#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P78560	uniprotkb:P42575	intact:EBI-520375|uniprotkb:B7Z2Q5|ensembl:ENSP00000327647|ensembl:ENSP00000439068	intact:EBI-520342|ensembl:ENSP00000312664|uniprotkb:P42576|uniprotkb:D3DXD6|uniprotkb:Q59F21|uniprotkb:Q7KZL6|uniprotkb:Q86UJ3|uniprotkb:Q9BUP7|uniprotkb:Q9BZK9|uniprotkb:A8K5F9|uniprotkb:E9PDN0|uniprotkb:Q9BZL0	psi-mi:cradd_human(display_long)|uniprotkb:Caspase and RIP adapter with death domain(gene name synonym)|uniprotkb:RIP-associated protein with a death domain(gene name synonym)|uniprotkb:CRADD(gene name)|psi-mi:CRADD(display_short)|uniprotkb:RAIDD(gene name synonym)	psi-mi:casp2_human(display_long)|uniprotkb:Protease ICH-1(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 2(gene name synonym)|uniprotkb:CASP2(gene name)|psi-mi:CASP2(display_short)|uniprotkb:ICH1(gene name synonym)|uniprotkb:NEDD2(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Duan et al. (1997)	mint:MINT-5221262|pubmed:8985253	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8668792|mint:MINT-17424	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003796.1|refseq:NP_001307029.1|refseq:NP_001307030.1|refseq:NP_001307028.1|refseq:XP_016875633.1|ensembl:ENSG00000169372(gene)|ensembl:ENST00000332896(transcript)|ensembl:ENST00000542893(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0070513"(death domain binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR037926|interpro:IPR037939|interpro:IPR042148|mint:P78560|rcsb pdb:2O71|rcsb pdb:2OF5|rcsb pdb:3CRD|reactome:R-HSA-6803207|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|mint:MINT-1520992(identity)	ensembl:ENSG00000106144(gene)|ensembl:ENST00000310447(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0003407"(neural retina development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR035702|rcsb pdb:1PYO|rcsb pdb:2P2C|rcsb pdb:3R5J|rcsb pdb:3R6G|rcsb pdb:3R6L|rcsb pdb:3R7B|rcsb pdb:3R7N|refseq:NP_001215.1|refseq:NP_116764.2|refseq:NP_116765.2|rcsb pdb:3R7S|rcsb pdb:3RJM|rcsb pdb:6GKF|rcsb pdb:6GKG|rcsb pdb:6S9K|rcsb pdb:6SAD|rcsb pdb:6Y8B|rcsb pdb:6Y8D|reactome:R-HSA-168638|reactome:R-HSA-205025|reactome:R-HSA-6803207|mint:MINT-1520995(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/09/17	2014/10/16	rogid:koYvv+L+23G4lMEFIFmYYBNaNkk9606	rogid:3WFvmDoYbW3J84Yd9RVGAOcR8ig9606	intact-crc:3EAF862A647FBF49|rigid:7tMjpEY+9Ja3G5UfWjSyrvSMq1Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)