#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O95407	uniprotkb:O43557	intact:EBI-524171|ensembl:ENSP00000359013	intact:EBI-524131|uniprotkb:Q6FHA1|uniprotkb:O75476|uniprotkb:Q8WVF8|uniprotkb:Q96LD2|ensembl:ENSP00000469049|ensembl:ENSP00000502837|uniprotkb:A8K7M2|uniprotkb:C9J5H4	psi-mi:tnf6b_human(display_long)|uniprotkb:Decoy receptor for Fas ligand(gene name synonym)|uniprotkb:Decoy receptor 3(gene name synonym)|uniprotkb:M68(gene name synonym)|uniprotkb:UNQ186/PRO212(orf name)|uniprotkb:TNFRSF6B(gene name)|psi-mi:TNFRSF6B(display_short)|uniprotkb:DCR3(gene name synonym)|uniprotkb:TR6(gene name synonym)	psi-mi:tnf14_human(display_long)|uniprotkb:Herpes virus entry mediator ligand(gene name synonym)|uniprotkb:UNQ391/PRO726(orf name)|uniprotkb:TNFSF14(gene name)|psi-mi:TNFSF14(display_short)|uniprotkb:HVEML(gene name synonym)|uniprotkb:LIGHT(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yu et al. (1999)	pubmed:10318773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-524167	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003814.1|ensembl:ENSG00000243509(gene)|ensembl:ENST00000369996(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR034023|rcsb pdb:3K51|rcsb pdb:3MHD|rcsb pdb:3MI8|rcsb pdb:4J6G|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4MSV|rcsb pdb:5L36|reactome:R-HSA-5669034	ensembl:ENSG00000125735(gene)|ensembl:ENST00000599359(transcript)|ensembl:ENST00000675206(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:4EN0|rcsb pdb:4J6G|rcsb pdb:4KG8|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4RSU|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_016882906.1|refseq:NP_003798.2|refseq:NP_742011.2|dip:DIP-3016N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/03/29	2014/10/16	rogid:6TcPTYX4msQy2jsSWmzZFE0+7MY9606	rogid:6Sbcq5MmsZT2GjqAblvfCc1bR449606	intact-crc:9E1D42257B364579|rigid:k+fmhsBi7T8R173Dr9AVzhWMcqE	false	his tag:c-c	flag tag:?-?|binding-associated region:74-240	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95407	uniprotkb:O43557	intact:EBI-524171|ensembl:ENSP00000359013	intact:EBI-524131|uniprotkb:Q6FHA1|uniprotkb:O75476|uniprotkb:Q8WVF8|uniprotkb:Q96LD2|ensembl:ENSP00000469049|ensembl:ENSP00000502837|uniprotkb:A8K7M2|uniprotkb:C9J5H4	psi-mi:tnf6b_human(display_long)|uniprotkb:Decoy receptor for Fas ligand(gene name synonym)|uniprotkb:Decoy receptor 3(gene name synonym)|uniprotkb:M68(gene name synonym)|uniprotkb:UNQ186/PRO212(orf name)|uniprotkb:TNFRSF6B(gene name)|psi-mi:TNFRSF6B(display_short)|uniprotkb:DCR3(gene name synonym)|uniprotkb:TR6(gene name synonym)	psi-mi:tnf14_human(display_long)|uniprotkb:Herpes virus entry mediator ligand(gene name synonym)|uniprotkb:UNQ391/PRO726(orf name)|uniprotkb:TNFSF14(gene name)|psi-mi:TNFSF14(display_short)|uniprotkb:HVEML(gene name synonym)|uniprotkb:LIGHT(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Yu et al. (1999)	pubmed:10318773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-524191	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003814.1|ensembl:ENSG00000243509(gene)|ensembl:ENST00000369996(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR034023|rcsb pdb:3K51|rcsb pdb:3MHD|rcsb pdb:3MI8|rcsb pdb:4J6G|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4MSV|rcsb pdb:5L36|reactome:R-HSA-5669034	ensembl:ENSG00000125735(gene)|ensembl:ENST00000599359(transcript)|ensembl:ENST00000675206(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:4EN0|rcsb pdb:4J6G|rcsb pdb:4KG8|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4RSU|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_016882906.1|refseq:NP_003798.2|refseq:NP_742011.2|dip:DIP-3016N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/03/29	2014/10/16	rogid:6TcPTYX4msQy2jsSWmzZFE0+7MY9606	rogid:6Sbcq5MmsZT2GjqAblvfCc1bR449606	intact-crc:38A45E833300372B|rigid:k+fmhsBi7T8R173Dr9AVzhWMcqE	false	his tag:?-?	his tag:?-?