IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells. AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells. Cell research 2021 imex curation Wang S., Qiu Z., Hou Y., Deng X., Xu W., Zheng T., Wu P., Xie S., Bian W., Zhang C., Sun Z., Liu K., Shan C., Lin A., Jiang S., Xie Y., Zhou Q., Lu L., Huang J., Li X. Virus - Publications including interactions involving viral proteins Coronavirus - Interactions investigated in the context of Coronavirus email sent:18/01/21:asking identity of TAP 22 "HC interactors"; NTDs for Spike + AXL; cell line for figure 4I;Figure 4F tags used. NO REPLY to email. The authors have stated that Spike NTD is 13-303. AXL NTD is 1-449. Figure 4F;constructs were MYC-tagged. The correct phrase should be: "The cells were fixed and subjected to immunofluorescence with an anti-MYC antibody against the indicated proteins (red)". Figure 4I: the cell line used was 293T. lul@fudan.edu.cn,huangjing@westlake.edu.cn,lixu@westlake.edu.cn 29-Mar-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-h1299 Homo sapiens lung lymph node carcinoma h1299 Human lung lymph node carcinoma p53 null. These cells have also been reported to secrete the peptide hormone neuromedin B (NMB), but not gastrin releasing peptide (GRP). Also known as NCI H1299 or CRL-5803. http://www.lgcpromochem.com/atcc/ ATCC number: CRL-5803. ATCC number of the cell line is CRL-5803. tap tandem affinity purification TAP TAP tap sequence tag sequence tag identification sequence tag Wang S., Qiu Z., Hou Y., Deng X., Xu W., Zheng T., Wu P., Xie S., Bian W., Zhang C., Sun Z., Liu K., Shan C., Lin A., Jiang S., Xie Y., Zhou Q., Lu L., Huang J., Li X. Virus - Publications including interactions involving viral proteins email sent:18/01/21:asking identity of TAP 22 "HC interactors"; NTDs for Spike + AXL; cell line for figure 4I;Figure 4F tags used. NO REPLY to email. The authors have stated that Spike NTD is 13-303. AXL NTD is 1-449. Figure 4F;constructs were MYC-tagged. The correct phrase should be: "The cells were fixed and subjected to immunofluorescence with an anti-MYC antibody against the indicated proteins (red)". Figure 4I: the cell line used was 293T. lul@fudan.edu.cn,huangjing@westlake.edu.cn,lixu@westlake.edu.cn Accepted 2021-JAN-29 AT 09:01 GMT AT 09:01 GMT by ORCHARD Cell research 2021 Only protein-protein interactions imex curation imex curation AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells. AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells. Cell research 2021 imex curation Wang S., Qiu Z., Hou Y., Deng X., Xu W., Zheng T., Wu P., Xie S., Bian W., Zhang C., Sun Z., Liu K., Shan C., Lin A., Jiang S., Xie Y., Zhou Q., Lu L., Huang J., Li X. Virus - Publications including interactions involving viral proteins Coronavirus - Interactions investigated in the context of Coronavirus email sent:18/01/21:asking identity of TAP 22 "HC interactors"; NTDs for Spike + AXL; cell line for figure 4I;Figure 4F tags used. NO REPLY to email. The authors have stated that Spike NTD is 13-303. AXL NTD is 1-449. Figure 4F;constructs were MYC-tagged. The correct phrase should be: "The cells were fixed and subjected to immunofluorescence with an anti-MYC antibody against the indicated proteins (red)". Figure 4I: the cell line used was 293T. lul@fudan.edu.cn,huangjing@westlake.edu.cn,lixu@westlake.edu.cn 29-Mar-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-beas_2b Human bronchial epithelial cell line BEAS-2B beas_2b Human bronchial epithelial cell line BEAS-2B http://cancerres.aacrjournals.org/cgi/content/abstract/48/7/1904?ijkey=330aa4101c1c77d6fbc2b1fc3d60b4ead4af2511&keytype2=tf_ipsecsha tap tandem affinity purification TAP TAP tap sequence tag sequence tag identification sequence tag Wang S., Qiu Z., Hou Y., Deng X., Xu W., Zheng T., Wu P., Xie S., Bian W., Zhang C., Sun Z., Liu K., Shan C., Lin A., Jiang S., Xie Y., Zhou Q., Lu L., Huang J., Li X. Virus - Publications including interactions involving viral proteins email sent:18/01/21:asking identity of TAP 22 "HC interactors"; NTDs for Spike + AXL; cell line for figure 4I;Figure 4F tags used. NO REPLY to email. The authors have stated that Spike NTD is 13-303. AXL NTD is 1-449. Figure 4F;constructs were MYC-tagged. The correct phrase should be: "The cells were fixed and subjected to immunofluorescence with an anti-MYC antibody against the indicated proteins (red)". Figure 4I: the cell line used was 293T. lul@fudan.edu.cn,huangjing@westlake.edu.cn,lixu@westlake.edu.cn