#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O70263	uniprotkb:P97792	intact:EBI-7650391|ensembl:ENSMUSP00000084405|ensembl:ENSMUSP00000113035|intact:MINT-253029|uniprotkb:O70264|uniprotkb:Q8BRI8|uniprotkb:Q8CFR3	intact:EBI-7429264|uniprotkb:Q91W66|uniprotkb:O09052|uniprotkb:Q3ULD0|uniprotkb:Q9DBJ8|intact:MINT-253068|uniprotkb:Q99KG0|ensembl:ENSMUSP00000023572	psi-mi:lnx1_mouse(display_long)|uniprotkb:Lnx1(gene name)|psi-mi:Lnx1(display_short)|uniprotkb:Lnx(gene name synonym)|uniprotkb:Ligand of Numb-binding protein 1(gene name synonym)|uniprotkb:Numb-binding protein 1(gene name synonym)|uniprotkb:Ligand of Numb protein X 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase LNX(gene name synonym)	psi-mi:cxar_mouse(display_long)|uniprotkb:Cxadr(gene name)|psi-mi:Cxadr(display_short)|uniprotkb:Car(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sollerbrant et al. (2003)	mint:MINT-5215971|pubmed:12468544	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8570015|mint:MINT-58724	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000029228(gene)|ensembl:ENSMUST00000087161(transcript)|ensembl:ENSMUST00000117388(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:O70263|rcsb pdb:3VQF|rcsb pdb:3VQG|reactome:R-MMU-983168|refseq:NP_001153050.1|refseq:NP_001153051.1|refseq:NP_034857.3|refseq:NP_001153052.1|refseq:NP_001153049.1|refseq:XP_006504317.1|mint:MINT-724936(identity)	refseq:NP_034118.1|refseq:NP_001263192.1|refseq:NP_001020363.1|refseq:XP_006522946.1|refseq:XP_006522947.1|ensembl:ENSMUSG00000022865(gene)|ensembl:ENSMUST00000023572(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0014704"(intercalated disc)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0070633"(transepithelial transport)|go:"GO:0071253"(connexin binding)|go:"GO:0086067"(AV node cell to bundle of His cell communication)|go:"GO:0086072"(AV node cell-bundle of His cell adhesion involved in cell communication)|go:"GO:0086082"(cell adhesive protein binding involved in AV node cell-bundle of His cell communication)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098904"(regulation of AV node cell action potential)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P97792|rcsb pdb:3JZ7|rcsb pdb:3MJ7|reactome:R-MMU-198933|reactome:R-MMU-202733|dip:DIP-41457N|mint:MINT-724946(identity)	-	function:Isoform 2 provides an endocytic scaffold for IGSF5/JAM4|function:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:"Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN"|function:"In vitro, acts as a receptor for group B coxsackieviruses and subgroup C of adenoviruses (AD2 and AD5)"|comment:"Stoichiometry: 1.0"	figure legend:F1 F2|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/06/20	2014/10/16	rogid:shmkiB+D/B2GzRLu117bgR7QopI10090	rogid:lIHRFvNBvpqsVCKArm+2uREslvo10090	intact-crc:70C152A00E194450|rigid:vLEQc3UGqHKBcsGG4ORRf/pq/CM	false	binding-associated region:385-467(MINT-724937)|tag:?-?(MINT-724941)	tag:?-?(MINT-724950)|binding-associated region:345-365(MINT-724947)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O70263	uniprotkb:P97792	intact:EBI-7650391|ensembl:ENSMUSP00000084405|ensembl:ENSMUSP00000113035|intact:MINT-253029|uniprotkb:O70264|uniprotkb:Q8BRI8|uniprotkb:Q8CFR3	intact:EBI-7429264|uniprotkb:Q91W66|uniprotkb:O09052|uniprotkb:Q3ULD0|uniprotkb:Q9DBJ8|intact:MINT-253068|uniprotkb:Q99KG0|ensembl:ENSMUSP00000023572	psi-mi:lnx1_mouse(display_long)|uniprotkb:Lnx1(gene name)|psi-mi:Lnx1(display_short)|uniprotkb:Lnx(gene name synonym)|uniprotkb:Ligand of Numb-binding protein 1(gene name synonym)|uniprotkb:Numb-binding protein 1(gene name synonym)|uniprotkb:Ligand of Numb protein X 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase LNX(gene name synonym)	psi-mi:cxar_mouse(display_long)|uniprotkb:Cxadr(gene name)|psi-mi:Cxadr(display_short)|uniprotkb:Car(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sollerbrant et al. (2003)	mint:MINT-5215971|pubmed:12468544	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8570045|mint:MINT-58725	