#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P0AA06 uniprotkb:P00550 intact:EBI-8518578|uniprotkb:P07006|intact:MINT-246002|uniprotkb:P05525|ensemblbacteria:AAG57534|ensemblbacteria:BAB36710 intact:EBI-547239|uniprotkb:Q2M7R2|ensemblbacteria:AAC76623|ensemblbacteria:BAE77694 psi-mi:pthp_eco57(display_long)|uniprotkb:ptsH(gene name)|psi-mi:ptsH(display_short)|uniprotkb:ECs3287(locus name)|uniprotkb:Z3681(locus name)|uniprotkb:Histidine-containing protein(gene name synonym) psi-mi:ptm3c_ecoli(display_long)|uniprotkb:mtlA(gene name)|psi-mi:mtlA(display_short)|uniprotkb:b3599(locus name)|uniprotkb:EIICBA-Mtl(gene name synonym)|uniprotkb:JW3573(locus name) psi-mi:"MI:0077"(nuclear magnetic resonance) Cornilescu et al. (2002) mint:MINT-5215694|pubmed:12202490 taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8518600|mint:MINT-24893 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_000487600.1|refseq:NP_311314.1|interpro:IPR035895|ensemblbacteria:AAG57534(transcript)|ensemblbacteria:BAB36710(transcript)|ensemblbacteria:ECs_3287(gene)|ensemblbacteria:Z3681(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0009401"(phosphoenolpyruvate-dependent sugar phosphotransferase system)|interpro:IPR000032(Phosphotransferase system, phosphocarrier HPr protein)|interpro:IPR001020(Phosphotransferase system, HPr histidine phosphorylation site)|interpro:IPR002114(Phosphotransferase system, HPr serine phosphorylation site)|mint:MINT-720051(identity) refseq:NP_418056.1|refseq:WP_000093247.1|ensemblbacteria:AAC76623(transcript)|ensemblbacteria:b3599(gene)|ensemblbacteria:BAE77694(gene)|ensemblbacteria:BAE77694(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009401"(phosphoenolpyruvate-dependent sugar phosphotransferase system)|go:"GO:0015797"(mannitol transport)|go:"GO:0016301"(kinase activity)|go:"GO:0022872"("protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity")|go:"GO:0090563"(protein-phosphocysteine-sugar phosphotransferase activity)|go:"GO:0090565"(protein-phosphocysteine-mannitol phosphotransferase system transporter activity)|interpro:IPR002178(Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2)|interpro:IPR003352(Phosphotransferase system, EIIC)|interpro:IPR003501(Phosphotransferase system, lactose/cellobiose-specific IIB subunit)|interpro:IPR004718(Phosphotransferase system, mannitol-specific enzyme IIC)|interpro:IPR013011(Phosphotransferase system, EIIB component, type 2)|interpro:IPR013014(Phosphotransferase system, EIIC component, type 2)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR029503|interpro:IPR036095|rcsb pdb:1A3A|rcsb pdb:1J6T|rcsb pdb:1VKR|rcsb pdb:1VRV|rcsb pdb:2FEW|dip:DIP-10267N|mint:MINT-720044(identity) - function:"General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III)"|comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:In the xray complex 1j6t, P00550 is chain A and P07006 is chain B Resolution|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/02/12 2014/10/16 rogid:PclWk4uLFrEfcs8pGZ3juGqwvzc83334 rogid:HEPisuXtMZqLfWnS+ZsWKuqhZwo83333 intact-crc:102581BC18E64533|rigid:ZuIkYv+0eYmXDma6M7VjqHSJxCQ false tag:?-?(MINT-720052) tag:?-?(MINT-720045) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)