#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P10914	uniprotkb:P03129	intact:EBI-1055781|uniprotkb:Q96GG7|ensembl:ENSP00000245414|ensembl:ENSP00000384406	intact:EBI-866453	psi-mi:irf1_human(display_long)|uniprotkb:IRF1(gene name)|psi-mi:IRF1(display_short)	psi-mi:ve7_hpv16(display_long)|uniprotkb:E7(gene name)|psi-mi:E7(display_short)	psi-mi:"MI:0018"(two hybrid)	Park et al. (2000)	pubmed:10702232|mint:MINT-5212286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7206665|mint:MINT-69571	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002189.1|ensembl:ENSG00000125347(gene)|ensembl:ENST00000245414(transcript)|ensembl:ENST00000405885(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034124"(regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043374"(CD8-positive, alpha-beta T cell differentiation)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR017431(Interferon regulatory factor, 1/2)|interpro:IPR019817|interpro:IPR031215|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-5620971|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983231|dip:DIP-40988N|mint:MINT-412876(identity)	refseq:NP_041326.1|dip:DIP-1090N|mint:P03129|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039560"(suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039650"(suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990216"(positive regulation by symbiont of host transcription)|interpro:IPR000148(Papillomavirus E7 protein)|rcsb pdb:4YOZ|rcsb pdb:6APN|mint:MINT-412869(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2005/11/14	2014/10/16	rogid:ToPrN31Dt6/EQuaX8gkxFBDJp5Q9606	rogid:O1EL1sc/Ks4kPu1hY4hB3gQ26MM333760	intact-crc:6346F01755C324B4|rigid:F0VH9DA3pFxJJec/LmNQ1t6qKdM	false	tag:?-?(MINT-412877)	tag:?-?(MINT-412870)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P10914	uniprotkb:P03129	intact:EBI-1055781|uniprotkb:Q96GG7|ensembl:ENSP00000245414|ensembl:ENSP00000384406	intact:EBI-866453	psi-mi:irf1_human(display_long)|uniprotkb:IRF1(gene name)|psi-mi:IRF1(display_short)	psi-mi:ve7_hpv16(display_long)|uniprotkb:E7(gene name)|psi-mi:E7(display_short)	psi-mi:"MI:0096"(pull down)	Park et al. (2000)	pubmed:10702232|mint:MINT-5212286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7206691|mint:MINT-69572	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002189.1|ensembl:ENSG00000125347(gene)|ensembl:ENST00000245414(transcript)|ensembl:ENST00000405885(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034124"(regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043374"(CD8-positive, alpha-beta T cell differentiation)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR017431(Interferon regulatory factor, 1/2)|interpro:IPR019817|interpro:IPR031215|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-5620971|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983231|dip:DIP-40988N|mint:MINT-412895(identity)	refseq:NP_041326.1|dip:DIP-1090N|mint:P03129|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039560"(suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039650"(suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990216"(positive regulation by symbiont of host transcription)|interpro:IPR000148(Papillomavirus E7 protein)|rcsb pdb:4YOZ|rcsb pdb:6APN|mint:MINT-412888(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/14	2014/10/16	rogid:ToPrN31Dt6/EQuaX8gkxFBDJp5Q9606	rogid:O1EL1sc/Ks4kPu1hY4hB3gQ26MM333760	intact-crc:DFFB047F20724DC1|rigid:F0VH9DA3pFxJJec/LmNQ1t6qKdM	false	-	glutathione s tranferase tag:?-?(MINT-412889)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04020	uniprotkb:P10914	intact:EBI-7005254|intact:MINT-123217	intact:EBI-1055781|uniprotkb:Q96GG7|ensembl:ENSP00000245414|ensembl:ENSP00000384406	psi-mi:ve7_hpv11(display_long)|uniprotkb:E7(gene name)|psi-mi:E7(display_short)	psi-mi:irf1_human(display_long)|uniprotkb:IRF1(gene name)|psi-mi:IRF1(display_short)	psi-mi:"MI:0018"(two hybrid)	Park et al. (2000)	pubmed:10702232|mint:MINT-5212286	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7206736|mint:MINT-69569	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR000148(Papillomavirus E7 protein)|mint:P04020|mint:MINT-412924(identity)	refseq:NP_002189.1|ensembl:ENSG00000125347(gene)|ensembl:ENST00000245414(transcript)|ensembl:ENST00000405885(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034124"(regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043374"(CD8-positive, alpha-beta T cell differentiation)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR017431(Interferon regulatory factor, 1/2)|interpro:IPR019817|interpro:IPR031215|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-5620971|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983231|dip:DIP-40988N|mint:MINT-412931(identity)	-	function:E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/11/14	2014/10/16	rogid:3+tTzqe5vnNihmOZiiGVKJNrmu410580	rogid:ToPrN31Dt6/EQuaX8gkxFBDJp5Q9606	intact-crc:F2C1FAFFD41104D2|rigid:qERlsK8RxrzmIW0K+3OXm+5h4oc	false	tag:?-?(MINT-412925)	tag:?-?(MINT-412934)|binding-associated region:217-325(MINT-412932)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P03129	uniprotkb:P10914	intact:EBI-866453	intact:EBI-1055781|uniprotkb:Q96GG7|ensembl:ENSP00000245414|ensembl:ENSP00000384406	psi-mi:ve7_hpv16(display_long)|uniprotkb:E7(gene name)|psi-mi:E7(display_short)	psi-mi:irf1_human(display_long)|uniprotkb:IRF1(gene name)|psi-mi:IRF1(display_short)	psi-mi:"MI:0018"(two hybrid)	Park et al. (2000)	pubmed:10702232|mint:MINT-5212286	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7206714|mint:MINT-69568	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041326.1|dip:DIP-1090N|mint:P03129|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039560"(suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039650"(suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990216"(positive regulation by symbiont of host transcription)|interpro:IPR000148(Papillomavirus E7 protein)|rcsb pdb:4YOZ|rcsb pdb:6APN|mint:MINT-412943(identity)	refseq:NP_002189.1|ensembl:ENSG00000125347(gene)|ensembl:ENST00000245414(transcript)|ensembl:ENST00000405885(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034124"(regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043374"(CD8-positive, alpha-beta T cell differentiation)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR017431(Interferon regulatory factor, 1/2)|interpro:IPR019817|interpro:IPR031215|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-5620971|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983231|dip:DIP-40988N|mint:MINT-412950(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/11/14	2014/10/16	rogid:O1EL1sc/Ks4kPu1hY4hB3gQ26MM333760	rogid:ToPrN31Dt6/EQuaX8gkxFBDJp5Q9606	intact-crc:3B91752FB899088F|rigid:F0VH9DA3pFxJJec/LmNQ1t6qKdM	false	tag:?-?(MINT-412944)	tag:?-?(MINT-412953)|binding-associated region:217-325(MINT-412951)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P03129	uniprotkb:P10914	intact:EBI-866453	intact:EBI-1055781|uniprotkb:Q96GG7|ensembl:ENSP00000245414|ensembl:ENSP00000384406	psi-mi:ve7_hpv16(display_long)|uniprotkb:E7(gene name)|psi-mi:E7(display_short)	psi-mi:irf1_human(display_long)|uniprotkb:IRF1(gene name)|psi-mi:IRF1(display_short)	psi-mi:"MI:0018"(two hybrid)	Park et al. (2000)	pubmed:10702232|mint:MINT-5212286	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7206758|mint:MINT-69570	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041326.1|dip:DIP-1090N|mint:P03129|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039560"(suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039650"(suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990216"(positive regulation by symbiont of host transcription)|interpro:IPR000148(Papillomavirus E7 protein)|rcsb pdb:4YOZ|rcsb pdb:6APN|mint:MINT-412905(identity)	refseq:NP_002189.1|ensembl:ENSG00000125347(gene)|ensembl:ENST00000245414(transcript)|ensembl:ENST00000405885(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034124"(regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043374"(CD8-positive, alpha-beta T cell differentiation)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR017431(Interferon regulatory factor, 1/2)|interpro:IPR019817|interpro:IPR031215|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-5620971|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983231|dip:DIP-40988N|mint:MINT-412914(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/11/14	2014/10/16	rogid:O1EL1sc/Ks4kPu1hY4hB3gQ26MM333760	rogid:ToPrN31Dt6/EQuaX8gkxFBDJp5Q9606	intact-crc:202F69D585A9FB05|rigid:F0VH9DA3pFxJJec/LmNQ1t6qKdM	false	mutation decreasing interaction:?-?(MINT-412906)|tag:?-?(MINT-412908)	tag:?-?(MINT-412915)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)