UniProt UniProt http://www.uniprot.org Perilipin 1 binds to aquaporin 7 in human adipocytes and controls its mobility via protein kinase A mediated phosphorylation. Perilipin 1 binds to aquaporin 7 in human adipocytes and controls its mobility via protein kinase A mediated phosphorylation. Metabolism: clinical and experimental 2016 imex curation Hansen JS., Krintel C., Hernebring M., Haataja TJ., de Marè S., Wasserstrom S., Kosinska-Eriksson U., Palmgren M., Holm C., Stenkula KG., Jones HA., Lindkvist-Petersson K., Hansen JS., Krintel C., Hernebring M., Haataja TJ., de Marè S., Wasserstrom S., Kosinska-Eriksson U., Palmgren M., Holm C., Stenkula KG., Jones HA., Lindkvist-Petersson K. karin.lindkvist@med.lu.se 24-May-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro pull down pull down ms participant Identification by mass spectrometry ms participant Hansen JS., Krintel C., Hernebring M., Haataja TJ., de Marè S., Wasserstrom S., Kosinska-Eriksson U., Palmgren M., Holm C., Stenkula KG., Jones HA., Lindkvist-Petersson K., Hansen JS., Krintel C., Hernebring M., Haataja TJ., de Marè S., Wasserstrom S., Kosinska-Eriksson U., Palmgren M., Holm C., Stenkula KG., Jones HA., Lindkvist-Petersson K. Interacting proteins were identified in lysates derived from human abdominal primary adipocytes. Data from 2 patients was merged. karin.lindkvist@med.lu.se Accepted 2021-APR-17 AT 17:09 BST AT 17:09 BST by KALPANAP Metabolism: clinical and experimental 2016 Only protein-protein interactions imex curation imex curation Perilipin 1 binds to aquaporin 7 in human adipocytes and controls its mobility via protein kinase A mediated phosphorylation. Perilipin 1 binds to aquaporin 7 in human adipocytes and controls its mobility via protein kinase A mediated phosphorylation. Metabolism: clinical and experimental 2016 imex curation Hansen JS., Krintel C., Hernebring M., Haataja TJ., de Marè S., Wasserstrom S., Kosinska-Eriksson U., Palmgren M., Holm C., Stenkula KG., Jones HA., Lindkvist-Petersson K., Hansen JS., Krintel C., Hernebring M., Haataja TJ., de Marè S., Wasserstrom S., Kosinska-Eriksson U., Palmgren M., Holm C., Stenkula KG., Jones HA., Lindkvist-Petersson K. karin.lindkvist@med.lu.se 24-May-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-adipocyte human adipocyte adipocyte ADIPOCYTE pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Hansen JS., Krintel C., Hernebring M., Haataja TJ., de Marè S., Wasserstrom S., Kosinska-Eriksson U., Palmgren M., Holm C., Stenkula KG., Jones HA., Lindkvist-Petersson K., Hansen JS., Krintel C., Hernebring M., Haataja TJ., de Marè S., Wasserstrom S., Kosinska-Eriksson U., Palmgren M., Holm C., Stenkula KG., Jones HA., Lindkvist-Petersson K. karin.lindkvist@med.lu.se Accepted 2021-APR-17 AT 17:09 BST AT 17:09 BST by KALPANAP Metabolism: clinical and experimental 2016 Only protein-protein interactions imex curation imex curation Perilipin 1 binds to aquaporin 7 in human adipocytes and controls its mobility via protein kinase A mediated phosphorylation. Perilipin 1 binds to aquaporin 7 in human adipocytes and controls its mobility via protein kinase A mediated phosphorylation. Metabolism: clinical and experimental 2016 imex curation