#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q95241	uniprotkb:P00763	intact:EBI-8619383|intact:MINT-1513021	intact:EBI-1029166|ensembl:ENSRNOP00000018853	psi-mi:a4_saisc(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:try2_rat(display_long)|uniprotkb:Prss2(gene name)|psi-mi:Prss2(display_short)|uniprotkb:Try2(gene name synonym)|uniprotkb:Anionic trypsin II(gene name synonym)|uniprotkb:Pretrypsinogen II(gene name synonym)|uniprotkb:Serine protease 2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Perona et al. (1993)	mint:MINT-5220837|pubmed:8478942	taxid:9521(saisc)|taxid:9521("Saimiri sciureus (Common squirrel monkey)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8661573|mint:MINT-24889	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003677"(DNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008201"(heparin binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016358"(dendrite development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0043204"(perikaryon)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048669"(collateral sprouting in absence of injury)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0005634"(nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0007155"(cell adhesion)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007617"(mating behavior)|go:"GO:0007626"(locomotory behavior)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019744|interpro:IPR020901|interpro:IPR019543|interpro:IPR019745|interpro:IPR013803(Amyloidogenic glycoprotein, amyloid-beta peptide)|interpro:IPR024329|interpro:IPR028866|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|interpro:IPR036880|interpro:IPR037071|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|mint:MINT-1513047(identity)	rgd:3418|refseq:NP_036861.1|ensembl:ENSRNOG00000032916(gene)|ensembl:ENSRNOT00000018852(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007584"(response to nutrient)|go:"GO:0007586"(digestion)|go:"GO:0030574"(collagen catabolic process)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1AMH|rcsb pdb:1ANB|rcsb pdb:1ANC|rcsb pdb:1AND|rcsb pdb:1ANE|rcsb pdb:1BRA|rcsb pdb:1BRB|rcsb pdb:1BRC|rcsb pdb:1CO7|rcsb pdb:1DPO|rcsb pdb:1EZS|rcsb pdb:1EZU|rcsb pdb:1F5R|rcsb pdb:1F7Z|rcsb pdb:1FY8|rcsb pdb:1J14|rcsb pdb:1J15|rcsb pdb:1J16|rcsb pdb:1J17|rcsb pdb:1K9O|rcsb pdb:1QL9|rcsb pdb:1SLU|rcsb pdb:1SLV|rcsb pdb:1SLW|rcsb pdb:1SLX|rcsb pdb:1TRM|rcsb pdb:1YKT|rcsb pdb:1YLC|rcsb pdb:1YLD|rcsb pdb:2TRM|rcsb pdb:3FP6|rcsb pdb:3FP7|rcsb pdb:3FP8|rcsb pdb:3TGI|rcsb pdb:3TGJ|rcsb pdb:3TGK|reactome:R-RNO-1462054|reactome:R-RNO-1592389|reactome:R-RNO-196741|reactome:R-RNO-6798695|reactome:R-RNO-6803157|dip:DIP-6112N|mint:MINT-1513040(identity)	-	comment:mint|function:The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis|function:"Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1/Tip60 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP (By similarity). Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation (By similarity). Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV (By similarity). The splice isoforms that contain the BPTI domain possess protease inhibitor activity"|function:Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:In the xray complex 1brc, P00763 is chain E and Q95241 is chain I Resolution 2.500|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/02/12	2014/10/16	rogid:QEcP5QCqC2OMPp7bJd0SIrIYD5Y9521	rogid:pd1mQna5A30w4eYG7/ryILU/IFw10116	intact-crc:BF717E0BDC9B1734|rigid:dNzHULUXfiuBmKEvNby66xG18+g	false	tag:?-?(MINT-1513048)	tag:?-?(MINT-1513041)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)