MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms. Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms. Nature communications 2018 imex curation Douse CH., Bloor S., Liu Y., Shamin M., Tchasovnikarova IA., Timms RT., Lehner PJ., Modis Y. Rare diseases - Interactions investigated in the context of Rare genetic disease as per MINT policy only protein-protein interactions were captured. cdouse@mrc-lmb.cam.ac.uk,ymodis@mrc-lmb.cam.ac.uk 24-May-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation spofr-sf_9 Spodoptera frugiperda insect cells Fall armyworm sf_9 insect cells Derived from pupal ovarian tissue of the fall armyworm Cloned from the parent cell line, IPLB-SF-21-AE (SF-21) derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae cells are susceptible to Baculovirus infection x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Douse CH., Bloor S., Liu Y., Shamin M., Tchasovnikarova IA., Timms RT., Lehner PJ., Modis Y. Rare diseases - Interactions investigated in the context of Rare genetic disease as per MINT policy only protein-protein interactions were captured. cdouse@mrc-lmb.cam.ac.uk,ymodis@mrc-lmb.cam.ac.uk Accepted 2021-APR-26 AT 15:36 BST AT 15:36 BST by MGT Nature communications 2018 Only protein-protein interactions imex curation imex curation Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms. Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms. Nature communications 2018 imex curation Douse CH., Bloor S., Liu Y., Shamin M., Tchasovnikarova IA., Timms RT., Lehner PJ., Modis Y. Rare diseases - Interactions investigated in the context of Rare genetic disease as per MINT policy only protein-protein interactions were captured. cdouse@mrc-lmb.cam.ac.uk,ymodis@mrc-lmb.cam.ac.uk 24-May-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation spofr-sf_9 Spodoptera frugiperda insect cells Fall armyworm sf_9 insect cells Derived from pupal ovarian tissue of the fall armyworm Cloned from the parent cell line, IPLB-SF-21-AE (SF-21) derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae cells are susceptible to Baculovirus infection molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Douse CH., Bloor S., Liu Y., Shamin M., Tchasovnikarova IA., Timms RT., Lehner PJ., Modis Y. Rare diseases - Interactions investigated in the context of Rare genetic disease as per MINT policy only protein-protein interactions were captured. cdouse@mrc-lmb.cam.ac.uk,ymodis@mrc-lmb.cam.ac.uk Accepted 2021-APR-26 AT 15:36 BST AT 15:36 BST by MGT Nature communications 2018 Only protein-protein interactions imex curation imex curation amp-pnp AMP-PNP small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) q9y6x9-1 ATPase MORC2 MORC family CW-type zinc finger protein 2 Zinc finger CW-type coiled-coil domain protein 1 MORC2 KIAA0852 ZCWCC1 protein protein human Homo sapiens Human MAFTNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDADATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPVTDNVEKFAIETELIYKYSPFRTEEEVMTQFMKIPGDSGTLVIIFNLKLMDNGEPELDIISNPRDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLYKPRMYKYTSSRFKTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRLGGDLTRDSRVMLRQVQNRAITLRREADVKKRIKEAKQRALKEPKELNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYWKDIAIAQRGIIKFWDEFGYLSANWNQPPSSELRYKRRRAMEIPTTIQCDLCLKWRTLPFQLSSVEKDYPDTWVCSMNPDPEQDRCEASEQKQKVPLGTFRKDMKTQEEKQKQLTEKIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTRPSTEEPVRRPQRPRSPPLPAVIRNAPSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEASTSRLLQPPEAPRKPANTLVKTASRPAPLVQQLSPSLLPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPSRKRSVAVSDEEEVEEEAERRKERCKRGRFVVKEEKKDSNELSDSAGEEDSADLKRAQKDKGLHVEVRVNREWYTGRVTAVEVGKHVVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNHETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDELISFPLKEYFKQYEVGLQNLCNSYQSRADSRAKASEESLRTSERKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKGD 7BEFA46E4150ABF5 morc2-dimer-1 1 4 unspecified role unspecified role neutral component neutral component purified purified region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Q9Y6X9-1:p.Thr424Arg mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain T R Q9Y6X9-1:p.Ser87Leu mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain S L direct interaction direct interaction Table 1 morc2-1 2 3 stimulator stimulator unspecified role unspecified role 4 unspecified role unspecified role neutral component neutral component purified purified region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Q9Y6X9-1:p.Thr424Arg mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain T R Q9Y6X9-1:p.Tyr18Ala mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain Y A direct interaction direct interaction Fig. 1C, 2F, 5C amp_pnp-morc2-1 2 4 unspecified role unspecified role neutral component neutral component purified purified region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Q9Y6X9-1:p.Thr424Arg mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain T R Q9Y6X9-1:p.Ser87Leu mutation causing mutation causing an interaction mutation enabling interaction mutation causing mutation causing an interaction certain certain sequence position certain certain certain sequence position certain S L direct interaction direct interaction Fig. 5C