#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32644	uniprotkb:P05453	intact:EBI-22223|uniprotkb:D3DM85|ensemblfungi:YER176W	intact:EBI-6540|uniprotkb:P05420|uniprotkb:D6VSF4|ensemblfungi:YDR172W	psi-mi:ecm32_yeast(display_long)|uniprotkb:Extracellular mutant protein 32(gene name synonym)|uniprotkb:Helicase 1(gene name synonym)|uniprotkb:DNA helicase B(gene name synonym)|uniprotkb:DNA helicase III(gene name synonym)|uniprotkb:Modulator of translation termination protein 1(gene name synonym)|uniprotkb:ECM32(gene name)|psi-mi:ECM32(display_short)|uniprotkb:HEL1(gene name synonym)|uniprotkb:MTT1(gene name synonym)|uniprotkb:SYGP-ORF61(orf name)|uniprotkb:YER176W(locus name)	psi-mi:erf3_yeast(display_long)|uniprotkb:SUP35(gene name)|psi-mi:SUP35(display_short)|uniprotkb:GST1(gene name synonym)|uniprotkb:PNM2(gene name synonym)|uniprotkb:SAL3(gene name synonym)|uniprotkb:SUF12(gene name synonym)|uniprotkb:SUP2(gene name synonym)|uniprotkb:YDR172W(locus name)|uniprotkb:YD9395.05(orf name)|uniprotkb:ERF2(gene name synonym)|uniprotkb:ERF-3(gene name synonym)|uniprotkb:Translation release factor 3(gene name synonym)|uniprotkb:Polypeptide release factor 3(gene name synonym)|uniprotkb:Omnipotent suppressor protein 2(gene name synonym)|uniprotkb:G1 to S phase transition protein 1(gene name synonym)|uniprotkb:PSI no more protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Czaplinski et al. (2000)	pubmed:10836794	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-491790	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011103.1|sgd:S000000978|dip:DIP-5404N|ensemblfungi:YER176W(gene)|ensemblfungi:YER176W_mRNA(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679	sgd:S000002579|refseq:NP_010457.3|mint:P05453|dip:DIP-376N|ensemblfungi:YDR172W(gene)|ensemblfungi:YDR172W_mRNA(transcript)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003729"(mRNA binding)|go:"GO:0003747"(translation release factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006415"(translational termination)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0018444"(translation release factor complex)|go:"GO:0042802"(identical protein binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR003285(Yeast eukaryotic release factor)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|rcsb pdb:1YJO|rcsb pdb:1YJP|rcsb pdb:2OMM|rcsb pdb:4CRN|rcsb pdb:5K2E|rcsb pdb:5K2F|rcsb pdb:5K2G|rcsb pdb:5K2H|reactome:R-SCE-72764|reactome:R-SCE-975956|reactome:R-SCE-975957	-	-	crc64:43912A6D77DFA153	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/02/08	2014/10/16	rogid:kt9l48/Wme0AJXUsEEUSiaMZ+l8559292	rogid:R4xSkfzHnSuHRDxWOd2dWMEuseI559292	intact-crc:B393ADD0956951C7|rigid:kVufQR74emYZXvGtVw+syazdDS8	false	flag tag:1-1	glutathione s tranferase tag:1-1	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P05453	uniprotkb:P32644	intact:EBI-6540|uniprotkb:P05420|uniprotkb:D6VSF4|ensemblfungi:YDR172W	intact:EBI-22223|uniprotkb:D3DM85|ensemblfungi:YER176W	psi-mi:erf3_yeast(display_long)|uniprotkb:SUP35(gene name)|psi-mi:SUP35(display_short)|uniprotkb:GST1(gene name synonym)|uniprotkb:PNM2(gene name synonym)|uniprotkb:SAL3(gene name synonym)|uniprotkb:SUF12(gene name synonym)|uniprotkb:SUP2(gene name synonym)|uniprotkb:YDR172W(locus name)|uniprotkb:YD9395.05(orf name)|uniprotkb:ERF2(gene name synonym)|uniprotkb:ERF-3(gene name synonym)|uniprotkb:Translation release factor 3(gene name synonym)|uniprotkb:Polypeptide release factor 3(gene name synonym)|uniprotkb:Omnipotent suppressor protein 2(gene name synonym)|uniprotkb:G1 to S phase transition protein 1(gene name synonym)|uniprotkb:PSI no more protein 2(gene name synonym)	psi-mi:ecm32_yeast(display_long)|uniprotkb:Extracellular mutant protein 32(gene name synonym)|uniprotkb:Helicase 1(gene name synonym)|uniprotkb:DNA helicase B(gene name synonym)|uniprotkb:DNA helicase III(gene name synonym)|uniprotkb:Modulator of translation termination protein 1(gene name synonym)|uniprotkb:ECM32(gene name)|psi-mi:ECM32(display_short)|uniprotkb:HEL1(gene name synonym)|uniprotkb:MTT1(gene name synonym)|uniprotkb:SYGP-ORF61(orf name)|uniprotkb:YER176W(locus name)	psi-mi:"MI:0096"(pull down)	Czaplinski et al. (2000)	pubmed:10836794	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-491799	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002579|refseq:NP_010457.3|mint:P05453|dip:DIP-376N|ensemblfungi:YDR172W(gene)|ensemblfungi:YDR172W_mRNA(transcript)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003729"(mRNA binding)|go:"GO:0003747"(translation release factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006415"(translational termination)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0018444"(translation release factor complex)|go:"GO:0042802"(identical protein binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR003285(Yeast eukaryotic release factor)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|rcsb pdb:1YJO|rcsb pdb:1YJP|rcsb pdb:2OMM|rcsb pdb:4CRN|rcsb pdb:5K2E|rcsb pdb:5K2F|rcsb pdb:5K2G|rcsb pdb:5K2H|reactome:R-SCE-72764|reactome:R-SCE-975956|reactome:R-SCE-975957	refseq:NP_011103.1|sgd:S000000978|dip:DIP-5404N|ensemblfungi:YER176W(gene)|ensemblfungi:YER176W_mRNA(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679	-	crc64:43912A6D77DFA153	-	comment:The interaction of the erf3 N-terminal regulatory domain with mtt1 is weaker than for the erf3 C-terminal functional domain with mtt1.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/02/08	2014/10/16	rogid:R4xSkfzHnSuHRDxWOd2dWMEuseI559292	rogid:kt9l48/Wme0AJXUsEEUSiaMZ+l8559292	intact-crc:3CCFB254D40107E2|rigid:kVufQR74emYZXvGtVw+syazdDS8	false	glutathione s tranferase tag:1-1|binding-associated region:1-254	flag tag:1-1	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P32644	uniprotkb:P05453	intact:EBI-22223|uniprotkb:D3DM85|ensemblfungi:YER176W	intact:EBI-6540|uniprotkb:P05420|uniprotkb:D6VSF4|ensemblfungi:YDR172W	psi-mi:ecm32_yeast(display_long)|uniprotkb:Extracellular mutant protein 32(gene name synonym)|uniprotkb:Helicase 1(gene name synonym)|uniprotkb:DNA helicase B(gene name synonym)|uniprotkb:DNA helicase III(gene name synonym)|uniprotkb:Modulator of translation termination protein 1(gene name synonym)|uniprotkb:ECM32(gene name)|psi-mi:ECM32(display_short)|uniprotkb:HEL1(gene name synonym)|uniprotkb:MTT1(gene name synonym)|uniprotkb:SYGP-ORF61(orf name)|uniprotkb:YER176W(locus name)	psi-mi:erf3_yeast(display_long)|uniprotkb:SUP35(gene name)|psi-mi:SUP35(display_short)|uniprotkb:GST1(gene name synonym)|uniprotkb:PNM2(gene name synonym)|uniprotkb:SAL3(gene name synonym)|uniprotkb:SUF12(gene name synonym)|uniprotkb:SUP2(gene name synonym)|uniprotkb:YDR172W(locus name)|uniprotkb:YD9395.05(orf name)|uniprotkb:ERF2(gene name synonym)|uniprotkb:ERF-3(gene name synonym)|uniprotkb:Translation release factor 3(gene name synonym)|uniprotkb:Polypeptide release factor 3(gene name synonym)|uniprotkb:Omnipotent suppressor protein 2(gene name synonym)|uniprotkb:G1 to S phase transition protein 1(gene name synonym)|uniprotkb:PSI no more protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Czaplinski et al. (2000)	pubmed:10836794	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-491813	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011103.1|sgd:S000000978|dip:DIP-5404N|ensemblfungi:YER176W(gene)|ensemblfungi:YER176W_mRNA(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679	