#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9W1A4	uniprotkb:P15330	intact:EBI-91385|uniprotkb:Q0E8W9|uniprotkb:Q8SZS5|ensemblmetazoa:FBpp0072188|ensemblmetazoa:FBpp0072189|ensemblmetazoa:FBpp0310082	intact:EBI-198375|uniprotkb:O77088|uniprotkb:Q0E8P9|uniprotkb:Q6AWP3|uniprotkb:Q9VJD9|uniprotkb:Q9VJE0|ensemblmetazoa:FBpp0080560|ensemblmetazoa:FBpp0309222	psi-mi:tamo_drome(display_long)|uniprotkb:tamo(gene name)|psi-mi:tamo(display_short)|uniprotkb:CG4057(orf name)	psi-mi:dors_drome(display_long)|uniprotkb:dl(gene name)|psi-mi:dl(display_short)|uniprotkb:CG6667(orf name)	psi-mi:"MI:0018"(two hybrid)	Minakhina et al. (2003)	pubmed:12653959	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-458370	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001286827.1|refseq:NP_611889.1|refseq:NP_726426.1|flybase:FBgn0041582|ensemblmetazoa:FBgn0041582(gene)|ensemblmetazoa:FBtr0072281(transcript)|ensemblmetazoa:FBtr0072282(transcript)|ensemblmetazoa:FBtr0343438(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007275"(multicellular organism development)|go:"GO:0015031"(protein transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR018997|interpro:IPR029746|interpro:IPR036339|interpro:IPR036443	refseq:NP_001286014.1|refseq:NP_001163000.1|refseq:NP_001163001.1|refseq:NP_724052.1|refseq:NP_724053.1|refseq:NP_724054.1|flybase:FBgn0260632|dip:DIP-17423N|ensemblmetazoa:FBgn0260632(gene)|ensemblmetazoa:FBtr0081007(transcript)|ensemblmetazoa:FBtr0340250(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034097"(response to cytokine)|go:"GO:0035006"(melanization defense response)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0035208"(positive regulation of hemocyte proliferation)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045612"(positive regulation of hemocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071212"(subsynaptic reticulum)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR032397|interpro:IPR033926|interpro:IPR037059|reactome:R-DME-1169091|reactome:R-DME-1810476|reactome:R-DME-202424|reactome:R-DME-209400|reactome:R-DME-209406|reactome:R-DME-209560|reactome:R-DME-214842|reactome:R-DME-214844|reactome:R-DME-214869|reactome:R-DME-2871837|reactome:R-DME-3134963|reactome:R-DME-445989|reactome:R-DME-4755510|reactome:R-DME-5607761|reactome:R-DME-5607764|reactome:R-DME-5621575|reactome:R-DME-5676590|reactome:R-DME-9020702|reactome:R-DME-933542	-	-	-	comment:"Tamo interacts with the dorsal RHR (Rel homology region)."	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/11/08	2014/10/16	rogid:Nr+2FqT/GOdgiH020rA+JijGHPs7227	rogid:NFjUIuH+t9TZGcAOMpUIz/e8aCQ7227	intact-crc:59B4BB0ECD19E76D|rigid:eA0BpPMAX/SEA+IXWz0krO3Y9Dw	false	binding-associated region:385-614	binding-associated region:47-403	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9W1A4	uniprotkb:P15330	intact:EBI-91385|uniprotkb:Q0E8W9|uniprotkb:Q8SZS5|ensemblmetazoa:FBpp0072188|ensemblmetazoa:FBpp0072189|ensemblmetazoa:FBpp0310082	intact:EBI-198375|uniprotkb:O77088|uniprotkb:Q0E8P9|uniprotkb:Q6AWP3|uniprotkb:Q9VJD9|uniprotkb:Q9VJE0|ensemblmetazoa:FBpp0080560|ensemblmetazoa:FBpp0309222	psi-mi:tamo_drome(display_long)|uniprotkb:tamo(gene name)|psi-mi:tamo(display_short)|uniprotkb:CG4057(orf name)	psi-mi:dors_drome(display_long)|uniprotkb:dl(gene name)|psi-mi:dl(display_short)|uniprotkb:CG6667(orf name)	psi-mi:"MI:0096"(pull down)	Minakhina et al. (2003)	pubmed:12653959	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-458495	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001286827.1|refseq:NP_611889.1|refseq:NP_726426.1|flybase:FBgn0041582|ensemblmetazoa:FBgn0041582(gene)|ensemblmetazoa:FBtr0072281(transcript)|ensemblmetazoa:FBtr0072282(transcript)|ensemblmetazoa:FBtr0343438(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007275"(multicellular