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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>MINT</shortLabel>
        <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
        <alias type="synonym" typeAc="MI:1041">MINT</alias>
      </names>
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      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it/mint</attribute>
        <attribute name="url" nameAc="MI:0614">url&amp;gt;http://mint.bio.uniroma2.it/mint/</attribute>
        <attribute name="url" nameAc="MI:0614">https://mint.bio.uniroma2.it</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">MINT-[0-9]+</attribute>
        <attribute name="search-url" nameAc="MI:0615">https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac}</attribute>
        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>JAZ (Znf346), a SIRT1-interacting protein, protects neurons by stimulating p21 (WAF/CIP1) protein expression.</fullName>
        </names>
        <bibref>
          <xref>
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          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">JAZ (Znf346), a SIRT1-interacting protein, protects neurons by stimulating p21 (WAF/CIP1) protein expression.</attribute>
            <attribute name="journal" nameAc="MI:0885">The Journal of biological chemistry</attribute>
            <attribute name="publication year" nameAc="MI:0886">2014</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Mallick S., D'Mello SR.</attribute>
            <attribute name="dataset" nameAc="MI:0875">Brain Disease - Neurological Diseases &amp; Disorders</attribute>
            <attribute name="remark-internal">27/05/2021. sent email to authors to request origin species of:SIRT-Flag (Fig. 2A) - email address NOT WORKING</attribute>
            <attribute name="contact-email" nameAc="MI:0634">sdmello@smu.edu,dmello@neugneron.com</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
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        <hostOrganismList>
          <hostOrganism ncbiTaxId="10116">
            <names>
              <shortLabel>rat-brain</shortLabel>
              <fullName>Rattus norvegicus brain</fullName>
            </names>
            <tissue>
              <names>
                <shortLabel>brain</shortLabel>
                <fullName>Brain [cerebrum]</fullName>
              </names>
              <xref>
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          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>anti bait coip</shortLabel>
            <fullName>anti bait coimmunoprecipitation</fullName>
            <alias type="synonym" typeAc="MI:1041">anti bait coip</alias>
          </names>
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        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
          </names>
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        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Mallick S., D'Mello SR.</attribute>
          <attribute name="dataset" nameAc="MI:0875">Brain Disease - Neurological Diseases &amp; Disorders</attribute>
          <attribute name="remark-internal">27/05/2021. sent email to authors to request origin species of:SIRT-Flag (Fig. 2A) - email address NOT WORKING</attribute>
          <attribute name="data-processing" nameAc="MI:0633">interactions from fig. 2a and b could not be captured as origin species of FLAG-SIRT1 was not provided.</attribute>
          <attribute name="contact-email" nameAc="MI:0634">sdmello@smu.edu,dmello@neugneron.com</attribute>
          <attribute name="accepted">Accepted 2021-JUN-08 AT 12:51 BST AT 12:51 BST by MGT</attribute>
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          <attribute name="publication year" nameAc="MI:0886">2014</attribute>
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          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>sir1_rat</shortLabel>
          <fullName>NAD-dependent protein deacetylase sirtuin-1</fullName>
          <alias type="gene name" typeAc="MI:0301">Sirt1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">NAD-dependent protein deacylase sirtuin-1</alias>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:1904638" version="SP_47"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1904644" version="SP_47"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1904646" version="SP_47"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1904648" version="SP_47"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1990254" version="SP_47"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1990830" version="SP_47"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1990841" version="SP_47"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000111" version="SP_47"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000270" version="SP_47"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000480" version="SP_47"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000481" version="SP_47"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000614" version="SP_47"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000619" version="SP_47"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000655" version="SP_47"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000757" version="SP_47"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000773" version="SP_47"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000774" version="SP_47"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003000"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR026590"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR026591"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR029035"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-3371453"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-427359"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9617629"/>
          <secondaryRef db="rgd" dbAc="MI:0483" id="1308542"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10116">
          <names>
            <shortLabel>rat</shortLabel>
            <fullName>Rattus norvegicus (Rat)</fullName>
            <alias type="synonym" typeAc="MI:1041">Rat</alias>
          </names>
        </organism>
        <sequence>MIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELVHLSELPPTPLHISEDSSSPERTVPQDSSVIATLVDQTIKNKVDDLEVSEPKSCVEEKSQEVQTYRNVESINVENPDFKAVGSSTGDKNERTSVAETVRKCWPNRLAKEQISKRLDGNQYLFVPPNRYIFHGAEVYSDSEDDALSSSSCGSNSDSGTCQSPSLEEPLEDESEIEEFYNGLEDDADRPECAGGSGADGGDQEAVNEAIAMKQELTDVNCTPDKSEHY</sequence>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>d3zql4_rat</shortLabel>
          <alias type="gene name" typeAc="MI:0301">Zfp346</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="D3ZQL4" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOP00000022646" version="TrEMBL_72" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-21996050" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="rgd" dbAc="MI:0483" id="1308068"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_006253690.1"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOG00000016867" version="TrEMBL_72" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOT00000022646" version="TrEMBL_72" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003725" version="TrEMBL_72"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="TrEMBL_72"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" version="TrEMBL_72"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005730" version="TrEMBL_72"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008270" version="TrEMBL_72"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019899" version="TrEMBL_72"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035198" version="TrEMBL_72"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043065" version="TrEMBL_72"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003604" version="TrEMBL_72"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013087" version="TrEMBL_72"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036236" version="TrEMBL_72"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10116">
          <names>
            <shortLabel>rat</shortLabel>
            <fullName>Rattus norvegicus (Rat)</fullName>
            <alias type="synonym" typeAc="MI:1041">Rat</alias>
          </names>
        </organism>
        <sequence>MRSSSTARLAEKMECPVPDFTEAADPGGAGPYKSSEEPEGREPDGVRFDRERARRLWEAVSGAQPAGREEVEHMIQKNQCLFTSTQCKVCCAMLISESQKLAHYQSKKHANKVKRYLAIHGMETLKGDVKRLDSDQKSSRSKDKNHCCPVCNMTFSSPVVAQSHYLGKTHARNLKLKQQPAKGAALQQHRETLDPDKFCSLCHSAFNDPAMAQQHYTGKRHRKQETKLKLMAHYGRLAGPTASDSPAGKGYPCKTCKIVLNSIEQYQAHVSGFKHKNQSPKTLVTLGSQMPVQTQPTPKDSSTVED</sequence>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-28996-1">
        <names>
          <shortLabel>jaz-sirt1-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-26981903" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-28996-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>physiological level</shortLabel>
                  <fullName>physiological level</fullName>
                  <alias type="go synonym" typeAc="MI:0303">endogenous level</alias>
                  <alias type="go synonym" typeAc="MI:0303">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous level</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
          </participant>
          <participant id="6">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>physiological level</shortLabel>
                  <fullName>physiological level</fullName>
                  <alias type="go synonym" typeAc="MI:0303">endogenous level</alias>
                  <alias type="go synonym" typeAc="MI:0303">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous level</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">Fig. 2C</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>