Accepted 2021-JAN-29 AT 09:01 GMT AT 09:01 GMT by ORCHARD Cell research 2021 Only protein-protein interactions imex curation imex curation AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells. AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells. Cell research 2021 imex curation Wang S., Qiu Z., Hou Y., Deng X., Xu W., Zheng T., Wu P., Xie S., Bian W., Zhang C., Sun Z., Liu K., Shan C., Lin A., Jiang S., Xie Y., Zhou Q., Lu L., Huang J., Li X. Virus - Publications including interactions involving viral proteins Coronavirus - Interactions investigated in the context of Coronavirus email sent:18/01/21:asking identity of TAP 22 "HC interactors"; NTDs for Spike + AXL; cell line for figure 4I;Figure 4F tags used. NO REPLY to email. The authors have stated that Spike NTD is 13-303. AXL NTD is 1-449. Figure 4F;constructs were MYC-tagged. The correct phrase should be: "The cells were fixed and subjected to immunofluorescence with an anti-MYC antibody against the indicated proteins (red)". Figure 4I: the cell line used was 293T. lul@fudan.edu.cn,huangjing@westlake.edu.cn,lixu@westlake.edu.cn 29-Mar-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Wang S., Qiu Z., Hou Y., Deng X., Xu W., Zheng T., Wu P., Xie S., Bian W., Zhang C., Sun Z., Liu K., Shan C., Lin A., Jiang S., Xie Y., Zhou Q., Lu L., Huang J., Li X. Virus - Publications including interactions involving viral proteins email sent:18/01/21:asking identity of TAP 22 "HC interactors"; NTDs for Spike + AXL; cell line for figure 4I;Figure 4F tags used. NO REPLY to email. The authors have stated that Spike NTD is 13-303. AXL NTD is 1-449. Figure 4F;constructs were MYC-tagged. The correct phrase should be: "The cells were fixed and subjected to immunofluorescence with an anti-MYC antibody against the indicated proteins (red)". Figure 4I: the cell line used was 293T. lul@fudan.edu.cn,huangjing@westlake.edu.cn,lixu@westlake.edu.cn Accepted 2021-JAN-29 AT 09:01 GMT AT 09:01 GMT by ORCHARD Cell research 2021 Only protein-protein interactions imex curation imex curation AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells. AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells. Cell research 2021 imex curation Wang S., Qiu Z., Hou Y., Deng X., Xu W., Zheng T., Wu P., Xie S., Bian W., Zhang C., Sun Z., Liu K., Shan C., Lin A., Jiang S., Xie Y., Zhou Q., Lu L., Huang J., Li X. Virus - Publications including interactions involving viral proteins Coronavirus - Interactions investigated in the context of Coronavirus email sent:18/01/21:asking identity of TAP 22 "HC interactors"; NTDs for Spike + AXL; cell line for figure 4I;Figure 4F tags used. NO REPLY to email. The authors have stated that Spike NTD is 13-303. AXL NTD is 1-449. Figure 4F;constructs were MYC-tagged. The correct phrase should be: "The cells were fixed and subjected to immunofluorescence with an anti-MYC antibody against the indicated proteins (red)". Figure 4I: the cell line used was 293T. lul@fudan.edu.cn,huangjing@westlake.edu.cn,lixu@westlake.edu.cn 29-Mar-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro pull down pull down anti tag western anti tag western blot anti tag western Wang S., Qiu Z., Hou Y., Deng X., Xu W., Zheng T., Wu P., Xie S., Bian W., Zhang C., Sun Z., Liu K., Shan C., Lin A., Jiang S., Xie Y., Zhou Q., Lu L., Huang J., Li X. Virus - Publications including interactions involving viral proteins email sent:18/01/21:asking identity of TAP 22 "HC interactors"; NTDs for Spike + AXL; cell line for figure 4I;Figure 4F tags used. NO REPLY to email. The authors have stated that Spike NTD is 13-303. AXL NTD is 1-449. Figure 4F;constructs were MYC-tagged. The correct phrase should be: "The cells were fixed and subjected to immunofluorescence with an anti-MYC antibody against the indicated proteins (red)". Figure 4I: the cell line used was 293T. lul@fudan.edu.cn,huangjing@westlake.edu.cn,lixu@westlake.edu.cn Accepted 2021-JAN-29 AT 09:01 GMT AT 09:01 GMT by ORCHARD Cell research 2021 Only protein-protein interactions imex curation imex curation AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells. AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells. Cell research 2021 imex curation Wang S., Qiu Z., Hou Y., Deng X., Xu W., Zheng T., Wu P., Xie S., Bian W., Zhang C., Sun Z., Liu K., Shan C., Lin A., Jiang S., Xie Y., Zhou Q., Lu L., Huang J., Li X. Virus - Publications including interactions involving viral proteins Coronavirus - Interactions