#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P52486	uniprotkb:Q9W196	intact:EBI-224571|uniprotkb:P91633|ensemblmetazoa:FBpp0076124|ensemblmetazoa:FBpp0311672|ensemblmetazoa:FBpp0311673	intact:EBI-128216|ensemblmetazoa:FBpp0072169	psi-mi:ubcd4_drome(display_long)|uniprotkb:Ubiquitin-protein ligase(gene name synonym)|uniprotkb:CG8284(orf name)|uniprotkb:Ubc4(gene name)|psi-mi:Ubc4(display_short)|uniprotkb:E2 ubiquitin-conjugating enzyme 4(gene name synonym)|uniprotkb:UbcD4(gene name synonym)|uniprotkb:Ubiquitin carrier protein(gene name synonym)	psi-mi:q9w196_drome(display_long)|uniprotkb:Dmel\CG3356(gene name)|psi-mi:Dmel\CG3356(display_short)|uniprotkb:CG3356(orf name)|uniprotkb:Dmel_CG3356(orf name)	psi-mi:"MI:0018"(two hybrid)	Canning et al. (2002)	pubmed:11862484	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-447980	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287013.1|refseq:NP_001287014.1|refseq:NP_524010.2|flybase:FBgn0015321|dip:DIP-20847N|ensemblmetazoa:FBgn0015321(gene)|ensemblmetazoa:FBtr0076395(transcript)|ensemblmetazoa:FBtr0345603(transcript)|ensemblmetazoa:FBtr0345604(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070628"(proteasome binding)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|interpro:IPR042614|reactome:R-DME-8866652|reactome:R-DME-983168	refseq:NP_611896.1|flybase:FBgn0034989|ensemblmetazoa:FBgn0034989(gene)|ensemblmetazoa:FBtr0072262(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000569(HECT)|interpro:IPR035983|interpro:IPR044611|reactome:R-DME-983168|go:"GO:0061630"(ubiquitin protein ligase activity)	-	-	-	comment:Authors have been unable to demonstrate co-immunoprecipitation of UbcD4 and CG3356 proteins in S2 cells so the significance of this Y2H interaction is not clear.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/10/11	2014/10/16	rogid:gbh56rl2Ssz/gQrKjx2HazwwKwo7227	rogid:m3oBILqKGuUrayRALcLzgOGnuJc7227	intact-crc:F960F276525040FD|rigid:qtIehh09jm25dDOwQWDQbV2x7pg	false	-	-	-	-	psi-mi:"MI:0056"(full identification by DNA sequencing)	psi-mi:"MI:0056"(full identification by DNA sequencing)
uniprotkb:P55035	uniprotkb:P52486	intact:EBI-146479|uniprotkb:Q86R87|uniprotkb:Q9V473|ensemblmetazoa:FBpp0078024|ensemblmetazoa:FBpp0305644	intact:EBI-224571|uniprotkb:P91633|ensemblmetazoa:FBpp0076124|ensemblmetazoa:FBpp0311672|ensemblmetazoa:FBpp0311673	psi-mi:psmd4_drome(display_long)|uniprotkb:Rpn10(gene name)|psi-mi:Rpn10(display_short)|uniprotkb:26S proteasome regulatory subunit RPN10(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S5A(gene name synonym)|uniprotkb:54 kDa subunit of mu particle(gene name synonym)|uniprotkb:Multiubiquitin chain-binding protein(gene name synonym)|uniprotkb:PROS-54(gene name synonym)|uniprotkb:Pros54(gene name synonym)|uniprotkb:p54(gene name synonym)|uniprotkb:CG7619(orf name)	psi-mi:ubcd4_drome(display_long)|uniprotkb:Ubiquitin-protein ligase(gene name synonym)|uniprotkb:CG8284(orf name)|uniprotkb:Ubc4(gene name)|psi-mi:Ubc4(display_short)|uniprotkb:E2 ubiquitin-conjugating enzyme 4(gene name synonym)|uniprotkb:UbcD4(gene name synonym)|uniprotkb:Ubiquitin carrier protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Canning et al. (2002)	pubmed:11862484	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-448008	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524204.1|flybase:FBgn0015283|refseq:NP_001262168.1|dip:DIP-22777N|ensemblmetazoa:FBgn0015283(gene)|ensemblmetazoa:FBtr0078368(transcript)|ensemblmetazoa:FBtr0333453(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR036465|reactome:R-DME-1169091|reactome:R-DME-1234176|reactome:R-DME-1236978|reactome:R-DME-174084|reactome:R-DME-174154|reactome:R-DME-174178|reactome:R-DME-174184|reactome:R-DME-187577|reactome:R-DME-195253|reactome:R-DME-202424|reactome:R-DME-209360|reactome:R-DME-209406|reactome:R-DME-209461|reactome:R-DME-216167|reactome:R-DME-2467813|reactome:R-DME-2871837|reactome:R-DME-350562|reactome:R-DME-382556|reactome:R-DME-432395|reactome:R-DME-432524|reactome:R-DME-432626|reactome:R-DME-450408|reactome:R-DME-4608870|reactome:R-DME-4641257|reactome:R-DME-4641258|reactome:R-DME-5358346|reactome:R-DME-538864|reactome:R-DME-5607761|reactome:R-DME-5607764|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5632684|reactome:R-DME-5668541|reactome:R-DME-5676590|reactome:R-DME-5687128|reactome:R-DME-5689603|reactome:R-DME-5689880|reactome:R-DME-68827|reactome:R-DME-68949|reactome:R-DME-69017|reactome:R-DME-69601|reactome:R-DME-75815|reactome:R-DME-8854050|reactome:R-DME-8932339|reactome:R-DME-8939236|reactome:R-DME-8941858|reactome:R-DME-8948751|reactome:R-DME-8951664|reactome:R-DME-9020702|reactome:R-DME-983168|reactome:R-DME-8939902	