|binding-associated region:74-240	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q06643	uniprotkb:O43557	intact:EBI-524217|uniprotkb:P78370|uniprotkb:Q99761|ensembl:ENSP00000365285|ensembl:ENSP00000372985|ensembl:ENSP00000393693|ensembl:ENSP00000395102|ensembl:ENSP00000398741|ensembl:ENSP00000404014|ensembl:ENSP00000404450|ensembl:ENSP00000410481|uniprotkb:Q52LU8	intact:EBI-524131|uniprotkb:Q6FHA1|uniprotkb:O75476|uniprotkb:Q8WVF8|uniprotkb:Q96LD2|ensembl:ENSP00000469049|ensembl:ENSP00000502837|uniprotkb:A8K7M2|uniprotkb:C9J5H4	psi-mi:tnfc_human(display_long)|uniprotkb:Tumor necrosis factor C(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 3(gene name synonym)|uniprotkb:LTB(gene name)|psi-mi:LTB(display_short)|uniprotkb:TNFC(gene name synonym)|uniprotkb:TNFSF3(gene name synonym)	psi-mi:tnf14_human(display_long)|uniprotkb:Herpes virus entry mediator ligand(gene name synonym)|uniprotkb:UNQ391/PRO726(orf name)|uniprotkb:TNFSF14(gene name)|psi-mi:TNFSF14(display_short)|uniprotkb:HVEML(gene name synonym)|uniprotkb:LIGHT(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Yu et al. (1999)	pubmed:10318773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-524211	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204487(gene)|ensembl:ENSG00000206437(gene)|ensembl:ENSG00000223448(gene)|ensembl:ENSG00000227507(gene)|ensembl:ENSG00000231314(gene)|ensembl:ENSG00000236237(gene)|ensembl:ENSG00000236925(gene)|ensembl:ENSG00000238114(gene)|ensembl:ENST00000376117(transcript)|ensembl:ENST00000383493(transcript)|ensembl:ENST00000420402(transcript)|ensembl:ENST00000421268(transcript)|ensembl:ENST00000429299(transcript)|ensembl:ENST00000444479(transcript)|ensembl:ENST00000456113(transcript)|ensembl:ENST00000457552(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0043588"(skin development)|go:"GO:0048535"(lymph node development)|interpro:IPR002961(Tumour necrosis factor c/lymphotoxin-beta)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|rcsb pdb:4MXW|reactome:R-HSA-5668541|reactome:R-HSA-5676594|go:"GO:0005102"(signaling receptor binding)|refseq:NP_002332.1|refseq:NP_033666.1|dip:DIP-2996N	ensembl:ENSG00000125735(gene)|ensembl:ENST00000599359(transcript)|ensembl:ENST00000675206(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:4EN0|rcsb pdb:4J6G|rcsb pdb:4KG8|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4RSU|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_016882906.1|refseq:NP_003798.2|refseq:NP_742011.2|dip:DIP-3016N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/03/29	2014/10/16	rogid:rf1zq2ooNyfvllGuon3bemfZU549606	rogid:6Sbcq5MmsZT2GjqAblvfCc1bR449606	intact-crc:1212442BAA850A49|rigid:dZHLmxLLa9nNy+x4dPOVVRMTnGo	false	tag:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q92956	uniprotkb:O43557	intact:EBI-1056653|uniprotkb:Q6IB95|uniprotkb:Q8WXR1|uniprotkb:Q96J31|uniprotkb:Q9UM65|uniprotkb:B9DI89|uniprotkb:B3KW30|uniprotkb:Q8N634|ensembl:ENSP00000347948|ensembl:ENSP00000478308	intact:EBI-524131|uniprotkb:Q6FHA1|uniprotkb:O75476|uniprotkb:Q8WVF8|uniprotkb:Q96LD2|ensembl:ENSP00000469049|ensembl:ENSP00000502837|uniprotkb:A8K7M2|uniprotkb:C9J5H4	psi-mi:tnr14_human(display_long)|uniprotkb:TNFRSF14(gene name)|psi-mi:TNFRSF14(display_short)|uniprotkb:HVEA(gene name synonym)|uniprotkb:HVEM(gene name synonym)|uniprotkb:UNQ329/PRO509(orf name)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym)	psi-mi:tnf14_human(display_long)|uniprotkb:Herpes virus entry mediator ligand(gene name synonym)|uniprotkb:UNQ391/PRO726(orf name)|uniprotkb:TNFSF14(gene name)|psi-mi:TNFSF14(display_short)|uniprotkb:HVEML(gene name synonym)|uniprotkb:LIGHT(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Yu et al. (1999)	pubmed:10318773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-524243	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003811.2|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|rcsb pdb:1JMA|rcsb pdb:2AW2|rcsb pdb:4FHQ|rcsb pdb:4RSU|rcsb pdb:5T2Q|rcsb pdb:6NG3|reactome:R-HSA-388841|reactome:R-HSA-5669034|rcsb pdb:5T2R|ensembl:ENSG00000157873(gene)|ensembl:ENSG00000273936(gene)|ensembl:ENST00000355716(transcript)|ensembl:ENST00000621877(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|refseq:XP_016858209.1|dip:DIP-34779N	ensembl:ENSG00000125735(gene)|ensembl:ENST00000599359(transcript)|ensembl:ENST00000675206(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:4EN0|rcsb pdb:4J6G|rcsb pdb:4KG8|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4RSU|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_016882906.1|refseq:NP_003798.2|refseq:NP_742011.2|dip:DIP-3016N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/03/29	2014/10/16	rogid:h0mNlFr7weiZLHYvGJofgj86y249606	rogid:6Sbcq5MmsZT2GjqAblvfCc1bR449606	intact-crc:924579EBBFAA5439|rigid:vTFiRkcXSpgdYnN0lcqiW336cK8	false	tag:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)