IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ The Biomarker TCONS_00016233 Drives Septic AKI by Targeting the miR-22-3p/AIFM1 Signaling Axis. The Biomarker TCONS_00016233 Drives Septic AKI by Targeting the miR-22-3p/AIFM1 Signaling Axis. Molecular therapy. Nucleic acids 2020 imex curation Zhang P., Yi L., Qu S., Dai J., Li X., Liu B., Li H., Ai K., Zheng P., Qiu S., Li Y., Wang Y., Xiang X., Chai X., Dong Z., Zhang D. dongshanzhang@csu.edu.cn Only protein-protein interactions imex curation human-hk2 Homo sapiens hk2 hk2 mirna interference luciferase assay miRNA interference luciferase reporter assay miRNA interference luciferase assay tag luciferase tag visualisation by luciferase assay tag luciferase Zhang P., Yi L., Qu S., Dai J., Li X., Liu B., Li H., Ai K., Zheng P., Qiu S., Li Y., Wang Y., Xiang X., Chai X., Dong Z., Zhang D. dongshanzhang@csu.edu.cn Accepted 2021-DEC-20 AT 07:06 GMT AT 07:06 GMT by KALPANAP Molecular therapy. Nucleic acids 2020 Only protein-protein interactions imex curation imex curation lnc-egfl7-1 Lnc-EGFL7-1 or TCONS_00016233 lncRNA lncrna long non-coding ribonucleic acid lncRNA long non coding RNA long non coding ribonucleic acid long non-coding RNA lncrna human Homo sapiens Human CUCAGUGCUCACACUUCCCACUAACUGCCAGCAUCCCCUACAACAUGGCCCACGUCUCAAGGGAUUGGAAGGAGCCCCCGCAGAGGCCAUCGGCACGGACUAGAAUGCAACCCAGUGGGGCAUCCACCGAUGUGGUCAAACGCUCAGCCAAGAUGGUGGGAAGCGUUCAGACAGAAGUAACUUCUAAAACAUUGCUAGGGAAACGCUCUGACAUCUUCCGUAGAGGUGAAAAAGCACAGGUCUGACUCAGGUAGCUGCGAGUUCAAGUUCAGCCGCAGGCUCUUCCCCAAGGUGCUGGUCUUCGCAGGAACCCCUUGCAGGCAGCUGCAAAGAGCAGCACGGCGCGCACACACAGGGUCCGGCUGGCGUCUGGCCAGAGCAAGGGAACAGUAAGUGUGUCCUGGAGGCGCUCGCCAUGCACUCACACGCCAUCUGUGGAUUCGGAAGUGACCUCCCCCUCGGUUGAUGAGGGUUCUCUGCGUCUGGAGAACACAGGACGUCCACAGGAAAGUUCUCCCUCCUGCACUCCCGGCUGGCUCUGAAAAUUAUGAAGGCAGAGACGU mrna_aifm1 apoptosis inducing factor mitochondria associated 1, mRNA mrna messenger rna mRNA mrna human Homo sapiens Human GTTCCCCTTCCCCGGCTCTAGCAGGCCGGCTTCTCTGTCCAATGCCCACCCGGAGCTGGGAGGAGGAGTCTGCGTAATGTGCGTGTGAAGAGACTGGGGGAGCTGGCCGGGGCTCACGGTGTTTGACCCGTCGGTCGTGCGTGAGAGGAAAGGGAAGGAGGAGGTCCCGAATAGCGGTCGCCGAAATGTTCCGGTGTGGAGGCCTGGCGGCGGGTGCTTTGAAGCAGAAGCTGGTGCCCTTGGTGCGGACCGTGTGCGTCCGAAGCCCGAGGCAGAGGAACCGGCTCCCAGGCAACTTGTTCCAGCGATGGCATGTTCCTCTAGAACTCCAGATGACAAGACAAATGGCTAGCTCTGGTGCATCAGGGGGCAAAATCGATAATTCTGTGTTAGTCCTTATTGTGGGCTTATCAACAGTAGGAGCTGGTGCCTATGCCTACAAGACTATGAAAGAGGATGAAAAAAGATACAATGAAAGAATTTCAGGGTTAGGGCTGACACCAGAACAGAAACAGAAAAAGGCCGCGTTATCTGCTTCAGAAGGAGAGGAAGTTCCTCAAGACAAGGCGCCAAGTCATGTTCCTTTCCTGCTAATTGGTGGAGGCACAGCTGCTTTTGCTGCAGCCAGATCCATCCGGGCTCGGGATCCTGGGGCCAGGGTACTGATTGTATCTGAAGATCCTGAGCTGCCGTACATGCGACCTCCTCTTTCAAAAGAACTGTGGTTTTCAGATGACCCAAATGTCACAAAGACACTGCGATTCAAACAGTGGAATGGAAAAGAGAGAAGCATATATTTCCAGCCACCTTCTTTCTATGTCTCTGCTCAGGACCTGCCTCATATTGAGAATGGTGGTGTGGCTGTCCTCACTGGGAAGAAGGTAGTACAGCTGGATGTGAGAGACAACATGGTGAAACTTAATGATGGCTCTCAAATAACCTATGAAAAGTGCTTGATTGCAACAGGAGGTACTCCAAGAAGTCTGTCTGCCATTGATAGGGCTGGAGCAGAGGTGAAGAGTAGAACAACGCTTTTCAGAAAGATTGGAGACTTTAGAAGCTTGGAGAAGATTTCACGGGAAGTCAAATCAATTACGATTATCGGTGGGGGCTTCCTTGGTAGCGAACTGGCCTGTGCTCTTGGCAGAAAGGCTCGAGCCTTGGGCACAGAAGTGATTCAACTCTTCCCCGAGAAAGGAAATATGGGAAAGATCCTCCCCGAATACCTCAGCAACTGGACCATGGAAAAAGTCAGACGAGAGGGGGTTAAGGTGATGCCCAATGCTATTGTGCAATCCGTTGGAGTCAGCAGTGGCAAGTTACTTATCAAGCTGAAAGACGGCAGGAAGGTAGAAACTGACCACATAGTGGCAGCTGTGGGCCTGGAGCCCAATGTTGAGTTGGCCAAGACTGGTGGCCTGGAAATAGACTCAGATTTTGGTGGCTTCCGGGTAAATGCAGAGCTACAAGCACGCTCTAACATCTGGGTGGCAGGAGATGCTGCATGCTTCTACGATATAAAGTTGGGAAGGAGGCGGGTAGAGCACCATGATCACGCTGTTGTGAGTGGAAGATTGGCTGGAGAAAATATGACTGGAGCTGCTAAGCCGTACTGGCATCAGTCAATGTTCTGGAGTGATTTGGGCCCCGATGTTGGCTATGAAGCTATTGGTCTTGTGGACAGTAGTTTGCCCACAGTTGGTGTTTTTGCAAAAGCAACTGCACAAGACAACCCCAAATCTGCCACAGAGCAGTCAGGAACTGGTATCCGATCAGAGAGTGAGACAGAGTCCGAGGCCTCAGAAATTACTATTCCTCCCAGCACCCCGGCAGTTCCACAGGCTCCCGTCCAGGGGGAGGACTACGGCAAAGGTGTCATCTTCTACCTCAGGGACAAAGTGGTCGTGGGGATTGTGCTATGGAACATCTTTAACCGAATGCCAATAGCAAGGAAGATCATTAAGGACGGTGAGCAGCATGAAGATCTCAATGAAGTAGCCAAACTATTCAACATTCATGAAGACTGAAGCCCCACAGTGGAATTGGCAAACCCACTGCAGCCCCTGAGAGGAGGTCGAATGGGTAAAGGAGCATTTTTTTATTCAGCAGACTTTCTCTGTGTATGAGTGTGAATGATCAAGTCCTTTGTGAATATTTTCAACTATGTAGGTAAATTCTTAATGTTCACATAGTGAAATAAATTCTGATTCTTCTAAATTAAA hsa-mir-22-3p Homo sapiens (human) hsa-miR-22-3p mirna micro rna micro RNA micro-RNA micro-rna mirna miRNA human Homo sapiens Human AAGCUGCCAGUUGAAGAACUGU hsa_mir_22_3p-lnc_egfl7_1-1 1 4 predetermined predetermined participant predetermined tag luciferase tag visualisation by luciferase assay tag luciferase regulator target regulator target regulator target modulator target neutral component neutral component engineered engineered purified purified 2 regulator regulator modulator regulator unspecified role unspecified role over-expressed over expressed level over-expressed living cell living cell engineered engineered tag luciferase tag luciferase tag 3' range 3' range 3' range 3' range URS00008B6A77_9606:r.320_326delinsttagtac mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain GGCAGCU TTAGTAC physical association physical association Fig 6 A B down-regulates quantity by destabilization hsa_mir_22_3p-mrna_aifm1-1 1 4 predetermined predetermined participant predetermined tag luciferase tag visualisation by luciferase assay tag luciferase regulator regulator modulator regulator neutral component neutral component engineered engineered purified purified 3 regulator target regulator target regulator target modulator target neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered tag luciferase tag luciferase tag 3' range 3' range 3' range 3' range ENST00000287295:r.1371_1374delinsatca mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain GCAG ATCA physical association physical association Fig 8 A, B down-regulates quantity by destabilization