#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04975	uniprotkb:O00291	intact:EBI-7374462|intact:MINT-1209554|ensembl:ENSBTAP00000055957	intact:EBI-473886|uniprotkb:O00328|uniprotkb:Q8TDL4|uniprotkb:Q2TB58|uniprotkb:V5LU97|uniprotkb:B4E3I7|uniprotkb:E7ES17|ensembl:ENSP00000336747	psi-mi:clcb_bovin(display_long)|uniprotkb:CLTB(gene name)|psi-mi:CLTB(display_short)|uniprotkb:CLTLB(gene name synonym)	psi-mi:hip1_human(display_long)|uniprotkb:HIP1(gene name)|psi-mi:HIP1(display_short)|uniprotkb:Huntingtin-interacting protein I(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Chen et al. (2005)	pubmed:15533940|mint:MINT-5217298	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7374457|mint:MINT-50713	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776702.1|refseq:XP_005209178.1|ensembl:ENSBTAG00000010740(gene)|ensembl:ENSBTAT00000064630(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|rcsb pdb:3LVG|rcsb pdb:3LVH|rcsb pdb:6WCJ|mint:MINT-1209621(identity)	go:"GO:0051015"(actin filament binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099637"(neurotransmitter receptor transport)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030554|interpro:IPR032422|interpro:IPR035964|mint:O00291|rcsb pdb:2NO2|rcsb pdb:2QA7|rcsb pdb:3I00|reactome:R-HSA-8856828|refseq:NP_005329.3|refseq:NP_001230127.1|refseq:XP_005250361.1|refseq:XP_011514418.1|ensembl:ENSG00000127946(gene)|ensembl:ENST00000336926(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050821"(protein stabilization)|dip:DIP-17041N|mint:MINT-1209630(identity)	-	comment:mint|function:Clathrin is the major protein of the polyhedral coat of coated pits and vesicles|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1A F1B F2A|comment:homomint|comment:mint|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2004/12/09	2014/10/16	rogid:2WBO5+9kK/GLUq7t3L4/HJDk1c49913	rogid:tv7gJyUeUPo98+42G8L980EnE/c9606	intact-crc:EEF771C4F99B3BE9|rigid:rm3LREgTMgr7eMLuX2qB2M3/8lw	false	fusion protein:?-?(MINT-1209625)|binding-associated region:1-44(MINT-1209622)	fusion protein:?-?(MINT-1209633)|binding-associated region:97-1010(MINT-1209631)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04973	uniprotkb:O00291	intact:EBI-7374562|intact:MINT-1209505|uniprotkb:Q17QD2|ensembl:ENSBTAP00000001518	intact:EBI-473886|uniprotkb:O00328|uniprotkb:Q8TDL4|uniprotkb:Q2TB58|uniprotkb:V5LU97|uniprotkb:B4E3I7|uniprotkb:E7ES17|ensembl:ENSP00000336747	psi-mi:clca_bovin(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short)	psi-mi:hip1_human(display_long)|uniprotkb:HIP1(gene name)|psi-mi:HIP1(display_short)|uniprotkb:Huntingtin-interacting protein I(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Chen et al. (2005)	pubmed:15533940|mint:MINT-5217298	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7374583|mint:MINT-50914	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776447.1|refseq:XP_005210116.1|refseq:XP_005210119.1|ensembl:ENSBTAG00000001137(gene)|ensembl:ENSBTAT00000001518(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|rcsb pdb:1XI4|rcsb pdb:3IYV|mint:MINT-1209545(identity)	go:"GO:0051015"(actin filament binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099637"(neurotransmitter receptor transport)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030554|interpro:IPR032422|interpro:IPR035964|mint:O00291|rcsb pdb:2NO2|rcsb pdb:2QA7|rcsb pdb:3I00|reactome:R-HSA-8856828|refseq:NP_005329.3|refseq:NP_001230127.1|refseq:XP_005250361.1|refseq:XP_011514418.1|ensembl:ENSG00000127946(gene)|ensembl:ENST00000336926(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050821"(protein