#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P12544	uniprotkb:P12544	intact:EBI-519800|uniprotkb:Q6IB36|ensembl:ENSP00000274306|uniprotkb:A4PHN1	intact:EBI-519800|uniprotkb:Q6IB36|ensembl:ENSP00000274306|uniprotkb:A4PHN1	psi-mi:graa_human(display_long)|uniprotkb:Granzyme-1(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte proteinase 1(gene name synonym)|uniprotkb:Hanukkah factor(gene name synonym)|uniprotkb:CTL tryptase(gene name synonym)|uniprotkb:Fragmentin-1(gene name synonym)|uniprotkb:GZMA(gene name)|psi-mi:GZMA(display_short)|uniprotkb:CTLA3(gene name synonym)|uniprotkb:HFSP(gene name synonym)	psi-mi:graa_human(display_long)|uniprotkb:Granzyme-1(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte proteinase 1(gene name synonym)|uniprotkb:Hanukkah factor(gene name synonym)|uniprotkb:CTL tryptase(gene name synonym)|uniprotkb:Fragmentin-1(gene name synonym)|uniprotkb:GZMA(gene name)|psi-mi:GZMA(display_short)|uniprotkb:CTLA3(gene name synonym)|uniprotkb:HFSP(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Hink-Schauer et al. (2003)	pubmed:12819770	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0195"(covalent binding)	psi-mi:"MI:0469"(IntAct)	intact:EBI-519830|rcsb pdb:1op8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006135.1|ensembl:ENSG00000145649(gene)|ensembl:ENST00000274306(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0009617"(response to bacterium)|go:"GO:0019835"(cytolysis)|go:"GO:0032078"(negative regulation of endodeoxyribonuclease activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070269"(pyroptosis)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1902483"(cytotoxic T cell pyroptotic process)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1HF1|rcsb pdb:1OP8|rcsb pdb:1ORF	refseq:NP_006135.1|ensembl:ENSG00000145649(gene)|ensembl:ENST00000274306(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0009617"(response to bacterium)|go:"GO:0019835"(cytolysis)|go:"GO:0032078"(negative regulation of endodeoxyribonuclease activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070269"(pyroptosis)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1902483"(cytotoxic T cell pyroptotic process)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1HF1|rcsb pdb:1OP8|rcsb pdb:1ORF	-	-	-	3d-structure:A disulfide bond between the two cys93 links the two dimers. An intramolecular disulfide bond links Cys179 and Cys197 in each monomer.|3d-resolution:2.50|3d-r-factors:working 21.8%, free 28.4%|complex-properties:|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/03/17	2014/10/16	rogid:8ftirjCyo9Y60L7sWDoQmXIa+M49606	rogid:8ftirjCyo9Y60L7sWDoQmXIa+M49606	intact-crc:D3B6CA52205E0EC2|rigid:VZQY4G2X0xqQGOE7s2HvY9jOVso	false	binding-associated region:105-105|binding-associated region:29-262(IPR001314)|binding-associated region:180-180|binding-associated region:198-198	binding-associated region:105-105|binding-associated region:29-262(IPR001314)|binding-associated region:198-198|binding-associated region:180-180	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)