#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P97762 uniprotkb:Q99PT3 intact:EBI-626715|ensembl:ENSMUSP00000034763 intact:EBI-626705|uniprotkb:Q9CY38 psi-mi:rp9_mouse(display_long)|uniprotkb:Pim-1-associated protein(gene name synonym)|uniprotkb:rp9(gene name)|psi-mi:rp9(display_short)|uniprotkb:Rp9h(gene name synonym) psi-mi:in80b_mouse(display_long)|uniprotkb:PAP-1-associated protein 1(gene name synonym)|uniprotkb:High mobility group AT-hook 1-like 4(gene name synonym)|uniprotkb:Ino80b(gene name)|psi-mi:Ino80b(display_short)|uniprotkb:Hmga1l4(gene name synonym)|uniprotkb:Papa1(gene name synonym)|uniprotkb:Znhit4(gene name synonym)|uniprotkb:Zinc finger HIT domain-containing protein 4(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maita et al. (2005) pubmed:15652350 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-626720 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000032239(gene)|ensembl:ENSMUST00000034763(transcript)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0046872"(metal ion binding)|go:"GO:0050890"(cognition)|interpro:IPR034585|mint:P97762|refseq:NP_061209.1|dip:DIP-33838N go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0031011"(Ino80 complex)|go:"GO:0043044"|go:"GO:0046872"(metal ion binding)|reactome:R-MMU-5689603|reactome:R-MMU-5696394|refseq:NP_076036.1|interpro:IPR006880(PAPA-1-like conserved region)|interpro:IPR007529(Zinc finger, HIT-type)|interpro:IPR029523|mint:Q99PT3 - - - dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2005/07/28 2014/10/16 rogid:I9CnYyV2FQEEGU2W11Y69VZ916o10090 rogid:fvkAtxGZQooUS7vCDmKSM5VI5SE10090 intact-crc:B255CA5D1764ACEB|rigid:FBZX1muNSCHM60FhFDrRrBJL2pM false - - - - psi-mi:"MI:0056"(full identification by DNA sequencing) psi-mi:"MI:0056"(full identification by DNA sequencing) uniprotkb:P97762 uniprotkb:Q9DA19 intact:EBI-626715|ensembl:ENSMUSP00000034763 intact:EBI-309693|uniprotkb:Q3V2N9|uniprotkb:Q4KL44|uniprotkb:Q52KL9|uniprotkb:Q5FW66|ensembl:ENSMUSP00000049834 psi-mi:rp9_mouse(display_long)|uniprotkb:Pim-1-associated protein(gene name synonym)|uniprotkb:rp9(gene name)|psi-mi:rp9(display_short)|uniprotkb:Rp9h(gene name synonym) psi-mi:cir1_mouse(display_long)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Cir(gene name synonym)|uniprotkb:Cir1(gene name)|psi-mi:Cir1(display_short) psi-mi:"MI:0018"(two hybrid) Maita et al. (2005) pubmed:15652350 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-626724 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000032239(gene)|ensembl:ENSMUST00000034763(transcript)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0046872"(metal ion binding)|go:"GO:0050890"(cognition)|interpro:IPR034585|mint:P97762|refseq:NP_061209.1|dip:DIP-33838N refseq:NP_080130.2|ensembl:ENSMUSG00000041777(gene)|ensembl:ENSMUST00000058615(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006397"(mRNA processing)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR019339|interpro:IPR040014 - - - dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2005/07/28 2014/10/16 rogid:I9CnYyV2FQEEGU2W11Y69VZ916o10090 rogid:+MYCc/qumk3suZAE6KtyRHuaok010090 intact-crc:9E2D34EACEACF132|rigid:Qm5mW1q6vPZHFnZ4V+tY2ZfXDh0 false - - - - psi-mi:"MI:0056"(full identification by DNA sequencing) psi-mi:"MI:0056"(full identification by DNA sequencing) uniprotkb:P97762 uniprotkb:Q9DA19 intact:EBI-626715|ensembl:ENSMUSP00000034763 intact:EBI-309693|uniprotkb:Q3V2N9|uniprotkb:Q4KL44|uniprotkb:Q52KL9|uniprotkb:Q5FW66|ensembl:ENSMUSP00000049834 psi-mi:rp9_mouse(display_long)|uniprotkb:Pim-1-associated protein(gene name synonym)|uniprotkb:rp9(gene name)|psi-mi:rp9(display_short)|uniprotkb:Rp9h(gene name synonym) psi-mi:cir1_mouse(display_long)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Cir(gene name synonym)|uniprotkb:Cir1(gene name)|psi-mi:Cir1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maita et al. (2005) pubmed:15652350 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-626732 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000032239(gene)|ensembl:ENSMUST00000034763(transcript)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0046872"(metal ion binding)|go:"GO:0050890"(cognition)|interpro:IPR034585|mint:P97762|refseq:NP_061209.1|dip:DIP-33838N refseq:NP_080130.2|ensembl:ENSMUSG00000041777(gene)|ensembl:ENSMUST00000058615(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006397"(mRNA processing)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR019339|interpro:IPR040014 - - - dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2005/07/28 2014/10/16 rogid:I9CnYyV2FQEEGU2W11Y69VZ916o10090 rogid:+MYCc/qumk3suZAE6KtyRHuaok010090 intact-crc:2775BEB09BBD7EEB|rigid:Qm5mW1q6vPZHFnZ4V+tY2ZfXDh0 false t7 tag:?