DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Crystal structure of the eukaryotic 60S ribosomal subunit in complex with initiation factor 6. Crystal structure of the eukaryotic 60S ribosomal subunit in complex with initiation factor 6. Science (New York, N.Y.) 2011 imex curation Klinge S., Voigts-Hoffmann F., Leibundgut M., Arpagaus S., Ban N. ban@mol.biol.ethz.ch 29-Mar-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation tetts Tetrahymena thermophila (strain SB210) x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Klinge S., Voigts-Hoffmann F., Leibundgut M., Arpagaus S., Ban N. ban@mol.biol.ethz.ch Accepted 2021-FEB-08 AT 09:25 GMT AT 09:25 GMT by PPORRAS Science (New York, N.Y.) 2011 Only protein-protein interactions imex curation imex curation rl28_tetth 60S ribosomal protein L28 RPL28 protein protein tetth Tetrahymena thermophila MSQLVWEIVKNNNAFLVKNNGVAFTTDPFSVTGRNTQVGLGFTHRHGVALKGGAKQAIATSLRKNQSHKVKKTGTIEAETLTVKGGVQRVAKVIRGRFQSKGLKQFALKKLVNFHRANVRAQANLKAESKAKKN E8D1A52C9C3BF60D rl5_tetts 60S ribosomal protein L5 RPL5 TTHERM_00736480 protein protein tetts Tetrahymena thermophila (strain SB210) MGFVKVLKTKAYFKRFQTKYRRRREGLTDYYARKRLIIQDKDKYNTPKYRLVARATNTRIIAQIVYATLKCDRVLCAADSYELKRFGVSTGLASYAAAYATGLLLARRLLKQIGLDTVYAGQTKVDGAYFNVDEDQKEKKPFKAILDAGLVRTTTGNRVFGVLKGACDGGINIPHSESRFPGYVRASDEGESSKYKPEDHKARIFGKHIDAYMKHLKGQSNEAFQKQFSKWSKTLEAAKVDSVEKLFTKVHAEIRKNPERVKSTKKNDKPKRDHKKFYPTKLTAAQRKDRVKTKFQLALSQ AF27B3D68534C6BC rl32_tetts 60S ribosomal protein L32 RPL32 TTHERM_00085180 protein protein tetts Tetrahymena thermophila (strain SB210) MAIKPVAHKKIIKKRTKKFVRFESEDFAKLDSSWRRPRGIDNRVRRRFRGQRRMAKIGFASDAATKHLLPNGFKKFLIRNPADLEILLMNNRTYCGEIAHNISAQVKAALVKRAAELGVRLTNANAKVKVQESA D4C015F3171724AB rl27a_tetth 60S ribosomal protein L27a RPL27A RPL28 protein protein tetth Tetrahymena thermophila MVSHLKKTRKLRGHVSHGHGRVGKHRKGGCRGGRGKAGGMHHHRILMEKWHPGYYGKLGMRTFHLKKNPLHCPVVNIDKLWSLVSDATRQKYAEDKKKVPVIDVTKAGFFKVLGKGRLPNQPVVVKAKYFSKTAERRIVAVGGACVLTA C9A2AB8EEA9B9ECC rl23_tetts 60S ribosomal protein L23 RPL23 TTHERM_00227270 protein protein tetts Tetrahymena thermophila (strain SB210) MAAARGRGGQVGTKAKVSLGLPVGAVMNCADNSGAKNLYTIACFGIKGHLSKLPSASIGDMILCSVKKGSPKLRKKVLQAIVIRQRRPWRRRDGVFIYFEDNAGVIANPKGEMKGSQITGPVAKECADIWPKVASNAGSVV 496BB177505EF577 rl9_tetts 60S ribosomal protein L9 RPL9 TTHERM_01142730A protein protein tetts Tetrahymena thermophila (strain SB210) MRHLLTEVNVPIPDKVTITAKQRVVEVKGPLGTIKRAFRYASVDIQKPTADNVKLQIWQASRKERAVLQSIASQIKNMIRGVTEGYKFKMKLAFAHFPIQEAVAKDGSSIEIKHFLGEKRIRRIQALPGVKISRKDEEKNTLTLQGIDLNNVSQTCALIHQSCLVKEKDIRQFLDGIYVSDKRLAMNE