DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit. Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit. Proceedings of the National Academy of Sciences of the United States of America 2016 imex curation Liu Z., Gutierrez-Vargas C., Wei J., Grassucci RA., Ramesh M., Espina N., Sun M., Tutuncuoglu B., Madison-Antenucci S., Woolford JL., Tong L., Frank J. jf2192@cumc.columbia.edu 29-Mar-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation trycr Trypanosoma cruzi 3d-em-single electron microscopy 3D single particle reconstruction 3D-EM-single predetermined predetermined participant predetermined Liu Z., Gutierrez-Vargas C., Wei J., Grassucci RA., Ramesh M., Espina N., Sun M., Tutuncuoglu B., Madison-Antenucci S., Woolford JL., Tong L., Frank J. T. cruzi Y-strain epimastigote cultures. jf2192@cumc.columbia.edu Accepted 2021-JAN-06 AT 15:06 GMT AT 15:06 GMT by MGT Proceedings of the National Academy of Sciences of the United States of America 2016 Only protein-protein interactions imex curation imex curation q4div9_trycc Tc00.1047053507709.50 protein protein trycc Trypanosoma cruzi (strain CL Brener) MATAKKKTATRKVAKKVSRKSPEYTTLRKSCKPGTIAIILAGRFRGRRVVILKQLPRNGPLVISGPMKYNGVPIRRIDSRYIIATSTKVDIKNVDVSGITPDIFKRPKQEKRVKSEGEFMGDKAKKAAEQKAKKTAKAAPKGIVSDARAQLQKKVDAALIEAIRKDPLGKEKAGYLHSVFTIKPGDAPHRMRW AC3C242514A02D65 q4cu61_trycc Tc00.1047053509671.80 Tc00.1047053510765.60 protein protein trycc Trypanosoma cruzi (strain CL Brener) MPFVKVVKNKAYFKRFQVKYRRRREGKTDYQARRQMVLQDKTKFGTPKYRLVVRITNRDIIAQVVQAKVVGDEVVMAAYSHELPQFGIQHGLTNYAAAYATGLLVARRMLTKLGLANKFEGTKEADGSYSAVRTKADDQGDDEKRFPFKAILDVGLARTTTGARVFGVMKGAVDGGLAVPHRPNRFPGYDKEKDSLNAKAHRDRILGLHVAEYLKQVREEASSNPEESTCQFSKYIKDKVVPNELEGMYKKAHAAIRADPMKRRARKERKEGAAVKKYNTPKRTGAQKKAAAKEKIAFLVASIRERASK 1E1FE816E307738C q4dav9_trycc Tc00.1047053504069.56 Tc00.1047053507641.233 Tc00.1047053511145.46 protein protein trycc Trypanosoma cruzi (strain CL Brener) MAKRTVKMGVMGRYGARYGANPRKRAKKLEVSQHARHFCSFCGKFAFRRKAVGIWRCDGCSKTMAGGAYTLSTPNNSTVRSTVRRLRELK EB275D4B83C4B001 q4dzn3_trycc Tc00.1047053504147.120 protein protein trycc Trypanosoma cruzi (strain CL Brener) MVAVRAKVGSRGFVRQKQLAKGKKVFKIDCTIPANDGIFSEEILGNFEQYFQENVKLNGRKGKLTEKVRVGLRNNVLTITTTMAYRKKYFKYLTKKFLKKKDLRDWIRILARGKDTYQLKYFNIQDQEEA D56F11704FE8DFDE v5c333_trycr TCDM_14322 protein protein Trypanosoma cruzi Dm28c Trypanosoma cruzi Dm28c MTRAGFKGKVLGKERKQALLDARKKAIASRKARDDRRWKRVLAKMDSEKRKKYHGVGNTAEHSRVRGITRAALRKRTGRKPDNITMEATIHLSKLLKRKTFHKRAPIAIKRIKAFVARLMKTKDNRIDASLNTYVWHKGVKGVPGRVRVHVERKSETLEGGKRKHFYTVISNVPVASFKNLTTKVTEQ 