organism development)|go:"GO:0015031"(protein transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR018997|interpro:IPR029746|interpro:IPR036339|interpro:IPR036443	refseq:NP_001286014.1|refseq:NP_001163000.1|refseq:NP_001163001.1|refseq:NP_724052.1|refseq:NP_724053.1|refseq:NP_724054.1|flybase:FBgn0260632|dip:DIP-17423N|ensemblmetazoa:FBgn0260632(gene)|ensemblmetazoa:FBtr0081007(transcript)|ensemblmetazoa:FBtr0340250(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034097"(response to cytokine)|go:"GO:0035006"(melanization defense response)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0035208"(positive regulation of hemocyte proliferation)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045612"(positive regulation of hemocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071212"(subsynaptic reticulum)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR032397|interpro:IPR033926|interpro:IPR037059|reactome:R-DME-1169091|reactome:R-DME-1810476|reactome:R-DME-202424|reactome:R-DME-209400|reactome:R-DME-209406|reactome:R-DME-209560|reactome:R-DME-214842|reactome:R-DME-214844|reactome:R-DME-214869|reactome:R-DME-2871837|reactome:R-DME-3134963|reactome:R-DME-445989|reactome:R-DME-4755510|reactome:R-DME-5607761|reactome:R-DME-5607764|reactome:R-DME-5621575|reactome:R-DME-5676590|reactome:R-DME-9020702|reactome:R-DME-933542	-	-	-	comment:Shows that tamo interacts with dorsal which contains an NLS.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/11/08	2014/10/16	rogid:Nr+2FqT/GOdgiH020rA+JijGHPs7227	rogid:NFjUIuH+t9TZGcAOMpUIz/e8aCQ7227	intact-crc:5B575AD9E2871CCA|rigid:eA0BpPMAX/SEA+IXWz0krO3Y9Dw	false	glutathione s tranferase tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9W1A4	uniprotkb:Q9W1A4	intact:EBI-91385|uniprotkb:Q0E8W9|uniprotkb:Q8SZS5|ensemblmetazoa:FBpp0072188|ensemblmetazoa:FBpp0072189|ensemblmetazoa:FBpp0310082	intact:EBI-91385|uniprotkb:Q0E8W9|uniprotkb:Q8SZS5|ensemblmetazoa:FBpp0072188|ensemblmetazoa:FBpp0072189|ensemblmetazoa:FBpp0310082	psi-mi:tamo_drome(display_long)|uniprotkb:tamo(gene name)|psi-mi:tamo(display_short)|uniprotkb:CG4057(orf name)	psi-mi:tamo_drome(display_long)|uniprotkb:tamo(gene name)|psi-mi:tamo(display_short)|uniprotkb:CG4057(orf name)	psi-mi:"MI:0096"(pull down)	Minakhina et al. (2003)	pubmed:12653959	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-462920	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001286827.1|refseq:NP_611889.1|refseq:NP_726426.1|flybase:FBgn0041582|ensemblmetazoa:FBgn0041582(gene)|ensemblmetazoa:FBtr0072281(transcript)|ensemblmetazoa:FBtr0072282(transcript)|ensemblmetazoa:FBtr0343438(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007275"(multicellular organism development)|go:"GO:0015031"(protein transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR018997|interpro:IPR029746|interpro:IPR036339|interpro:IPR036443	refseq:NP_001286827.1|refseq:NP_611889.1|refseq:NP_726426.1|flybase:FBgn0041582|ensemblmetazoa:FBgn0041582(gene)|ensemblmetazoa:FBtr0072281(transcript)|ensemblmetazoa:FBtr0072282(transcript)|ensemblmetazoa:FBtr0343438(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007275"(multicellular organism development)|go:"GO:0015031"(protein transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR018997|interpro:IPR029746|interpro:IPR036339|interpro:IPR036443	-	-	-	comment:Shows that tamo interacts with itself due to the NLS.