DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu The structures of four macrolide antibiotics bound to the large ribosomal subunit. The structures of four macrolide antibiotics bound to the large ribosomal subunit. Molecular cell 2002 imex curation Hansen JL., Ippolito JA., Ban N., Nissen P., Moore PB., Steitz TA. eatherton@csb.yale.edu 24-May-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Hansen JL., Ippolito JA., Ban N., Nissen P., Moore PB., Steitz TA. eatherton@csb.yale.edu Accepted 2021-APR-02 AT 03:33 BST AT 03:33 BST by KALPANAP Molecular cell 2002 Only protein-protein interactions imex curation imex curation rl13_halma 50S ribosomal protein L13 Hmal13 rrnAC0065 rpl13 protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MSVAEFDADVIVDARDCIMGRVASQVAEQALDGETVAVVNAERAVITGREEQIVEKYEKRVDIGNDNGYFYPKRPDGIFKRTIRGMLPHKKQRGREAFESVRVYLGNPYDEDGEVLDGTSLDRLSNIKFVTLGEISETLGANKTW 069CE666662AE3BC rl39_halma 50S ribosomal protein L39e Hl39e Hl46e rrnAC3112 rpl39e protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MGKKSKATKKRLAKLDNQNSRVPAWVMLKTDREVQRNHKRRHWRRNDTDE 4999D410AB7B331A rl18e_halma 50S ribosomal protein L18e Hl29 L19 rrnAC0064 rpl18e protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MSKTNPRLSSLIADLKSAARSSGGAVWGDVAERLEKPRRTHAEVNLGRIERYAQEDETVVVPGKVLGSGVLQKDVTVAAVDFSGTAETKIDQVGEAVSLEQAIENNPEGSHVRVIR BFACD702AE94474D rl37a_halma 50S ribosomal protein L37Ae Ribosomal protein L43e rrnAC1669 rpl37ae protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MASKSGKTGSSGRFGARYGRVSRRRVAEIESEMNEDHACPNCGEDRVDRQGTGIWQCSYCDYKFTGGSYKPETPGGKTVRRSIRAALSEDEE 89E52AFE761E9837 rl21_halma 50S ribosomal protein L21e Hl31 rrnAC0260 rpl21e protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MPSSNGPLEGTRGKLKNKPRDRGTSPPQRAVEEFDDGEKVHLKIDPSVPNGRFHPRFDGQTGTVEGKQGDAYKVDIVDGGKEKTIIVTAAHLRRQE DE6DE036844EF1F2 rl3_halma 50S ribosomal protein L3 Hl1 Hmal3 rrnAC1611 rpl3 protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MPQPSRPRKGSLGFGPRKRSTSETPRFNSWPSDDGQPGVQGFAGYKAGMTHVVLVNDEPNSPREGMEETVPVTVIETPPMRAVALRAYEDTPYGQRPLTEVWTDEFHSELDRTLDVPEDHDPDAAEEQIRDAHEAGDLGDLRLITHTVPDAVPSVPKKKPDVMETRVGGGSVSDRLDHALDIVEDGGEHAMNDIFRAGEYADVAGVTKGKGTQGPVKRWGVQKRKGKHARQGWRRRIGNLGPWNPSRVRSTVPQQGQTGYHQRTELNKRLIDIGEGDEPTVDGGFVNYGEVDGPYTLVKGSVPGPDKRLVRFRPAVRPNDQPRLDPEVRYVSNESNQG 996D3BE503F4DBD4 rl37_halma 50S ribosomal protein L37e L35e rrnAC0797.1 rpl37e protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MTGAGTPSQGKKNTTTHTKCRRCGEKSYHTKKKVCSSCGFGKSAKRRDYEWQSKAGE A21A05AACA3112EC rl29_halma 50S ribosomal protein L29 Hl33 Hmal29 rrnAC1604 rpl29 protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MTVLHVQEIRDMTPAEREAELDDLKTELLNARAVQAAGGAPENPGRIKELRKAIARIKTIQGEEGDLQENE 31779CA339CC699A rl24_halma 50S ribosomal protein L24 Hl15 Hl16 Hmal24 rrnAC1601 rpl24 protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MSKQPDKQRKSQRRAPLHERHKQVRATLSADLREEYGQRNVRVNAGDTVEVLRGDFAGEEGEVINVDLDKAVIHVEDVTLEKTDGEEVPRPLDTSNVRVTDLDLEDEKREARLESEDDSA