6A3A170E2C501241 q4e581_trycc Tc00.1047053506559.470 protein protein trycc Trypanosoma cruzi (strain CL Brener) MAMLRKFHGSLAANRSKKIQQLTKKTSTVKRNRKSPRLYMKAVLAGYTRGLHGQNKNTAIVRIENVNTKEDAAWYVGKRVCYVYHGYKMKRCVRWSKAPARRSNTRAIWGRVTRPHGGSGAVRAKFNGSAVPASAIGKRVRVYLYPSRI 632FFD3AD364E032 q4e2e0_trycc Tc00.1047053509979.90 Tc00.1047053509979.95 Tc00.1047053510039.90 protein protein trycc Trypanosoma cruzi (strain CL Brener) MSHHVKIRDLRDKSKDELLKQLMEFKKELSQLRVAQQLNSAGTRLGRIRLIRKSIARILTVLNRNQRESLRKVYAGRRLRLAMPKALRPKLTRRRRLALKDNEKNRKTRRQLRMARKFPRRVYAVKL 6768BBE2498C7BE2 q4dnz7_trycc Tc00.1047053507519.110 protein protein trycc Trypanosoma cruzi (strain CL Brener) MPAKSVPAPESAIKRAAFKRQQTENFKKAIAANKAARVALKKAAYARGLRYSREYRSAEKKLVHLRRQAKSCGNYYLEAKPKVAVVTRIRGIAKVAPKQRKILQLLRLRQIFNTVFVRLNKPMENMLRAVEPYIAYGYPSLRTVRMMVYKRGHLKINGQRVKIVNNQMIESKYNNENIVCAEDIVNQIYTGGKHFREVTNGLWPFKLSPPAGGMRQKRRHFVEGGDYGNRDALINRFLARMI F0A805BD87522240 q4dc23_trycc Tc00.1047053506213.80 Tc00.1047053511287.30 protein protein trycc Trypanosoma cruzi (strain CL Brener) MVHYSRKPQVSSKSAKAKVSDLRCHFKNTFETANVINGMPLRKAQQLYRQVLAKTRCIPFKRYNGKIGRTAQAKEWGQTKGRWPRKSVVAMLSLLKNAEANAIEKGLDPNKMVIKHVQVDQAARMRRRTYRAHGRITPYMCSPCHVQLFMTQPQERVPVPKSKPKK 5753F32207E52A37 q4dg45_trycc Tc00.1047053510761.14 Tc00.1047053511067.20 Tc00.1047053511903.130 protein protein trycc Trypanosoma cruzi (strain CL Brener) MASIKCGSRRKARRAHFQAPSHVRRILMSAPLSKELRAKYNVRAMPVRKDDEVRVKRGAYKGREGKVTACYRLRWVIHIDKVNREKANGTTVPVGVHPSNVEITKLKLNHNRKAILERKDRSTKSDKGKGKVTAAEKAMQQMD 03535832BF6A99E6 q4ctg9_trycc Ribosomal protein L15 Tc00.1047053510767.10 protein protein trycc Trypanosoma cruzi (strain CL Brener) MGFVVVCCVCHRKVSEMGAFMYLNELWKKKSSDVMRFIQRVRAWEFRHQHTVVRLRRPTRPEKARMLGYKTKQGFSVFRVRVRRGGRKRPVHKGITYGKPKTSGVLGVKLNKNSRAIAEQRLGKKYGNLRVLNSYWVNADSTFVWYEVVAVDPMCRTIRRDPRINWIVNAVHKHREQRGLTSAGRKHRGLRHKGHKASKLRPSVRAAWRRNNRMVFLRKR 7A11EB8A6ADF8FE0 v5dct1_trycr TCDM_14423 protein protein Trypanosoma cruzi Dm28c Trypanosoma cruzi Dm28c MVLPTRQAVDRRSRKGCKKHRPEIIVVDLKDHVLGRAAAIVAKQLLLGKKITAVRCEQLTIAGTEIRNKIKYLQFLRKRKLSNPKLGPFHHRSPSDIFLRTVRSMLPRYTKRGQKALRQLVAYEGIPTNVVRTGGRVVIPKAQRHYCYRSERPYTVLGNMCKHVGWKYSDVVKKLETARVEKAARHHKKTEKLRAAWKSARKEALSKVSKNNLEVLKKFGYA F4F5B0A082FED3B7 q4dvc6_trycc Tc00.1047053506573.81 Tc00.1047053511217.145 protein protein trycc Trypanosoma cruzi (strain CL Brener) MGRFKPLAIKKKYAKKLKQNRPVPYWIRLRTGNRIKWNEKRRHWRRTKLHY BA0287F7F269B489 q4db26_trycc Tc00.1047053506963.20 Tc00.1047053507831.90 protein protein trycc Trypanosoma cruzi (strain CL