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  <entry>
    <source releaseDate="2022-02-04">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Single-particle cryo-EM at atomic resolution.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="33087931" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-26495038" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-28884" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Single-particle cryo-EM at atomic resolution.</attribute>
            <attribute name="journal" nameAc="MI:0885">Nature</attribute>
            <attribute name="publication year" nameAc="MI:0886">2020</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Nakane T., Kotecha A., Sente A., McMullan G., Masiulis S., Brown PMGE., Grigoras IT., Malinauskaite L., Malinauskas T., Miehling J., Uchański T., Yu L., Karia D., Pechnikova EV., de Jong E., Keizer J., Bischoff M., McCormack J., Tiemeijer P., Hardwick SW., Chirgadze DY., Murshudov G., Aricescu AR., Scheres SHW.</attribute>
            <attribute name="contact-email" nameAc="MI:0634">scheres@mrc-lmb.cam.ac.uk</attribute>
            <attribute name="author-announcement">24-May-2021: Contacted by IntAct-Help.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="33087931" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-28884" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="10090">
            <names>
              <shortLabel>mouse</shortLabel>
              <fullName>Mus musculus</fullName>
              <alias type="synonym" typeAc="MI:1041">Mouse</alias>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>3d-em</shortLabel>
            <fullName>3D electron microscopy</fullName>
            <alias type="synonym" typeAc="MI:1041">3D-EM</alias>
            <alias type="synonym" typeAc="MI:1041">electron tomog</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0410" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608522" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="12160704" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>experimental particp</shortLabel>
            <fullName>experimental participant identification</fullName>
            <alias type="synonym" typeAc="MI:1041">experimental particp</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0661" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-933978" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Nakane T., Kotecha A., Sente A., McMullan G., Masiulis S., Brown PMGE., Grigoras IT., Malinauskaite L., Malinauskas T., Miehling J., Uchański T., Yu L., Karia D., Pechnikova EV., de Jong E., Keizer J., Bischoff M., McCormack J., Tiemeijer P., Hardwick SW., Chirgadze DY., Murshudov G., Aricescu AR., Scheres SHW.</attribute>
          <attribute name="contact-email" nameAc="MI:0634">scheres@mrc-lmb.cam.ac.uk</attribute>
          <attribute name="accepted">Accepted 2021-APR-19 AT 14:09 BST AT 14:09 BST by PPORRAS</attribute>
          <attribute name="journal" nameAc="MI:0885">Nature</attribute>
          <attribute name="publication year" nameAc="MI:0886">2020</attribute>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>frih_mouse</shortLabel>
          <fullName>Ferritin heavy chain</fullName>
          <alias type="gene name" typeAc="MI:0301">Fth1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Fth</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P09528" version="SP_81" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q3UI44" version="SP_81" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000025563" version="SP_195" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000158539" version="SP_195" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-308950" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_034369.1"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000024661" version="SP_195" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000025563" version="SP_195" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000235196" version="SP_195" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004322" version="SP_195"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005506" version="SP_195"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005576" version="SP_195"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_195"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" version="SP_195"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006826" version="SP_195"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006880" version="SP_195"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006955" version="SP_195"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008198" version="SP_195"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008199" version="SP_195"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P09528" version="SP_195"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3WNW" version="SP_195"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008285" version="SP_195"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5OBA" version="SP_195"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0044754" version="SP_195"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5OBB" version="SP_195"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048147" version="SP_195"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6S61" version="SP_195"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6SHT" version="SP_195"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6V21" version="SP_195"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7A4M" version="SP_195"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7KOD" version="SP_195"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071682" version="SP_195"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-432722" version="SP_195"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-6798695" version="SP_195"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-917937" version="SP_195"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001519" version="SP_195"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008331" version="SP_195"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009040" version="SP_195"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009078" version="SP_195"/>
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          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR014034" version="SP_195"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10090">
          <names>
            <shortLabel>mouse</shortLabel>
            <fullName>Mus musculus</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse</alias>
          </names>
        </organism>
        <sequence>MTTASPSQVRQNYHQDAEAAINRQINLELYASYVYLSMSCYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDRDDWESGLNAMECALHLEKSVNQSLLELHKLATDKNDPHLCDFIETYYLSEQVKSIKELGDHVTNLRKMGAPEAGMAEYLFDKHTLGHGDES</sequence>
        <attributeList>
          <attribute name="crc64">129A8887A2BC650B</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="3" imexId="IM-28884-1">
        <names>
          <shortLabel>fth1-12</shortLabel>
        </names>
        <xref>
          <primaryRef db="wwpdb" dbAc="MI:0805" id="7A4M" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="emdb" dbAc="MI:0936" id="EMD-11638" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-26495055" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-28884-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="4">
            <interactorRef>2</interactorRef>
            <participantIdentificationMethodList>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>predetermined</shortLabel>
                  <fullName>predetermined participant</fullName>
                  <alias type="synonym" typeAc="MI:1041">predetermined</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
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                </xref>
              </participantIdentificationMethod>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>structure determination</shortLabel>
                  <fullName>identification by structure determination</fullName>
                  <alias type="synonym" typeAc="MI:1041">identification by structure determination</alias>
                  <alias type="synonym" typeAc="MI:1041">structure determination</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:2287" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-20597534" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="7877166" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>experimental particp</shortLabel>
                  <fullName>experimental participant identification</fullName>
                  <alias type="synonym" typeAc="MI:1041">experimental particp</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0661" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-933978" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
            </participantIdentificationMethodList>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
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              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>purified</shortLabel>
                  <fullName>purified</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="10090">
                <names>
                  <shortLabel>mouse</shortLabel>
                  <fullName>Mus musculus</fullName>
                  <alias type="synonym" typeAc="MI:1041">Mouse</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
            <stoichiometry value="24"/>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">Fig 1, Extended Data Fig 1, Extended Data Table 1, 2</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
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