BDEEF21DE1587096 rl7a_halma 50S ribosomal protein L7Ae Hs6 Ribosomal protein L8e rrnAC0103 rpl7ae protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MPVYVDFDVPADLEDDALEALEVARDTGAVKKGTNETTKSIERGSAELVFVAEDVQPEEIVMHIPELADEKGVPFIFVEQQDDLGHAAGLEVGSAAAAVTDAGEADADVEDIADKVEELR 96132F5CB51840A0 rl18_halma 50S ribosomal protein L18 Hl12 Hmal18 rrnAC1593 rpl18 protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MATGPRYKVPMRRRREARTDYHQRLRLLKSGKPRLVARKSNKHVRAQLVTLGPNGDDTLASAHSSDLAEYGWEAPTGNMPSAYLTGLLAGLRAQEAGVEEAVLDIGLNSPTPGSKVFAIQEGAIDAGLDIPHNDDVLADWQRTRGAHIAEYDEQLEEPLYSGDFDAADLPEHFDELRETLLDGDIEL 60E9AF3CB64E7CA5 rl32_halma 50S ribosomal protein L32e Hl5 rrnAC1595 rpl32e protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MADNEEDVEAEEEYTELTDISGVGPSKAESLREAGFESVEDVRGADQSALADVSGIGNALAARIKADVGGLEVESETEAEVEEEGGEEAPDEDVETELQARGLTEKTPDLSDEDARLLTQRHRVGKPQFNRQDHHKKKRVSTSWRKPRGQLSKQRRGIKGKGDTVEAGFRSPTAVRGKHPSGFEEVRVHNVDDLEGVDGDTEAVRIASKVGARKRERIEEEAEDAGIRVLNPTYVEVEVSE F4FFF58DE34B3711 rl5_halma 50S ribosomal protein L5 Hl13 Hmal5 rrnAC1598 rpl5 protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MSSESESGGDFHEMREPRIEKVVVHMGIGHGGRDLANAEDILGEITGQMPVRTKAKRTVGEFDIREGDPIGAKVTLRDEMAEEFLQTALPLAELATSQFDDTGNFSFGVEEHTEFPSQEYDPSIGIYGLDVTVNLVRPGYRVAKRDKASRSIPTKHRLNPADAVAFIESTYDVEVSE 565902FAA3D95FB6 rl4_halma 50S ribosomal protein L4 Hl6 Hmal4 rrnAC1610 rpl4 protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MQATIYDLDGNTDGEVDLPDVFETPVRSDLIGKAVRAAQANRKQDYGSDEYAGLRTPAESFGSGRGQAHVPKQDGRARRVPQAVKGRSAHPPKTEKDRSLDLNDKERQLAVRSALAATADADLVADRGHEFDRDEVPVVVSDDFEDLVKTQEVVSLLEALDVHADIDRADETKIKAGQGSARGRKYRRPASILFVTSDEPSTAARNLAGADVATASEVNTEDLAPGGAPGRLTVFTESALAEVAER 4BCA2FE20EE24EDF rl6_halma 50S ribosomal protein L6 Hl10 Hmal6 rrnAC1596 rpl6 protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MPRVELEIPEDVDAEQDHLDITVEGDNGSVTRRLWYPDIDVSVDGDTVVIESDEDNAKTMSTIGTFQSHIENMFHGVTEGWEYGMEVFYSHFPMQVNVEGDEVVIENFLGEKAPRRTTIHGDTDVEIDGEELTVSGPDIEAVGQTAADIEQLTRINDKDVRVFQDGVYITRKPNRGDA 380872452165689C rl30_halma 50S ribosomal protein L30 Hl16 Hl20 Hmal30 rrnAC1591 rpl30 protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MHALVQLRGEVNMHTDIQDTLEMLNIHHVNHCTLVPETDAYRGMVAKVNDFVAFGEPSQETLETVLATRAEPLEGDADVDDEWVAEHTDYDDISGLAFALLSEETTLREQGLSPTLRLHPPRGGHDGVKHPVKEGGQLGKHDTEGIDDLLEAMR ED673F036E974C14 rl31_halma 50S ribosomal protein L31e Hl30 L34 rrnAC3113 rpl31e protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MSASDFEERVVTIPLRDARAEPNHKRADKAMILIREHLAKHFSVDEDAVRLDPSINEAAWARGRANTPSKIRVRAARFEEEGEAIVEAETAE 0FF505E03E8F6C4A rl15e_halma 50S ribosomal protein L15e 50S ribosomal protein LC12 rrnAC2065 rpl15e protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MARSAYSYIRDAWKNPGDGQLAELQWQRQQEWRNEGAVERIERPTRLDKARSQGYKAKQGVIVARVSVRKGSARKRRHKAGRRSKRQGVTRITRRKDIQRVAEERASRTFPNLRVLNSYSVGQDGRQKWHEVILIDPNHPAIQNDDDLSWICADDQADRVFRGLTGAGRRNRGLSGKGKGSEKTRPSLRSNGGKGK 