Brener) MACPRVQYRRRMHYATRGNRMKLVRTPGNRLVMQKRVKRSQGPHTPWVLGHKRLAGTKALRHTEARLASRHEKSTSRPYGGVLSHEQVRDRIVRAFLIEEQRIVKRALKAHAKSQKEKKRRDSKKKRKEEKKAALTKKIAAKVGARSALTKKTTAKKKAASRVPVGAKVKK F612A01E2C7868D1 q4d1h8_trycc Tc00.1047053504069.30 Tc00.1047053511145.20 protein protein trycc Trypanosoma cruzi (strain CL Brener) MVKPFVQKRIVKKRTKRFTRHKCELFPQLSSSWRKPRGEDSPVRRRYKGQKAMPNKGYGSDRKTKYITPSGFKNFPIHNVQDLYMLLMQNRKYAGVISHTVGAKSRKAIVRKAHELDVRLINGNAKLRRCESH F721FBC365BC39D9 q4dic9_trycc Tc00.1047053506959.120 protein protein trycc Trypanosoma cruzi (strain CL Brener) MAKKNKTKVDTINTKIQLVMKSGKYVLGTKQTLKTLRQGRSKLVVISSNCPPIRKAEIEYYCTLSKTPMHHYAGNNLDLGTACGRHFRSCVFSITDVGDSDITSA 55C482B946B06577 rl28_trycr 60S ribosomal protein L28 protein protein trycr Trypanosoma cruzi MTHSTDLQWLLVRQNSKFLQKRNGIRLSSDPFNNNANWTKRHAGFLNTKAAVVKTKGDRILVTTKDGKAGNKPKSMYKKAVMDAGVEASVVSKAVAAVRPDLASIASRRARKMASTLEHMKKVRAARKERSSKITFQRKAVRPKRH 3E3A794DC4971588 q9u4h7_trycr 60S ribosomal protein L27 C3747_12g1558c C3747_12g1559c C4B63_9g2155c C4B63_9g2158c protein protein trycr Trypanosoma cruzi MKFLKPGKVVIVTSGRYAGKKAVIVQNTDSKSKERPYGHSLIAGMKKYPKKVVRGMSKRTIQRRSRVGVFLRVVNHKHFLPTRYNMDLSRELRGRINVSDASKKAKSKQLVRKLFQARYNAGSNRWFFQRLRF A98C924B3005229F q4dxw6_trycc Ribosomal protein L37 Tc00.1047053506885.14 Tc00.1047053507773.34 Tc00.1047053510431.274 protein protein trycc Trypanosoma cruzi (strain CL Brener) MTKGTTSMGQRHGRTHILCRRCGRNAYHVQWERCAACAYPRASRRRYNWSVKAIKRRRTGTGRCRYLKEVNRRIKNHFKTSLKA D62DE7CB7225EE18 q4e661_trycc 60S ribosomal protein L13 Tc00.1047053508153.280 Tc00.1047053508153.290 Tc00.1047053510323.30 protein protein trycc Trypanosoma cruzi (strain CL Brener) MPKGKNAIPHVHQRKHWNPCSSQKGNVKVFLNQPAQKLRRRRLRLLKAKKTFPRPLKALRPQVNCPTVRHNMKKRLGRGFTVEELKAAGINPRFAPTIGIRVDRRRKNKSEEGMSINIQRLKTYMSKLVLFPMSYKNVQKGEATEEEVKSATQDRTRFGTAAVGGFVTPAPEAPRKVTEEERTKNVYKFLKKNHSAVRFFGIRRARQERREAKENEKK 05A75BAAB0DF3805 q4cnf4_trycc Tc00.1047053508197.10 protein protein trycc Trypanosoma cruzi (strain CL Brener) METHAVSEKKATNPMREIVVKKLCLNICVGESGDRLTRASKVLEQLCEQTPVLSRARLTVRTFGIRRNEKIAVHCTVRGKKAEELLEKGLKVKEFELKSYNFSDTGSFGFGISEHIDLGIKYDPSTGIYGMDFYVVLGRRGERVAHRRRKTSRVGCPHRVRKEEAMHWFERTYDGIIFQAKKKKVMTRRRRR DF8CFC5CBA5DE7AC q9bmp0_trycr 60S ribosomal protein L7a RpL7a C3747_15g157 protein protein trycr Trypanosoma cruzi MPGKEVKKAAKPAAKTAAKTAAKPAAKSAAKPAAKPAAKPAAKPAAKPAAKTAAKPAKKPAVKPTVKPAAKAAAPYKKPAAISPFVARPKNFGIGHDVPYARDLSRFMRWPTFVTMQRKKRVLQRRLKVPPALHQFTKVLDRSSRNELLKLVKKYPSETRRARRQRLFDVATEKKKNPEAASKKAPLSVVTGLQEVTRTIEKKTARLVMIANNVDPIELVLWMPTLCRANKVPYAIVKDKARLGDAVGRKTATCVAITDVNAEDEAALKNLIRSVNARFLARSDVIRRQWGGLQLSLRSRAELRKKRARNAGKDAAAVM 