#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q07889	uniprotkb:Q15811	intact:EBI-297487|intact:EBI-28968641|uniprotkb:A8K2G3|ensembl:ENSP00000384675|uniprotkb:B4DXG2	intact:EBI-602041|uniprotkb:B4DTM2|uniprotkb:O95216|uniprotkb:Q9UET5|uniprotkb:Q9UK60|uniprotkb:Q9UNK1|uniprotkb:Q9UNK2|uniprotkb:Q9UQ92|uniprotkb:Q1ED40|uniprotkb:Q0PW97|uniprotkb:E7ERJ1|uniprotkb:Q14BD3|uniprotkb:Q20BK3|intact:EBI-11029034|uniprotkb:A7Y322|uniprotkb:A8CTX8|uniprotkb:A8CTY3|uniprotkb:A8CTY7|uniprotkb:A8D7D0|uniprotkb:A8DCP3|uniprotkb:E9PE44|uniprotkb:E9PG01|uniprotkb:E9PHV2|uniprotkb:Q0PW94|uniprotkb:Q0PW95|intact:EBI-28971797|ensembl:ENSP00000370719	psi-mi:sos1_human(display_long)|uniprotkb:SOS1(gene name)|psi-mi:SOS1(display_short)	psi-mi:itsn1_human(display_long)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)	psi-mi:"MI:0045"(experimental interaction detection)	Tong et al. (2000)	pubmed:10716926|mint:MINT-5212328	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7222790|mint:MINT-16775	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005624.2|ensembl:ENSP00000384675|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9013149|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|ensembl:ENSG00000115904(gene)|ensembl:ENST00000402219(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001942"(hair follicle development)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:1904693"(midbrain morphogenesis)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005737"(cytoplasm)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|mint:Q07889|rcsb pdb:1AWE|rcsb pdb:1BKD|rcsb pdb:1DBH|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1Q9C|rcsb pdb:1XD2|rcsb pdb:1XD4|rcsb pdb:1XDV|rcsb pdb:2II0|rcsb pdb:3KSY|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:5OVD|rcsb pdb:5OVE|rcsb pdb:5OVF|rcsb pdb:5OVG|rcsb pdb:5OVH|rcsb pdb:5OVI|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F08|rcsb pdb:6SCM|rcsb pdb:6SFR|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6Y44|rcsb pdb:7AVI|rcsb pdb:7AVL|rcsb pdb:7AVS|rcsb pdb:7AVT|rcsb pdb:7AVU|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|rcsb pdb:7AVV|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-193648|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-416482|reactome:R-HSA-428540|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|dip:DIP-31802N|mint:MINT-1716969(identity)	ensembl:ENST00000381291|ensembl:ENSP00000370691|ensembl:ENSP00000370719|ensembl:ENST00000399338|ensembl:ENSP00000382275|ensembl:ENST00000399349|ensembl:ENSP00000382286|ensembl:ENSP00000382289|ensembl:ENST00000399353|ensembl:ENSP00000382290|ensembl:ENST00000399367|ensembl:ENSP00000382301|ensembl:ENST00000399352|refseq:NP_001001132.1|refseq:NP_003015.2|refseq:XP_011527994.1|refseq:XP_011527995.1|refseq:NP_001317938.1|refseq:NP_001317939.1|refseq:NP_001317940.1|refseq:NP_001317941.1|refseq:XP_016883917.1|refseq:XP_016883921.1|refseq:XP_016883922.1|refseq:XP_016883929.1|dip:DIP-33609N|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381318(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q15811|rcsb pdb:1KI1|rcsb pdb:2KGR|rcsb pdb:2KHN|rcsb pdb:3FIA|rcsb pdb:3QBV|rcsb pdb:4IIM|rcsb pdb:5HZI|rcsb pdb:5HZJ|rcsb pdb:5HZK|rcsb pdb:6GBU|rcsb pdb:6H5T|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416482|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013408|mint:MINT-1716962(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2002/09/06	2014/10/16	rogid:SPXIrLMDF+XVcqKxBFgWsRGCFw89606	rogid:gYC3xiyk4dbnCXhZ8Rzn3rzafyU9606	intact-crc:AB6CD83FA723DD11|rigid:CPbEkwtBgHn6k2KrIXCuZKp7G14	false	binding-associated region:1148-1161(MINT-1716970)	binding-associated