refseq:NP_001287013.1|refseq:NP_001287014.1|refseq:NP_524010.2|flybase:FBgn0015321|dip:DIP-20847N|ensemblmetazoa:FBgn0015321(gene)|ensemblmetazoa:FBtr0076395(transcript)|ensemblmetazoa:FBtr0345603(transcript)|ensemblmetazoa:FBtr0345604(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070628"(proteasome binding)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|interpro:IPR042614|reactome:R-DME-8866652|reactome:R-DME-983168	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/10/11	2014/10/16	rogid:6bY+j4is8NW2IQHx1lviY1+oTuk7227	rogid:gbh56rl2Ssz/gQrKjx2HazwwKwo7227	intact-crc:7F29FDD69D05607A|rigid:Pt8yWKF2jIolcsUhVpXQuscSPus	false	-	-	-	-	psi-mi:"MI:0056"(full identification by DNA sequencing)	psi-mi:"MI:0056"(full identification by DNA sequencing)
uniprotkb:P52486	uniprotkb:P55035	intact:EBI-224571|uniprotkb:P91633|ensemblmetazoa:FBpp0076124|ensemblmetazoa:FBpp0311672|ensemblmetazoa:FBpp0311673	intact:EBI-146479|uniprotkb:Q86R87|uniprotkb:Q9V473|ensemblmetazoa:FBpp0078024|ensemblmetazoa:FBpp0305644	psi-mi:ubcd4_drome(display_long)|uniprotkb:Ubiquitin-protein ligase(gene name synonym)|uniprotkb:CG8284(orf name)|uniprotkb:Ubc4(gene name)|psi-mi:Ubc4(display_short)|uniprotkb:E2 ubiquitin-conjugating enzyme 4(gene name synonym)|uniprotkb:UbcD4(gene name synonym)|uniprotkb:Ubiquitin carrier protein(gene name synonym)	psi-mi:psmd4_drome(display_long)|uniprotkb:Rpn10(gene name)|psi-mi:Rpn10(display_short)|uniprotkb:26S proteasome regulatory subunit RPN10(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S5A(gene name synonym)|uniprotkb:54 kDa subunit of mu particle(gene name synonym)|uniprotkb:Multiubiquitin chain-binding protein(gene name synonym)|uniprotkb:PROS-54(gene name synonym)|uniprotkb:Pros54(gene name synonym)|uniprotkb:p54(gene name synonym)|uniprotkb:CG7619(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Canning et al. (2002)	pubmed:11862484	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-448022	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287013.1|refseq:NP_001287014.1|refseq:NP_524010.2|flybase:FBgn0015321|dip:DIP-20847N|ensemblmetazoa:FBgn0015321(gene)|ensemblmetazoa:FBtr0076395(transcript)|ensemblmetazoa:FBtr0345603(transcript)|ensemblmetazoa:FBtr0345604(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070628"(proteasome binding)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|interpro:IPR042614|reactome:R-DME-8866652|reactome:R-DME-983168	refseq:NP_524204.1|flybase:FBgn0015283|refseq:NP_001262168.1|dip:DIP-22777N|ensemblmetazoa:FBgn0015283(gene)|ensemblmetazoa:FBtr0078368(transcript)|ensemblmetazoa:FBtr0333453(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR036465|reactome:R-DME-1169091|reactome:R-DME-1234176|reactome:R-DME-1236978|reactome:R-DME-174084|reactome:R-DME-174154|reactome:R-DME-174178|reactome:R-DME-174184|reactome:R-DME-187577|reactome:R-DME-195253|reactome:R-DME-202424|reactome:R-DME-209360|reactome:R-DME-209406|reactome:R-DME-209461|reactome:R-DME-216167|reactome:R-DME-2467813|reactome:R-DME-2871837|reactome:R-DME-350562|reactome:R-DME-382556|reactome:R-DME-432395|reactome:R-DME-432524|reactome:R-DME-432626|reactome:R-DME-450408|reactome:R-DME-4608870|reactome:R-DME-4641257|reactome:R-DME-4641258|reactome:R-DME-5358346|reactome:R-DME-538864|reactome:R-DME-5607761|reactome:R-DME-5607764|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5632684|reactome:R-DME-5668541|reactome:R-DME-5676590|reactome:R-DME-5687128|reactome:R-DME-5689603|reactome:R-DME-5689880|reactome:R-DME-68827|reactome:R-DME-68949|reactome:R-DME-69017|reactome:R-DME-69601|reactome:R-DME-75815|reactome:R-DME-8854050|reactome:R-DME-8932339|reactome:R-DME-8939236|reactome:R-DME-8941858|reactome:R-DME-8948751|reactome:R-DME-8951664|reactome:R-DME-9020702|reactome:R-DME-983168|reactome:R-DME-8939902	-	-	-	-	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2004/10/11	2014/10/16	rogid:gbh56rl2Ssz/gQrKjx2HazwwKwo7227	rogid:6bY+j4is8NW2IQHx1lviY1+oTuk7227	intact-crc:3864D3CB050015DA|rigid:Pt8yWKF2jIolcsUhVpXQuscSPus	false	uncategorized protein modification:n-n|radiolabel:?-?	v5 tag:c-c|uncategorized protein modification:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)