374E268A7BD3FE3B q4e4q8_trycc 60S ribosomal protein L27a Tc00.1047053508461.500 Tc00.1047053508461.510 protein protein trycc Trypanosoma cruzi (strain CL Brener) MPTRFKKTRHQRGSTFCGYGRVGKHRKHPSGRGNAGGQHHHRINFDKYHPGYFGKCGMNHYHLKKNPLWKPTINLNNLAKLIAKDEALKAKKGETLPVVDLLANGYSKLLGNGHLQTPCIVKARWVSKLADKKIRKAGGAVVLQA A1F84FA0BB0A2F48 q9bmp1_trycr RpL19 protein protein trycr Trypanosoma cruzi MVSLKLQARLAADILRCGRHRVWLDPNEASEISNANSRKSVRKLIKDGLIIRKPVKVHSRSRWRHMKEAKSMGRHEGAGRREGTREARMPSKELWMRRLRILRRLLRKYREEKKIDRHIYRELYVKAKGNVFRNKRNLMEHIHKVKNEKKKERQLAEQLAAKRLKDEQHRHKARKQELRKREKDRERARREDAAAAAAAKQKAAAKKAAAPSGKKSAKAAAPAKAAAAPAKAAAPPAKTAAAPAKAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAAPAKTAAPPAKAAAAPAKTAAPPAKTAAPPAKAATPPAKAAAPPAKAAAAPVGKKAGGKK 42A2DC8B4631F8AF q4dpq8_trycc Tc00.1047053511181.100 protein protein trycc Trypanosoma cruzi (strain CL Brener) MGKTVLTCRKGNGSIYQVHGHKRLGPAKLRILDYAERHGFMRGVVKTIEHEPGRGAPLARVEFRHPYKYRRVKELMVAPEGMFTGQSVLCGVKAPLAIGNVLPLGQITEGCIVCNVEAKVGDRGTIARASGDYCIIISHNHETGRTRLKLPSGQKKTVPSNCRAMIGIIAGGGRIEKPVLKAGNSFYRFRGKRNCWPKVRGVARNPVEHPHGGGNHQHIGHPSTVSRHAPPGQKVGLIAARRTGRIRGSRAVKGAWHPEE 56014D939850A0E8 q4e078_trycc Tc00.1047053503611.20 Tc00.1047053503611.40 Tc00.1047053506679.230 Tc00.1047053506679.250 protein protein trycc Trypanosoma cruzi (strain CL Brener) MRTIDCEFSHFAVHPGHGRRYVPFAFLSTKPVLTFARPKCFAMYMRKKNPRFVPWTRTYRRINRKMTTDRVGRRRAARTVKVERGIVGADLSYIQEVRAKTKKVDRSAKGKAVRAEMAERKAAKK B066F47F6BC87806 q4e2y1_trycc Tc00.1047053508175.146 protein protein trycc Trypanosoma cruzi (strain CL Brener) MPAKTAVSKAAAPQKAAAPKKAAAPQKAAAPKKAAAQQKAAVAKKAVREAPKKGVKKTAKKGAPAAMTKVVKVTKRKAYTRPQFRRPHTYRRPSIPKPSNNMSAISNKWDAFRVIRYPLTTDKAMKKIEENNTLTFIVDSNANKTEIKKAMRKLYQVKAVKVNTLIRPDGLKKAYIRLSASYDALETANKMGLL 03A9A9E2EB10D97F v5bdj2_trycr TCDM_14524 protein protein Trypanosoma cruzi Dm28c Trypanosoma cruzi Dm28c MPARKKEVPKAEAPAPRTGIIAGFNKGHKTTRRARAPSSNDRYALPHKKLRAVKAIITDLVGLSPMERRVQELLRVGKDKRALKFCKKRLGNFKAAKKRRAKMEEALRHQIKKK 28E778D664B2C7D6 q4dq60_trycc Tc00.1047053508119.144 protein protein trycc Trypanosoma cruzi (strain CL Brener) MPREIKNLKEFLAICSRKDARCVKVKHNPAQTKFKVRCSRYLYTLVVADKKKADKIERSIHPSVKKITVTARSHAKTNAGSK 2B5B2C3B25CCD182 v5b599_trycr TCDM_02783 protein protein Trypanosoma cruzi Dm28c Trypanosoma cruzi Dm28c