region:740-806(MINT-1716963)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07889	uniprotkb:Q15811	intact:EBI-297487|intact:EBI-28968641|uniprotkb:A8K2G3|ensembl:ENSP00000384675|uniprotkb:B4DXG2	intact:EBI-602041|uniprotkb:B4DTM2|uniprotkb:O95216|uniprotkb:Q9UET5|uniprotkb:Q9UK60|uniprotkb:Q9UNK1|uniprotkb:Q9UNK2|uniprotkb:Q9UQ92|uniprotkb:Q1ED40|uniprotkb:Q0PW97|uniprotkb:E7ERJ1|uniprotkb:Q14BD3|uniprotkb:Q20BK3|intact:EBI-11029034|uniprotkb:A7Y322|uniprotkb:A8CTX8|uniprotkb:A8CTY3|uniprotkb:A8CTY7|uniprotkb:A8D7D0|uniprotkb:A8DCP3|uniprotkb:E9PE44|uniprotkb:E9PG01|uniprotkb:E9PHV2|uniprotkb:Q0PW94|uniprotkb:Q0PW95|intact:EBI-28971797|ensembl:ENSP00000370719	psi-mi:sos1_human(display_long)|uniprotkb:SOS1(gene name)|psi-mi:SOS1(display_short)	psi-mi:itsn1_human(display_long)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)	psi-mi:"MI:0045"(experimental interaction detection)	Tong et al. (2000)	pubmed:10716926|mint:MINT-5212328	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7222810|mint:MINT-14434	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005624.2|ensembl:ENSP00000384675|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9013149|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|ensembl:ENSG00000115904(gene)|ensembl:ENST00000402219(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001942"(hair follicle development)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:1904693"(midbrain morphogenesis)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005737"(cytoplasm)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|mint:Q07889|rcsb pdb:1AWE|rcsb pdb:1BKD|rcsb pdb:1DBH|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1Q9C|rcsb pdb:1XD2|rcsb pdb:1XD4|rcsb pdb:1XDV|rcsb pdb:2II0|rcsb pdb:3KSY|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:5OVD|rcsb pdb:5OVE|rcsb pdb:5OVF|rcsb pdb:5OVG|rcsb pdb:5OVH|rcsb pdb:5OVI|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F08|rcsb pdb:6SCM|rcsb pdb:6SFR|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6Y44|rcsb pdb:7AVI|rcsb pdb:7AVL|rcsb pdb:7AVS|rcsb pdb:7AVT|rcsb pdb:7AVU|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|rcsb pdb:7AVV|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-193648|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-416482|reactome:R-HSA-428540|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|dip:DIP-31802N|mint:MINT-1716985(identity)	ensembl:ENST00000381291|ensembl:ENSP00000370691|ensembl:ENSP00000370719|ensembl:ENST00000399338|ensembl:ENSP00000382275|ensembl:ENST00000399349|ensembl:ENSP00000382286|ensembl:ENSP00000382289|ensembl:ENST00000399353|ensembl:ENSP00000382290|ensembl:ENST00000399367|ensembl:ENSP00000382301|ensembl:ENST00000399352|refseq:NP_001001132.1|refseq:NP_003015.2|refseq:XP_011527994.1|refseq:XP_011527995.1|refseq:NP_001317938.1|refseq:NP_001317939.1|refseq:NP_001317940.1|refseq:NP_001317941.1|refseq:XP_016883917.1|refseq:XP_016883921.1|refseq:XP_016883922.1|refseq:XP_016883929.1|dip:DIP-33609N|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381318(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q15811|rcsb pdb:1KI1|rcsb pdb:2KGR|rcsb pdb:2KHN|rcsb pdb:3FIA|rcsb pdb:3QBV|rcsb pdb:4IIM|rcsb pdb:5HZI|rcsb pdb:5HZJ|rcsb pdb:5HZK|rcsb pdb:6GBU|rcsb pdb:6H5T|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416482|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013408|mint:MINT-1716978(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2002/09/06	2014/10/16	rogid:SPXIrLMDF+XVcqKxBFgWsRGCFw89606	rogid:gYC3xiyk4dbnCXhZ8Rzn3rzafyU9606	intact-crc:451763DE6B79D21C|rigid:CPbEkwtBgHn6k2KrIXCuZKp7G14	false	binding-associated region:1208-1221(MINT-1716986)	