investigated in the context of Coronavirus email sent:18/01/21:asking identity of TAP 22 "HC interactors"; NTDs for Spike + AXL; cell line for figure 4I;Figure 4F tags used. NO REPLY to email. The authors have stated that Spike NTD is 13-303. AXL NTD is 1-449. Figure 4F;constructs were MYC-tagged. The correct phrase should be: "The cells were fixed and subjected to immunofluorescence with an anti-MYC antibody against the indicated proteins (red)". Figure 4I: the cell line used was 293T. lul@fudan.edu.cn,huangjing@westlake.edu.cn,lixu@westlake.edu.cn 29-Mar-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. confocal microscopy confocal microscopy anti-tag immunocytochemistry anti-tag immunocytochemistry Wang S., Qiu Z., Hou Y., Deng X., Xu W., Zheng T., Wu P., Xie S., Bian W., Zhang C., Sun Z., Liu K., Shan C., Lin A., Jiang S., Xie Y., Zhou Q., Lu L., Huang J., Li X. Virus - Publications including interactions involving viral proteins email sent:18/01/21:asking identity of TAP 22 "HC interactors"; NTDs for Spike + AXL; cell line for figure 4I;Figure 4F tags used. NO REPLY to email. The authors have stated that Spike NTD is 13-303. AXL NTD is 1-449. Figure 4F;constructs were MYC-tagged. The correct phrase should be: "The cells were fixed and subjected to immunofluorescence with an anti-MYC antibody against the indicated proteins (red)". Figure 4I: the cell line used was 293T. lul@fudan.edu.cn,huangjing@westlake.edu.cn,lixu@westlake.edu.cn Accepted 2021-JAN-29 AT 09:01 GMT AT 09:01 GMT by ORCHARD Cell research 2021 Only protein-protein interactions imex curation imex curation AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells. AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells. Cell research 2021 imex curation Wang S., Qiu Z., Hou Y., Deng X., Xu W., Zheng T., Wu P., Xie S., Bian W., Zhang C., Sun Z., Liu K., Shan C., Lin A., Jiang S., Xie Y., Zhou Q., Lu L., Huang J., Li X. Virus - Publications including interactions involving viral proteins Coronavirus - Interactions investigated in the context of Coronavirus email sent:18/01/21:asking identity of TAP 22 "HC interactors"; NTDs for Spike + AXL; cell line for figure 4I;Figure 4F tags used. NO REPLY to email. The authors have stated that Spike NTD is 13-303. AXL NTD is 1-449. Figure 4F;constructs were MYC-tagged. The correct phrase should be: "The cells were fixed and subjected to immunofluorescence with an anti-MYC antibody against the indicated proteins (red)". Figure 4I: the cell line used was 293T. lul@fudan.edu.cn,huangjing@westlake.edu.cn,lixu@westlake.edu.cn 29-Mar-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. fluorescence imaging fluorescence microscopy fluorescence imaging anti-tag immunocytochemistry anti-tag immunocytochemistry Wang S., Qiu Z., Hou Y., Deng X., Xu W., Zheng T., Wu P., Xie S., Bian W., Zhang C., Sun Z., Liu K., Shan C., Lin A., Jiang S., Xie Y., Zhou Q., Lu L., Huang J., Li X. Virus - Publications including interactions involving viral proteins email sent:18/01/21:asking identity of TAP 22 "HC interactors"; NTDs for Spike + AXL; cell line for figure 4I;Figure 4F tags used. NO REPLY to email. The authors have stated that Spike NTD is 13-303. AXL NTD is 1-449. Figure 4F;constructs were MYC-tagged. The correct phrase should be: "The cells were fixed and subjected to immunofluorescence with an anti-MYC antibody against the indicated proteins (red)". Figure 4I: the cell line used was 293T. lul@fudan.edu.cn,huangjing@westlake.edu.cn,lixu@westlake.edu.cn Accepted 2021-JAN-29 AT 09:01 GMT AT 09:01 GMT by ORCHARD Cell research 2021 Only protein-protein interactions imex curation imex curation AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells. AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells. Cell research 2021 imex curation Wang S., Qiu Z., Hou Y., Deng X., Xu W., Zheng T., Wu P., Xie S., Bian W., Zhang C., Sun Z., Liu K., Shan C., Lin A., Jiang S., Xie Y., Zhou Q., Lu L., Huang J., Li X. Virus - Publications including interactions involving viral proteins Coronavirus - Interactions investigated in the context of Coronavirus email sent:18/01/21:asking identity of TAP 22 "HC interactors"; NTDs for Spike + AXL; cell line for figure 4I;Figure 4F tags used. NO REPLY to email. The authors have stated that Spike NTD is 13-303. AXL NTD is 1-449. Figure 4F;constructs were MYC-tagged. The correct phrase should be: "The cells were fixed and subjected to immunofluorescence with an anti-MYC antibody against