#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q06187	uniprotkb:Q9QUN3	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	intact:EBI-642145|uniprotkb:O88504|ensembl:ENSMUSP00000057844	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:blnk_mouse(display_long)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:Lymphocyte antigen 57(gene name synonym)|uniprotkb:Blnk(gene name)|psi-mi:Blnk(display_short)|uniprotkb:Bash(gene name synonym)|uniprotkb:Ly57(gene name synonym)|uniprotkb:Slp65(gene name synonym)	psi-mi:"MI:0096"(pull down)	Su et al. (1999)	pubmed:10556826|mint:MINT-5211965	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7137102|mint:MINT-59463	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N|mint:MINT-376616(identity)	refseq:NP_032554.2|ensembl:ENSMUSG00000061132(gene)|ensembl:ENSMUST00000054769(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|rcsb pdb:2EO6|reactome:R-MMU-983695|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|mint:MINT-376623(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1A|comment:Interaction occurs after pervanadate stimulation|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/28	2014/10/16	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	rogid:usS1n4qdW7RcYvhLK2O11z9O4uw10090	intact-crc:C382EE9023F0DC9E|rigid:wuGwpUbsqJtuCyrCGerKVLaAlJs	false	binding-associated region:281-362(MINT-376617)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q8WV28	uniprotkb:P62993	intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0096"(pull down)	Su et al. (1999)	pubmed:10556826|mint:MINT-5211965	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7137221|mint:MINT-59467	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-376761(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|mint:MINT-376752(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B|comment:Interaction occurs after anti-IgM stimulation|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/28	2014/10/16	rogid:befGiho6PlVSSMPyb84d31TT/So9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:1CC424BAEF061B02|rigid:uXM4HQkEeOesO8LUV0VHiAn8/ow	false	-	tag:?-?(MINT-376756)|binding-associated region:60-135(MINT-376753)	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06187	uniprotkb:Q8WV28	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short)	psi-mi:"MI:0096"(pull down)	Su et al. (1999)	pubmed:10556826|mint:MINT-5211965	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7137167|mint:MINT-59465	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N|mint:MINT-376769(identity)	refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-376778(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B|comment:Interaction occurs after anti-IgM stimulation|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/28	2014/10/16	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	rogid:befGiho6PlVSSMPyb84d31TT/So9606	intact-crc:54008B746CC220A2|rigid:37F4SzGV+Am2M5wgv3X/fpL1jec	false	binding-associated region:281-362(MINT-376770)|tag:?-?(MINT-376773)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q13094	uniprotkb:Q03526	intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794	intact:EBI-647969|ensembl:ENSMUSP00000104860	psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym)	psi-mi:itk_mouse(display_long)|uniprotkb:T-cell-specific kinase(gene name synonym)|uniprotkb:IL-2-inducible T-cell kinase(gene name synonym)|uniprotkb:Kinase EMT(gene name synonym)|uniprotkb:Kinase TLK(gene name synonym)|uniprotkb:Itk(gene name)|psi-mi:Itk(display_short)|uniprotkb:Emt(gene name synonym)|uniprotkb:Tlk(gene name synonym)|uniprotkb:Tsk(gene name synonym)	psi-mi:"MI:0096"(pull down)	Su et al. (1999)	pubmed:10556826|mint:MINT-5211965	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7137341|mint:MINT-59471	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|mint:MINT-376694(identity)	refseq:NP_034713.2|refseq:NP_001268894.1|refseq:NP_001268895.1|refseq:NP_001268897.1|dip:DIP-29283N|ensembl:ENSMUSG00000020395(gene)|ensembl:ENSMUST00000109237(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035583|interpro:IPR036028|interpro:IPR036860|interpro:IPR042785|mint:Q03526|rcsb pdb:1AWJ|rcsb pdb:1LUI|rcsb pdb:1LUK|rcsb pdb:1LUM|rcsb pdb:1LUN|rcsb pdb:2ETZ|rcsb pdb:2EU0|rcsb pdb:2K79|rcsb pdb:2K7A|rcsb pdb:2RN8|rcsb pdb:2RNA|rcsb pdb:3S9K|reactome:R-MMU-202433|reactome:R-MMU-2871809|go:"GO:0004713"(protein tyrosine kinase activity)|mint:MINT-376685(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3|comment:Interaction occurs after OKT-3 stimulation|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/28	2014/10/16	rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606	rogid:dcWqyqFSAMw1j5Ifa96f85GrdTA10090	intact-crc:B75ECFC7217CAEF0|rigid:553/MhjWhKMfkYrO1XLMXwqNnnA	false	-	binding-associated region:245-328(MINT-376686)|tag:?-?