binding-associated region:740-806(MINT-1716979)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15811	uniprotkb:Q07889	intact:EBI-602041|uniprotkb:B4DTM2|uniprotkb:O95216|uniprotkb:Q9UET5|uniprotkb:Q9UK60|uniprotkb:Q9UNK1|uniprotkb:Q9UNK2|uniprotkb:Q9UQ92|uniprotkb:Q1ED40|uniprotkb:Q0PW97|uniprotkb:E7ERJ1|uniprotkb:Q14BD3|uniprotkb:Q20BK3|intact:EBI-11029034|uniprotkb:A7Y322|uniprotkb:A8CTX8|uniprotkb:A8CTY3|uniprotkb:A8CTY7|uniprotkb:A8D7D0|uniprotkb:A8DCP3|uniprotkb:E9PE44|uniprotkb:E9PG01|uniprotkb:E9PHV2|uniprotkb:Q0PW94|uniprotkb:Q0PW95|intact:EBI-28971797|ensembl:ENSP00000370719	intact:EBI-297487|intact:EBI-28968641|uniprotkb:A8K2G3|ensembl:ENSP00000384675|uniprotkb:B4DXG2	psi-mi:itsn1_human(display_long)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)	psi-mi:sos1_human(display_long)|uniprotkb:SOS1(gene name)|psi-mi:SOS1(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Tong et al. (2000)	pubmed:10716926|mint:MINT-5212328	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7222870|mint:MINT-14435	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000381291|ensembl:ENSP00000370691|ensembl:ENSP00000370719|ensembl:ENST00000399338|ensembl:ENSP00000382275|ensembl:ENST00000399349|ensembl:ENSP00000382286|ensembl:ENSP00000382289|ensembl:ENST00000399353|ensembl:ENSP00000382290|ensembl:ENST00000399367|ensembl:ENSP00000382301|ensembl:ENST00000399352|refseq:NP_001001132.1|refseq:NP_003015.2|refseq:XP_011527994.1|refseq:XP_011527995.1|refseq:NP_001317938.1|refseq:NP_001317939.1|refseq:NP_001317940.1|refseq:NP_001317941.1|refseq:XP_016883917.1|refseq:XP_016883921.1|refseq:XP_016883922.1|refseq:XP_016883929.1|dip:DIP-33609N|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381318(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q15811|rcsb pdb:1KI1|rcsb pdb:2KGR|rcsb pdb:2KHN|rcsb pdb:3FIA|rcsb pdb:3QBV|rcsb pdb:4IIM|rcsb pdb:5HZI|rcsb pdb:5HZJ|rcsb pdb:5HZK|rcsb pdb:6GBU|rcsb pdb:6H5T|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416482|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013408|mint:MINT-1736847(identity)	refseq:NP_005624.2|ensembl:ENSP00000384675|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9013149|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|ensembl:ENSG00000115904(gene)|ensembl:ENST00000402219(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001942"(hair follicle development)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:1904693"(midbrain morphogenesis)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005737"(cytoplasm)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|mint:Q07889|rcsb pdb:1AWE|rcsb pdb:1BKD|rcsb pdb:1DBH|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1Q9C|rcsb pdb:1XD2|rcsb pdb:1XD4|rcsb pdb:1XDV|rcsb pdb:2II0|rcsb pdb:3KSY|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:5OVD|rcsb pdb:5OVE|rcsb pdb:5OVF|rcsb pdb:5OVG|rcsb pdb:5OVH|rcsb pdb:5OVI|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F08|rcsb pdb:6SCM|rcsb pdb:6SFR|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6Y44|rcsb pdb:7AVI|rcsb pdb:7AVL|rcsb pdb:7AVS|rcsb pdb:7AVT|rcsb pdb:7AVU|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|rcsb pdb:7AVV|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-193648|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-416482|reactome:R-HSA-428540|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|dip:DIP-31802N|mint:MINT-1736853(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/09/06	2014/10/16	rogid:gYC3xiyk4dbnCXhZ8Rzn3rzafyU9606	rogid:SPXIrLMDF+XVcqKxBFgWsRGCFw89606	intact-crc:94DD5AEC2B1FF751|rigid:CPbEkwtBgHn6k2KrIXCuZKp7G14	false	binding-associated region:740-806(MINT-1736848)	