#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9JLH6 uniprotkb:Q28199 intact:EBI-307800|ensembl:ENSRNOP00000021418 intact:EBI-307814|uniprotkb:Q0II69|uniprotkb:Q28865|uniprotkb:Q29462|ensembl:ENSBTAP00000052270 psi-mi:ck5p1_rat(display_long)|uniprotkb:Cdk5rap1(gene name)|psi-mi:Cdk5rap1(display_short)|uniprotkb:CDK5 activator-binding protein C42(gene name synonym)|uniprotkb:CDK5 regulatory subunit-associated protein 1(gene name synonym)|uniprotkb:mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase(gene name synonym)|uniprotkb:"mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase"(gene name synonym) psi-mi:cd5r1_bovin(display_long)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ching et al. (2000) pubmed:10721722 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-307828 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:708387|refseq:NP_663773.1|ensembl:ENSRNOG00000015696(gene)|ensembl:ENSRNOT00000021418(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007420"(brain development)|go:"GO:0035597"(N6-isopentenyladenosine methylthiotransferase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0070900"(mitochondrial tRNA modification)|interpro:IPR002792(Deoxyribonuclease/rho motif-related TRAM)|interpro:IPR005839(Protein of unknown function UPF0004)|interpro:IPR006463("tRNA-i(6)A37 modification enzyme MiaB")|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013848(Protein of unknown function UPF0004, N-terminal)|interpro:IPR020612|interpro:IPR023404|interpro:IPR038135|refseq:XP_006235369.1 go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|ensembl:ENSBTAG00000004475(gene)|ensembl:ENSBTAT00000056064(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0002020"(protease binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016301"(kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|reactome:R-BTA-399956|reactome:R-BTA-6804756|refseq:NP_776937.2 go:"GO:0045664"(regulation of neuron differentiation) - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/04/21 2014/10/16 rogid:0AIOH8RP8fyrZGQQLEikVTNC+yw10116 rogid:r9TF1JLenz6Wq8eP4HFLnskLGu09913 intact-crc:E0A0D322A0C83458|rigid:etvxZAQYk2h6Uq6tTvENRGjio8U false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9JLH5 uniprotkb:Q28199 intact:EBI-307832|uniprotkb:K7QQW0 intact:EBI-307814|uniprotkb:Q0II69|uniprotkb:Q28865|uniprotkb:Q29462|ensembl:ENSBTAP00000052270 psi-mi:ck5p2_rat(display_long)|uniprotkb:Cdk5rap2(gene name)|psi-mi:Cdk5rap2(display_short)|uniprotkb:CDK5 activator-binding protein C48(gene name synonym) psi-mi:cd5r1_bovin(display_long)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ching et al. (2000) pubmed:10721722 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-307840 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:708451|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000976"(transcription cis-regulatory region binding)|interpro:IPR012943(Spindle associated) go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|ensembl:ENSBTAG00000004475(gene)|ensembl:ENSBTAT00000056064(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0002020"(protease binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016301"(kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|reactome:R-BTA-399956|reactome:R-BTA-6804756|refseq:NP_776937.2 go:"GO:0045664"(regulation of neuron differentiation) - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/04/21 2018/03/08 rogid:AUM66comLnZl6YEJorF89up+gAo10116 rogid:r9TF1JLenz6Wq8eP4HFLnskLGu09913 intact-crc:F142C10D70CAC976|rigid:aTOaE4TrccTuBj1HynmptDycHlw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9JLH7 uniprotkb:Q28199 intact:EBI-307845 intact:EBI-307814|uniprotkb:Q0II69|uniprotkb:Q28865|uniprotkb:Q29462|ensembl:ENSBTAP00000052270 psi-mi:ck5p3_rat(display_long)|uniprotkb:Cdk5rap3(gene name)|psi-mi:Cdk5rap3(display_short)|uniprotkb:CDK5 activator-binding protein C53(gene name synonym) psi-mi:cd5r1_bovin(display_long)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ching et al. (2000) pubmed:10721722 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-307855 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR008491(Protein of unknown function DUF773)|rgd:620002|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0001889"(liver development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010921"(regulation of phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0071569"(protein ufmylation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1903363"(negative