(MINT-376689)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QUN3	uniprotkb:Q03526	intact:EBI-642145|uniprotkb:O88504|ensembl:ENSMUSP00000057844	intact:EBI-647969|ensembl:ENSMUSP00000104860	psi-mi:blnk_mouse(display_long)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:Lymphocyte antigen 57(gene name synonym)|uniprotkb:Blnk(gene name)|psi-mi:Blnk(display_short)|uniprotkb:Bash(gene name synonym)|uniprotkb:Ly57(gene name synonym)|uniprotkb:Slp65(gene name synonym)	psi-mi:itk_mouse(display_long)|uniprotkb:T-cell-specific kinase(gene name synonym)|uniprotkb:IL-2-inducible T-cell kinase(gene name synonym)|uniprotkb:Kinase EMT(gene name synonym)|uniprotkb:Kinase TLK(gene name synonym)|uniprotkb:Itk(gene name)|psi-mi:Itk(display_short)|uniprotkb:Emt(gene name synonym)|uniprotkb:Tlk(gene name synonym)|uniprotkb:Tsk(gene name synonym)	psi-mi:"MI:0096"(pull down)	Su et al. (1999)	pubmed:10556826|mint:MINT-5211965	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7137282|mint:MINT-59469	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032554.2|ensembl:ENSMUSG00000061132(gene)|ensembl:ENSMUST00000054769(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|rcsb pdb:2EO6|reactome:R-MMU-983695|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|mint:MINT-376744(identity)	refseq:NP_034713.2|refseq:NP_001268894.1|refseq:NP_001268895.1|refseq:NP_001268897.1|dip:DIP-29283N|ensembl:ENSMUSG00000020395(gene)|ensembl:ENSMUST00000109237(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035583|interpro:IPR036028|interpro:IPR036860|interpro:IPR042785|mint:Q03526|rcsb pdb:1AWJ|rcsb pdb:1LUI|rcsb pdb:1LUK|rcsb pdb:1LUM|rcsb pdb:1LUN|rcsb pdb:2ETZ|rcsb pdb:2EU0|rcsb pdb:2K79|rcsb pdb:2K7A|rcsb pdb:2RN8|rcsb pdb:2RNA|rcsb pdb:3S9K|reactome:R-MMU-202433|reactome:R-MMU-2871809|go:"GO:0004713"(protein tyrosine kinase activity)|mint:MINT-376735(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1D|comment:Interaction occurs after pervanadate stimulation|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/28	2014/10/16	rogid:usS1n4qdW7RcYvhLK2O11z9O4uw10090	rogid:dcWqyqFSAMw1j5Ifa96f85GrdTA10090	intact-crc:2F56EABEF1C26DFF|rigid:yrClve0UosnOVgwSqIuJHw8UX7w	false	-	binding-associated region:245-328(MINT-376736)|tag:?-?(MINT-376739)	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13094	uniprotkb:P06239	intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym)	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Su et al. (1999)	pubmed:10556826|mint:MINT-5211965	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7137424|mint:MINT-59474	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|mint:MINT-376660(identity)	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374|mint:MINT-376651(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:Interaction occurs after OKT-3 stimulation|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/28	2014/10/16	rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	intact-crc:2A3AB2FF8DA1BE26|rigid:GbFwCULP955zX1mE+jx2uzgiQ/M	false	-	binding-associated region:126-208(MINT-376652)|tag:?-?(MINT-376655)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06187	uniprotkb:Q8WV28	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short)	psi-mi:"MI:0047"(far western blotting)	Su et al. (1999)	pubmed:10556826|mint:MINT-5211965	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7137368|mint:MINT-59470	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N|mint:MINT-376719(identity)	refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-376728(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/28	2014/10/16	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	rogid:befGiho6PlVSSMPyb84d31TT/So9606	intact-crc:A945DCEC3C5C9653|rigid:37F4SzGV+Am2M5wgv3X/fpL1jec	false	binding-associated region:281-362(MINT-376720)|tag:?-?(MINT-376723)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q03526	uniprotkb:Q13094	intact:EBI-647969|ensembl:ENSMUSP00000104860	intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794	psi-mi:itk_mouse(display_long)|uniprotkb:T-cell-specific kinase(gene name synonym)|uniprotkb:IL-2-inducible T-cell kinase(gene name synonym)|uniprotkb:Kinase EMT(gene name synonym)|uniprotkb:Kinase TLK(gene name synonym)|uniprotkb:Itk(gene name)|psi-mi:Itk(display_short)|uniprotkb:Emt(gene name synonym)|uniprotkb:Tlk(gene name synonym)|uniprotkb:Tsk(gene name synonym)	psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Su et al. (1999)	pubmed:10556826|mint:MINT-5211965	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7137404|mint:MINT-59472	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034713.2|refseq:NP_001268894.1|refseq:NP_001268895.1|refseq:NP_001268897.1|dip:DIP-29283N|ensembl:ENSMUSG00000020395(gene)|ensembl:ENSMUST00000109237(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035583|interpro:IPR036028|interpro:IPR036860|interpro:IPR042785|mint:Q03526|rcsb pdb:1AWJ|rcsb pdb:1LUI|rcsb pdb:1LUK|rcsb pdb:1LUM|rcsb pdb:1LUN|rcsb pdb:2ETZ|rcsb pdb:2EU0|rcsb pdb:2K79|rcsb pdb:2K7A|rcsb pdb:2RN8|rcsb pdb:2RNA|rcsb pdb:3S9K|reactome:R-MMU-202433|reactome:R-MMU-2871809|go:"GO:0004713"(protein tyrosine kinase activity)|mint:MINT-376668(identity)	refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|mint:MINT-376677(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:Interaction occurs after OKT-3 stimulation|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/28	2014/10/16	rogid:dcWqyqFSAMw1j5Ifa96f85GrdTA10090	rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606	intact-crc:B5B694D6E3608F5D|rigid:553/MhjWhKMfkYrO1XLMXwqNnnA	false	binding-associated region:245-328(MINT-376669)|tag:?