-? flag tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q9DA19 uniprotkb:P97762 intact:EBI-309693|uniprotkb:Q3V2N9|uniprotkb:Q4KL44|uniprotkb:Q52KL9|uniprotkb:Q5FW66|ensembl:ENSMUSP00000049834 intact:EBI-626715|ensembl:ENSMUSP00000034763 psi-mi:cir1_mouse(display_long)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Cir(gene name synonym)|uniprotkb:Cir1(gene name)|psi-mi:Cir1(display_short) psi-mi:rp9_mouse(display_long)|uniprotkb:Pim-1-associated protein(gene name synonym)|uniprotkb:rp9(gene name)|psi-mi:rp9(display_short)|uniprotkb:Rp9h(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maita et al. (2005) pubmed:15652350 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-626777 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_080130.2|ensembl:ENSMUSG00000041777(gene)|ensembl:ENSMUST00000058615(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006397"(mRNA processing)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR019339|interpro:IPR040014 ensembl:ENSMUSG00000032239(gene)|ensembl:ENSMUST00000034763(transcript)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0046872"(metal ion binding)|go:"GO:0050890"(cognition)|interpro:IPR034585|mint:P97762|refseq:NP_061209.1|dip:DIP-33838N - - - dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2005/07/28 2014/10/16 rogid:+MYCc/qumk3suZAE6KtyRHuaok010090 rogid:I9CnYyV2FQEEGU2W11Y69VZ916o10090 intact-crc:833C1809380E9592|rigid:Qm5mW1q6vPZHFnZ4V+tY2ZfXDh0 false - binding-associated region:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9DA19 uniprotkb:P97762 intact:EBI-309693|uniprotkb:Q3V2N9|uniprotkb:Q4KL44|uniprotkb:Q52KL9|uniprotkb:Q5FW66|ensembl:ENSMUSP00000049834 intact:EBI-626715|ensembl:ENSMUSP00000034763 psi-mi:cir1_mouse(display_long)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Cir(gene name synonym)|uniprotkb:Cir1(gene name)|psi-mi:Cir1(display_short) psi-mi:rp9_mouse(display_long)|uniprotkb:Pim-1-associated protein(gene name synonym)|uniprotkb:rp9(gene name)|psi-mi:rp9(display_short)|uniprotkb:Rp9h(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maita et al. (2005) pubmed:15652350 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-626797 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_080130.2|ensembl:ENSMUSG00000041777(gene)|ensembl:ENSMUST00000058615(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006397"(mRNA processing)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR019339|interpro:IPR040014 ensembl:ENSMUSG00000032239(gene)|ensembl:ENSMUST00000034763(transcript)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0046872"(metal ion binding)|go:"GO:0050890"(cognition)|interpro:IPR034585|mint:P97762|refseq:NP_061209.1|dip:DIP-33838N - - - dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2005/07/28 2014/10/16 rogid:+MYCc/qumk3suZAE6KtyRHuaok010090 rogid:I9CnYyV2FQEEGU2W11Y69VZ916o10090 intact-crc:37E1748E5EA44269|rigid:Qm5mW1q6vPZHFnZ4V+tY2ZfXDh0 false binding-associated region:204-232 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9DA19 uniprotkb:P97762 intact:EBI-309693|uniprotkb:Q3V2N9|uniprotkb:Q4KL44|uniprotkb:Q52KL9|uniprotkb:Q5FW66|ensembl:ENSMUSP00000049834 intact:EBI-626715|ensembl:ENSMUSP00000034763 psi-mi:cir1_mouse(display_long)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Cir(gene name synonym)|uniprotkb:Cir1(gene name)|psi-mi:Cir1(display_short) psi-mi:rp9_mouse(display_long)|uniprotkb:Pim-1-associated protein(gene name synonym)|uniprotkb:rp9(gene name)|psi-mi:rp9(display_short)|uniprotkb:Rp9h(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maita et al. (2005) pubmed:15652350 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-626821 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_080130.2|ensembl:ENSMUSG00000041777(gene)|ensembl:ENSMUST00000058615(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006397"(mRNA processing)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR019339|interpro:IPR040014 ensembl:ENSMUSG00000032239(gene)|ensembl:ENSMUST00000034763(transcript)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0046872"(metal ion binding)|go:"GO:0050890"(cognition)|interpro:IPR034585|mint:P97762|refseq:NP_061209.1|dip:DIP-33838N - - - comment:"Only wild-type CIR (Q9DA19) and not deletion AA203-232 CIR was co-immunoprecipitated with FLAG-PAP-1."