binding-associated region:1208-1221(MINT-1736854)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07889	uniprotkb:Q15811	intact:EBI-297487|intact:EBI-28968641|uniprotkb:A8K2G3|ensembl:ENSP00000384675|uniprotkb:B4DXG2	intact:EBI-602041|uniprotkb:B4DTM2|uniprotkb:O95216|uniprotkb:Q9UET5|uniprotkb:Q9UK60|uniprotkb:Q9UNK1|uniprotkb:Q9UNK2|uniprotkb:Q9UQ92|uniprotkb:Q1ED40|uniprotkb:Q0PW97|uniprotkb:E7ERJ1|uniprotkb:Q14BD3|uniprotkb:Q20BK3|intact:EBI-11029034|uniprotkb:A7Y322|uniprotkb:A8CTX8|uniprotkb:A8CTY3|uniprotkb:A8CTY7|uniprotkb:A8D7D0|uniprotkb:A8DCP3|uniprotkb:E9PE44|uniprotkb:E9PG01|uniprotkb:E9PHV2|uniprotkb:Q0PW94|uniprotkb:Q0PW95|intact:EBI-28971797|ensembl:ENSP00000370719	psi-mi:sos1_human(display_long)|uniprotkb:SOS1(gene name)|psi-mi:SOS1(display_short)	psi-mi:itsn1_human(display_long)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Tong et al. (2000)	pubmed:10716926|mint:MINT-5212328	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7222905|mint:MINT-16776	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005624.2|ensembl:ENSP00000384675|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9013149|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|ensembl:ENSG00000115904(gene)|ensembl:ENST00000402219(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001942"(hair follicle development)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:1904693"(midbrain morphogenesis)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005737"(cytoplasm)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|mint:Q07889|rcsb pdb:1AWE|rcsb pdb:1BKD|rcsb pdb:1DBH|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1Q9C|rcsb pdb:1XD2|rcsb pdb:1XD4|rcsb pdb:1XDV|rcsb pdb:2II0|rcsb pdb:3KSY|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:5OVD|rcsb pdb:5OVE|rcsb pdb:5OVF|rcsb pdb:5OVG|rcsb pdb:5OVH|rcsb pdb:5OVI|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F08|rcsb pdb:6SCM|rcsb pdb:6SFR|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6Y44|rcsb pdb:7AVI|rcsb pdb:7AVL|rcsb pdb:7AVS|rcsb pdb:7AVT|rcsb pdb:7AVU|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|rcsb pdb:7AVV|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-193648|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-416482|reactome:R-HSA-428540|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|dip:DIP-31802N|mint:MINT-1736883(identity)	ensembl:ENST00000381291|ensembl:ENSP00000370691|ensembl:ENSP00000370719|ensembl:ENST00000399338|ensembl:ENSP00000382275|ensembl:ENST00000399349|ensembl:ENSP00000382286|ensembl:ENSP00000382289|ensembl:ENST00000399353|ensembl:ENSP00000382290|ensembl:ENST00000399367|ensembl:ENSP00000382301|ensembl:ENST00000399352|refseq:NP_001001132.1|refseq:NP_003015.2|refseq:XP_011527994.1|refseq:XP_011527995.1|refseq:NP_001317938.1|refseq:NP_001317939.1|refseq:NP_001317940.1|refseq:NP_001317941.1|refseq:XP_016883917.1|refseq:XP_016883921.1|refseq:XP_016883922.1|refseq:XP_016883929.1|dip:DIP-33609N|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381318(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q15811|rcsb pdb:1KI1|rcsb pdb:2KGR|rcsb pdb:2KHN|rcsb pdb:3FIA|rcsb pdb:3QBV|rcsb pdb:4IIM|rcsb pdb:5HZI|rcsb pdb:5HZJ|rcsb pdb:5HZK|rcsb pdb:6GBU|rcsb pdb:6H5T|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416482|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013408|mint:MINT-1736877(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/09/06	2014/10/16	rogid:SPXIrLMDF+XVcqKxBFgWsRGCFw89606	rogid:gYC3xiyk4dbnCXhZ8Rzn3rzafyU9606	intact-crc:E6308591710811D5|rigid:CPbEkwtBgHn6k2KrIXCuZKp7G14	false	binding-associated region:1148-1161(MINT-1736884)	binding-associated