g	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)