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/11/08	2014/10/16	rogid:Nr+2FqT/GOdgiH020rA+JijGHPs7227	rogid:Nr+2FqT/GOdgiH020rA+JijGHPs7227	intact-crc:C65FC73E66188A3C|rigid:0z+On9ivNKkUwa0ixC3CaB1gFUw	false	radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50535	uniprotkb:Q9W1A4	intact:EBI-155450|uniprotkb:Q3ZAP1|uniprotkb:Q9VJ66|ensemblmetazoa:FBpp0080674|ensemblmetazoa:FBpp0309817	intact:EBI-91385|uniprotkb:Q0E8W9|uniprotkb:Q8SZS5|ensemblmetazoa:FBpp0072188|ensemblmetazoa:FBpp0072189|ensemblmetazoa:FBpp0310082	psi-mi:msl1_drome(display_long)|uniprotkb:msl-1(gene name)|psi-mi:msl-1(display_short)|uniprotkb:CG10385(orf name)	psi-mi:tamo_drome(display_long)|uniprotkb:tamo(gene name)|psi-mi:tamo(display_short)|uniprotkb:CG4057(orf name)	psi-mi:"MI:0096"(pull down)	Minakhina et al. (2003)	pubmed:12653959	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-464009	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001286054.1|refseq:NP_476896.1|flybase:FBgn0005617|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005694"(chromosome)|go:"GO:0007549"(dosage compensation)|go:"GO:0009047"(dosage compensation by hyperactivation of X chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0016456"(X chromosome located dosage compensation complex, transcription activating)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0046536"(dosage compensation complex)|go:"GO:0072487"(MSL complex)|interpro:IPR026711|interpro:IPR029332|ensemblmetazoa:FBgn0005617(gene)|ensemblmetazoa:FBtr0081130(transcript)|ensemblmetazoa:FBtr0343118(transcript)|go:"GO:0000228"(nuclear chromosome)|dip:DIP-18144N	refseq:NP_001286827.1|refseq:NP_611889.1|refseq:NP_726426.1|flybase:FBgn0041582|ensemblmetazoa:FBgn0041582(gene)|ensemblmetazoa:FBtr0072281(transcript)|ensemblmetazoa:FBtr0072282(transcript)|ensemblmetazoa:FBtr0343438(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007275"(multicellular organism development)|go:"GO:0015031"(protein transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR018997|interpro:IPR029746|interpro:IPR036339|interpro:IPR036443	-	-	-	comment:Shows that tamo interacts with msl-1 which contains an NLS.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/11/08	2014/10/16	rogid:fNvqBYYRB/IiH3KrLoXW3sTtpJc7227	rogid:Nr+2FqT/GOdgiH020rA+JijGHPs7227	intact-crc:AB95EB4FA87A1B75|rigid:55ebuD7KK1AJlzHlZDWp3kHJMVc	false	radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GYU8	uniprotkb:Q9W1A4	intact:EBI-161961|uniprotkb:Q9VG41|ensemblmetazoa:FBpp0082137	intact:EBI-91385|uniprotkb:Q0E8W9|uniprotkb:Q8SZS5|ensemblmetazoa:FBpp0072188|ensemblmetazoa:FBpp0072189|ensemblmetazoa:FBpp0310082	psi-mi:nup88_drome(display_long)|uniprotkb:mbo(gene name)|psi-mi:mbo(display_short)|uniprotkb:Nup88(gene name synonym)|uniprotkb:Nucleoporin Nup88(gene name synonym)|uniprotkb:dNup88(gene name synonym)|uniprotkb:88 kDa nuclear pore complex protein(gene name synonym)|uniprotkb:Protein members only(gene name synonym)|uniprotkb:CG6819(orf name)	psi-mi:tamo_drome(display_long)|uniprotkb:tamo(gene name)|psi-mi:tamo(display_short)|uniprotkb:CG4057(orf name)	psi-mi:"MI:0096"(pull down)	Minakhina et al. (2003)	pubmed:12653959	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-464017	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524330.2|flybase:FBgn0026207|ensemblmetazoa:FBgn0026207(gene)|ensemblmetazoa:FBtr0082668(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019730"(antimicrobial humoral response)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031981"(nuclear lumen)|go:"GO:0046826"(negative regulation of protein export from nucleus)|interpro:IPR019321|interpro:IPR037700|reactome:R-DME-159227|reactome:R-DME-159230|reactome:R-DME-159231|reactome:R-DME-159236|reactome:R-DME-3301854|reactome:R-DME-3371453|reactome:R-DME-4551638|reactome:R-DME-4615885|reactome:R-DME-5578749|dip:DIP-18195N	