region:740-806(MINT-1736878)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07889	uniprotkb:Q15811	intact:EBI-297487|intact:EBI-28968641|uniprotkb:A8K2G3|ensembl:ENSP00000384675|uniprotkb:B4DXG2	intact:EBI-602041|uniprotkb:B4DTM2|uniprotkb:O95216|uniprotkb:Q9UET5|uniprotkb:Q9UK60|uniprotkb:Q9UNK1|uniprotkb:Q9UNK2|uniprotkb:Q9UQ92|uniprotkb:Q1ED40|uniprotkb:Q0PW97|uniprotkb:E7ERJ1|uniprotkb:Q14BD3|uniprotkb:Q20BK3|intact:EBI-11029034|uniprotkb:A7Y322|uniprotkb:A8CTX8|uniprotkb:A8CTY3|uniprotkb:A8CTY7|uniprotkb:A8D7D0|uniprotkb:A8DCP3|uniprotkb:E9PE44|uniprotkb:E9PG01|uniprotkb:E9PHV2|uniprotkb:Q0PW94|uniprotkb:Q0PW95|intact:EBI-28971797|ensembl:ENSP00000370719	psi-mi:sos1_human(display_long)|uniprotkb:SOS1(gene name)|psi-mi:SOS1(display_short)	psi-mi:itsn1_human(display_long)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Tong et al. (2000)	pubmed:10716926|mint:MINT-5212328	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7222965|mint:MINT-14436	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005624.2|ensembl:ENSP00000384675|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9013149|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|ensembl:ENSG00000115904(gene)|ensembl:ENST00000402219(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001942"(hair follicle development)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:1904693"(midbrain morphogenesis)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005737"(cytoplasm)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|mint:Q07889|rcsb pdb:1AWE|rcsb pdb:1BKD|rcsb pdb:1DBH|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1Q9C|rcsb pdb:1XD2|rcsb pdb:1XD4|rcsb pdb:1XDV|rcsb pdb:2II0|rcsb pdb:3KSY|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:5OVD|rcsb pdb:5OVE|rcsb pdb:5OVF|rcsb pdb:5OVG|rcsb pdb:5OVH|rcsb pdb:5OVI|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F08|rcsb pdb:6SCM|rcsb pdb:6SFR|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6Y44|rcsb pdb:7AVI|rcsb pdb:7AVL|rcsb pdb:7AVS|rcsb pdb:7AVT|rcsb pdb:7AVU|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|rcsb pdb:7AVV|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-193648|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-416482|reactome:R-HSA-428540|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|dip:DIP-31802N|mint:MINT-1736869(identity)	ensembl:ENST00000381291|ensembl:ENSP00000370691|ensembl:ENSP00000370719|ensembl:ENST00000399338|ensembl:ENSP00000382275|ensembl:ENST00000399349|ensembl:ENSP00000382286|ensembl:ENSP00000382289|ensembl:ENST00000399353|ensembl:ENSP00000382290|ensembl:ENST00000399367|ensembl:ENSP00000382301|ensembl:ENST00000399352|refseq:NP_001001132.1|refseq:NP_003015.2|refseq:XP_011527994.1|refseq:XP_011527995.1|refseq:NP_001317938.1|refseq:NP_001317939.1|refseq:NP_001317940.1|refseq:NP_001317941.1|refseq:XP_016883917.1|refseq:XP_016883921.1|refseq:XP_016883922.1|refseq:XP_016883929.1|dip:DIP-33609N|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381318(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q15811|rcsb pdb:1KI1|rcsb pdb:2KGR|rcsb pdb:2KHN|rcsb pdb:3FIA|rcsb pdb:3QBV|rcsb pdb:4IIM|rcsb pdb:5HZI|rcsb pdb:5HZJ|rcsb pdb:5HZK|rcsb pdb:6GBU|rcsb pdb:6H5T|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416482|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013408|mint:MINT-1736863(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/09/06	2014/10/16	rogid:SPXIrLMDF+XVcqKxBFgWsRGCFw89606	rogid:gYC3xiyk4dbnCXhZ8Rzn3rzafyU9606	intact-crc:F431B7DD3B47B2D5|rigid:CPbEkwtBgHn6k2KrIXCuZKp7G14	false	binding-associated region:1208-1221(MINT-1736870)	binding-associated region:740-806(MINT-1736864)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07889	