stabilization)|dip:DIP-17041N|mint:MINT-1209537(identity)	-	comment:mint|function:Clathrin is the major protein of the polyhedral coat of coated pits and vesicles|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:NFA|comment:homomint|comment:mint|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2004/12/09	2014/10/16	rogid:UnWDBqaiDqgwBuFauw8oMDaTIio9913	rogid:tv7gJyUeUPo98+42G8L980EnE/c9606	intact-crc:52E0EAA326844AA7|rigid:C/CqrditKyH9kmdGdBis6cJZ/0E	false	tag:?-?(MINT-1209546)	binding-associated region:97-1010(MINT-1209538)|tag:?-?(MINT-1209540)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04975	uniprotkb:O00291	intact:EBI-7374462|intact:MINT-1209554|ensembl:ENSBTAP00000055957	intact:EBI-473886|uniprotkb:O00328|uniprotkb:Q8TDL4|uniprotkb:Q2TB58|uniprotkb:V5LU97|uniprotkb:B4E3I7|uniprotkb:E7ES17|ensembl:ENSP00000336747	psi-mi:clcb_bovin(display_long)|uniprotkb:CLTB(gene name)|psi-mi:CLTB(display_short)|uniprotkb:CLTLB(gene name synonym)	psi-mi:hip1_human(display_long)|uniprotkb:HIP1(gene name)|psi-mi:HIP1(display_short)|uniprotkb:Huntingtin-interacting protein I(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Chen et al. (2005)	pubmed:15533940|mint:MINT-5217298	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7374503|mint:MINT-50913	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776702.1|refseq:XP_005209178.1|ensembl:ENSBTAG00000010740(gene)|ensembl:ENSBTAT00000064630(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|rcsb pdb:3LVG|rcsb pdb:3LVH|rcsb pdb:6WCJ|mint:MINT-1209612(identity)	go:"GO:0051015"(actin filament binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099637"(neurotransmitter receptor transport)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030554|interpro:IPR032422|interpro:IPR035964|mint:O00291|rcsb pdb:2NO2|rcsb pdb:2QA7|rcsb pdb:3I00|reactome:R-HSA-8856828|refseq:NP_005329.3|refseq:NP_001230127.1|refseq:XP_005250361.1|refseq:XP_011514418.1|ensembl:ENSG00000127946(gene)|ensembl:ENST00000336926(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050821"(protein stabilization)|dip:DIP-17041N|mint:MINT-1209604(identity)	-	comment:mint|function:Clathrin is the major protein of the polyhedral coat of coated pits and vesicles|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1A|comment:homomint|comment:mint|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2004/12/09	2014/10/16	rogid:2WBO5+9kK/GLUq7t3L4/HJDk1c49913	rogid:tv7gJyUeUPo98+42G8L980EnE/c9606	intact-crc:B3901FC0CE58BBE7|rigid:rm3LREgTMgr7eMLuX2qB2M3/8lw	false	tag:?-?(MINT-1209613)	binding-associated region:97-1010(MINT-1209605)|tag:?-?(MINT-1209607)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04973	uniprotkb:Q9JKY5	intact:EBI-7374562|intact:MINT-1209505|uniprotkb:Q17QD2|ensembl:ENSBTAP00000001518	intact:EBI-642457|uniprotkb:Q3UJ14|ensembl:ENSMUSP00000000939	psi-mi:clca_bovin(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short)	psi-mi:hip1r_mouse(display_long)|uniprotkb:Hip1r(gene name)|psi-mi:Hip1r(display_short)	psi-mi:"MI:0018"(two hybrid)	Chen et al. (2005)	pubmed:15533940|mint:MINT-5217298	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7374625|mint:MINT-50916	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776447.1|refseq:XP_005210116.1|refseq:XP_005210119.1|ensembl:ENSBTAG00000001137(gene)|ensembl:ENSBTAT00000001518(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|rcsb pdb:1XI4|rcsb pdb:3IYV|mint:MINT-1209528(identity)	