the indicated proteins (red)". Figure 4I: the cell line used was 293T. lul@fudan.edu.cn,huangjing@westlake.edu.cn,lixu@westlake.edu.cn 29-Mar-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro bio-layer interferometry bio-layer interferometry bli bli predetermined predetermined participant predetermined Wang S., Qiu Z., Hou Y., Deng X., Xu W., Zheng T., Wu P., Xie S., Bian W., Zhang C., Sun Z., Liu K., Shan C., Lin A., Jiang S., Xie Y., Zhou Q., Lu L., Huang J., Li X. Virus - Publications including interactions involving viral proteins email sent:18/01/21:asking identity of TAP 22 "HC interactors"; NTDs for Spike + AXL; cell line for figure 4I;Figure 4F tags used. NO REPLY to email. The authors have stated that Spike NTD is 13-303. AXL NTD is 1-449. Figure 4F;constructs were MYC-tagged. The correct phrase should be: "The cells were fixed and subjected to immunofluorescence with an anti-MYC antibody against the indicated proteins (red)". Figure 4I: the cell line used was 293T. lul@fudan.edu.cn,huangjing@westlake.edu.cn,lixu@westlake.edu.cn Accepted 2021-JAN-29 AT 09:01 GMT AT 09:01 GMT by ORCHARD Cell research 2021 Only protein-protein interactions imex curation imex curation spike_sars2 Spike glycoprotein S E2 Peplomer protein 2 protein protein SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 2019-nCoV MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT ace2_human Angiotensin-converting enzyme 2 ACE2 UNQ868/PRO1885 Angiotensin-converting enzyme homolog Metalloprotease MPROT15 Angiotensin-converting enzyme-related carboxypeptidase protein protein human Homo sapiens Human MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLNDNSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGENPYASIDISKGENNPGFQNTDDVQTSF mint Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses 8EE6EB0A931550E8 ldlr_human Low-density lipoprotein receptor LDLR protein protein human Homo sapiens Human MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSRQMVSLEDDVA DIP protein P01130 original sequence version: 115 DIP protein P01130 original sequence version: 122 DIP protein P01130 original sequence version: 140 DIP protein P01130 original sequence version: 173 A4C28E9B8BADAD5E ufo_human Tyrosine-protein kinase receptor UFO UFO AXL oncogene AXL protein protein human Homo sapiens Human MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA 262D3659218E3202 egfr_human Epidermal growth factor receptor ERBB1 EGFR Receptor tyrosine-protein kinase erbB-1 Proto-oncogene c-ErbB-1 ERBB HER1 protein protein human Homo sapiens Human MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA DIP protein P00533 original sequence version: 213 DIP protein P00533 original sequence version: 214 DIP protein P00533 original sequence version: 119 DIP protein P00533 original sequence version: 207 DIP protein P00533 original sequence version: 132 DIP protein P00533-1 original sequence version: 197 DIP protein P00533 original sequence version: 163 DIP protein P00533-1 original sequence version: 159 DIP protein P00533 original sequence version: 184 DIP protein P00533-1 original sequence version: 174 DIP protein P00533-1 original sequence version: 191 DIP protein P00533 original sequence version: 218 DIP protein P00533 original sequence version: 221 DIP protein P00533-1 original sequence version: 221 DIP protein P00533 original sequence version: 226 DIP protein P00533 original sequence version: 166 DIP protein P00533-1 original sequence version: 166 DIP protein P00533 original sequence version: 194 DIP protein P00533-1 original sequence version: 194 DIP protein P00533-1 original sequence version: 224 DIP protein P00533 original sequence version: 189 DIP protein P00533-1 original sequence version: 207 DIP protein P00533 original sequence version: 177 DIP protein P00533 original sequence version: 168 D8A2A50B4EFB6ED2 s-axl-1 1 10 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 12 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 11 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 8 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus s tag s tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus sbp sbp n-term range n-terminal range n-term range n-term range n-terminal range n-term range association association 2 Three human receptor proteins, AXL, LDLR and EGFR, bound the SARS-CoV-2-S NTD or RBD with reasonable affinity. s-axl-2 2 10 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 12 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 