|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2005/07/28 2014/10/16 rogid:+MYCc/qumk3suZAE6KtyRHuaok010090 rogid:I9CnYyV2FQEEGU2W11Y69VZ916o10090 intact-crc:B77F1D559933D5E8|rigid:Qm5mW1q6vPZHFnZ4V+tY2ZfXDh0 false t7 tag:?-? flag tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q9DA19 uniprotkb:P97762 intact:EBI-309693|uniprotkb:Q3V2N9|uniprotkb:Q4KL44|uniprotkb:Q52KL9|uniprotkb:Q5FW66|ensembl:ENSMUSP00000049834 intact:EBI-626715|ensembl:ENSMUSP00000034763 psi-mi:cir1_mouse(display_long)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Cir(gene name synonym)|uniprotkb:Cir1(gene name)|psi-mi:Cir1(display_short) psi-mi:rp9_mouse(display_long)|uniprotkb:Pim-1-associated protein(gene name synonym)|uniprotkb:rp9(gene name)|psi-mi:rp9(display_short)|uniprotkb:Rp9h(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Maita et al. (2005) pubmed:15652350 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-626897 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_080130.2|ensembl:ENSMUSG00000041777(gene)|ensembl:ENSMUST00000058615(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006397"(mRNA processing)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR019339|interpro:IPR040014 ensembl:ENSMUSG00000032239(gene)|ensembl:ENSMUST00000034763(transcript)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0046872"(metal ion binding)|go:"GO:0050890"(cognition)|interpro:IPR034585|mint:P97762|refseq:NP_061209.1|dip:DIP-33838N go:"GO:0005634"(nucleus) - - dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2005/07/28 2014/10/16 rogid:+MYCc/qumk3suZAE6KtyRHuaok010090 rogid:I9CnYyV2FQEEGU2W11Y69VZ916o10090 intact-crc:DD148F03E9E463CB|rigid:Qm5mW1q6vPZHFnZ4V+tY2ZfXDh0 false green fluorescent protein tag:?-? flag tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q86X95 uniprotkb:Q01130 intact:EBI-627102|ensembl:ENSP00000339723|uniprotkb:A6NFI6|uniprotkb:A8K8M4|uniprotkb:O95367|uniprotkb:Q12804|uniprotkb:Q4G1B9|uniprotkb:Q6PJI4|uniprotkb:Q8IWI2 intact:EBI-627047|uniprotkb:B3KWD5|ensembl:ENSP00000353089|ensembl:ENSP00000376276|ensembl:ENSP00000391278|ensembl:ENSP00000462425|uniprotkb:B4DN89|uniprotkb:H0YG49 psi-mi:cir1_human(display_long)|uniprotkb:CIR(gene name synonym)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Recepin(gene name synonym)|uniprotkb:CIR1(gene name)|psi-mi:CIR1(display_short) psi-mi:srsf2_human(display_long)|uniprotkb:Splicing factor SC35(gene name synonym)|uniprotkb:Splicing component, 35 kDa(gene name synonym)|uniprotkb:Protein PR264(gene name synonym)|uniprotkb:SRSF2(gene name)|psi-mi:SRSF2(display_short)|uniprotkb:SFRS2(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 2(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Maita et al. (2005) pubmed:15652350 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-627056 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000138433(gene)|ensembl:ENST00000342016(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR019339|interpro:IPR040014|mint:Q86X95|rcsb pdb:6ZYM|refseq:NP_004873.3 ensembl:ENSG00000161547(gene)|ensembl:ENST00000359995(transcript)|ensembl:ENST00000392485(transcript)|ensembl:ENST00000452355(transcript)|ensembl:ENST00000585202(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033197"(response to vitamin E)|go:"GO:0035061"(interchromatin granule)|go:"GO:0036002"(pre-mRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034893|interpro:IPR035979|mint:Q01130|rcsb pdb:2KN4|rcsb pdb:2LEA|rcsb pdb:2LEB|rcsb pdb:2LEC|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|go:"GO:0003723"(RNA binding)|refseq:NP_001182356.1|refseq:NP_003007.2|refseq:XP_016880431.1|dip:DIP-33836N go:"GO:0005634"(nucleus) - - dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2005/07/28 2014/10/16 rogid:DMnBG746eQpvLsf9D+lgeUKnni09606 rogid:/LUrJ8xa42APUsgH5ke590Kxsh89606 intact-crc:C8EDD849A5BE4F99|rigid:JAgE1Yek2+rBHjk+MimHdjIgeQQ false green fluorescent protein tag:?-? - - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0707"(anti tag immunostaining) uniprotkb:Q8TA86 uniprotkb:Q07955 intact:EBI-630339|ensembl:ENSP00000297157 intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962 psi-mi:rp9_human(display_long)|uniprotkb:Pim-1-associated protein(gene name synonym)|uniprotkb:RP9(gene name)|psi-mi:RP9(display_short) psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Maita et al. (2005) pubmed:15652350 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-630350 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_976033.1|ensembl:ENSG00000164610(gene)|ensembl:ENST00000297157(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0008380"(RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:0050890"(cognition)|interpro:IPR034585 refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A go:"GO:0005785"(signal recognition particle receptor complex) - - comment:It was determined from a previous experiment that Q8TA86 does not directly bind Q07955, however the results from this experiment indicate that PAP-1 is involved in the SR protein complex and that PAP-1 might directly associate wtih CIR or U2AF35|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2005/07/28 2014/10/16 rogid:aLu5MPtPUaFvJYBLKJ+ObI4c0OQ9606 rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606 intact-crc:FD7EB49B7C48D94A|rigid:w+7EYuMPdRcGRJOF7Zhdnsg/ja4 false green fluorescent protein tag:?-? ha tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q01130 uniprotkb:Q86X95 intact:EBI-627047|uniprotkb:B3KWD5|ensembl:ENSP00000353089|ensembl:ENSP00000376276|ensembl:ENSP00000391278|ensembl:ENSP00000462425|uniprotkb:B4DN89|uniprotkb:H0YG49 intact:EBI-627102|ensembl:ENSP00000339723|uniprotkb:A6NFI6|uniprotkb:A8K8M4|uniprotkb:O95367|uniprotkb:Q12804|uniprotkb:Q4G1B9|uniprotkb:Q6PJI4|uniprotkb:Q8IWI2 psi-mi:srsf2_human(display_long)|uniprotkb:Splicing factor SC35(gene name synonym)|uniprotkb:Splicing component, 35 kDa(gene name synonym)|uniprotkb:Protein PR264(gene name synonym)|uniprotkb:SRSF2(gene name)|psi-mi:SRSF2(display_short)|uniprotkb:SFRS2(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 2(gene name synonym) psi-mi:cir1_human(display_long)|uniprotkb:CIR(gene name synonym)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Recepin(gene name synonym)|uniprotkb:CIR1(gene name)|psi-mi:CIR1(display_short) psi-mi:"MI:0018"(two hybrid) Maita et al. (2005) pubmed:15652350 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-630737 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000161547(gene)|ensembl:ENST00000359995(transcript)|ensembl:ENST00000392485(transcript)|ensembl:ENST00000452355(transcript)|ensembl:ENST00000585202(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033197"(response to vitamin E)|go:"GO:0035061"(interchromatin granule)|go:"GO:0036002"(pre-mRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034893|interpro:IPR035979|mint:Q01130|rcsb pdb:2KN4|rcsb pdb:2LEA|rcsb pdb:2LEB|rcsb pdb:2LEC|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|go:"GO:0003723"(RNA binding)|refseq:NP_001182356.1|refseq:NP_003007.2|refseq:XP_016880431.1|dip:DIP-33836N ensembl:ENSG00000138433(gene)|ensembl:ENST00000342016(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR019339|interpro:IPR040014|mint:Q86X95|rcsb pdb:6ZYM|refseq:NP_004873.3 - - - comment:region 234-297AA of CIR was found to be unimportant for this interaction.|comment:Results from the maita-2005-10 experiment suggest that interaction of CIR with sfrs2 and sfr1 requires some modifications in the RS domain of CIR or is mediated via other factors that bridge CIR to SR proteins.