refseq:NP_659507.3|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0061024"(membrane organization)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR035964|mint:Q9JKY5|reactome:R-MMU-432722|reactome:R-MMU-8856828|ensembl:ENSMUSG00000000915(gene)|ensembl:ENSMUST00000000939(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|mint:MINT-1209520(identity)	-	comment:mint|function:Clathrin is the major protein of the polyhedral coat of coated pits and vesicles|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:NFA|comment:homomint|comment:mint|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2004/12/09	2014/10/16	rogid:UnWDBqaiDqgwBuFauw8oMDaTIio9913	rogid:IpLk7O7ZLqC+jq27bna4y8VwO1I10090	intact-crc:03EA8A9824AB10DA|rigid:OTsin8qRSlc35bI/Po0UQEMOi1Y	false	tag:?-?(MINT-1209529)	tag:?-?(MINT-1209523)|binding-associated region:346-655(MINT-1209521)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04975	uniprotkb:Q9JKY5	intact:EBI-7374462|intact:MINT-1209554|ensembl:ENSBTAP00000055957	intact:EBI-642457|uniprotkb:Q3UJ14|ensembl:ENSMUSP00000000939	psi-mi:clcb_bovin(display_long)|uniprotkb:CLTB(gene name)|psi-mi:CLTB(display_short)|uniprotkb:CLTLB(gene name synonym)	psi-mi:hip1r_mouse(display_long)|uniprotkb:Hip1r(gene name)|psi-mi:Hip1r(display_short)	psi-mi:"MI:0018"(two hybrid)	Chen et al. (2005)	pubmed:15533940|mint:MINT-5217298	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7374604|mint:MINT-50915	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776702.1|refseq:XP_005209178.1|ensembl:ENSBTAG00000010740(gene)|ensembl:ENSBTAT00000064630(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|rcsb pdb:3LVG|rcsb pdb:3LVH|rcsb pdb:6WCJ|mint:MINT-1209595(identity)	refseq:NP_659507.3|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0061024"(membrane organization)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR035964|mint:Q9JKY5|reactome:R-MMU-432722|reactome:R-MMU-8856828|ensembl:ENSMUSG00000000915(gene)|ensembl:ENSMUST00000000939(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|mint:MINT-1209587(identity)	-	comment:mint|function:Clathrin is the major protein of the polyhedral coat of coated pits and vesicles|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1A|comment:homomint|comment:mint|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2004/12/09	2014/10/16	rogid:2WBO5+9kK/GLUq7t3L4/HJDk1c49913	rogid:IpLk7O7ZLqC+jq27bna4y8VwO1I10090	intact-crc:36F0FEBC1F4CC3AA|rigid:wXpM9ME2OrcliWNiur5fzAnykfE	false	tag:?-?(MINT-1209596)	tag:?-?(MINT-1209590)|binding-associated region:346-655(MINT-1209588)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49951	uniprotkb:P18484	intact:EBI-448355|ensembl:ENSBTAP00000060092	intact:EBI-539360	psi-mi:clh1_bovin(display_long)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)	psi-mi:ap2a2_rat(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-2(gene name synonym)|uniprotkb:Alpha2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit(gene name synonym)|uniprotkb:Alpha-adaptin C(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-C large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein C(gene name synonym)|uniprotkb:Ap2a2(gene name)|psi-mi:Ap2a2(display_short)|uniprotkb:Adtab(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Chen et al. (2005)	pubmed:15533940|mint:MINT-5217298	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7374666|mint:MINT-50922	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776448.1|dip:DIP-31603N|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:P49951|rcsb pdb:1B89|rcsb pdb:1UTC|rcsb pdb:1XI4|rcsb pdb:1XI5|rcsb pdb:3GC3|rcsb pdb:3GD1|rcsb pdb:3IYV|rcsb pdb:3LVH|rcsb pdb:3QIL|rcsb pdb:5M5R|rcsb pdb:5M5S|rcsb pdb:5M5T|rcsb pdb:5M5U|rcsb pdb:5M5V|rcsb pdb:5M61|rcsb pdb:6WCJ|rcsb pdb:3LVG|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|ensembl:ENSBTAG00000016708(gene)|ensembl:ENSBTAT00000077192(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|mint:MINT-1209470(identity)	rgd:71015|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|rcsb pdb:2VGL|rcsb pdb:2XA7|go:"GO:0008021"(synaptic vesicle)|rcsb pdb:4NEE|rcsb pdb:4UQI|rcsb pdb:6OWT|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6QH7|go:"GO:0019900"(kinase binding)|rcsb pdb:6URI|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|reactome:R-RNO-177504|reactome:R-RNO-2132295|reactome:R-RNO-416993|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-6798695|reactome:R-RNO-8856825|go:"GO:0019901"(protein kinase binding)|reactome:R-RNO-8856828|go:"GO:0019904"(protein domain specific binding)|reactome:R-RNO-8866427|reactome:R-RNO-8964038|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140312"(cargo adaptor activity)|mint:P18484|dip:DIP-29765N|mint:MINT-1209478(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1A|comment:mint|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2004/12/09	2014/10/16	rogid:wpLSa4t2I+sHqUBOftWeW3eCayU9913	rogid:/3UaX0n3j6Lo0w7GMn0uWzL5GI010116	intact-crc:AA089D29BA9E723F|rigid:wKm66pt+z0G7LY6hvgI2pLnzyxs	false	tag:?-?(MINT-1209473)|binding-associated region:1-495(MINT-1209471)	tag:?-?(MINT-1209482)|binding-associated region:616-937(MINT-1209479)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04975	uniprotkb:P49951	intact:EBI-7374462|intact:MINT-1209554|ensembl:ENSBTAP00000055957	intact:EBI-448355|ensembl:ENSBTAP00000060092	psi-mi:clcb_bovin(display_long)|uniprotkb:CLTB(gene name)|psi-mi:CLTB(display_short)|uniprotkb:CLTLB(gene name synonym)	psi-mi:clh1_bovin(display_long)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)	psi-mi:"MI:0018"(two hybrid)	Chen et al. (2005)	pubmed:15533940|mint:MINT-5217298	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7374646|mint:MINT-50917	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776702.1|refseq:XP_005209178.1|ensembl:ENSBTAG00000010740(gene)|ensembl:ENSBTAT00000064630(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|rcsb pdb:3LVG|rcsb pdb:3LVH|rcsb pdb:6WCJ|mint:MINT-1209578(identity)	refseq:NP_776448.1|dip:DIP-31603N|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:P49951|rcsb pdb:1B89|rcsb pdb:1UTC|rcsb pdb:1XI4|rcsb pdb:1XI5|rcsb pdb:3GC3|rcsb pdb:3GD1|rcsb pdb:3IYV|rcsb pdb:3LVH|rcsb pdb:3QIL|rcsb pdb:5M5R|rcsb pdb:5M5S|rcsb pdb:5M5T|rcsb pdb:5M5U|rcsb pdb:5M5V|rcsb pdb:5M61|rcsb pdb:6WCJ|rcsb pdb:3LVG|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|ensembl:ENSBTAG00000016708(gene)|ensembl:ENSBTAT00000077192(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|mint:MINT-1209570(identity)	-	comment:mint|function:Clathrin is the major protein of the polyhedral coat of coated pits and vesicles|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1A|comment:mint|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2004/12/09	2014/10/16	rogid:2WBO5+9kK/GLUq7t3L4/HJDk1c49913	rogid:wpLSa4t2I+sHqUBOftWeW3eCayU9913	intact-crc:E114807C3225816F|rigid:yw4D5Ot5gQtWymC+TolzbJSxT4E	false	tag:?-?(MINT-1209579)	tag:?-?