#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P15927 uniprotkb:P03070 intact:EBI-621404|ensembl:ENSP00000363021|uniprotkb:Q52II0|uniprotkb:Q5TEI9|uniprotkb:Q5TEJ5 intact:EBI-617698 psi-mi:rfa2_human(display_long)|uniprotkb:RPA34(gene name synonym)|uniprotkb:Replication protein A 34 kDa subunit(gene name synonym)|uniprotkb:Replication factor A protein 2(gene name synonym)|uniprotkb:RPA2(gene name)|psi-mi:RPA2(display_short)|uniprotkb:REPA2(gene name synonym)|uniprotkb:RPA32(gene name synonym) psi-mi:lt_sv40(display_long) psi-mi:"MI:0077"(nuclear magnetic resonance) Arunkumar et al. (2005) pubmed:15793585|mint:MINT-5217622 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:1891767(sv40)|taxid:1891767(sv40) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7560645|mint:MINT-69735 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:1Z1D|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|rcsb pdb:4MQV|rcsb pdb:4OU0|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|rcsb pdb:1DPU|ensembl:ENSG00000117748(gene)|ensembl:ENST00000373912(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|mint:P15927|refseq:NP_001273005.1|refseq:NP_002937.1|refseq:NP_001284487.1|dip:DIP-24187N|mint:MINT-1343618(identity) go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039576"(suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039686"(bidirectional double-stranded viral DNA replication)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003133(T antigen, Ori-binding)|interpro:IPR010932(Large T antigen, polyomavirus, C-terminus)|interpro:IPR016392(Large T antigen, polyomaviridae)|interpro:IPR017910|interpro:IPR027417|interpro:IPR036869|rcsb pdb:1EJL|rcsb pdb:1GH6|rcsb pdb:1N25|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1SVL|rcsb pdb:1SVM|rcsb pdb:1SVO|rcsb pdb:1TBD|rcsb pdb:1Z1D|rcsb pdb:2FUF|rcsb pdb:2H1L|rcsb pdb:2IF9|rcsb pdb:2IPR|rcsb pdb:2ITJ|rcsb pdb:2ITL|rcsb pdb:2NL8|rcsb pdb:2NTC|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|rcsb pdb:2TBD|rcsb pdb:3QK2|rcsb pdb:3QN2|rcsb pdb:4E2I|rcsb pdb:4FGN|rcsb pdb:4GDF|rcsb pdb:4RXH|rcsb pdb:5D9I|refseq:YP_003708382.1|mint:P03070|dip:DIP-24251N|mint:MINT-1343628(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" kd:500 versus 60 micromolar|figure legend:F2FG F3ABC|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/11/21 2019/10/18 rogid:+Ute8Lq5hnN0sLAQNWZb0cAbcTI9606 rogid:IMcAp2PRxZXkbJ1eiXhJU9rD2JM1891767 intact-crc:16C845B7FA86931E|rigid:Dc2nJtFXlOoxdZCxhqsgit345XE false binding-associated region:252-268(MINT-1343619)|mutation decreasing interaction:252-252,268-268(MINT-1343621) binding-associated region:154-259(MINT-1343629)|mutation decreasing interaction:154-154(MINT-1343631) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P15927 uniprotkb:P03070 intact:EBI-621404|ensembl:ENSP00000363021|uniprotkb:Q52II0|uniprotkb:Q5TEI9|uniprotkb:Q5TEJ5 intact:EBI-617698 psi-mi:rfa2_human(display_long)|uniprotkb:RPA34(gene name synonym)|uniprotkb:Replication protein A 34 kDa subunit(gene name synonym)|uniprotkb:Replication factor A protein 2(gene name synonym)|uniprotkb:RPA2(gene name)|psi-mi:RPA2(display_short)|uniprotkb:REPA2(gene name synonym)|uniprotkb:RPA32(gene name synonym) psi-mi:lt_sv40(display_long) psi-mi:"MI:0004"(affinity chromatography technology) Arunkumar et al. (2005) pubmed:15793585|mint:MINT-5217622 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:1891767(sv40)|taxid:1891767(sv40) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7560731|mint:MINT-69732 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:1Z1D|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|rcsb pdb:4MQV|rcsb pdb:4OU0|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|rcsb pdb:1DPU|ensembl:ENSG00000117748(gene)|ensembl:ENST00000373912(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|mint:P15927|refseq:NP_001273005.1|refseq:NP_002937.1|refseq:NP_001284487.1|dip:DIP-24187N|mint:MINT-1343643(identity) go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039576"(suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039686"(bidirectional double-stranded viral DNA replication)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003133(T antigen, Ori-binding)|interpro:IPR010932(Large T antigen, polyomavirus, C-terminus)|interpro:IPR016392(Large T antigen, polyomaviridae)|interpro:IPR017910|interpro:IPR027417|interpro:IPR036869|rcsb pdb:1EJL|rcsb pdb:1GH6|rcsb pdb:1N25|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1SVL|rcsb pdb:1SVM|rcsb pdb:1SVO|rcsb pdb:1TBD|rcsb pdb:1Z1D|rcsb pdb:2FUF|rcsb pdb:2H1L|rcsb pdb:2IF9|rcsb pdb:2IPR|rcsb pdb:2ITJ|rcsb pdb:2ITL|rcsb pdb:2NL8|rcsb pdb:2NTC|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|rcsb pdb:2TBD|rcsb pdb:3QK2|rcsb pdb:3QN2|rcsb pdb:4E2I|rcsb pdb:4FGN|rcsb pdb:4GDF|rcsb pdb:4RXH|rcsb pdb:5D9I|refseq:YP_003708382.1|mint:P03070|dip:DIP-24251N|mint:MINT-1343648(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/11/21 2019/10/18 rogid:+Ute8Lq5hnN0sLAQNWZb0cAbcTI9606 rogid:IMcAp2PRxZXkbJ1eiXhJU9rD2JM1891767 intact-crc:FBD7C5487A3F7FD4|rigid:Dc2nJtFXlOoxdZCxhqsgit345XE false - binding-associated region:137-258(MINT-1343649) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)