regulation of cellular protein catabolic process) go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|ensembl:ENSBTAG00000004475(gene)|ensembl:ENSBTAT00000056064(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0002020"(protease binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016301"(kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|reactome:R-BTA-399956|reactome:R-BTA-6804756|refseq:NP_776937.2 go:"GO:0045664"(regulation of neuron differentiation) - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/04/21 2014/10/16 rogid:NByIIIZDrcnUq199ofAknxV/u+s10116 rogid:r9TF1JLenz6Wq8eP4HFLnskLGu09913 intact-crc:EFFEDD3810C99F42|rigid:G3N6kMm2UjsptSxipCjA2CV/wYI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9JLH6 uniprotkb:Q02399 intact:EBI-307800|ensembl:ENSRNOP00000021418 intact:EBI-307876|uniprotkb:Q0VCN5|uniprotkb:Q6LBE2|ensembl:ENSBTAP00000010212 psi-mi:ck5p1_rat(display_long)|uniprotkb:Cdk5rap1(gene name)|psi-mi:Cdk5rap1(display_short)|uniprotkb:CDK5 activator-binding protein C42(gene name synonym)|uniprotkb:CDK5 regulatory subunit-associated protein 1(gene name synonym)|uniprotkb:mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase(gene name synonym)|uniprotkb:"mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase"(gene name synonym) psi-mi:cdk5_bovin(display_long)|uniprotkb:CDK5(gene name)|psi-mi:CDK5(display_short)|uniprotkb:Cell division protein kinase 5(gene name synonym)|uniprotkb:Tau protein kinase II catalytic subunit(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PSSALRE(gene name synonym)|uniprotkb:Proline-directed protein kinase 33 kDa subunit(gene name synonym)|uniprotkb:CDKN5(gene name synonym) psi-mi:"MI:0096"(pull down) Ching et al. (2000) pubmed:10721722 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-307861 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:708387|refseq:NP_663773.1|ensembl:ENSRNOG00000015696(gene)|ensembl:ENSRNOT00000021418(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007420"(brain development)|go:"GO:0035597"(N6-isopentenyladenosine methylthiotransferase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0070900"(mitochondrial tRNA modification)|interpro:IPR002792(Deoxyribonuclease/rho motif-related TRAM)|interpro:IPR005839(Protein of unknown function UPF0004)|interpro:IPR006463("tRNA-i(6)A37 modification enzyme MiaB")|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013848(Protein of unknown function UPF0004, N-terminal)|interpro:IPR020612|interpro:IPR023404|interpro:IPR038135|refseq:XP_006235369.1 ensembl:ENSBTAG00000007766(gene)|ensembl:ENSBTAT00000010212(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008542"(visual learning)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016477"(cell migration)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031914"(negative regulation of synaptic plasticity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035173"(histone kinase activity)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043204"(perikaryon)|go:"GO:0022038"(corpus callosum development)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070509"(calcium ion import)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-BTA-399956|reactome:R-BTA-6804756|refseq:NP_776442.1 go:"GO:0045664"(regulation of neuron differentiation) - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/04/21 2014/10/16 rogid:0AIOH8RP8fyrZGQQLEikVTNC+yw10116 rogid:mFzCd7zhLyXpxPDQwc1xXCraDQI9913 intact-crc:333452B444A732F6|rigid:vAWZB+3oEtIXTSvjxDNGulj4rvk false glutathione s tranferase tag:?-? - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q9JLH6 uniprotkb:Q28199 intact:EBI-307800|ensembl:ENSRNOP00000021418 intact:EBI-307814|uniprotkb:Q0II69|uniprotkb:Q28865|uniprotkb:Q29462|ensembl:ENSBTAP00000052270 psi-mi:ck5p1_rat(display_long)|uniprotkb:Cdk5rap1(gene name)|psi-mi:Cdk5rap1(display_short)|uniprotkb:CDK5 activator-binding protein C42(gene name synonym)|uniprotkb:CDK5 regulatory subunit-associated protein 1(gene name synonym)|uniprotkb:mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase(gene name synonym)|uniprotkb:"mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase"(gene name synonym) psi-mi:cd5r1_bovin(display_long)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym) psi-mi:"MI:0096"(pull down) Ching et al. (2000) pubmed:10721722 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-307861 