-?(MINT-376672)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P43403	uniprotkb:P06239	intact:EBI-1211276|uniprotkb:A6NFP4|uniprotkb:Q6PIA4|uniprotkb:Q8IXD6|uniprotkb:Q9UBS6|ensembl:ENSP00000264972	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	psi-mi:zap70_human(display_long)|uniprotkb:ZAP70(gene name)|psi-mi:ZAP70(display_short)|uniprotkb:SRK(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym)	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Su et al. (1999)	pubmed:10556826|mint:MINT-5211965	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7137445|mint:MINT-59476	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070.2|refseq:NP_997402.1|dip:DIP-38781N|ensembl:ENSG00000115085(gene)|ensembl:ENST00000264972(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0042113"(B cell activation)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070489"(T cell aggregation)|go:"GO:0072678"(T cell migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43403|rcsb pdb:1FBV|rcsb pdb:1M61|rcsb pdb:1U59|rcsb pdb:2CBL|rcsb pdb:2OQ1|rcsb pdb:2OZO|rcsb pdb:2Y1N|rcsb pdb:3ZNI|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4K2R|rcsb pdb:4XZ0|rcsb pdb:4XZ1|rcsb pdb:5O76|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-9013407|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation)|mint:MINT-376642(identity)	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374|mint:MINT-376633(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:Interaction occurs after OKT-3 stimulation|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/28	2014/10/16	rogid:21kVb/nxY2BBZPBNVwWba+qUOgc9606	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	intact-crc:3E203CCF0BC7711D|rigid:CpcTr36vrqJ5sbHaBsfIYI+rmIc	false	-	binding-associated region:126-208(MINT-376634)|tag:?-?(MINT-376637)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q08881	uniprotkb:Q13094	intact:EBI-968552|intact:EBI-5773727|intact:EBI-28978067|ensembl:ENSP00000398655|uniprotkb:Q32ML7|uniprotkb:B2R752	intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794	psi-mi:itk_human(display_long)|uniprotkb:ITK(gene name)|psi-mi:ITK(display_short)|uniprotkb:EMT(gene name synonym)|uniprotkb:LYK(gene name synonym)|uniprotkb:T-cell-specific kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase Lyk(gene name synonym)|uniprotkb:Kinase EMT(gene name synonym)|uniprotkb:Interleukin-2-inducible T-cell kinase(gene name synonym)	psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Su et al. (1999)	pubmed:10556826|mint:MINT-5211965	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7137489|mint:MINT-59473	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113263(gene)|ensembl:ENST00000422843(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042110"(T cell activation)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035583|interpro:IPR036028|interpro:IPR036860|interpro:IPR042785|mint:Q08881|rcsb pdb:1SM2|rcsb pdb:1SNU|rcsb pdb:1SNX|rcsb pdb:2E6I|rcsb pdb:2LMJ|rcsb pdb:2YUQ|rcsb pdb:3MIY|rcsb pdb:3MJ1|rcsb pdb:3MJ2|rcsb pdb:3QGW|rcsb pdb:3QGY|rcsb pdb:3T9T|interpro:IPR001849(Pleckstrin-like)|rcsb pdb:3V5J|rcsb pdb:3V5L|rcsb pdb:3V8T|rcsb pdb:3V8W|rcsb pdb:4HCT|rcsb pdb:4HCU|rcsb pdb:4HCV|rcsb pdb:4KIO|rcsb pdb:4L7S|rcsb pdb:4M0Y|rcsb pdb:4M0Z|rcsb pdb:4M12|rcsb pdb:4M13|rcsb pdb:4M14|rcsb pdb:4M15|rcsb pdb:4MF0|rcsb pdb:4MF1|rcsb pdb:4PP9|rcsb pdb:4PPA|rcsb pdb:4PPB|rcsb pdb:4PPC|rcsb pdb:4PQN|rcsb pdb:4QD6|rcsb pdb:4RFM|reactome:R-HSA-202433|reactome:R-HSA-2871809|refseq:NP_005537.3|ensembl:ENSP00000398655|dip:DIP-29974N|mint:MINT-376704(identity)	refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|mint:MINT-376711(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5|comment:Interaction occurs after OKT-3 and pervanadate stimulation|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:9606(human-jurkat)|taxid:9606(Homo sapiens)	-	2005/06/28	2014/10/16	rogid:DbmEoJ3gxf6xJrG1Qn4mAXASfw89606	rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606	intact-crc:B8BC6C78A6FF88E1|rigid:huC/Qss4b2yqgGR8zRsfEVO3Lro	false	binding-associated region:239-323(MINT-376705)	-	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)