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2005/07/28 2014/10/16 rogid:/LUrJ8xa42APUsgH5ke590Kxsh89606 rogid:DMnBG746eQpvLsf9D+lgeUKnni09606 intact-crc:89E00766A74E2510|rigid:JAgE1Yek2+rBHjk+MimHdjIgeQQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q01081 uniprotkb:Q86X95 intact:EBI-632461|intact:EBI-14082807|ensembl:ENSP00000291552|intact:EBI-1053464|uniprotkb:Q701P4|uniprotkb:Q71RF1 intact:EBI-627102|ensembl:ENSP00000339723|uniprotkb:A6NFI6|uniprotkb:A8K8M4|uniprotkb:O95367|uniprotkb:Q12804|uniprotkb:Q4G1B9|uniprotkb:Q6PJI4|uniprotkb:Q8IWI2 psi-mi:u2af1_human(display_long)|uniprotkb:U2 auxiliary factor 35 kDa subunit(gene name synonym)|uniprotkb:U2 snRNP auxiliary factor small subunit(gene name synonym)|uniprotkb:U2AF1(gene name)|psi-mi:U2AF1(display_short)|uniprotkb:U2AF35(gene name synonym)|uniprotkb:U2AFBP(gene name synonym)|uniprotkb:U2 small nuclear RNA auxiliary factor 1(gene name synonym)|uniprotkb:FP793(orf name) psi-mi:cir1_human(display_long)|uniprotkb:CIR(gene name synonym)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Recepin(gene name synonym)|uniprotkb:CIR1(gene name)|psi-mi:CIR1(display_short) psi-mi:"MI:0018"(two hybrid) Maita et al. (2005) pubmed:15652350 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-632474 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001307575.1|refseq:NP_006749.1|refseq:NP_001307577.1|ensembl:ENSG00000160201(gene)|ensembl:ENST00000291552(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0089701"(U2AF complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR009145(U2 auxiliary factor small subunit)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:Q01081|rcsb pdb:1JMT|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|refseq:NP_001307580.1|refseq:NP_001020374.1|refseq:NP_001020375.1|dip:DIP-1108N ensembl:ENSG00000138433(gene)|ensembl:ENST00000342016(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR019339|interpro:IPR040014|mint:Q86X95|rcsb pdb:6ZYM|refseq:NP_004873.3 - - - dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2005/07/28 2014/10/16 rogid:n7tE+B4qBNnI/hiwspeQKrviXv89606 rogid:DMnBG746eQpvLsf9D+lgeUKnni09606 intact-crc:4A793F11086BF5B6|rigid:7Qkw3awPRlJtDZ91hwircNlLZ3M false binding-associated region:?-? - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86X95 uniprotkb:Q07955 intact:EBI-627102|ensembl:ENSP00000339723|uniprotkb:A6NFI6|uniprotkb:A8K8M4|uniprotkb:O95367|uniprotkb:Q12804|uniprotkb:Q4G1B9|uniprotkb:Q6PJI4|uniprotkb:Q8IWI2 intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962 psi-mi:cir1_human(display_long)|uniprotkb:CIR(gene name synonym)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Recepin(gene name synonym)|uniprotkb:CIR1(gene name)|psi-mi:CIR1(display_short) psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maita et al. (2005) pubmed:15652350 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-632478 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000138433(gene)|ensembl:ENST00000342016(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR019339|interpro:IPR040014|mint:Q86X95|rcsb pdb:6ZYM|refseq:NP_004873.3 refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A - - - comment:region 234-297AA of CIR was found to be unimportant for this interaction.|comment:Results from the maita-2005-10 experiment suggest that interaction of CIR with sfrs2 and sfr1 requires some modifications in the RS domain of CIR or is mediated via other factors that bridge CIR to SR proteins.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2005/07/28 2014/10/16 rogid:DMnBG746eQpvLsf9D+lgeUKnni09606 rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606 intact-crc:58CABD71B3ECE4F1|rigid:YjMMord/abGS2Km+KDFn4yd2ba8 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86X95 uniprotkb:Q01081 intact:EBI-627102|ensembl:ENSP00000339723|uniprotkb:A6NFI6|uniprotkb:A8K8M4|uniprotkb:O95367|uniprotkb:Q12804|uniprotkb:Q4G1B9|uniprotkb:Q6PJI4|uniprotkb:Q8IWI2 intact:EBI-632461|intact:EBI-14082807|ensembl:ENSP00000291552|intact:EBI-1053464|uniprotkb:Q701P4|uniprotkb:Q71RF1 psi-mi:cir1_human(display_long)|uniprotkb:CIR(gene name synonym)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Recepin(gene name synonym)|uniprotkb:CIR1(gene name)|psi-mi:CIR1(display_short) psi-mi:u2af1_human(display_long)|uniprotkb:U2 auxiliary factor 35 kDa subunit(gene name synonym)|uniprotkb:U2 snRNP auxiliary factor small subunit(gene name synonym)|uniprotkb:U2AF1(gene name)|psi-mi:U2AF1(display_short)|uniprotkb:U2AF35(gene name synonym)|uniprotkb:U2AFBP(gene name