CCD2BE3016A8030B rl8_tetts 60S ribosomal protein L8 RPL8 RPL2 TTHERM_00716240 protein protein tetts Tetrahymena thermophila (strain SB210) MGRVIRAQRKGRANGVYKSHKSGRIAPAQYRVYDFAERQGYIRGCIRDIVHEPGRGAPLAEVAFRDPYRYKTNKEHFIAAEGQYSGQYVYCGLKAQIAVGNVLPINRIPEGTVVCNVEEKVGDRGTFSRASGCYATIIGHSEDGDKTRIRLPSGARKTIPGSCRATVGIVAGGGRTDKPILKAGNQFHKYARKRKSWPRVRGVAMNPVDHPHGGGNHQHIGHPATVSKWASAGQKVGLRAARRTGLVRGGQKEKMAMKAAAAGV 3A15F5E20A8BE067 rl30_tetts 60S ribosomal protein L30 RPL30 TTHERM_00446280A protein protein tetts Tetrahymena thermophila (strain SB210) MVKKVTQDNIQSKLALVMRSGKATLGYKSTIKAIRNGTAKLVFISNNCPTVRKSEIEYYASLAQISIHHFVGSNVELGTACGKYHRCSTMAILDAGDSDILKTE 315D69133E04982D rl6_tetts 60S ribosomal protein L6 RPL6 TTHERM_00136120A protein protein tetts Tetrahymena thermophila (strain SB210) MARGPAGKNRGVSKISKWYKADDEATPFHRRQLKKATATKLRNDIAPGTVLILLAGRFRGKRVVFLKQLKSGLLLVTGPYKVNGVPLKRVNQAYTLSTSTKVDLTGVNTAKFEDDYFGREKARKNHKNLFKAELTEEQKKKETERKNARKQDQQAVDTPLLAAVKKVEFLKNYLASKFTLNNNDRPHEMKF D0D749737F91918F rl7_tetth 60S ribosomal protein L7 RPL7 protein protein tetth Tetrahymena thermophila MSKFVPENVQKKLARDEKLRKAKAEQRKASSAQMKQRKAEWISKAQKYAAEYEAAEKKIVDEKRKARKTGAFYVPAEAKVAFAIRIRGVNQLHPDVKRVLRLFRLRQLHNGAFFRVNKASLNMIKRVLPFITFGYPTRNTISKLIYKRGFAKVNGQRIPLTDNTIVEKSLGKFGITCVEDLIHEITTVGPHFKEANNFLWPFKLDTPRGGFRNKRHAYHQGGDWGNREVYINDLVKAML 950C2EFBD29C4A8A rl11_tetth 60S ribosomal protein L11 L21 RPL11 protein protein tetth Tetrahymena thermophila MTDKKENKMREVKIAKLVINCCVGESGDKLTKAAKVLKDLSGQEPVFSRARYTIRSFGIKRNEKMAVHVTIRGDKARDILTRGLKVKEMELRKKNFSNTGNFGFGIQEHIDLGMKYDPSTGIFGMDFYVVLERPGTRVARRRRATSRVGNNQMISKEECINWFKTEFEGNVY 1BD0B725D23A9338 rl4_tetts 60S ribosomal protein L4 RPL4 TTHERM_00333210 protein protein tetts Tetrahymena thermophila (strain SB210) MTSRPQIHVHDAKEANKQTATKLTLPAVFTAPIRTDIVHKVFTDLNKNRKQASGVKISTRGTAGMGHSAESWGTGRAVARIPRVGGSGTHRSGQAAFGNQCRKGRMFAPLKTYRRVHRRVNVNQKRHAVAAALAASALVPLVFARGHRISNVQELPYVFDDSVESYEKTKQAVAFLKRVGAYDDVLRVAETKALRAGQGKLRNRRYKLRRGPLVVYGNEKSTLTRALRNIPGVDVCNVNRLNLLQLAPGGHVGRFIIWTESAFKKLNEIFGTYSTTGVQKSGYQLQRPLLANADIARIINSNEVQSVVKVAGTTETHERKKNPLTNNNALFKLNPAAKIVKEQAKKAAEASKAKRQATLKANRKAAKTHKKGSQAWIAAFNKANEEAIAKARQEDADFIAQGQEIKEGDE E8BF0AECD50F6D6C rl24_tetts 60S ribosomal protein L24 RPL24 TTHERM_00476640A protein protein tetts Tetrahymena thermophila (strain SB210) MVVRTGTCSFCEYRIYPGRGQRFIAKDGRGFFFLTKKAKCLSLRKVKAQKITWTIARRRLWKKVKATDIAQKKKKRNVTVARAIVGISLEEINRRKNLDASHKKAEAEKAVRELKQKKANDIEKKRADRKLQGKDVKAAKKAETKKTKQPVGAKGGKK 305ABE526A314DF7 rl38_tetts 60S ribosomal protein L38 RPL38 TTHERM_00812780 protein protein tetts Tetrahymena thermophila (strain SB210) MPKEITDIKKFMKLWQNNKDTPATAGAKKVVYVKTNKRITKFKLRGKKYLYTFKTADPKIAKGIKDAIPATYSKIEIKGKNTKKATKRS 558956CC934E3516 rl17_tetts 60S ribosomal protein L17 RPL17 protein protein tetts Tetrahymena thermophila (strain SB210) MGKTNYSREPANQAKAVKTSASDLRVHFKNTYEVVRAIKGLNLENAKRYLKAVIDRKRCIPFTRFTGCIGRTAQAHEFGRTQGRWPVKSVKVILGLLDNLSANAQAKSLNTANLVIQHGQVNRAQKGRRRTYRAHGRINPYLNSGCHVEIFAQEVAAKVRKEAPKDAAKKVPKTKKGKLAIGN 6DC0A9A527B31446 rl31_tetts 60S ribosomal protein L31 RPL31 TTHERM_00943010 protein protein tetts Tetrahymena thermophila (strain SB210) MVKQEEKSIDTTVNLHKQCHKISFKKKAPRAIREIVAIAKKTMGTDDVRIDTELNKFIWSNGIRNIPRRVRVRLCKRKNEEEGAQSQFYTLVQHLQVDSYHGLLTEKTKAE F3BC102C2585450C rl40_tetts Ubiquitin-60S ribosomal protein L40 RPL40 protein protein tetts Tetrahymena thermophila (strain SB210) MQIFVKTLTGKTITLDVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGGMEPTIAALAKKYNCEKKVCRDCYARLPPKATNCRKRKCGHSNSLRLKKKPKE F008EFC6F279EDE9 rl37_tetts 60S ribosomal protein L37 RPL37 TTHERM_01068180 protein protein tetts Tetrahymena thermophila (strain SB210) MTRGTPAFGKRHQKTHTLCRRCGKATYHKQKLRCAACGYPDAKMRRYDGWGQKVRDRKGQGTGRMRYMKTIARRAKNGFRSGTQAAPKVKAATN E4BB7D5B24880194 rl3_tetth Ribosomal protein L3 RPL3 protein protein tetth Tetrahymena thermophila MSHRKFEAPRHGSLGFRPRRRTRHHRGRCRSFPKDDPSKKPHLTAFTGFKAGMTHILREVDRSGSRHNKKEVVEAVTVIECPPMTIVGVVGYIDTPRGLRALTTVWAKTIDNNTKKRFYKNWANSNKKAFTHHEKNFDQKAQDLLLKRIEKYCSVVRVIAHTNMSKLNLRQKKNHILEIQVNGGKVAEKVAFAKSLLEKEVKVDSIFAENEMLDVLGVTKGKGFAGVIKRFGVKHLQKKTHRGYRKVGCIGAWHPSRIRFTVPRAGQLGYHHRTETNKKVYRVGKGDDASNASTAGDVTDKAITPLGGFPHYGVVKNDFIMIKGCCVGPKKRVLTLRKSIIPQTHGAAKEIINLKFIDTSSKIGHGRFQTVEEKDKFFGRDRTKKVEAKSE 9A8B267AFCDA9DE6 rl13_tetts 60S ribosomal protein L13 RPL13 TTHERM_00578640A protein protein tetts Tetrahymena thermophila (strain SB210) MKHNNQLPVAQLRKHQQFRIKTFFNQAAQKKARLHARRAQAAAVFPRPTEKLQPVVRKQTQRYNKSTKLGRGFTLQELKAAGISAAFAQSIGIKVDHRRKNRCQESLELNKKRLLAYVSKLVLFPRHQGKAKKGLVNDTADTSSAAQNALQTSVPLPSVSKREKAVSNIAELRKKKVYRIIRQEKTNQKWDGKRKAKAQAAAEPKA 5E8EFA80157A2DA3 rl35_tetts 60S ribosomal protein L35 RPL35 TTHERM_00561680A protein protein tetts Tetrahymena thermophila (strain SB210) MDKSVRVFKLRTQTEEQLVGELGKLQTELSQLRIAKIAGGTANKLGRIGIVRKAIAKYLTIINEKRRQAVKDQFKGKSLKPLDIRVKKTRAIRRKLTKKQREAVLVKTQKKLNNFGLRKFALKA D994D581EBC47197 rl18_tetth 60S ribosomal protein L18 RPL18 