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000029228(gene)|ensembl:ENSMUST00000087161(transcript)|ensembl:ENSMUST00000117388(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:O70263|rcsb pdb:3VQF|rcsb pdb:3VQG|reactome:R-MMU-983168|refseq:NP_001153050.1|refseq:NP_001153051.1|refseq:NP_034857.3|refseq:NP_001153052.1|refseq:NP_001153049.1|refseq:XP_006504317.1|mint:MINT-724888(identity)	refseq:NP_034118.1|refseq:NP_001263192.1|refseq:NP_001020363.1|refseq:XP_006522946.1|refseq:XP_006522947.1|ensembl:ENSMUSG00000022865(gene)|ensembl:ENSMUST00000023572(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0014704"(intercalated disc)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0070633"(transepithelial transport)|go:"GO:0071253"(connexin binding)|go:"GO:0086067"(AV node cell to bundle of His cell communication)|go:"GO:0086072"(AV node cell-bundle of His cell adhesion involved in cell communication)|go:"GO:0086082"(cell adhesive protein binding involved in AV node cell-bundle of His cell communication)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098904"(regulation of AV node cell action potential)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P97792|rcsb pdb:3JZ7|rcsb pdb:3MJ7|reactome:R-MMU-198933|reactome:R-MMU-202733|dip:DIP-41457N|mint:MINT-724898(identity)	-	function:Isoform 2 provides an endocytic scaffold for IGSF5/JAM4|function:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:"Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN"|function:"In vitro, acts as a receptor for group B coxsackieviruses and subgroup C of adenoviruses (AD2 and AD5)"|comment:"Stoichiometry: 1.0"	figure legend:F1 F2|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/06/20	2014/10/16	rogid:shmkiB+D/B2GzRLu117bgR7QopI10090	rogid:lIHRFvNBvpqsVCKArm+2uREslvo10090	intact-crc:E0A2522D2EAD0F64|rigid:vLEQc3UGqHKBcsGG4ORRf/pq/CM	false	tag:?-?(MINT-724893)|binding-associated region:385-467(MINT-724889)	binding-associated region:339-352(MINT-724899)|tag:?-?(MINT-724902)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O70263	uniprotkb:P97792	intact:EBI-7650391|ensembl:ENSMUSP00000084405|ensembl:ENSMUSP00000113035|intact:MINT-253029|uniprotkb:O70264|uniprotkb:Q8BRI8|uniprotkb:Q8CFR3	intact:EBI-7429264|uniprotkb:Q91W66|uniprotkb:O09052|uniprotkb:Q3ULD0|uniprotkb:Q9DBJ8|intact:MINT-253068|uniprotkb:Q99KG0|ensembl:ENSMUSP00000023572	psi-mi:lnx1_mouse(display_long)|uniprotkb:Lnx1(gene name)|psi-mi:Lnx1(display_short)|uniprotkb:Lnx(gene name synonym)|uniprotkb:Ligand of Numb-binding protein 1(gene name synonym)|uniprotkb:Numb-binding protein 1(gene name synonym)|uniprotkb:Ligand of Numb protein X 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase LNX(gene name synonym)	psi-mi:cxar_mouse(display_long)|uniprotkb:Cxadr(gene name)|psi-mi:Cxadr(display_short)|uniprotkb:Car(gene name synonym)	psi-mi:"MI:0096"(pull down)	Sollerbrant et al. (2003)	mint:MINT-5215971|pubmed:12468544	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8570084|mint:MINT-58723	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000029228(gene)|ensembl:ENSMUST00000087161(transcript)|ensembl:ENSMUST00000117388(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:O70263|rcsb pdb:3VQF|rcsb pdb:3VQG|reactome:R-MMU-983168|refseq:NP_001153050.1|refseq:NP_001153051.1|refseq:NP_034857.3|refseq:NP_001153052.1|refseq:NP_001153049.1|refseq:XP_006504317.1|mint:MINT-724913(identity)	refseq:NP_034118.1|refseq:NP_001263192.1|refseq:NP_001020363.1|refseq:XP_006522946.1|refseq:XP_006522947.1|ensembl:ENSMUSG00000022865(gene)|ensembl:ENSMUST00000023572(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0014704"(intercalated disc)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0070633"(transepithelial transport)|go:"GO:0071253"(connexin binding)|go:"GO:0086067"(AV node cell to bundle of His cell communication)|go:"GO:0086072"(AV node cell-bundle of His cell adhesion involved in cell communication)|go:"GO:0086082"(cell adhesive protein binding involved in AV node cell-bundle of His cell