Hansen JS., Krintel C., Hernebring M., Haataja TJ., de Marè S., Wasserstrom S., Kosinska-Eriksson U., Palmgren M., Holm C., Stenkula KG., Jones HA., Lindkvist-Petersson K., Hansen JS., Krintel C., Hernebring M., Haataja TJ., de Marè S., Wasserstrom S., Kosinska-Eriksson U., Palmgren M., Holm C., Stenkula KG., Jones HA., Lindkvist-Petersson K. karin.lindkvist@med.lu.se 24-May-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro far western blotting far western blotting Affinity blotting Affinity blotting western blot western blot Immuno blot Immuno blot Hansen JS., Krintel C., Hernebring M., Haataja TJ., de Marè S., Wasserstrom S., Kosinska-Eriksson U., Palmgren M., Holm C., Stenkula KG., Jones HA., Lindkvist-Petersson K., Hansen JS., Krintel C., Hernebring M., Haataja TJ., de Marè S., Wasserstrom S., Kosinska-Eriksson U., Palmgren M., Holm C., Stenkula KG., Jones HA., Lindkvist-Petersson K. karin.lindkvist@med.lu.se Accepted 2021-APR-17 AT 17:09 BST AT 17:09 BST by KALPANAP Metabolism: clinical and experimental 2016 Only protein-protein interactions imex curation imex curation Perilipin 1 binds to aquaporin 7 in human adipocytes and controls its mobility via protein kinase A mediated phosphorylation. Perilipin 1 binds to aquaporin 7 in human adipocytes and controls its mobility via protein kinase A mediated phosphorylation. Metabolism: clinical and experimental 2016 imex curation Hansen JS., Krintel C., Hernebring M., Haataja TJ., de Marè S., Wasserstrom S., Kosinska-Eriksson U., Palmgren M., Holm C., Stenkula KG., Jones HA., Lindkvist-Petersson K., Hansen JS., Krintel C., Hernebring M., Haataja TJ., de Marè S., Wasserstrom S., Kosinska-Eriksson U., Palmgren M., Holm C., Stenkula KG., Jones HA., Lindkvist-Petersson K. karin.lindkvist@med.lu.se 24-May-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-adipocyte human adipocyte adipocyte ADIPOCYTE confocal microscopy confocal microscopy immunohistochemistry immunohistochemistry Hansen JS., Krintel C., Hernebring M., Haataja TJ., de Marè S., Wasserstrom S., Kosinska-Eriksson U., Palmgren M., Holm C., Stenkula KG., Jones HA., Lindkvist-Petersson K., Hansen JS., Krintel C., Hernebring M., Haataja TJ., de Marè S., Wasserstrom S., Kosinska-Eriksson U., Palmgren M., Holm C., Stenkula KG., Jones HA., Lindkvist-Petersson K. Human primary adipocytes were stimulated with either isoprenaline or insulin to mimic lipolytic and lipogenic conditions, respectively. karin.lindkvist@med.lu.se Accepted 2021-APR-17 AT 17:09 BST AT 17:09 BST by KALPANAP Metabolism: clinical and experimental 2016 Only protein-protein interactions imex curation imex curation aqp7_human Aquaporin-7 AQP7 AQP7L AQP9 Aquaglyceroporin-7 Aquaporin adipose Aquaporin-7-like protein protein human Homo sapiens Human MVQASGHRRSTRGSKMVSWSVIAKIQEILQRKMVREFLAEFMSTYVMMVFGLGSVAHMVLNKKYGSYLGVNLGFGFGVTMGVHVAGRISGAHMNAAVTFANCALGRVPWRKFPVYVLGQFLGSFLAAATIYSLFYTAILHFSGGQLMVTGPVATAGIFATYLPDHMTLWRGFLNEAWLTGMLQLCLFAITDQENNPALPGTEALVIGILVVIIGVSLGMNTGYAINPSRDLPPRIFTFIAGWGKQVFSNGENWWWVPVVAPLLGAYLGGIIYLVFIGSTIPREPLKLEDSVAYEDHGITVLPKMGSHEPTISPLTPVSVSPANRSSVHPAPPLHESMALEHF 8A05F92B977D2F93 k1c9_human Keratin, type I cytoskeletal 9 KRT9 Keratin-9 Cytokeratin-9 protein