#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9UPU3 uniprotkb:P01138 intact:EBI-7484437|uniprotkb:Q9NQJ2|intact:MINT-1326895|uniprotkb:Q5VXF9|ensembl:ENSP00000358715 intact:EBI-1028250|uniprotkb:Q6FHA0|uniprotkb:Q96P60|uniprotkb:Q9P2Q8|uniprotkb:Q9UKL8|uniprotkb:A1A4E5|ensembl:ENSP00000358525|ensembl:ENSP00000502380|ensembl:ENSP00000502831|ensembl:ENSP00000505694|ensembl:ENSP00000506492|ensembl:ENSP00000506569|ensembl:ENSP00000505558 psi-mi:sorc3_human(display_long)|uniprotkb:SORCS3(gene name)|psi-mi:SORCS3(display_short)|uniprotkb:KIAA1059(gene name synonym) psi-mi:ngf_human(display_long)|uniprotkb:NGF(gene name)|psi-mi:NGF(display_short)|uniprotkb:NGFB(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Westergaard et al. (2005) pubmed:15710408|imex:IM-14131|mint:MINT-5217534 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7484429|mint:MINT-56550|imex:IM-14131-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055793.1|ensembl:ENSG00000156395(gene)|ensembl:ENST00000369701(transcript)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1900452"(regulation of long-term synaptic depression)|interpro:IPR000601(PKD)|interpro:IPR006581(VPS10)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|interpro:IPR035986|mint:Q9UPU3|mint:MINT-1326939(identity) refseq:NP_002497.2|ensembl:ENSG00000134259(gene)|ensembl:ENST00000369512(transcript)|ensembl:ENST00000675637(transcript)|ensembl:ENST00000676038(transcript)|ensembl:ENST00000679806(transcript)|ensembl:ENST00000680116(transcript)|ensembl:ENST00000680540(transcript)|ensembl:ENST00000680752(transcript)|go:"GO:0005163"(nerve growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021675"(nerve development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031904"(endosome lumen)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038177"(death receptor agonist activity)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR002072(Nerve growth factor)|interpro:IPR019846|interpro:IPR020408|interpro:IPR020425|interpro:IPR020437|rcsb pdb:1SG1|rcsb pdb:1WWW|rcsb pdb:2IFG|rcsb pdb:4EDW|rcsb pdb:4EDX|rcsb pdb:4ZBN|rcsb pdb:5JZ7|rcsb pdb:6YW8|reactome:R-HSA-167021|reactome:R-HSA-167044|interpro:IPR029034|reactome:R-HSA-167060|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-177504|reactome:R-HSA-187042|reactome:R-HSA-187706|reactome:R-HSA-193648|reactome:R-HSA-193670|reactome:R-HSA-193681|reactome:R-HSA-198203|reactome:R-HSA-198745|reactome:R-HSA-205017|reactome:R-HSA-205025|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-209563|refseq:XP_006710726.1|dip:DIP-5712N|mint:MINT-1326945(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2|kd:70 picomolar|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/03/10 2014/10/16 rogid:lT3HTfWJN1KbRETpE8RIBNCRtYM9606 rogid:qUmDPZg27gpyP0gOpOpUZJyV7mI9606 intact-crc:12A183D20258E738|rigid:Fs4ErPlkfrpKwJhX/j8FT018HXY false binding-associated region:41-1084(MINT-1326940) tag:?-?(MINT-1326946) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UPU3 uniprotkb:P01138 intact:EBI-7484437|uniprotkb:Q9NQJ2|intact:MINT-1326895|uniprotkb:Q5VXF9|ensembl:ENSP00000358715 intact:EBI-1028250|uniprotkb:Q6FHA0|uniprotkb:Q96P60|uniprotkb:Q9P2Q8|uniprotkb:Q9UKL8|uniprotkb:A1A4E5|ensembl:ENSP00000358525|ensembl:ENSP00000502380|ensembl:ENSP00000502831|ensembl:ENSP00000505694|ensembl:ENSP00000506492|ensembl:ENSP00000506569|ensembl:ENSP00000505558 psi-mi:sorc3_human(display_long)|uniprotkb:SORCS3(gene name)|psi-mi:SORCS3(display_short)|uniprotkb:KIAA1059(gene name synonym) psi-mi:ngf_human(display_long)|uniprotkb:NGF(gene name)|psi-mi:NGF(display_short)|uniprotkb:NGFB(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Westergaard et al. (2005) pubmed:15710408|imex:IM-14131|mint:MINT-5217534 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7484484|mint:MINT-56551|imex:IM-14131-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055793.1|ensembl:ENSG00000156395(gene)|ensembl:ENST00000369701(transcript)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1900452"(regulation of long-term synaptic depression)|interpro:IPR000601(PKD)|interpro:IPR006581(VPS10)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|interpro:IPR035986|mint:Q9UPU3|mint:MINT-1326919(identity) refseq:NP_002497.2|ensembl:ENSG00000134259(gene)|ensembl:ENST00000369512(transcript)|ensembl:ENST00000675637(transcript)|ensembl:ENST00000676038(transcript)|ensembl:ENST00000679806(transcript)|ensembl:ENST00000680116(transcript)|ensembl:ENST00000680540(transcript)|ensembl:ENST00000680752(transcript)|go:"GO:0005163"(nerve growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021675"(nerve development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031904"(endosome lumen)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038177"(death receptor agonist activity)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR002072(Nerve growth factor)|interpro:IPR019846|interpro:IPR020408|interpro:IPR020425|interpro:IPR020437|rcsb pdb:1SG1|rcsb pdb:1WWW|rcsb pdb:2IFG|rcsb pdb:4EDW|rcsb pdb:4EDX|rcsb pdb:4ZBN|rcsb pdb:5JZ7|rcsb pdb:6YW8|reactome:R-HSA-167021|reactome:R-HSA-167044|interpro:IPR029034|reactome:R-HSA-167060|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-177504|reactome:R-HSA-187042|reactome:R-HSA-187706|reactome:R-HSA-193648|reactome:R-HSA-193670|reactome:R-HSA-193681|reactome:R-HSA-198203|reactome:R-HSA-198745|reactome:R-HSA-205017|reactome:R-HSA-205025|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-209563|refseq:XP_006710726.1|dip:DIP-5712N|mint:MINT-1326925(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2|kd:30 picomolar|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/03/10 2014/10/16 rogid:lT3HTfWJN1KbRETpE8RIBNCRtYM9606 rogid:qUmDPZg27gpyP0gOpOpUZJyV7mI9606 intact-crc:0F835844200C145E|rigid:Fs4ErPlkfrpKwJhX/j8FT018HXY false binding-associated region:41-1084(MINT-1326920) binding-associated region:19-121(MINT-1326926)|tag:?-?(MINT-1326929) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UPU3 uniprotkb:P01138 intact:EBI-7484437|uniprotkb:Q9NQJ2|intact:MINT-1326895|uniprotkb:Q5VXF9|ensembl:ENSP00000358715 intact:EBI-1028250|uniprotkb:Q6FHA0|uniprotkb:Q96P60|uniprotkb:Q9P2Q8|uniprotkb:Q9UKL8|uniprotkb:A1A4E5|ensembl:ENSP00000358525|ensembl:ENSP00000502380|ensembl:ENSP00000502831|ensembl:ENSP00000505694|ensembl:ENSP00000506492|ensembl:ENSP00000506569|ensembl:ENSP00000505558 psi-mi:sorc3_human(display_long)|uniprotkb:SORCS3(gene name)|psi-mi:SORCS3(display_short)|uniprotkb:KIAA1059(gene name synonym) psi-mi:ngf_human(display_long)|uniprotkb:NGF(gene name)|psi-mi:NGF(display_short)|uniprotkb:NGFB(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Westergaard et al. (2005) pubmed:15710408|imex:IM-14131|mint:MINT-5217534 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7484510|mint:MINT-56552|imex:IM-14131-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055793.1|ensembl:ENSG00000156395(gene)|ensembl:ENST00000369701(transcript)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1900452"(regulation of long-term synaptic depression)|interpro:IPR000601(PKD)|interpro:IPR006581(VPS10)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|interpro:IPR035986|mint:Q9UPU3|mint:MINT-1326956(identity) refseq:NP_002497.2|ensembl:ENSG00000134259(gene)|ensembl:ENST00000369512(transcript)|ensembl:ENST00000675637(transcript)|ensembl:ENST00000676038(transcript)|ensembl:ENST00000679806(transcript)|ensembl:ENST00000680116(transcript)|ensembl:ENST00000680540(transcript)|ensembl:ENST00000680752(transcript)|go:"GO:0005163"(nerve growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021675"(nerve development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031904"(endosome lumen)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038177"(death receptor agonist activity)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR002072(Nerve growth factor)|interpro:IPR019846|interpro:IPR020408|interpro:IPR020425|interpro:IPR020437|rcsb pdb:1SG1|rcsb pdb:1WWW|rcsb pdb:2IFG|rcsb pdb:4EDW|rcsb pdb:4EDX|rcsb pdb:4ZBN|rcsb pdb:5JZ7|rcsb pdb:6YW8|reactome:R-HSA-167021|reactome:R-HSA-167044|interpro:IPR029034|reactome:R-HSA-167060|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-177504|reactome:R-HSA-187042|reactome:R-HSA-187706|reactome:R-HSA-193648|reactome:R-HSA-193670|reactome:R-HSA-193681|reactome:R-HSA-198203|reactome:R-HSA-198745|reactome:R-HSA-205017|reactome:R-HSA-205025|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-209563|refseq:XP_006710726.1|dip:DIP-5712N|mint:MINT-1326962(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2|kd:40 picomolar|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/03/10 2014/10/16 rogid:lT3HTfWJN1KbRETpE8RIBNCRtYM9606 rogid:qUmDPZg27gpyP0gOpOpUZJyV7mI9606 intact-crc:59F834F19F59B601|rigid:Fs4ErPlkfrpKwJhX/j8FT018HXY false binding-associated region:41-1084(MINT-1326957) tag:?-?(MINT-1326965)|binding-associated region:122-241(MINT-1326963) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)