protein protein tetth Tetrahymena thermophila MAIDLHKQGRVVKRSVVRQTKSTNVYHKLLIKLYKFLVRRTDSKFNQNILKRLSSSRLNKFPLSLSRIVKNLNETNKEQVIVSTSTVTNDERLLTVPKLTVCALKFTETARKRILAAGGKCLTFDQLALKAPTGTNCFLLRAPKSREAYRHWGKAPGQRGSHSAPYVRSEGRKFERAHGLK 57E5D98013FD4226 rl36_tetts 60S ribosomal protein L36 RPL36 TTHERM_01129660 protein protein tetts Tetrahymena thermophila (strain SB210) MAKGQAVGINKGFITTQLEKKLQKHSAVQRKGKLGKRVALVRQVIREVTGFAPYEKRIIELIKAGSAKDSKKATKIARKRLGTHRRAKVKKALLEEAVRAQRKK 1E641533F4303BF0 rl27_tetth 60S ribosomal protein L27 RPL27 protein protein tetth Tetrahymena thermophila MAKFLKYGRVVILLQGRFAGKKAVIVKSSEDGTKDRKFGHVLVAGVERSPKKVTKRMGSKKIQKRTSVKPFIKYVNLNHIMPTRYSVKELCDFKELVKEDKIKNNAKSEVRDTLKKVFVEKYRTINPEEKSASHTKFFFSKLRF E635784F68F44D09 rl15_tetts 60S ribosomal protein L15 RPL15 TTHERM_01289110 protein protein tetts Tetrahymena thermophila (strain SB210) MGAYKYLEELWRKKQSDLMSFILRLRTWEYRQLPVIHKASRSSRPDKARKLGYKNKDGYAIWRVRVRRGGRKRPVSKGIVYGKPSSVGINQLKFARNLRSCAEERVGKRVPELRVLNSYWVGQDGTYKFYEVILADPSHNAIRNDPRINWICESAHKHRELRGLTSAGRKGRGLRVKGHRAKSLRTSRKGNWRARQMLKLRRYR 3470D7F2E0494701 rl14_tetts 60S ribosomal protein L14 RPL14 TTHERM_00697490A protein protein tetts Tetrahymena thermophila (strain SB210) MVFNKFVQVGRVVYINYGADKGKLAVIVNIINQNRILIDGEHIVRQVIPIRRVHLTKFQIDNVELNQRTVLLKKKIAKFDLTKKYAETSFAKKQAIKTKRANLGDFDRFRVMVLKKKLARTSAKSK 69DDBEAC2B769FDE rl39_tetts 60S ribosomal protein L39 RPL39 TTHERM_00526400A protein protein tetts Tetrahymena thermophila (strain SB210) MGANKTLNMKKRFGRKIKQNRPLPNWYRYKSDTNIRYNSKRRNWRRTKLKIY 736FE917A34B11F4 rl23a_tetts 60S ribosomal protein L23A RPL23A RPL25 TTHERM_00134940A protein protein tetts Tetrahymena thermophila (strain SB210) MNKENKTQAVNKAKNTAKVAKKGSSITKHKTYTGVRFFRPKTLQLAKAPKYSRTVRAHLKVSGHLDNHSVVKTPLTTEKAMKKMEDENTMVFYVHNRSTKPQIKSAFEKLYNVKVRSVNTLNTITGNKKAYIRLAADSDSLTLANKIGLI 4559D0203B3D1D5E rl13a_tetts 60S ribosomal protein L13a RPL13A RPL16 protein protein tetts Tetrahymena thermophila (strain SB210) MFDKLVVIDAKGHLLGRLASYVAKELLSGQRIVVVRTEAINISGSLFRNRVKFSEFLNKWMNHNPRRGVQHFRAPSRIFWRAVRGMLPHKTPKGAAALERLKIFEGIPTPYDRVKKQVVVDALKVQRLRNSRPVCKLGDLSASVGWGKQTLIEKLEEKRRARAKTYHDKKVKQADARKKELAAPALKAIKDKLAQFGY DC8AA8A8538C3306 rl36a_tetts 60S ribosomal protein L36a 60S ribosomal protein L44 RPL36A RPL42 RPL44 TTHERM_00633150 protein protein tetts Tetrahymena thermophila (strain SB210) MVQVPKTRKTYCKKCNSHTNHKVSQYKKSKESTHAQGRRRYDMKQSGFGGQTKPIFRKKAKTTKKVALKFDCTTCKTKRVIPIKRCKTIVFMDITQIKKAKVNKKDPNW B071F8D1F02B2E17 rl37a_tetts 60S ribosomal