protein human Homo sapiens Human MSCRQFSSSYLSRSGGGGGGGLGSGGSIRSSYSRFSSSGGGGGGGRFSSSSGYGGGSSRVCGRGGGGSFGYSYGGGSGGGFSASSLGGGFGGGSRGFGGASGGGYSSSGGFGGGFGGGSGGGFGGGYGSGFGGFGGFGGGAGGGDGGILTANEKSTMQELNSRLASYLDKVQALEEANNDLENKIQDWYDKKGPAAIQKNYSPYYNTIDDLKDQIVDLTVGNNKTLLDIDNTRMTLDDFRIKFEMEQNLRQGVDADINGLRQVLDNLTMEKSDLEMQYETLQEELMALKKNHKEEMSQLTGQNSGDVNVEINVAPGKDLTKTLNDMRQEYEQLIAKNRKDIENQYETQITQIEHEVSSSGQEVQSSAKEVTQLRHGVQELEIELQSQLSKKAALEKSLEDTKNRYCGQLQMIQEQISNLEAQITDVRQEIECQNQEYSLLLSIKMRLEKEIETYHNLLEGGQEDFESSGAGKIGLGGRGGSGGSYGRGSRGGSGGSYGGGGSGGGYGGGSGSRGGSGGSYGGGSGSGGGSGGGYGGGSGGGHSGGSGGGHSGGSGGNYGGGSGSGGGSGGGYGGGSGSRGGSGGSHGGGSGFGGESGGSYGGGEEASGSGGGYGGGSGKSSHS 45C833749B63873D shrm3_human Protein Shroom3 KIAA1481 SHRML Shroom-related protein MSTP013 SHROOM3 protein protein human Homo sapiens Human MMRTTEDFHKPSATLNSNTATKGRYIYLEAFLEGGAPWGFTLKGGLEHGEPLIISKVEEGGKADTLSSKLQAGDEVVHINEVTLSSSRKEAVSLVKGSYKTLRLVVRRDVCTDPGHADTGASNFVSPEHLTSGPQHRKAAWSGGVKLRLKHRRSEPAGRPHSWHTTKSGEKQPDASMMQISQGMIGPPWHQSYHSSSSTSDLSNYDHAYLRRSPDQCSSQGSMESLEPSGAYPPCHLSPAKSTGSIDQLSHFHNKRDSAYSSFSTSSSILEYPHPGISGRERSGSMDNTSARGGLLEGMRQADIRYVKTVYDTRRGVSAEYEVNSSALLLQGREARASANGQGYDKWSNIPRGKGVPPPSWSQQCPSSLETATDNLPPKVGAPLPPARSDSYAAFRHRERPSSWSSLDQKRLCRPQANSLGSLKSPFIEEQLHTVLEKSPENSPPVKPKHNYTQKAQPGQPLLPTSIYPVPSLEPHFAQVPQPSVSSNGMLYPALAKESGYIAPQGACNKMATIDENGNQNGSGRPGFAFCQPLEHDLLSPVEKKPEATAKYVPSKVHFCSVPENEEDASLKRHLTPPQGNSPHSNERKSTHSNKPSSHPHSLKCPQAQAWQAGEDKRSSRLSEPWEGDFQEDHNANLWRRLEREGLGQSLSGNFGKTKSAFSSLQNIPESLRRHSSLELGRGTQEGYPGGRPTCAVNTKAEDPGRKAAPDLGSHLDRQVSYPRPEGRTGASASFNSTDPSPEEPPAPSHPHTSSLGRRGPGPGSASALQGFQYGKPHCSVLEKVSKFEQREQGSQRPSVGGSGFGHNYRPHRTVSTSSTSGNDFEETKAHIRFSESAEPLGNGEQHFKNGELKLEEASRQPCGQQLSGGASDSGRGPQRPDARLLRSQSTFQLSSEPEREPEWRDRPGSPESPLLDAPFSRAYRNSIKDAQSRVLGATSFRRRDLELGAPVASRSWRPRPSSAHVGLRSPEASASASPHTPRERHSVTPAEGDLARPVPPAARRGARRRLTPEQKKRSYSEPEKMNEVGIVEEAEPAPLGPQRNGMRFPESSVADRRRLFERDGKACSTLSLSGPELKQFQQSALADYIQRKTGKRPTSAAGCSLQEPGPLRERAQSAYLQPGPAALEGSGLASASSLSSLREPSLQPRREATLLPATVAETQQAPRDRSSSFAGGRRLGERRRGDLLSGANGGTRGTQRGDETPREPSSWGARAGKSMSAEDLLERSDVLAGPVHVRSRSSPATADKRQDVLLGQDSGFGLVKDPCYLAGPGSRSLSCSERGQEEMLPLFHHLTPRWGGSGCKAIGDSSVPSECPGTLDHQRQASRTPCPRPPLAGTQGLVTDTRAAPLTPIGTPLPSAIPSGYCSQDGQTGRQPLPPYTPAMMHRSNGHTLTQPPGPRGCEGDGPEHGVEEGTRKRVSLPQWPPPSRAKWAHAAREDSLPEESSAPDFANLKHYQKQQSLPSLCSTSDPDTPLGAPSTPGRISLRISESVLRDSPPPHEDYEDEVFVRDPHPKATSSPTFEPLPPPPPPPPSQETPVYSMDDFPPPPPHTVCEAQLDSEDPEGPRPSFNKLSKVTIARERHMPGAAHVVGSQTLASRLQTSIKGSEAESTPPSFMSVHAQLAGSLGGQPAPIQTQSLSHDPVSGTQGLEKKVSPDPQKSSEDIRTEALAKEIVHQDKSLADILDPDSRLKTTMDLMEGLFPRDVNLLKENSVKRKAIQRTVSSSGCEGKRNEDKEAVSMLVNCPAYYSVSAPKAELLNKIKEMPAEVNEEEEQADVNEKKAELIGSLTHKLETLQEAKGSLLTDIKLNNALGEEVEALISELCKPNEFDKYRMFIGDLDKVVNLLLSLSGRLARVENVLSGLGEDASNEERSSLYEKRKILAGQHEDARELKENLDRRERVVLGILANYLSEEQLQDYQHFVKMKSTLLIEQRKLDDKIKLGQEQVKCLLESLPSDFIPKAGALALPPNLTSEPIPAGGCTFSGIFPTLTSPL 735F6CD20FF64BC6 k2c6b_human Keratin, type II cytoskeletal 6B Cytokeratin-6B Keratin-6B KRT6B K6B KRTL1 Type-II keratin Kb10 protein protein human Homo sapiens Human MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSISVSRSRGSGGLGGACGGAGFGSRSLYGLGGSKRISIGGGSCAISGGYGSRAGGSYGFGGAGSGFGFGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPAIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDNIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQITAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNISVVQSTVSSGYGGASGVGSGLGLGGGSSYSYGSGLGVGGGFSSSSGRATGGGLSSVGGGSSTIKYTTTSSSSRKSYKH