uniprotkb:Q15811	intact:EBI-297487|intact:EBI-28968641|uniprotkb:A8K2G3|ensembl:ENSP00000384675|uniprotkb:B4DXG2	intact:EBI-602041|uniprotkb:B4DTM2|uniprotkb:O95216|uniprotkb:Q9UET5|uniprotkb:Q9UK60|uniprotkb:Q9UNK1|uniprotkb:Q9UNK2|uniprotkb:Q9UQ92|uniprotkb:Q1ED40|uniprotkb:Q0PW97|uniprotkb:E7ERJ1|uniprotkb:Q14BD3|uniprotkb:Q20BK3|intact:EBI-11029034|uniprotkb:A7Y322|uniprotkb:A8CTX8|uniprotkb:A8CTY3|uniprotkb:A8CTY7|uniprotkb:A8D7D0|uniprotkb:A8DCP3|uniprotkb:E9PE44|uniprotkb:E9PG01|uniprotkb:E9PHV2|uniprotkb:Q0PW94|uniprotkb:Q0PW95|intact:EBI-28971797|ensembl:ENSP00000370719	psi-mi:sos1_human(display_long)|uniprotkb:SOS1(gene name)|psi-mi:SOS1(display_short)	psi-mi:itsn1_human(display_long)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Tong et al. (2000)	pubmed:10716926|mint:MINT-5212328	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7222985|mint:MINT-16777	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005624.2|ensembl:ENSP00000384675|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9013149|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|ensembl:ENSG00000115904(gene)|ensembl:ENST00000402219(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001942"(hair follicle development)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:1904693"(midbrain morphogenesis)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005737"(cytoplasm)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|mint:Q07889|rcsb pdb:1AWE|rcsb pdb:1BKD|rcsb pdb:1DBH|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1Q9C|rcsb pdb:1XD2|rcsb pdb:1XD4|rcsb pdb:1XDV|rcsb pdb:2II0|rcsb pdb:3KSY|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:5OVD|rcsb pdb:5OVE|rcsb pdb:5OVF|rcsb pdb:5OVG|rcsb pdb:5OVH|rcsb pdb:5OVI|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F08|rcsb pdb:6SCM|rcsb pdb:6SFR|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6Y44|rcsb pdb:7AVI|rcsb pdb:7AVL|rcsb pdb:7AVS|rcsb pdb:7AVT|rcsb pdb:7AVU|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|rcsb pdb:7AVV|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-193648|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-416482|reactome:R-HSA-428540|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|dip:DIP-31802N|mint:MINT-1736897(identity)	ensembl:ENST00000381291|ensembl:ENSP00000370691|ensembl:ENSP00000370719|ensembl:ENST00000399338|ensembl:ENSP00000382275|ensembl:ENST00000399349|ensembl:ENSP00000382286|ensembl:ENSP00000382289|ensembl:ENST00000399353|ensembl:ENSP00000382290|ensembl:ENST00000399367|ensembl:ENSP00000382301|ensembl:ENST00000399352|refseq:NP_001001132.1|refseq:NP_003015.2|refseq:XP_011527994.1|refseq:XP_011527995.1|refseq:NP_001317938.1|refseq:NP_001317939.1|refseq:NP_001317940.1|refseq:NP_001317941.1|refseq:XP_016883917.1|refseq:XP_016883921.1|refseq:XP_016883922.1|refseq:XP_016883929.1|dip:DIP-33609N|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381318(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q15811|rcsb pdb:1KI1|rcsb pdb:2KGR|rcsb pdb:2KHN|rcsb pdb:3FIA|rcsb pdb:3QBV|rcsb pdb:4IIM|rcsb pdb:5HZI|rcsb pdb:5HZJ|rcsb pdb:5HZK|rcsb pdb:6GBU|rcsb pdb:6H5T|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416482|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013408|mint:MINT-1736891(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/09/06	2014/10/16	rogid:SPXIrLMDF+XVcqKxBFgWsRGCFw89606	rogid:gYC3xiyk4dbnCXhZ8Rzn3rzafyU9606	intact-crc:A1C01967BA3DE28A|rigid:CPbEkwtBgHn6k2KrIXCuZKp7G14	false	binding-associated region:1148-1161(MINT-1736898)	binding-associated region:740-806(MINT-1736892)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)