refseq:NP_001286827.1|refseq:NP_611889.1|refseq:NP_726426.1|flybase:FBgn0041582|ensemblmetazoa:FBgn0041582(gene)|ensemblmetazoa:FBtr0072281(transcript)|ensemblmetazoa:FBtr0072282(transcript)|ensemblmetazoa:FBtr0343438(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007275"(multicellular organism development)|go:"GO:0015031"(protein transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR018997|interpro:IPR029746|interpro:IPR036339|interpro:IPR036443	-	-	-	comment:Shows that tamo interacts with nup88 which contains an NLS.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/11/08	2014/10/16	rogid:a58sYPQ56KDVGtSnPUhqq/P9wnI7227	rogid:Nr+2FqT/GOdgiH020rA+JijGHPs7227	intact-crc:49AC9A78D4BCE4E6|rigid:86YlImNUVEGRSP8DPd7cmrZ+MCo	false	radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9W1A4	uniprotkb:Q9VZ23	intact:EBI-91385|uniprotkb:Q0E8W9|uniprotkb:Q8SZS5|ensemblmetazoa:FBpp0072188|ensemblmetazoa:FBpp0072189|ensemblmetazoa:FBpp0310082	intact:EBI-191663|uniprotkb:Q9NH14|uniprotkb:Q9NHN9|ensemblmetazoa:FBpp0073327|ensemblmetazoa:FBpp0073328|ensemblmetazoa:FBpp0309150|ensemblmetazoa:FBpp0309151	psi-mi:tamo_drome(display_long)|uniprotkb:tamo(gene name)|psi-mi:tamo(display_short)|uniprotkb:CG4057(orf name)	psi-mi:ran_drome(display_long)|uniprotkb:Ran(gene name)|psi-mi:Ran(display_short)|uniprotkb:Ran10A(gene name synonym)|uniprotkb:Ras-related nuclear protein(gene name synonym)|uniprotkb:CG1404(orf name)	psi-mi:"MI:0096"(pull down)	Minakhina et al. (2003)	pubmed:12653959	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-464026	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001286827.1|refseq:NP_611889.1|refseq:NP_726426.1|flybase:FBgn0041582|ensemblmetazoa:FBgn0041582(gene)|ensemblmetazoa:FBtr0072281(transcript)|ensemblmetazoa:FBtr0072282(transcript)|ensemblmetazoa:FBtr0343438(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007275"(multicellular organism development)|go:"GO:0015031"(protein transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR018997|interpro:IPR029746|interpro:IPR036339|interpro:IPR036443	refseq:NP_651969.1|refseq:NP_727499.1|flybase:FBgn0020255|refseq:NP_001285111.1|refseq:NP_001285112.1|ensemblmetazoa:FBgn0020255(gene)|ensemblmetazoa:FBtr0073471(transcript)|ensemblmetazoa:FBtr0073472(transcript)|ensemblmetazoa:FBtr0340164(transcript)|ensemblmetazoa:FBtr0340165(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0046872"(metal ion binding)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051301"(cell division)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR002041(Ran GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DME-1655829|reactome:R-DME-5578749|reactome:R-DME-9615933	-	-	-	comment:"Tamo was N-terminally deleted of AA 25-613 to make it more stable (since full-length tamo is cleaved at ~AA 760) and retain the RanGDP binding domain (at AA 738-766). Shows that tamo interacts with ran-1."	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/11/08	2014/10/16	rogid:Nr+2FqT/GOdgiH020rA+JijGHPs7227	rogid:qb0kyEy/95Xt7MWg7lgA8VW+nO87227	intact-crc:17F9C878E4206140|rigid:5FDwkDIBY1EuMhF4OKqf/zWA+mg	false	glutathione s tranferase tag:?-?