502449E0A6BC23BB rl19e_halma 50S ribosomal protein L19e Hl24 Hmal19 rrnAC1594 rpl19e protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MTDLSAQKRLAADVLDVGKNRVWFNPERQGDIADAITREDVRELVDEGAIQAKDKKGNSRGRARERQKKRAYGHQKGAGSRKGKAGARQNSKEDWESRIRAQRTKLRELRDEGTLSSSQYRDLYDKAGGGEFDSVADLERYIDANHGDA 210F99E836B0B817 rl22_halma 50S ribosomal protein L22 Hl23 Hmal22 rrnAC1606 rpl22 protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MGISYSVEADPDTTAKAMLRERQMSFKHSKAIAREIKGKTAGEAVDYLEAVIEGDQPVPFKQHNSGVGHKSKVDGWDAGRYPEKASKAFLDLLENAVGNADHQGFDGEAMTIKHVAAHKVGEQQGRKPRAMGRASAWNSPQVDVELILEEPEVED E6730272296C0D7C rl14_halma 50S ribosomal protein L14 Hl27 Hmal14 rrnAC1602 rpl14 protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MEALGADVTQGLEKGSLITCADNTGARELKVISVHGYSGTKNRHPKAGLGDKITVSVTKGTPEMRRQVLEAVVVRQRKPIRRPDGTRVKFEDNAAVIVDENEDPRGTELKGPIAREVAQRFGSVASAATMIV 536F9C4461B7EA87 rl10e_halma 50S ribosomal protein L10e rpl10e rrnAC2357 protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MSDKPASMYRDIDKPAYTRREYITGIPGSKIAQHKMGRKQKDADDYPVQISLIVEETVQLRHGSLEASRLSANRHLIKELGEEGDYKMTLRKFPHQVLRENKQATGAGADRVSDGMRAAFGKIVGTAARVQAGEQLFTAYCNVEDAEHVKEAFRRAYNKITPSCRIKVERGEELLIA E7A72FE3683D2BDB rl10_halma 50S ribosomal protein L10 rpl10 rpl10e rplP0 rrnAC1417 Acidic ribosomal protein P0 homolog HMal10 L10E protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MSAESERKTETIPEWKQEEVDAIVEMIESYESVGVVNIAGIPSRQLQDMRRDLHGTAELRVSRNTLLERALDDVDDGLEDLNGYITGQVGLIGTDDNPFSLFQELEASKTPAPIGAGEVAPNDIVIPEGDTGVDPGPFVGELQSVGADARIQEGSIQVLSDSTVLDTGEEVSQELSNVLNELGIEPKEVGLDLRAVFADGVLFEPEELELDIDEYRSDIQAAAGRAFNLSVNADYPTATTAPTMLQSARGNAKSLALQAAIEDPEVVPDLVSKADAQVRALASQIDDEEALPEELQGVEADVATEEPTDDQDDDTASEDDADADDAAEEADDDDDDDEDAGDALGAMF 4063B1C9D2FCB164 rl2_halma 50S ribosomal protein L2 Hl4 Hmal2 rrnAC1608 rpl2 protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MGRRIQGQRRGRGTSTFRAPSHRYKADLEHRKVEDGDVIAGTVVDIEHDPARSAPVAAVEFEDGDRRLILAPEGVGVGDELQVGVSAEIAPGNTLPLAEIPEGVPVCNVESSPGDGGKFARASGVNAQLLTHDRNVAVVKLPSGEMKRLDPQCRATIGVVAGGGRTDKPFVKAGNKHHKMKARGTKWPNVRGVAMNAVDHPFGGGGRQHPGKPKSISRNAPPGRKVGDIASKRTGRGGNE 986CA69D432C7F74 rl44e_halma 50S ribosomal protein L44e HLA La rrnAC3514 rpl44e protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MQMPRRFNTYCPHCNEHQEHEVEKVRSGRQTGMKWIDRQRERNSGIGNDGKFSKVPGGDKPTKKTDLKYRCGECGKAHLREGWRAGRLEFQE 14197AA6AE7AC07A rl23_halma 50S ribosomal protein L23 Hl25 Hmal23 L21 rrnAC1609 rpl23 protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MSWDVIKHPHVTEKAMNDMDFQNKLQFAVDDRASKGEVADAVEEQYDVTVEQVNTQNTMDGEKKAVVRLSEDDDAQEVASRIGVF 2A2E869D640D5B60 rl15_halma 50S ribosomal protein L15 Hl9 Hmal15 rrnAC1590 rpl15 protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MTSKKKRQRGSRTHGGGSHKNRRGAGHRGGRGDAGRDKHEFHNHEPLGKSGFKRPQKVQEEAATIDVREIDENVTLLAADDVAEVEDGGFRVDVRDVVEEADDADYVKVLGAGQVRHELTLIADDFSEGAREKVEGAGGSVELTDLGEERQAEAEETEDADADEE