#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03950	uniprotkb:P35609	intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077	intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5	psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym)	psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hu et al. (2005)	pubmed:15737636	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525300	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton)	refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/04/05	2014/10/16	rogid:CSOTublnrV3DIGJfeyCfT14p8m89606	rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606	intact-crc:D7F526E91BB2E864|rigid:2zIALojZuUhWV5MiO0qCN800evo	false	-	binding-associated region:375-894	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P35609	uniprotkb:P03950	intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5	intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077	psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hu et al. (2005)	pubmed:15737636	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525326	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N	refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton)	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/05	2014/10/16	rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606	rogid:CSOTublnrV3DIGJfeyCfT14p8m89606	intact-crc:9E498C2FD4E9F3E2|rigid:2zIALojZuUhWV5MiO0qCN800evo	false	binding-associated region:375-894|his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03950	uniprotkb:P35609	intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077	intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5	psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym)	psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hu et al. (2005)	pubmed:15737636	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525368	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton)	refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/05	2014/10/16	rogid:CSOTublnrV3DIGJfeyCfT14p8m89606	rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606	intact-crc:0AF809736836CBD3|rigid:2zIALojZuUhWV5MiO0qCN800evo	false	-	binding-associated region:375-894|radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35609	uniprotkb:P03950	intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5	intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077	psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Hu et al. (2005)	pubmed:15737636	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525404	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N	refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton)	-	-	-	-	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/04/05	2014/10/16	rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606	rogid:CSOTublnrV3DIGJfeyCfT14p8m89606	intact-crc:F9121F8AA3E180DC|rigid:2zIALojZuUhWV5MiO0qCN800evo	false	tag:?-?|binding-associated region:375-894	tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)