protein L37a RPL37A RPL43 TTHERM_00075670 protein protein tetts Tetrahymena thermophila (strain SB210) MAKRTQKVGITRKYGTRYGASLRKVVKKFEITQHAKYGCPFCGKVAVKRAAVGIWKCKPCKKIIAGGAWELTTPPAVTAKTTMNRLKKLQEEQAAAAALEKKN 8D5DDF22E7DD6582 rl22_tetts 60S ribosomal protein L22 RPL22 TTHERM_00227270 protein protein tetts Tetrahymena thermophila (strain SB210) MSFRKKTKQVKKVNLGFKIDCSQPVEDKVILIGEFAEFLKSKIKVGGKLGNLGENITISNDDKKINVQSTIPFSKRYLKYLTKKYLKKQDLRNYLYVTSSDKNSYQLRYFNIQQDQAE CEF0CC6C9D1E16D7 rl19_tetts 60S ribosomal protein L19 RPL19 TTHERM_00444510A protein protein tetts Tetrahymena thermophila (strain SB210) MVSLRLQKRLAASVLKCGQKRLWLDPNESSEISMANSRASIRKLIKDGLVMKRSTVIHSRSRARAFLEAKRKGRHTGSGKRKGTRNARMPTKVLWMRRQRVLRRLLRKYRAAKKIDKHQYHEFYLGSKGNLYKNKTVLIEAIHVSKADKIKSDKLTSQQEARRAKNTASRAKRNEKAQIVAKVDV 8C13F943D5C71333 rl10_tetts 60S ribosomal protein L10 RPL10 TTHERM_01053000 protein protein tetts Tetrahymena thermophila (strain SB210) MGRRPARCYRQPKGKPYPKSRYNRGVPDARIRIYDSGRKKATVEEFPYVVHIVSDEKEQITSEALEAARIAANKNLIKFISKDAFHLRCRVHPWHVLRINKMLSCAGADRLQSGMRGAFGKALGKAARVDIGSILFSVRVKEPHVKYAIDALTRAKAKFPGRQKVVTSQKWGFTKLTRAQYSRLRNQKKLVTDGSNVKVIGERGPLSRLELFRKI C3AFFC5FC2BFD2A4 rl18a_tetth 60S ribosomal protein L18a RPL18A RPL20 protein protein tetth Tetrahymena thermophila MVRKAAQEPKDDTLQMKVRQYVVSAARLPIEQGTKPEILQMRVFARDEVHAKTKFWYNMRKLNKIKRSQGRILSVNEIYEKSLNTVKTYGIVLKYQSRTAIHNMYKEYRDVSLNGAVSQLIQDMAGNHRAQPDTIQIIRTATLEPKDIKRPATLAMRNAALKFPIVKTIHRPSEKKYRTVYKATRPTTF 3F30D7C0F40E65B8 if6_tetts Eukaryotic translation initiation factor 6 EIF6 TTHERM_00732590 protein protein tetts Tetrahymena thermophila (strain SB210) MARRCQFENSNDIGVFCKLTSAYCLVSVGASENFYSVFESELVPHIPVIHTSIGGTRIVGRVTCGNKNGLLVPNTCNDNELRNIRNSLPDNVRVRRIEEKLSALGNCVVANDYVALIHPDLDRESEEIIADTLGVEVFRTTIANNVLVGTYCVINNRGGLVHPLASVEELDELANLLQIPLCAGTINRGSDVIGAGLVVNDWAAFCGLDTTSTEISVVENIFKLNEMKDENMDNEMRKDFVMNLE 3B91352EB069696E rl21_tetts 60S ribosomal protein L21 RPL21 TTHERM_00666540 protein protein tetts Tetrahymena thermophila (strain SB210) MTHSYGYRRQTRKKFAKAYKTKGHVRISRYLTTYKVGEYVDIMVDGSQHKGMPYKLYHGRTGKVFNVNPRSIGVIVHRIVNGRYIEKRLHVKIEHVRPSNVKTALSKRYQANDQAKAEGNKAGKRVSTKRNPGQPLEAVQVQGAVNFQHPKVFREIF 8DE83B7B21140A32 rl35a_tetts 60S ribosomal protein L35a RPL35A RL33A TTHERM_00992730 protein protein tetts Tetrahymena thermophila (strain SB210) MAKTSTSPVAPTRLWVKAAFTGFRRSKHTQNSNQALLKLQNVNTKEDVAFYQGKRVVYIYKGQKKNGSNYRTIWGRIGKAHGNNGVAVARFAHNLPPQAIGSVLRVMLYPNRA D40046514B7EA8DF rl7a_tetth 60S ribosomal protein L7a RPL7A RPL8 protein protein tetth