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:708387|refseq:NP_663773.1|ensembl:ENSRNOG00000015696(gene)|ensembl:ENSRNOT00000021418(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007420"(brain development)|go:"GO:0035597"(N6-isopentenyladenosine methylthiotransferase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0070900"(mitochondrial tRNA modification)|interpro:IPR002792(Deoxyribonuclease/rho motif-related TRAM)|interpro:IPR005839(Protein of unknown function UPF0004)|interpro:IPR006463("tRNA-i(6)A37 modification enzyme MiaB")|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013848(Protein of unknown function UPF0004, N-terminal)|interpro:IPR020612|interpro:IPR023404|interpro:IPR038135|refseq:XP_006235369.1 go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|ensembl:ENSBTAG00000004475(gene)|ensembl:ENSBTAT00000056064(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0002020"(protease binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016301"(kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|reactome:R-BTA-399956|reactome:R-BTA-6804756|refseq:NP_776937.2 go:"GO:0045664"(regulation of neuron differentiation) - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/04/21 2014/10/16 rogid:0AIOH8RP8fyrZGQQLEikVTNC+yw10116 rogid:r9TF1JLenz6Wq8eP4HFLnskLGu09913 intact-crc:333452B444A732F6|rigid:vAWZB+3oEtIXTSvjxDNGulj4rvk false glutathione s tranferase tag:?-? - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q9JLH5 uniprotkb:Q02399 intact:EBI-307832|uniprotkb:K7QQW0 intact:EBI-307876|uniprotkb:Q0VCN5|uniprotkb:Q6LBE2|ensembl:ENSBTAP00000010212 psi-mi:ck5p2_rat(display_long)|uniprotkb:Cdk5rap2(gene name)|psi-mi:Cdk5rap2(display_short)|uniprotkb:CDK5 activator-binding protein C48(gene name synonym) psi-mi:cdk5_bovin(display_long)|uniprotkb:CDK5(gene name)|psi-mi:CDK5(display_short)|uniprotkb:Cell division protein kinase 5(gene name synonym)|uniprotkb:Tau protein kinase II catalytic subunit(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PSSALRE(gene name synonym)|uniprotkb:Proline-directed protein kinase 33 kDa subunit(gene name synonym)|uniprotkb:CDKN5(gene name synonym) psi-mi:"MI:0096"(pull down) Ching et al. (2000) pubmed:10721722 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-307892 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:708451|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000976"(transcription cis-regulatory region binding)|interpro:IPR012943(Spindle associated) ensembl:ENSBTAG00000007766(gene)|ensembl:ENSBTAT00000010212(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008542"(visual learning)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016477"(cell migration)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031914"(negative regulation of synaptic plasticity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035173"(histone kinase activity)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043204"(perikaryon)|go:"GO:0022038"(corpus callosum development)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070509"(calcium ion import)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-BTA-399956|reactome:R-BTA-6804756|refseq:NP_776442.1 go:"GO:0045664"(regulation of neuron differentiation) - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/04/21 2018/03/08 rogid:AUM66comLnZl6YEJorF89up+gAo10116 rogid:mFzCd7zhLyXpxPDQwc1xXCraDQI9913 intact-crc:30FA4F6558692F26|rigid:lWV7hUtqpLpYNXQ60q9m2rPooFc false glutathione s tranferase tag:?-? - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q9JLH5 uniprotkb:Q28199 intact:EBI-307832|uniprotkb:K7QQW0 intact:EBI-307814|uniprotkb:Q0II69|uniprotkb:Q28865|uniprotkb:Q29462|ensembl:ENSBTAP00000052270 psi-mi:ck5p2_rat(display_long)|uniprotkb:Cdk5rap2(gene name)|psi-mi:Cdk5rap2(display_short)|uniprotkb:CDK5 activator-binding protein C48(gene name synonym) psi-mi:cd5r1_bovin(display_long)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym) psi-mi:"MI:0096"(pull down) Ching et al. (2000) pubmed:10721722 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-307892 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:708451|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000976"(transcription cis-regulatory region binding)|interpro:IPR012943(Spindle associated) go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|ensembl:ENSBTAG00000004475(gene)|ensembl:ENSBTAT00000056064(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0002020"(protease binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016301"(kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|reactome:R-BTA-399956|reactome:R-BTA-6804756|refseq:NP_776937.2 go:"GO:0045664"(regulation of neuron differentiation) - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/04/21 2018/03/08 rogid:AUM66comLnZl6YEJorF89up+gAo10116 rogid:r9TF1JLenz6Wq8eP4HFLnskLGu09913 intact-crc:30FA4F6558692F26|rigid:lWV7hUtqpLpYNXQ60q9m2rPooFc false glutathione s tranferase tag:?-? - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q9JLH7 uniprotkb:Q02399 intact:EBI-307845 intact:EBI-307876|uniprotkb:Q0VCN5|uniprotkb:Q6LBE2|ensembl:ENSBTAP00000010212 psi-mi:ck5p3_rat(display_long)|uniprotkb:Cdk5rap3(gene name)|psi-mi:Cdk5rap3(display_short)|uniprotkb:CDK5 activator-binding protein C53(gene name synonym) psi-mi:cdk5_bovin(display_long)|uniprotkb:CDK5(gene name)|psi-mi:CDK5(display_short)|uniprotkb:Cell division protein kinase 5(gene name synonym)|uniprotkb:Tau protein kinase II catalytic subunit(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PSSALRE(gene name synonym)|uniprotkb:Proline-directed protein kinase 33 kDa subunit(gene name synonym)|uniprotkb:CDKN5(gene name synonym) psi-mi:"MI:0096"(pull down) Ching et al. (2000) pubmed:10721722 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-307897 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR008491(Protein of unknown function DUF773)|rgd:620002|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0001889"(liver development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010921"(regulation of phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0071569"(protein ufmylation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1903363"(negative regulation of cellular protein catabolic process) ensembl:ENSBTAG00000007766(gene)|ensembl:ENSBTAT00000010212(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008542"(visual learning)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016477"(cell migration)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031914"(negative regulation of synaptic plasticity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035173"(histone kinase activity)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043204"(perikaryon)|go:"GO:0022038"(corpus callosum development)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070509"(calcium ion import)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-BTA-399956|reactome:R-BTA-6804756|refseq:NP_776442.1 go:"GO:0045664"(regulation of neuron differentiation) - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/04/21 2014/10/16 rogid:NByIIIZDrcnUq199ofAknxV/u+s10116 rogid:mFzCd7zhLyXpxPDQwc1xXCraDQI9913 intact-crc:3271A604B0E2C646|rigid:W7j2vVXgC4tsp7eA5vP7gxc3JiE false glutathione s tranferase tag:?-? - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q9JLH7 uniprotkb:Q28199 intact:EBI-307845 intact:EBI-307814|uniprotkb:Q0II69|uniprotkb:Q28865|uniprotkb:Q29462|ensembl:ENSBTAP00000052270 psi-mi:ck5p3_rat(display_long)|uniprotkb:Cdk5rap3(gene name)|psi-mi:Cdk5rap3(display_short)|uniprotkb:CDK5 activator-binding protein C53(gene name synonym) psi-mi:cd5r1_bovin(display_long)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym) psi-mi:"MI:0096"(pull down) Ching et al. (2000) pubmed:10721722 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-307897 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR008491(Protein of unknown function DUF773)|rgd:620002|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0001889"(liver development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010921"(regulation of phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0071569"(protein ufmylation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1903363"(negative regulation of cellular protein catabolic process) go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|ensembl:ENSBTAG00000004475(gene)|ensembl:ENSBTAT00000056064(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0002020"(protease binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016301"(kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|reactome:R-BTA-399956|reactome:R-BTA-6804756|refseq:NP_776937.2 go:"GO:0045664"(regulation of neuron differentiation) - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/04/21 2014/10/16 rogid:NByIIIZDrcnUq199ofAknxV/u+s10116 rogid:r9TF1JLenz6Wq8eP4HFLnskLGu09913 intact-crc:3271A604B0E2C646|rigid:W7j2vVXgC4tsp7eA5vP7gxc3JiE false glutathione s tranferase tag:?-? - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot)