#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P55284	uniprotkb:B2RU80	intact:EBI-7087433|ensembl:ENSMUSP00000034339|uniprotkb:O35542|intact:MINT-247286	intact:EBI-7087472|ensembl:ENSMUSP00000089805|uniprotkb:Q3UGZ7|uniprotkb:Q8CIW2|intact:MINT-247274|intact:MINT-8298798	psi-mi:cadh5_mouse(display_long)|uniprotkb:Cdh5(gene name)|psi-mi:Cdh5(display_short)|uniprotkb:Vascular endothelial cadherin(gene name synonym)	psi-mi:ptprb_mouse(display_long)|uniprotkb:Ptprb(gene name)|psi-mi:Ptprb(display_short)|uniprotkb:Vascular endothelial protein tyrosine phosphatase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nawroth et al. (2002)	mint:MINT-5215744|pubmed:12234928	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8530277|mint:MINT-49812	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530693.1|ensembl:ENSMUSG00000031871(gene)|ensembl:ENSMUST00000034339(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001944"(vasculature development)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030052|interpro:IPR039808|mint:P55284|rcsb pdb:2KOH|reactome:R-MMU-418990|reactome:R-MMU-5218920|refseq:NP_033998.2|mint:MINT-720802(identity)	ensembl:ENSMUSG00000020154(gene)|ensembl:ENSMUST00000092167(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0043235"(receptor complex)|go:"GO:0045296"(cadherin binding)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|reactome:R-MMU-6798695|refseq:NP_084204.2|mint:MINT-720793(identity)	-	comment:mint|function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions|comment:"Stoichiometry: 1.0"	comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|partial coverage:partial coverage	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2004/05/24	2014/10/16	rogid:OU7DgfEEwHyVcX7XGNJnQQw4sTk10090	rogid:aQEta8FlG3ri6i9330xKJf854qw10090	intact-crc:48221C71A1FB8661|rigid:DGn92/8IQy+dc2xfgREVLMgts0M	false	binding-associated region:477-593(MINT-720803)	binding-associated region:1356-1435(MINT-720794)|tag:?-?(MINT-720797)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:B2RU80	uniprotkb:P55284	intact:EBI-7087472|ensembl:ENSMUSP00000089805|uniprotkb:Q3UGZ7|uniprotkb:Q8CIW2|intact:MINT-247274|intact:MINT-8298798	intact:EBI-7087433|ensembl:ENSMUSP00000034339|uniprotkb:O35542|intact:MINT-247286	psi-mi:ptprb_mouse(display_long)|uniprotkb:Ptprb(gene name)|psi-mi:Ptprb(display_short)|uniprotkb:Vascular endothelial protein tyrosine phosphatase(gene name synonym)	psi-mi:cadh5_mouse(display_long)|uniprotkb:Cdh5(gene name)|psi-mi:Cdh5(display_short)|uniprotkb:Vascular endothelial cadherin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Nawroth et al. (2002)	mint:MINT-5215744|pubmed:12234928	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8530375|mint:MINT-49813	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020154(gene)|ensembl:ENSMUST00000092167(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0043235"(receptor complex)|go:"GO:0045296"(cadherin binding)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|reactome:R-MMU-6798695|refseq:NP_084204.2|mint:MINT-720813(identity)	refseq:XP_006530693.1|ensembl:ENSMUSG00000031871(gene)|ensembl:ENSMUST00000034339(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001944"(vasculature development)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030052|interpro:IPR039808|mint:P55284|rcsb pdb:2KOH|reactome:R-MMU-418990|reactome:R-MMU-5218920|refseq:NP_033998.2|mint:MINT-720820(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions|comment:"Stoichiometry: 1.0"	comment:mint|partial coverage:partial coverage	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2004/05/24	2014/10/16	rogid:aQEta8FlG3ri6i9330xKJf854qw10090	rogid:OU7DgfEEwHyVcX7XGNJnQQw4sTk10090	intact-crc:BD5C8314961666F0|rigid:DGn92/8IQy+dc2xfgREVLMgts0M	false	binding-associated region:1356-1435(MINT-720814)	binding-associated region:477-593(MINT-720821)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P55284	uniprotkb:B2RU80	intact:EBI-7087433|ensembl:ENSMUSP00000034339|uniprotkb:O35542|intact:MINT-247286	intact:EBI-7087472|ensembl:ENSMUSP00000089805|uniprotkb:Q3UGZ7|uniprotkb:Q8CIW2|intact:MINT-247274|intact:MINT-8298798	psi-mi:cadh5_mouse(display_long)|uniprotkb:Cdh5(gene name)|psi-mi:Cdh5(display_short)|uniprotkb:Vascular endothelial cadherin(gene name synonym)	psi-mi:ptprb_mouse(display_long)|uniprotkb:Ptprb(gene name)|psi-mi:Ptprb(display_short)|uniprotkb:Vascular endothelial protein tyrosine phosphatase(gene name synonym)	psi-mi:"MI:0045"(experimental interaction detection)	Nawroth et al. (2002)	mint:MINT-5215744|pubmed:12234928	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8530439|mint:MINT-49814	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530693.1|ensembl:ENSMUSG00000031871(gene)|ensembl:ENSMUST00000034339(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001944"(vasculature development)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030052|interpro:IPR039808|mint:P55284|rcsb pdb:2KOH|reactome:R-MMU-418990|reactome:R-MMU-5218920|refseq:NP_033998.2|mint:MINT-720855(identity)	ensembl:ENSMUSG00000020154(gene)|ensembl:ENSMUST00000092167(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0043235"(receptor complex)|go:"GO:0045296"(cadherin binding)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|reactome:R-MMU-6798695|refseq:NP_084204.2|mint:MINT-720845(identity)	-	comment:mint|function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions|comment:"Stoichiometry: 1.0"	comment:mint|comment:"Stoichiometry: 1.0"	comment:VE-cadherin is dephosphorylated by VE-PTP|comment:mint|partial coverage:partial coverage	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2004/05/24	2014/10/16	rogid:OU7DgfEEwHyVcX7XGNJnQQw4sTk10090	rogid:aQEta8FlG3ri6i9330xKJf854qw10090	intact-crc:5E90DECB2698F5FD|rigid:DGn92/8IQy+dc2xfgREVLMgts0M	false	binding-associated region:477-593(MINT-720856)	binding-associated region:1356-1435(MINT-720846)|tag:?-?(MINT-720849)	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)