Tetrahymena thermophila MPKAPKKITKPKKAEKKKNPLFQAKPRSFRVGGDIQPKRDLTRFVRWPRYITLQRQKRVLLQRLKVPPQIHQFTKTLDKNQSSNLFKLLASYAPEKPAEKKQRLVAQAEAKKDGKQVETKKPIVLKYGLNHITTLIENKQAKLVVIAHDVDPIELVIFLPQLCRKNDVPFAFVKGKAALGKLVNKKTATAVALTEVRNEDKAKLQQFSELFKTNYNANDELRKTWGGGILGQKSQHKVEALAKAVQEEQIKKAKL 8C82222C600B87A0 rl29_tetth 60S ribosomal protein L29 RPL29 protein protein tetth Tetrahymena thermophila MAKSKNSTNKNQISKSHRNGIKKPKDHRHISTKGVNPRFLRNRRRAIKNDPSIKKSKNLEKKVNKE 83AE3BE1972DC5B6 rl26_tetts 60S ribosomal protein L26 RPL26 TTHERM_00382350 protein protein tetts Tetrahymena thermophila (strain SB210) MKTHVEVSSARRKQRKAHFASPSHLRQTLMSAHLSKDLRSKYNVRSMPVRKDDEVLIVRGKFKGNKGKVTQVYRKKWAIHVEKISKNKLNGAPYQIPLSASQLVLTKLKLDKSRQSLLTRKAASLKTKGQKHTVA 197DB6307833CFB4 rl34_tetts 60S ribosomal protein L34 RPL34 protein protein tetts Tetrahymena thermophila (strain SB210) MAQRITYRRRCSYNTRSNKVRKVKTPGGRLVAQYVKKVVNYTKCSEAGCNVALNGIAQVRPAEYATIARSAKTVSRVYGGELCHTCVRSRIIRAFLTEEVKIVKRKMISKPKTDKKKKRSQKK D3216B19406D7C53 eif6-rpl10-1 1 34 unspecified role unspecified role neutral component neutral component purified purified 32 unspecified role unspecified role neutral component neutral component purified purified 4 unspecified role unspecified role neutral component neutral component purified purified 17 unspecified role unspecified role neutral component neutral component purified purified 11 unspecified role unspecified role neutral component neutral component purified purified 22 unspecified role unspecified role neutral component neutral component purified purified 14 unspecified role unspecified role neutral component neutral component purified purified 42 unspecified role unspecified role neutral component neutral component purified purified 29 unspecified role unspecified role neutral component neutral component purified purified 16 unspecified role unspecified role neutral component neutral component purified purified 38 unspecified role unspecified role neutral component neutral component purified purified 34 unspecified role unspecified role neutral component neutral component purified purified 23 unspecified role unspecified role neutral component neutral component purified purified 3 unspecified role unspecified role neutral component neutral component purified purified 26 unspecified role unspecified role neutral component neutral component purified purified 5 unspecified role unspecified role neutral component neutral component purified purified 6 unspecified role unspecified