|binding-associated region:614-797,1-24	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9VUN3	uniprotkb:Q9W1A4	intact:EBI-190736|ensemblmetazoa:FBpp0075369	intact:EBI-91385|uniprotkb:Q0E8W9|uniprotkb:Q8SZS5|ensemblmetazoa:FBpp0072188|ensemblmetazoa:FBpp0072189|ensemblmetazoa:FBpp0310082	psi-mi:ranl_drome(display_long)|uniprotkb:Ran-like(gene name)|psi-mi:Ran-like(display_short)|uniprotkb:CG7815(orf name)	psi-mi:tamo_drome(display_long)|uniprotkb:tamo(gene name)|psi-mi:tamo(display_short)|uniprotkb:CG4057(orf name)	psi-mi:"MI:0096"(pull down)	Minakhina et al. (2003)	pubmed:12653959	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-464040	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524082.1|flybase:FBgn0036497|dip:DIP-20704N|ensemblmetazoa:FBgn0036497(gene)|ensemblmetazoa:FBtr0075616(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|interpro:IPR001806(Ras GTPase)|interpro:IPR002041(Ran GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417	refseq:NP_001286827.1|refseq:NP_611889.1|refseq:NP_726426.1|flybase:FBgn0041582|ensemblmetazoa:FBgn0041582(gene)|ensemblmetazoa:FBtr0072281(transcript)|ensemblmetazoa:FBtr0072282(transcript)|ensemblmetazoa:FBtr0343438(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007275"(multicellular organism development)|go:"GO:0015031"(protein transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR018997|interpro:IPR029746|interpro:IPR036339|interpro:IPR036443	-	-	-	comment:"Tamo was N-terminally deleted of AA 25-613 to make it more stable (since full-length tamo is cleaved at ~AA 760) and retain the RanGDP binding domain (at AA 738-766). Shows that tamo interacts with ran-like."	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/11/08	2014/10/16	rogid:WuTxjIo5lNJkWPse57QZqUJWpzo7227	rogid:Nr+2FqT/GOdgiH020rA+JijGHPs7227	intact-crc:D0EEA7BA67A66796|rigid:AU8jnQ3m3EiCu/7j9D5PSVfZxmU	false	radiolabel:?-?	glutathione s tranferase tag:?-?|binding-associated region:1-24,614-797	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9W1A4	uniprotkb:P15330	intact:EBI-91385|uniprotkb:Q0E8W9|uniprotkb:Q8SZS5|ensemblmetazoa:FBpp0072188|ensemblmetazoa:FBpp0072189|ensemblmetazoa:FBpp0310082	intact:EBI-198375|uniprotkb:O77088|uniprotkb:Q0E8P9|uniprotkb:Q6AWP3|uniprotkb:Q9VJD9|uniprotkb:Q9VJE0|ensemblmetazoa:FBpp0080560|ensemblmetazoa:FBpp0309222	psi-mi:tamo_drome(display_long)|uniprotkb:tamo(gene name)|psi-mi:tamo(display_short)|uniprotkb:CG4057(orf name)	psi-mi:dors_drome(display_long)|uniprotkb:dl(gene name)|psi-mi:dl(display_short)|uniprotkb:CG6667(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Minakhina et al. (2003)	pubmed:12653959	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-464076	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001286827.1|refseq:NP_611889.1|refseq:NP_726426.1|flybase:FBgn0041582|ensemblmetazoa:FBgn0041582(gene)|ensemblmetazoa:FBtr0072281(transcript)|ensemblmetazoa:FBtr0072282(transcript)|ensemblmetazoa:FBtr0343438(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007275"(multicellular organism development)|go:"GO:0015031"(protein transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR018997|interpro:IPR029746|interpro:IPR036339|interpro:IPR036443	refseq:NP_001286014.1|refseq:NP_001163000.1|refseq:NP_001163001.1|refseq:NP_724052.1|refseq:NP_724053.1|refseq:NP_724054.1|flybase:FBgn0260632|dip:DIP-17423N|ensemblmetazoa:FBgn0260632(gene)|ensemblmetazoa:FBtr0081007(transcript)|ensemblmetazoa:FBtr0340250(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034097"(response to cytokine)|go:"GO:0035006"(melanization defense response)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0035208"(positive regulation of hemocyte proliferation)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045612"(positive regulation of hemocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071212"(subsynaptic reticulum)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR032397|interpro:IPR033926|interpro:IPR037059|reactome:R-DME-1169091|reactome:R-DME-1810476|reactome:R-DME-202424|reactome:R-DME-209400|reactome:R-DME-209406|reactome:R-DME-209560|reactome:R-DME-214842|reactome:R-DME-214844|reactome:R-DME-214869|reactome:R-DME-2871837|reactome:R-DME-3134963|reactome:R-DME-445989|reactome:R-DME-4755510|reactome:R-DME-5607761|reactome:R-DME-5607764|reactome:R-DME-5621575|reactome:R-DME-5676590|reactome:R-DME-9020702|reactome:R-DME-933542	go:"GO:0005737"(cytoplasm)	-	-	comment:Tamo and dorsal interact in the cytoplasm.	