synonym)|uniprotkb:U2 small nuclear RNA auxiliary factor 1(gene name synonym)|uniprotkb:FP793(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maita et al. (2005) pubmed:15652350 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-632490 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000138433(gene)|ensembl:ENST00000342016(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR019339|interpro:IPR040014|mint:Q86X95|rcsb pdb:6ZYM|refseq:NP_004873.3 refseq:NP_001307575.1|refseq:NP_006749.1|refseq:NP_001307577.1|ensembl:ENSG00000160201(gene)|ensembl:ENST00000291552(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0089701"(U2AF complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR009145(U2 auxiliary factor small subunit)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:Q01081|rcsb pdb:1JMT|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|refseq:NP_001307580.1|refseq:NP_001020374.1|refseq:NP_001020375.1|dip:DIP-1108N - - - dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2005/07/28 2014/10/16 rogid:DMnBG746eQpvLsf9D+lgeUKnni09606 rogid:n7tE+B4qBNnI/hiwspeQKrviXv89606 intact-crc:78C766741A22ADA1|rigid:7Qkw3awPRlJtDZ91hwircNlLZ3M false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q86X95 uniprotkb:Q01130 intact:EBI-627102|ensembl:ENSP00000339723|uniprotkb:A6NFI6|uniprotkb:A8K8M4|uniprotkb:O95367|uniprotkb:Q12804|uniprotkb:Q4G1B9|uniprotkb:Q6PJI4|uniprotkb:Q8IWI2 intact:EBI-627047|uniprotkb:B3KWD5|ensembl:ENSP00000353089|ensembl:ENSP00000376276|ensembl:ENSP00000391278|ensembl:ENSP00000462425|uniprotkb:B4DN89|uniprotkb:H0YG49 psi-mi:cir1_human(display_long)|uniprotkb:CIR(gene name synonym)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Recepin(gene name synonym)|uniprotkb:CIR1(gene name)|psi-mi:CIR1(display_short) psi-mi:srsf2_human(display_long)|uniprotkb:Splicing factor SC35(gene name synonym)|uniprotkb:Splicing component, 35 kDa(gene name synonym)|uniprotkb:Protein PR264(gene name synonym)|uniprotkb:SRSF2(gene name)|psi-mi:SRSF2(display_short)|uniprotkb:SFRS2(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maita et al. (2005) pubmed:15652350 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-632497 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000138433(gene)|ensembl:ENST00000342016(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR019339|interpro:IPR040014|mint:Q86X95|rcsb pdb:6ZYM|refseq:NP_004873.3 ensembl:ENSG00000161547(gene)|ensembl:ENST00000359995(transcript)|ensembl:ENST00000392485(transcript)|ensembl:ENST00000452355(transcript)|ensembl:ENST00000585202(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033197"(response to vitamin E)|go:"GO:0035061"(interchromatin granule)|go:"GO:0036002"(pre-mRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034893|interpro:IPR035979|mint:Q01130|rcsb pdb:2KN4|rcsb pdb:2LEA|rcsb pdb:2LEB|rcsb pdb:2LEC|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|go:"GO:0003723"(RNA binding)|refseq:NP_001182356.1|refseq:NP_003007.2|refseq:XP_016880431.1|dip:DIP-33836N - - - comment:Results from the maita-2005-10 experiment suggest that interaction of CIR with sfrs2 and sfr1 requires some modifications in the RS domain of CIR or is mediated via other factors that bridge CIR to SR proteins.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2005/07/28 2014/10/16 rogid:DMnBG746eQpvLsf9D+lgeUKnni09606 rogid:/LUrJ8xa42APUsgH5ke590Kxsh89606 intact-crc:29112ED73FB0776A|rigid:JAgE1Yek2+rBHjk+MimHdjIgeQQ false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q86X95 uniprotkb:Q07955 intact:EBI-627102|ensembl:ENSP00000339723|uniprotkb:A6NFI6|uniprotkb:A8K8M4|uniprotkb:O95367|uniprotkb:Q12804|uniprotkb:Q4G1B9|uniprotkb:Q6PJI4|uniprotkb:Q8IWI2 intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962 psi-mi:cir1_human(display_long)|uniprotkb:CIR(gene name synonym)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Recepin(gene name synonym)|uniprotkb:CIR1(gene name)|psi-mi:CIR1(display_short) psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maita et al. (2005) pubmed:15652350 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-632504 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000138433(gene)|ensembl:ENST00000342016(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR019339|interpro:IPR040014|mint:Q86X95|rcsb pdb:6ZYM|refseq:NP_004873.3 refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A - - - comment:Results from the maita-2005-10 experiment suggest that interaction of CIR with sfrs2 and sfr1 requires some modifications in the RS domain of CIR or is mediated via other factors that bridge CIR to SR proteins.