11 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 8 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus s tag s tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus sbp sbp n-term range n-terminal range n-term range n-term range n-terminal range n-term range association association 2 Three human receptor proteins, AXL, LDLR and EGFR, bound the SARS-CoV-2-S NTD or RBD with reasonable affinity. s-axl-3 3 11 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed n-terminus myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 8 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association 3A s-egfr-1 3 12 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed n-terminus myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 8 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association 3A s-ldlr-1 3 10 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed n-terminus myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 8 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association 3A s-ace2-63 3 9 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed n-terminus myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 8 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association 3A s-ldlr-2 6 10 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed n-terminus myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 8 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined colocalization colocalization 3B LDLR and EGFR did not co-localize to the cell membrane. s-axl-4 6 11 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed n-terminus myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 8 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined colocalization colocalization 3B s-ace2-64 6 9 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed n-terminus myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 8 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined colocalization colocalization 3B s-egfr-2 6 12 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed n-terminus myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 8 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined colocalization colocalization 3B LDLR and EGFR did not co-localize to the cell membrane. axl-s-1 4 11 unspecified role unspecified role bait bait purified purified region his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecd sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. 8 unspecified role unspecified role prey prey purified purified region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. physical association physical association 3C s-axl-5 7 11 unspecified role unspecified role prey prey purified purified region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human-293f Homo sapiens HEK293F cell line 293f embryonic kidney cell 293f 8 unspecified role unspecified role bait bait purified purified region his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined NTD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human-293f Homo sapiens HEK293F cell line 293f embryonic kidney cell 293f direct interaction direct interaction 3D s-axl-6 4 11 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human-h1299 Homo sapiens lung lymph node carcinoma h1299 Human lung lymph node carcinoma p53 null. These cells have also been reported to secrete the peptide hormone neuromedin B (NMB), but not gastrin releasing peptide (GRP). Also known as NCI H1299 or CRL-5803. http://www.lgcpromochem.com/atcc/ ATCC number: CRL-5803. ATCC number of the cell line is CRL-5803. 8 unspecified role unspecified role bait bait purified purified region his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined NTD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human-293f Homo sapiens HEK293F cell line 293f embryonic kidney cell 293f physical association physical association 3E axl-s-2 5 11 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 8 unspecified role unspecified role neutral component neutral component infection infection colocalization colocalization 4F ace2-s-83 5 9 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 8 unspecified role unspecified role neutral component neutral component infection infection colocalization colocalization 4F axl-s-3 3 11 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range NTD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 8 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association 4I