FFA4C351FBF09F09 plin1_human Perilipin-1 PLIN1 PERI PLIN Lipid droplet-associated protein protein protein human Homo sapiens Human MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLALGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLSSLAQWGASVAMQAVSRRRSEVRVPWLHSLAAAQEEDHEDQTDTEGEDTEEEEELETEENKFSEVAALPGPRGLLGGVAHTLQKTLQTTISAVTWAPAAVLGMAGRVLHLTPAPAVSSTKGRAMSLSDALKGVTDNVVDTVVHYVPLPRLSLMEPESEFRDIDNPPAEVERREAERRASGAPSAGPEPAPRLAQPRRSLRSAQSPGAPPGPGLEDEVATPAAPRPGFPAVPREKPKRRVSDSFFRPSVMEPILGRTHYSQLRKKS 394FC14388EB5DCC k22e_human Keratin, type II cytoskeletal 2 epidermal KRT2 KRT2A KRT2E Cytokeratin-2e Keratin-2e Type-II keratin Kb2 Keratin-2 epidermis Epithelial keratin-2e protein protein human Homo sapiens Human MSCQISCKSRGRGGGGGGFRGFSSGSAVVSGGSRRSTSSFSCLSRHGGGGGGFGGGGFGSRSLVGLGGTKSISISVAGGGGGFGAAGGFGGRGGGFGGGSSFGGGSGFSGGGFGGGGFGGGRFGGFGGPGGVGGLGGPGGFGPGGYPGGIHEVSVNQSLLQPLNVKVDPEIQNVKAQEREQIKTLNNKFASFIDKVRFLEQQNQVLQTKWELLQQMNVGTRPINLEPIFQGYIDSLKRYLDGLTAERTSQNSELNNMQDLVEDYKKKYEDEINKRTAAENDFVTLKKDVDNAYMIKVELQSKVDLLNQEIEFLKVLYDAEISQIHQSVTDTNVILSMDNSRNLDLDSIIAEVKAQYEEIAQRSKEEAEALYHSKYEELQVTVGRHGDSLKEIKIEISELNRVIQRLQGEIAHVKKQCKNVQDAIADAEQRGEHALKDARNKLNDLEEALQQAKEDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGDLSSNVTVSVTSSTISSNVASKAAFGGSGGRGSSSGGGYSSGSSSYGSGGRQSGSRGGSGGGGSISGGGYGSGGGSGGRYGSGGGSKGGSISGGGYGSGGGKHSSGGGSRGGSSSGGGYGSGGGGSSSVKGSSGEAFGSSVTFSFR B80526BAF70078A7 asph_human Aspartyl/asparaginyl beta-hydroxylase ASPH Aspartate beta-hydroxylase Peptide-aspartate beta-dioxygenase BAH protein protein human Homo sapiens Human MAQRKNAKSSGNSSSSGSGSGSTSAGSSSPGARRETKHGGHKNGRKGGLSGTSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLGKLGIYDADGDGDFDVDDAKVLLGLKERSTSEPAVPPEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVHAEHVEGEDLQQEDGPTGEPQQEDDEFLMATDVDDRFETLEPEVSHEETEHSYHVEETVSQDCNQDMEEMMSEQENPDSSEPVVEDERLHHDTDDVTYQVYEEQAVYEPLENEGIEITEVTAPPEDNPVEDSQVIVEEVSIFPVEEQQEVPPETNRKTDDPEQKAKVKKKKPKLLNKFDKTIKAELDAAEKLRKRGKIEEAVNAFKELVRKYPQSPRARYGKAQCEDDLAEKRRSNEVLRGAIETYQEVASLPDVPADLLKLSLKRRSDRQQFLGHMRGSLLTLQRLVQLFPNDTSLKNDLGVGYLLIGDNDNAKKVYEEVLSVTPNDGFAKVHYGFILKAQNKIAESIPYLKEGIESGDPGTDDGRFYFHLGDAMQRVGNKEAYKWYELGHKRGHFASVWQRSLYNVNGLKAQPWWTPKETGYTELVKSLERNWKLIRDEGLAVMDKAKGLFLPEDENLREKGDWSQFTLWQQGRRNENACKGAPKTCTLLEKFPETTGCRRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKIRCANETKTWEEGKVLIFDDSFEHEVWQDASSFRLIFIVDVWHPELTPQQRRSLPAI 4AE56D1D8DF0AF0C aqp7-asph-1 1 9 unspecified role unspecified role prey prey cell lysate cell lysate physiological level physiological level endogenous level endogenous endogenous endogenous level human-adipocyte human adipocyte adipocyte ADIPOCYTE 5 unspecified role unspecified role bait bait purified purified n-terminal mbp tag maltose binding protein tag maltose binding protein tag maltose binding protein tag mbp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminal his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecoli Escherichia coli (strain K12) 11 unspecified role unspecified role prey prey cell lysate cell lysate physiological level physiological