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2005/07/28 2014/10/16 rogid:DMnBG746eQpvLsf9D+lgeUKnni09606 rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606 intact-crc:82CA26824BEA4384|rigid:YjMMord/abGS2Km+KDFn4yd2ba8 false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q01130 uniprotkb:Q86X95 intact:EBI-627047|uniprotkb:B3KWD5|ensembl:ENSP00000353089|ensembl:ENSP00000376276|ensembl:ENSP00000391278|ensembl:ENSP00000462425|uniprotkb:B4DN89|uniprotkb:H0YG49 intact:EBI-627102|ensembl:ENSP00000339723|uniprotkb:A6NFI6|uniprotkb:A8K8M4|uniprotkb:O95367|uniprotkb:Q12804|uniprotkb:Q4G1B9|uniprotkb:Q6PJI4|uniprotkb:Q8IWI2 psi-mi:srsf2_human(display_long)|uniprotkb:Splicing factor SC35(gene name synonym)|uniprotkb:Splicing component, 35 kDa(gene name synonym)|uniprotkb:Protein PR264(gene name synonym)|uniprotkb:SRSF2(gene name)|psi-mi:SRSF2(display_short)|uniprotkb:SFRS2(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 2(gene name synonym) psi-mi:cir1_human(display_long)|uniprotkb:CIR(gene name synonym)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Recepin(gene name synonym)|uniprotkb:CIR1(gene name)|psi-mi:CIR1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maita et al. (2005) pubmed:15652350 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-632512 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000161547(gene)|ensembl:ENST00000359995(transcript)|ensembl:ENST00000392485(transcript)|ensembl:ENST00000452355(transcript)|ensembl:ENST00000585202(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033197"(response to vitamin E)|go:"GO:0035061"(interchromatin granule)|go:"GO:0036002"(pre-mRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034893|interpro:IPR035979|mint:Q01130|rcsb pdb:2KN4|rcsb pdb:2LEA|rcsb pdb:2LEB|rcsb pdb:2LEC|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|go:"GO:0003723"(RNA binding)|refseq:NP_001182356.1|refseq:NP_003007.2|refseq:XP_016880431.1|dip:DIP-33836N ensembl:ENSG00000138433(gene)|ensembl:ENST00000342016(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR019339|interpro:IPR040014|mint:Q86X95|rcsb pdb:6ZYM|refseq:NP_004873.3 - - - comment:Results from the maita-2005-10 experiment suggest that interaction of CIR with sfrs2 and sfr1 requires some modifications in the RS domain of CIR or is mediated via other factors that bridge CIR to SR proteins.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2005/07/28 2014/10/16 rogid:/LUrJ8xa42APUsgH5ke590Kxsh89606 rogid:DMnBG746eQpvLsf9D+lgeUKnni09606 intact-crc:F345ECE252D5640B|rigid:JAgE1Yek2+rBHjk+MimHdjIgeQQ false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q86X95 uniprotkb:Q01081 intact:EBI-627102|ensembl:ENSP00000339723|uniprotkb:A6NFI6|uniprotkb:A8K8M4|uniprotkb:O95367|uniprotkb:Q12804|uniprotkb:Q4G1B9|uniprotkb:Q6PJI4|uniprotkb:Q8IWI2 intact:EBI-632461|intact:EBI-14082807|ensembl:ENSP00000291552|intact:EBI-1053464|uniprotkb:Q701P4|uniprotkb:Q71RF1 psi-mi:cir1_human(display_long)|uniprotkb:CIR(gene name synonym)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Recepin(gene name synonym)|uniprotkb:CIR1(gene name)|psi-mi:CIR1(display_short) psi-mi:u2af1_human(display_long)|uniprotkb:U2 auxiliary factor 35 kDa subunit(gene name synonym)|uniprotkb:U2 snRNP auxiliary factor small subunit(gene name synonym)|uniprotkb:U2AF1(gene name)|psi-mi:U2AF1(display_short)|uniprotkb:U2AF35(gene name synonym)|uniprotkb:U2AFBP(gene name synonym)|uniprotkb:U2 small nuclear RNA auxiliary factor 1(gene name synonym)|uniprotkb:FP793(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maita et al. (2005) pubmed:15652350 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-632519 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000138433(gene)|ensembl:ENST00000342016(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR019339|interpro:IPR040014|mint:Q86X95|rcsb