role neutral component neutral component purified purified 30 unspecified role unspecified role neutral component neutral component purified purified 35 unspecified role unspecified role neutral component neutral component purified purified 40 unspecified role unspecified role neutral component neutral component purified purified 7 unspecified role unspecified role neutral component neutral component purified purified 12 unspecified role unspecified role neutral component neutral component purified purified 13 unspecified role unspecified role neutral component neutral component purified purified 20 unspecified role unspecified role neutral component neutral component purified purified 8 unspecified role unspecified role neutral component neutral component purified purified 36 unspecified role unspecified role neutral component neutral component purified purified 21 unspecified role unspecified role neutral component neutral component purified purified 41 unspecified role unspecified role neutral component neutral component purified purified 24 unspecified role unspecified role neutral component neutral component purified purified 15 unspecified role unspecified role neutral component neutral component purified purified 2 unspecified role unspecified role neutral component neutral component purified purified 25 unspecified role unspecified role neutral component neutral component purified purified 33 unspecified role unspecified role neutral component neutral component purified purified 43 unspecified role unspecified role neutral component neutral component purified purified 18 unspecified role unspecified role neutral component neutral component purified purified 37 unspecified role unspecified role neutral component neutral component purified purified 39 unspecified role unspecified role neutral component neutral component purified purified 9 unspecified role unspecified role neutral component neutral component purified purified 27 unspecified role unspecified role neutral component neutral component purified purified 10 unspecified role unspecified role neutral component neutral component purified purified 31 unspecified role unspecified role neutral component neutral component purified purified 28 unspecified role unspecified role neutral component neutral component purified purified 19 unspecified role unspecified role neutral component neutral component purified purified physical association physical association Fig 1, Table S1