level endogenous level endogenous endogenous endogenous level human-adipocyte human adipocyte adipocyte ADIPOCYTE 10 unspecified role unspecified role prey prey cell lysate cell lysate physiological level physiological level endogenous level endogenous endogenous endogenous level human-adipocyte human adipocyte adipocyte ADIPOCYTE 8 unspecified role unspecified role prey prey cell lysate cell lysate physiological level physiological level endogenous level endogenous endogenous endogenous level human-adipocyte human adipocyte adipocyte ADIPOCYTE 7 unspecified role unspecified role prey prey cell lysate cell lysate physiological level physiological level endogenous level endogenous endogenous endogenous level human-adipocyte human adipocyte adipocyte ADIPOCYTE 6 unspecified role unspecified role prey prey cell lysate cell lysate physiological level physiological level endogenous level endogenous endogenous endogenous level human-adipocyte human adipocyte adipocyte ADIPOCYTE association association Table 1 aqp7-plin1-1 2 5 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level 9 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level proximity proximity close-contact colocalization neighbourhood interaction Figs. 2, 7 Isoprenaline-stimulated adipocytes exhibited significantly less AQP7-PLIN1complexes as compared to adipocytes stimulated withinsulin Isoprenaline (CHEBI:64317) Insulin (CHEBI:145810) plin1-aqp7-1 3 5 unspecified role unspecified role prey prey purified purified c-terminal his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range region required to bind necessary binding region required to bind certain certain sequence position certain certain certain sequence position certain region required to bind necessary binding region required to bind certain certain sequence position certain certain certain sequence position certain O14520:p.Ser10_Thr11delinsAlaAla mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain ST AA Thu Apr 22 10:36:06 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'O14520:p.[Ser10Ala;Thr11Ala]' region phosres phosphorylated residue PhosRes Phospho Phosphorylation Phosphorylation (O of Serine, Threonine, Tyrosine and Aspartate, N epsilon of Lysine) undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined prerequisite-ptm prerequisite-ptm prerequisite ptm required ptm prerequisite-ptm required-ptm picpa Pichia pastoris (Yeast) Yeast Pichia pastoris 9 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed cell lysate cell lysate n-terminal mbp tag maltose binding protein tag maltose binding protein tag maltose binding protein tag mbp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminal his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecoli Escherichia coli (strain K12) physical association physical association Figs. 3, 4, 5 aqp7-plin1-2 4 5 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level 9 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level colocalization colocalization Fig. 6 In insulin-stimulated adipocytes, AQP7 and PLIN1co-distribute to apparent clusters, whereas this enrichment pattern disappears with isoprenaline treatment,resulting in a more homogenous distribution