pdb:6ZYM|refseq:NP_004873.3 refseq:NP_001307575.1|refseq:NP_006749.1|refseq:NP_001307577.1|ensembl:ENSG00000160201(gene)|ensembl:ENST00000291552(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0089701"(U2AF complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR009145(U2 auxiliary factor small subunit)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:Q01081|rcsb pdb:1JMT|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|refseq:NP_001307580.1|refseq:NP_001020374.1|refseq:NP_001020375.1|dip:DIP-1108N - - - dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2005/07/28 2014/10/16 rogid:DMnBG746eQpvLsf9D+lgeUKnni09606 rogid:n7tE+B4qBNnI/hiwspeQKrviXv89606 intact-crc:B376D90D6C7EE7BC|rigid:7Qkw3awPRlJtDZ91hwircNlLZ3M false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q86X95 uniprotkb:Q07955 intact:EBI-627102|ensembl:ENSP00000339723|uniprotkb:A6NFI6|uniprotkb:A8K8M4|uniprotkb:O95367|uniprotkb:Q12804|uniprotkb:Q4G1B9|uniprotkb:Q6PJI4|uniprotkb:Q8IWI2 intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962 psi-mi:cir1_human(display_long)|uniprotkb:CIR(gene name synonym)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Recepin(gene name synonym)|uniprotkb:CIR1(gene name)|psi-mi:CIR1(display_short) psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maita et al. (2005) pubmed:15652350 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-632543 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000138433(gene)|ensembl:ENST00000342016(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR019339|interpro:IPR040014|mint:Q86X95|rcsb pdb:6ZYM|refseq:NP_004873.3 refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A - - - comment:Results from the maita-2005-10 experiment suggest that interaction of CIR with sfrs2 and sfr1 requires some modifications in the RS domain of CIR or is mediated via other factors that bridge CIR to SR proteins.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2005/07/28 2014/10/16 rogid:DMnBG746eQpvLsf9D+lgeUKnni09606 rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606 intact-crc:589EE4B7268F50E5|rigid:YjMMord/abGS2Km+KDFn4yd2ba8 false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q01081 uniprotkb:Q86X95 intact:EBI-632461|intact:EBI-14082807|ensembl:ENSP00000291552|intact:EBI-1053464|uniprotkb:Q701P4|uniprotkb:Q71RF1 intact:EBI-627102|ensembl:ENSP00000339723|uniprotkb:A6NFI6|uniprotkb:A8K8M4|uniprotkb:O95367|uniprotkb:Q12804|uniprotkb:Q4G1B9|uniprotkb:Q6PJI4|uniprotkb:Q8IWI2 psi-mi:u2af1_human(display_long)|uniprotkb:U2 auxiliary factor 35 kDa subunit(gene name synonym)|uniprotkb:U2 snRNP auxiliary factor small subunit(gene name synonym)|uniprotkb:U2AF1(gene name)|psi-mi:U2AF1(display_short)|uniprotkb:U2AF35(gene name synonym)|uniprotkb:U2AFBP(gene name synonym)|uniprotkb:U2 small nuclear RNA auxiliary factor 1(gene name synonym)|uniprotkb:FP793(orf name) psi-mi:cir1_human(display_long)|uniprotkb:CIR(gene name synonym)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Recepin(gene name synonym)|uniprotkb:CIR1(gene name)|psi-mi:CIR1(display_short) psi-mi:"MI:0096"(pull down) Maita et al. (2005) pubmed:15652350 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-632530 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001307575.1|refseq:NP_006749.1|refseq:NP_001307577.1|ensembl:ENSG00000160201(gene)|ensembl:ENST00000291552(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0089701"(U2AF complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR009145(U2 auxiliary factor small subunit)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:Q01081|rcsb pdb:1JMT|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|refseq:NP_001307580.1|refseq:NP_001020374.1|refseq:NP_001020375.1|dip:DIP-1108N ensembl:ENSG00000138433(gene)|ensembl:ENST00000342016(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR019339|interpro:IPR040014|mint:Q86X95|rcsb pdb:6ZYM|refseq:NP_004873.3 - - - dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/07/28 2014/10/16 rogid:n7tE+B4qBNnI/hiwspeQKrviXv89606 rogid:DMnBG746eQpvLsf9D+lgeUKnni09606 intact-crc:309AB105E29B3429|rigid:7Qkw3awPRlJtDZ91hwircNlLZ3M false 35s radiolabel:?-? glutathione s tranferase tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)