MLVLTFLLLLLLFYFWXXXXATLDDLTLFLGNPRHTQMSHCKFEHPRHGHLGFLPRKRSRQIRGRVRSFPKDDPSQKPHLTSFMVFKAGMTHIVRDVDRPGSKVNKKEVVEPVTILEAPPMVVVGIVGYRQTPVGHKTIGTVWAHHTSVEFRRRFYKNWKQSAQLAFTKRKQFARTTEGRLAEARTLKAFAKKADIIRVVAHTQLRKLRNNRVGVKKAHVSEIQINGGTIAEKIELAKSLLEKEVRIDSIFQQSETCDVCAVTKGHGFTGVVKRWGVACLPRKTHRGLRKVACIGAWHPARVMYTVARAGQHGYHHRTHLNKKIYQLGRAVSMEPNQATTTYDLTAKSITPMGGFVGYGTVRNDYIMLKGSVAGPRRRVITLRRPMAPQTSRKLTEQITLKFIDTSSKIGHGRFQTKKEKSQWFGPLKKDRIRREERLRKERVARAAERKAKGVAVTAAPKKAKK 23F430583565E592 q4cv79_trycc Tc00.1047053506815.60 Tc00.1047053507105.40 protein protein trycc Trypanosoma cruzi (strain CL Brener) MVNYPKKKTMYCPDARCKAHKSFKVVQYKAGKARLYARGKRRYDRKQSGYGGQTKPIFHKKAKTTKKIVLKLQCSNCKSIIQNVLKRTKHFELNDKKKTGNKDPTW D934A3AADD99AD73 q4ded2_trycc Tc00.1047053506405.149 protein protein trycc Trypanosoma cruzi (strain CL Brener) MVHSHGYKCGTRHLFAKKFRKHGVPSVSTILTNFKVGDYVDVVADSAVRAGMPHKYYHGRTGIVWNVTPRGVGVIVNKPVRNRTVRKRICVRFEHVRKSRCQEAFKQKQKDFLAFQAAKKAGKPLPPLKRSSRNGGIVRAKRVEVLARRAAEYEAMIPY 5FE17C9B98846703 q4cpd8_trycc 60S ribosomal protein L29 Tc00.1047053509749.33 Tc00.1047053509749.36 protein protein trycc Trypanosoma cruzi (strain CL Brener) MAKSKNHTNHNQSRKNHRNGIKRALPMYLHNSKRGSWLPALINARRVRKNNQKAAVKARRERLAAHKAKQN 4158D0E5F5CAA454 rl18_trycc 60S ribosomal protein L18 RPL18 Tc00.1047053504147.20 protein protein trycc Trypanosoma cruzi (strain CL Brener) MGVDLTGVQKKKRVVRHHTYSTNPYIKLLIKLYKFLAQRTNSAFNKLVHQRLLKSRSNRAPISLSRIAVCMKRKSVWLEKGKKAPIAVIVGDVLDDVRMARIPALRVCALRFSKSARERITGAGGECLTFDQLAMVAPTGKNTFLLRGRKSGRESVKHFGAAGVPGSHAKPFTSNRGKERQRSSARRRAFRHK 864B45A2E8F44039 q4cqw2_trycc Tc00.1047053504121.30 protein protein trycc Trypanosoma cruzi (strain CL Brener) MTARPSVSVYSASEDKVVGTCPLPAVFTAPIRHDIVQFVHTNMAKNSRQAYAVNRLSGMNHSAESWGTGRAVARIPRIGGGGTSTSGAGAFGNMCRGGRMFAPTKIFRRWHRKINLHQKRFAVVSALAASSVPALVMSRGHKIENVAEVPLVVEDAVQGYEKTKEAMAFLKAIGAVDDVNRVNDSREIRAGRGKMRNRRYVARRGPMLVMPDNKGTRAFRNIFGLDLANVNALNLLHLAPGGHVGRFVVWTKGAFEKLDSIFGTFTKASAVKKGFMLPAPMLTNTDVTRIMQSEEVRRVLKPKKLQPKKASRLTQPTNGFRNRRLRLRLNPFQKKESAMVKGLRNRKNREVRHKSKAVRIAKAKKAIAGGAKKK BB1D6A5FFCA5C849 q4e4r0_trycc Tc00.1047053508461.490 protein protein trycc Trypanosoma cruzi (strain CL Brener) MGKDKANVKGCRFRVSLALPVGAVVNCADNTGAKNLYIISVKGYHGRLNRLPAAALGDIVMASVKKGKPELRRKVLNAVIIRQRKSWRRKDGTVIYFEDNAGVIVNPKGEMKGSGIAGPVAKEAADLWPKISSHAPAIV 0FA1DF75FAC01B3C q4dz31_trycc 60S ribosomal protein L18a Tc00.1047053511001.120 protein protein trycc Trypanosoma cruzi (strain CL Brener) MVKPHLRHYCVVGRETPSEKNPAPTVYKFEVFAPNFVVAKSRFWRMMREKNKVKSTHGDVLSCKVVKDRKLAARNYSVDIAYYSQRCGYTHMVKEFRDVSKAGAVSQAYHDLASRHRARYHNIEVLGVKSIPNHQVKRLSISEYHASNLSFPLLHRRVKAPRKDRVVFVKKNTKRAVVA 244F40C87AE3581A q4dq35_trycc Tc00.1047053511825.200 protein protein trycc Trypanosoma cruzi (strain CL Brener) MVIFLAYWRNETTQTGKHANRRKCVQMIIKRWFSRVHERICVFRLCSFLFPFFFLYYFYTCKCNSIATYVMHIYIYIYIYIYIYIYLPFPLFFYLFCISIELVKKRSQMVKANYIRAGRLVRIIRGPRQDRVGVVVDIIDGNRVLVENPADKKMWRHVQNLKNVEPLKFSVELSRNCSTRTLKNVLAEKKILEKYAATKSARRIAAKRAFARSTDFERYQLRVAKRSRAFWTRKVFDENDKKKPVSWHKVALKKLQKNAKKVDSKPAAKKRIEKARAARKAKAAAGKK F9B28DE6C31866F8 q4cnf4_trycc-q4cpd8_trycc-1 1 38 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 23 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 9 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 2 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 3 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 32 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 36 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 14 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 30 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 4 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 20 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 29 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 7 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 8 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 15 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 16 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 6 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 17 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 31 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 26 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 34 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 18 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 24 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 19 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 11 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 27 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 28 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 37 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 5 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 33 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 25 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 10 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 12 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 39 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 13 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 21 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 22 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 35 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified physical association physical association Table S2