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2004/11/08	2014/10/16	rogid:Nr+2FqT/GOdgiH020rA+JijGHPs7227	rogid:NFjUIuH+t9TZGcAOMpUIz/e8aCQ7227	intact-crc:76729C60206CD7D5|rigid:eA0BpPMAX/SEA+IXWz0krO3Y9Dw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15330	uniprotkb:Q9W1A4	intact:EBI-198375|uniprotkb:O77088|uniprotkb:Q0E8P9|uniprotkb:Q6AWP3|uniprotkb:Q9VJD9|uniprotkb:Q9VJE0|ensemblmetazoa:FBpp0080560|ensemblmetazoa:FBpp0309222	intact:EBI-91385|uniprotkb:Q0E8W9|uniprotkb:Q8SZS5|ensemblmetazoa:FBpp0072188|ensemblmetazoa:FBpp0072189|ensemblmetazoa:FBpp0310082	psi-mi:dors_drome(display_long)|uniprotkb:dl(gene name)|psi-mi:dl(display_short)|uniprotkb:CG6667(orf name)	psi-mi:tamo_drome(display_long)|uniprotkb:tamo(gene name)|psi-mi:tamo(display_short)|uniprotkb:CG4057(orf name)	psi-mi:"MI:0400"(affinity technology)	Minakhina et al. (2003)	pubmed:12653959	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-493450	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001286014.1|refseq:NP_001163000.1|refseq:NP_001163001.1|refseq:NP_724052.1|refseq:NP_724053.1|refseq:NP_724054.1|flybase:FBgn0260632|dip:DIP-17423N|ensemblmetazoa:FBgn0260632(gene)|ensemblmetazoa:FBtr0081007(transcript)|ensemblmetazoa:FBtr0340250(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034097"(response to cytokine)|go:"GO:0035006"(melanization defense response)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0035208"(positive regulation of hemocyte proliferation)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045612"(positive regulation of hemocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071212"(subsynaptic reticulum)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR032397|interpro:IPR033926|interpro:IPR037059|reactome:R-DME-1169091|reactome:R-DME-1810476|reactome:R-DME-202424|reactome:R-DME-209400|reactome:R-DME-209406|reactome:R-DME-209560|reactome:R-DME-214842|reactome:R-DME-214844|reactome:R-DME-214869|reactome:R-DME-2871837|reactome:R-DME-3134963|reactome:R-DME-445989|reactome:R-DME-4755510|reactome:R-DME-5607761|reactome:R-DME-5607764|reactome:R-DME-5621575|reactome:R-DME-5676590|reactome:R-DME-9020702|reactome:R-DME-933542	refseq:NP_001286827.1|refseq:NP_611889.1|refseq:NP_726426.1|flybase:FBgn0041582|ensemblmetazoa:FBgn0041582(gene)|ensemblmetazoa:FBtr0072281(transcript)|ensemblmetazoa:FBtr0072282(transcript)|ensemblmetazoa:FBtr0343438(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007275"(multicellular organism development)|go:"GO:0015031"(protein transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR018997|interpro:IPR029746|interpro:IPR036339|interpro:IPR036443	-	-	-	comment:"A 32-P end-labelled double-stranded zen B DNA fragment (TAACTGGGAGAAACCCAATCA) was present during the interaction. Both the dorsalRHR and the dorsalRHR with a deletion of the 6AA NLS effectively bind the labelled DNA.  Result indicates that tamo-dorsal interaction requires the NLS."|inhibition:Tamo inhibits the dorsal-DNA binding of the wild type dorsal but not when the NLS is deleted.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/11/08	2014/10/16	rogid:NFjUIuH+t9TZGcAOMpUIz/e8aCQ7227	rogid:Nr+2FqT/GOdgiH020rA+JijGHPs7227	intact-crc:F31493FD1F288139|rigid:eA0BpPMAX/SEA+IXWz0krO3Y9Dw	false	binding-associated region:47-403|binding-associated region:335-341	binding-associated region:385-614	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)