(MINT-1209573)|binding-associated region:1074-1675(MINT-1209571)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04975	uniprotkb:Q9JKY5	intact:EBI-7374462|intact:MINT-1209554|ensembl:ENSBTAP00000055957	intact:EBI-642457|uniprotkb:Q3UJ14|ensembl:ENSMUSP00000000939	psi-mi:clcb_bovin(display_long)|uniprotkb:CLTB(gene name)|psi-mi:CLTB(display_short)|uniprotkb:CLTLB(gene name synonym)	psi-mi:hip1r_mouse(display_long)|uniprotkb:Hip1r(gene name)|psi-mi:Hip1r(display_short)	psi-mi:"MI:0010"(beta galactosidase complementation)	Chen et al. (2005)	pubmed:15533940|mint:MINT-5217298	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7374714|mint:MINT-50923	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776702.1|refseq:XP_005209178.1|ensembl:ENSBTAG00000010740(gene)|ensembl:ENSBTAT00000064630(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|rcsb pdb:3LVG|rcsb pdb:3LVH|rcsb pdb:6WCJ|mint:MINT-1209643(identity)	refseq:NP_659507.3|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0061024"(membrane organization)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR035964|mint:Q9JKY5|reactome:R-MMU-432722|reactome:R-MMU-8856828|ensembl:ENSMUSG00000000915(gene)|ensembl:ENSMUST00000000939(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|mint:MINT-1209668(identity)	-	comment:mint|function:Clathrin is the major protein of the polyhedral coat of coated pits and vesicles|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2A F2B F2C|comment:homomint|comment:mint|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2004/12/09	2014/10/16	rogid:2WBO5+9kK/GLUq7t3L4/HJDk1c49913	rogid:IpLk7O7ZLqC+jq27bna4y8VwO1I10090	intact-crc:05AA60CCAD732F94|rigid:wXpM9ME2OrcliWNiur5fzAnykfE	false	mutation:32-32(MINT-1209650)|mutation:12-12(MINT-1209646)|tag:?-?(MINT-1209662)|mutation decreasing interaction:22-22,31-31,35-35,38-38,39-39(MINT-1209656)|mutation:34-34(MINT-1209652)|mutation:17-17(MINT-1209648)|binding-associated region:1-44(MINT-1209644)|mutation:33-33(MINT-1209654)	tag:?-?(MINT-1209669)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04975	uniprotkb:Q9JKY5	intact:EBI-7374462|intact:MINT-1209554|ensembl:ENSBTAP00000055957	intact:EBI-642457|uniprotkb:Q3UJ14|ensembl:ENSMUSP00000000939	psi-mi:clcb_bovin(display_long)|uniprotkb:CLTB(gene name)|psi-mi:CLTB(display_short)|uniprotkb:CLTLB(gene name synonym)	psi-mi:hip1r_mouse(display_long)|uniprotkb:Hip1r(gene name)|psi-mi:Hip1r(display_short)	psi-mi:"MI:0096"(pull down)	Chen et al. (2005)	pubmed:15533940|mint:MINT-5217298	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7374780|mint:MINT-50924	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776702.1|refseq:XP_005209178.1|ensembl:ENSBTAG00000010740(gene)|ensembl:ENSBTAT00000064630(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|rcsb pdb:3LVG|rcsb pdb:3LVH|rcsb pdb:6WCJ|mint:MINT-1209680(identity)	refseq:NP_659507.3|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0061024"(membrane organization)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR035964|mint:Q9JKY5|reactome:R-MMU-432722|reactome:R-MMU-8856828|ensembl:ENSMUSG00000000915(gene)|ensembl:ENSMUST00000000939(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|mint:MINT-1209684(identity)	-	comment:mint|function:Clathrin is the major protein of the polyhedral coat of coated pits and vesicles|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2D|comment:homomint|comment:mint|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/12/09	2014/10/16	rogid:2WBO5+9kK/GLUq7t3L4/HJDk1c49913	rogid:IpLk7O7ZLqC+jq27bna4y8VwO1I10090	intact-crc:CE12BEEAD7FC561B|rigid:wXpM9ME2OrcliWNiur5fzAnykfE	false	-	binding-associated region:346-655(MINT-1209685)|tag:?-?(MINT-1209687)	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)