#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P16118	uniprotkb:P16118	intact:EBI-709807|ensembl:ENSP00000364145|uniprotkb:Q5JXS5|uniprotkb:B2RA88|uniprotkb:Q99951|uniprotkb:B4DUN5	intact:EBI-709807|ensembl:ENSP00000364145|uniprotkb:Q5JXS5|uniprotkb:B2RA88|uniprotkb:Q99951|uniprotkb:B4DUN5	psi-mi:f261_human(display_long)|uniprotkb:6PF-2-K/Fru-2,6-P2ase liver isozyme(gene name synonym)|uniprotkb:PFKFB1(gene name)|psi-mi:PFKFB1(display_short)|uniprotkb:F6PK(gene name synonym)|uniprotkb:PFRX(gene name synonym)	psi-mi:f261_human(display_long)|uniprotkb:6PF-2-K/Fru-2,6-P2ase liver isozyme(gene name synonym)|uniprotkb:PFKFB1(gene name)|psi-mi:PFKFB1(display_short)|uniprotkb:F6PK(gene name synonym)|uniprotkb:PFRX(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Lee et al. (2003)	pubmed:12379646	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709820|rcsb pdb:1K6M	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002616.2|ensembl:ENSG00000158571(gene)|ensembl:ENST00000375006(transcript)|go:"GO:0003873"(6-phosphofructo-2-kinase activity)|go:"GO:0004331"(fructose-2,6-bisphosphate 2-phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006003"(fructose 2,6-bisphosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032868"(response to insulin)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033762"(response to glucagon)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043540"(6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0070095"(fructose-6-phosphate binding)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR003094(Fructose-2,6-bisphosphatase)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR013079(6-phosphofructo-2-kinase)|interpro:IPR027417|interpro:IPR029033|rcsb pdb:1K6M|reactome:R-HSA-163358|reactome:R-HSA-163767|reactome:R-HSA-9634600|refseq:NP_001258733.1|refseq:NP_001258734.1	refseq:NP_002616.2|ensembl:ENSG00000158571(gene)|ensembl:ENST00000375006(transcript)|go:"GO:0003873"(6-phosphofructo-2-kinase activity)|go:"GO:0004331"(fructose-2,6-bisphosphate 2-phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006003"(fructose 2,6-bisphosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032868"(response to insulin)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033762"(response to glucagon)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043540"(6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0070095"(fructose-6-phosphate binding)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR003094(Fructose-2,6-bisphosphatase)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR013079(6-phosphofructo-2-kinase)|interpro:IPR027417|interpro:IPR029033|rcsb pdb:1K6M|reactome:R-HSA-163358|reactome:R-HSA-163767|reactome:R-HSA-9634600|refseq:NP_001258733.1|refseq:NP_001258734.1	go:"GO:0003873"(6-phosphofructo-2-kinase activity)|go:"GO:0004331"(fructose-2,6-bisphosphate 2-phosphatase activity)|go:"GO:0042803"(protein homodimerization activity)	-	-	3d-r-factors:working 21.7%, free 25.7%|3d-resolution:2.40�|3d-structure:"A head-to-head homodimer of 432 amino acid residues per monomer (residues 39-470). Each subunit contains an ATPS, ADP, or Pi molecule bound to the kinase domain, and two inorganic phosphates bound to the bisphosphatase domain. No electron density is interpretable for the N-terminal regulatory fragment of residues 1-38, in which the phosphorylation site Ser-32 is located."|comment:"The W0 mutant form of the enzyme (all Trp residues and Pro2 mutated to Phe and Arg, respectively) was employed for this study because it has better expression in Escherichia coli with the same kinetic properties as the wild type"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/16	2014/10/16	rogid:PlV0xnOZK0nDHS3tfKG1B1YgyoY9606	rogid:PlV0xnOZK0nDHS3tfKG1B1YgyoY9606	intact-crc:054D49FD16CCD1CE|rigid:uf8ojyktpQpQaiQ5Vh5RsvMe0C8	false	binding-associated region:40-471|binding-associated region:209-209	binding-associated region:40-471|binding-associated region:226-226	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)