communication)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098904"(regulation of AV node cell action potential)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P97792|rcsb pdb:3JZ7|rcsb pdb:3MJ7|reactome:R-MMU-198933|reactome:R-MMU-202733|dip:DIP-41457N|mint:MINT-724923(identity)	-	function:Isoform 2 provides an endocytic scaffold for IGSF5/JAM4|function:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:"Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN"|function:"In vitro, acts as a receptor for group B coxsackieviruses and subgroup C of adenoviruses (AD2 and AD5)"|comment:"Stoichiometry: 1.0"	figure legend:F3|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/20	2014/10/16	rogid:shmkiB+D/B2GzRLu117bgR7QopI10090	rogid:lIHRFvNBvpqsVCKArm+2uREslvo10090	intact-crc:D86B073A3903B8BC|rigid:vLEQc3UGqHKBcsGG4ORRf/pq/CM	false	tag:?-?(MINT-724918)|binding-associated region:385-467(MINT-724914)	binding-associated region:339-352(MINT-724924)|tag:?-?(MINT-724927)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O70263	uniprotkb:P97792	intact:EBI-7650391|ensembl:ENSMUSP00000084405|ensembl:ENSMUSP00000113035|intact:MINT-253029|uniprotkb:O70264|uniprotkb:Q8BRI8|uniprotkb:Q8CFR3	intact:EBI-7429264|uniprotkb:Q91W66|uniprotkb:O09052|uniprotkb:Q3ULD0|uniprotkb:Q9DBJ8|intact:MINT-253068|uniprotkb:Q99KG0|ensembl:ENSMUSP00000023572	psi-mi:lnx1_mouse(display_long)|uniprotkb:Lnx1(gene name)|psi-mi:Lnx1(display_short)|uniprotkb:Lnx(gene name synonym)|uniprotkb:Ligand of Numb-binding protein 1(gene name synonym)|uniprotkb:Numb-binding protein 1(gene name synonym)|uniprotkb:Ligand of Numb protein X 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase LNX(gene name synonym)	psi-mi:cxar_mouse(display_long)|uniprotkb:Cxadr(gene name)|psi-mi:Cxadr(display_short)|uniprotkb:Car(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Sollerbrant et al. (2003)	mint:MINT-5215971|pubmed:12468544	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8570123|mint:MINT-58726	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000029228(gene)|ensembl:ENSMUST00000087161(transcript)|ensembl:ENSMUST00000117388(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:O70263|rcsb pdb:3VQF|rcsb pdb:3VQG|reactome:R-MMU-983168|refseq:NP_001153050.1|refseq:NP_001153051.1|refseq:NP_034857.3|refseq:NP_001153052.1|refseq:NP_001153049.1|refseq:XP_006504317.1|mint:MINT-724961(identity)	refseq:NP_034118.1|refseq:NP_001263192.1|refseq:NP_001020363.1|refseq:XP_006522946.1|refseq:XP_006522947.1|ensembl:ENSMUSG00000022865(gene)|ensembl:ENSMUST00000023572(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0014704"(intercalated disc)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0070633"(transepithelial transport)|go:"GO:0071253"(connexin binding)|go:"GO:0086067"(AV node cell to bundle of His cell communication)|go:"GO:0086072"(AV node cell-bundle of His cell adhesion involved in cell communication)|go:"GO:0086082"(cell adhesive protein binding involved in AV node cell-bundle of His cell communication)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098904"(regulation of AV node cell action potential)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P97792|rcsb pdb:3JZ7|rcsb pdb:3MJ7|reactome:R-MMU-198933|reactome:R-MMU-202733|dip:DIP-41457N|mint:MINT-724971(identity)	-	function:Isoform 2 provides an endocytic scaffold for IGSF5/JAM4|function:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:"Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN"|function:"In vitro, acts as a receptor for group B coxsackieviruses and subgroup C of adenoviruses (AD2 and AD5)"|comment:"Stoichiometry: 1.0"	figure legend:F6|comment:homomint|comment:mint	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/06/20	2014/10/16	rogid:shmkiB+D/B2GzRLu117bgR7QopI10090	rogid:lIHRFvNBvpqsVCKArm+2uREslvo10090	intact-crc:9345AD9229C1C478|rigid:vLEQc3UGqHKBcsGG4ORRf/pq/CM	false	tag:?-?(MINT-724965)|binding-associated region:?-?(MINT-724962)	tag:?-?(MINT-724972)	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)