AAF4318ADF0D8879 rl24e_halma 50S ribosomal protein L24e Hl21/Hl22 rrnAC0104 rpl24e protein protein Halobacterium marismortui Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) MPRTRECDYCGTDIEPGTGTMFVHKDGATTHFCSSKCENNADLGREARNLEWTDTARGEAGEAEDEA D4FCAE00935B7305 rpl10-rpl10e-4 1 26 unspecified role unspecified role neutral component neutral component purified purified 3 unspecified role unspecified role neutral component neutral component purified purified 8 unspecified role unspecified role neutral component neutral component purified purified 5 unspecified role unspecified role neutral component neutral component purified purified 13 unspecified role unspecified role neutral component neutral component purified purified 18 unspecified role unspecified role neutral component neutral component purified purified 17 unspecified role unspecified role neutral component neutral component purified purified 9 unspecified role unspecified role neutral component neutral component purified purified 29 unspecified role unspecified role neutral component neutral component purified purified 10 unspecified role unspecified role neutral component neutral component purified purified 27 unspecified role unspecified role neutral component neutral component purified purified 21 unspecified role unspecified role neutral component neutral component purified purified 6 unspecified role unspecified role neutral component neutral component purified purified 20 unspecified role unspecified role neutral component neutral component purified purified 4 unspecified role unspecified role neutral component neutral component purified purified 12 unspecified role unspecified role neutral component neutral component purified purified 19 unspecified role unspecified role neutral component neutral component purified purified 28 unspecified role unspecified role neutral component neutral component purified purified 22 unspecified role unspecified role neutral component neutral component purified purified 2 unspecified role unspecified role neutral component neutral component purified purified 23 unspecified role unspecified role neutral component neutral component purified purified 24 unspecified role unspecified role neutral component neutral component purified purified 11 unspecified role unspecified role neutral component neutral component purified purified 16 unspecified role unspecified role neutral component neutral component purified purified 14 unspecified role unspecified role neutral component neutral component purified purified 15 unspecified role unspecified role neutral component neutral component purified purified 7 unspecified role unspecified role neutral component neutral component purified purified 25 unspecified role unspecified role neutral component neutral component purified purified physical association physical association Fig 3, Table 1