sgd:S000002579|refseq:NP_010457.3|mint:P05453|dip:DIP-376N|ensemblfungi:YDR172W(gene)|ensemblfungi:YDR172W_mRNA(transcript)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003729"(mRNA binding)|go:"GO:0003747"(translation release factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006415"(translational termination)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0018444"(translation release factor complex)|go:"GO:0042802"(identical protein binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR003285(Yeast eukaryotic release factor)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|rcsb pdb:1YJO|rcsb pdb:1YJP|rcsb pdb:2OMM|rcsb pdb:4CRN|rcsb pdb:5K2E|rcsb pdb:5K2F|rcsb pdb:5K2G|rcsb pdb:5K2H|reactome:R-SCE-72764|reactome:R-SCE-975956|reactome:R-SCE-975957	-	-	crc64:43912A6D77DFA153	comment:The interaction of the erf3 N-terminal regulatory domain with mtt1 is weaker than for the erf3 C-terminal functional domain with mtt1.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/02/08	2014/10/16	rogid:kt9l48/Wme0AJXUsEEUSiaMZ+l8559292	rogid:R4xSkfzHnSuHRDxWOd2dWMEuseI559292	intact-crc:CAFF200E71ACD132|rigid:kVufQR74emYZXvGtVw+syazdDS8	false	flag tag:1-1	glutathione s tranferase tag:254-254|binding-associated region:254-685	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P32644	uniprotkb:P12385	intact:EBI-22223|uniprotkb:D3DM85|ensemblfungi:YER176W	intact:EBI-6533|uniprotkb:D6VQD9|ensemblfungi:YBR143C	psi-mi:ecm32_yeast(display_long)|uniprotkb:Extracellular mutant protein 32(gene name synonym)|uniprotkb:Helicase 1(gene name synonym)|uniprotkb:DNA helicase B(gene name synonym)|uniprotkb:DNA helicase III(gene name synonym)|uniprotkb:Modulator of translation termination protein 1(gene name synonym)|uniprotkb:ECM32(gene name)|psi-mi:ECM32(display_short)|uniprotkb:HEL1(gene name synonym)|uniprotkb:MTT1(gene name synonym)|uniprotkb:SYGP-ORF61(orf name)|uniprotkb:YER176W(locus name)	psi-mi:erf1_yeast(display_long)|uniprotkb:SUP45(gene name)|psi-mi:SUP45(display_short)|uniprotkb:SAL4(gene name synonym)|uniprotkb:SUP1(gene name synonym)|uniprotkb:YBR143C(locus name)|uniprotkb:YBR1120(orf name)|uniprotkb:Omnipotent suppressor protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Czaplinski et al. (2000)	pubmed:10836794	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-491826	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011103.1|sgd:S000000978|dip:DIP-5404N|ensemblfungi:YER176W(gene)|ensemblfungi:YER176W_mRNA(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679	sgd:S000000347|refseq:NP_009701.3|mint:P12385|dip:DIP-800N|ensemblfungi:YBR143C(gene)|ensemblfungi:YBR143C_mRNA(transcript)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003747"(translation release factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006415"(translational termination)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016149"(translation release factor activity, codon specific)|go:"GO:0018444"(translation release factor complex)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR004403(Peptide chain release factor eRF/aRF subunit 1)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR024049|interpro:IPR029064|interpro:IPR042226|rcsb pdb:4CRM|rcsb pdb:4CRN|reactome:R-SCE-72764|reactome:R-SCE-975956|reactome:R-SCE-975957	-	-	crc64:9B59133EE3B1F61E	comment:The mtt1-erf1 interaction is weaker than the mtt1-erf3 interaction.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/02/08	2014/10/16	rogid:kt9l48/Wme0AJXUsEEUSiaMZ+l8559292	rogid:gy6qwRrMC3d3s/uaS2PzFoK6/Do559292	intact-crc:4C32EE743B9E4F9B|rigid:IzB/ZMyCrZdD7jMOfksyyiazLzs	false	flag tag:1-1	glutathione s tranferase tag:1-1	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)