DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science (New York, N.Y.) 2012 imex curation Huang N., Chelliah Y., Shan Y., Taylor CA., Yoo SH., Partch C., Green CB., Zhang H., Takahashi JS. joseph.takahashi@utsouthwestern.edu 24-May-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro bifc bimolecular fluorescence complementation bifc predetermined predetermined participant predetermined Huang N., Chelliah Y., Shan Y., Taylor CA., Yoo SH., Partch C., Green CB., Zhang H., Takahashi JS. joseph.takahashi@utsouthwestern.edu Accepted 2021-APR-27 AT 12:43 BST AT 12:43 BST by PPORRAS Science (New York, N.Y.) 2012 Only protein-protein interactions imex curation imex curation Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science (New York, N.Y.) 2012 imex curation Huang N., Chelliah Y., Shan Y., Taylor CA., Yoo SH., Partch C., Green CB., Zhang H., Takahashi JS. joseph.takahashi@utsouthwestern.edu 24-May-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Huang N., Chelliah Y., Shan Y., Taylor CA., Yoo SH., Partch C., Green CB., Zhang H., Takahashi JS. joseph.takahashi@utsouthwestern.edu Accepted 2021-APR-27 AT 12:43 BST AT 12:43 BST by PPORRAS Science (New York, N.Y.) 2012 Only protein-protein interactions imex curation imex curation Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science (New York, N.Y.) 2012 imex curation Huang N., Chelliah Y., Shan Y., Taylor CA., Yoo SH., Partch C., Green CB., Zhang H., Takahashi JS. joseph.takahashi@utsouthwestern.edu 24-May-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Huang N., Chelliah Y., Shan Y., Taylor CA., Yoo SH., Partch C., Green CB., Zhang H., Takahashi JS. joseph.takahashi@utsouthwestern.edu Accepted 2021-APR-27 AT 12:43 BST AT 12:43 BST by PPORRAS Science (New York, N.Y.) 2012 Only protein-protein interactions imex curation imex curation bmal1_mouse Aryl hydrocarbon receptor nuclear translocator-like protein 1 Arntl Bmal1 Brain and muscle ARNT-like 1 Arnt3 protein protein mouse Mus musculus Mouse MADQRMDISSTISDFMSPGPTDLLSGSLGTSGVDCNRKRKGSATDYQLDDFAFEESMDTDKDDPHGRLEYAEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFASTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHMVPQPANGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTAPPHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSTGLLPGQAQETPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL DIP protein Q9WTL8 original sequence version: 134 DIP protein Q9WTL8 original sequence version: 123 DIP protein Q9WTL8 original sequence version: 94 DIP protein Q9WTL8 original sequence version: 128 DIP protein Q9WTL8 original sequence version: 144 DIP protein Q9WTL8 original sequence version: 145 9669C3712A95C2DE q9wtl8-4 Aryl hydrocarbon receptor nuclear translocator-like protein 1 Arntl Bmal1 Arnt3 Brain and muscle ARNT-like 1 protein protein mouse Mus musculus Mouse MADQRMDISSTISDFMSPGPTDLLSGSLGTSGVDCNRKRKGSATDYQESMDTDKDDPHGRLEYAEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFASTCSKKKADRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHMVPQPANGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTAPPHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSTGLLPGQAQETPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL DIP protein Q9WTL8-4 original sequence version: 140 837330EF65406CE4 clock_mouse Circadian locomoter output cycles protein kaput Clock protein protein mouse Mus musculus Mouse MVFTVSCSKMSSIVDRDDSSIFDGLVEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHKETTAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSKNQLEFCCHMLRGTIDPKEPSTYEYVRFIGNFKSLTSVSTSTHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAERRRELGIEESLPETAADKSQDSGSDNRINTVSLKEALERFDHSPTPSASSRSSRKSSHTAVSDPSSTPTKIPTDTSTPPRQHLPAHEKMTQRRSSFSSQSINSQSVGPSLTQPAMSQAANLPIPQGMSQFQFSAQLGAMQHLKDQLEQRTRMIEANIHRQQEELRKIQEQLQMVHGQGLQMFLQQSNPGLNFGSVQLSSGNSNIQQLTPVNMQGQVVPANQVQSGHISTGQHMIQQQTLQSTSTQQSQQSVMSGHSQQTSLPSQTPSTLTAPLYNTMVISQPAAGSMVQIPSSMPQNSTQSATVTTFTQDRQIRFSQGQQLVTKLVTAPVACGAVMVPSTMLMGQVVTAYPTFATQQQQAQTLSVTQQQQQQQQQPPQQQQQQQQSSQEQQLPSVQQPAQAQLGQPPQQFLQTSRLLHGNPSTQLILSAAFPLQQSTFPPSHHQQHQPQQQQQLPRHRTDSLTDPSKVQPQ DIP protein O08785 original sequence version: 149 DIP protein O08785-1 original sequence version: 138 DIP protein O08785 original sequence version: 138 DIP protein O08785 original sequence version: 108 DIP protein O08785 original sequence version: 143 DIP protein O08785 original sequence version: 155 DIP protein O08785 original sequence version: 159 DIP protein O08785 original sequence version: 160 9864D947049742F4 arntl-clock-21 3 4 unspecified role unspecified role neutral component neutral component purified purified binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr-sf_9 Spodoptera frugiperda insect cells Fall armyworm sf_9 insect cells Derived from pupal ovarian tissue of the fall armyworm Cloned from the parent cell line, IPLB-SF-21-AE (SF-21) derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae cells are susceptible to Baculovirus infection 6 unspecified role unspecified role neutral component neutral component purified purified HIS tag HIS tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr-sf_9 Spodoptera frugiperda insect cells Fall armyworm sf_9 insect cells Derived from pupal ovarian tissue of the fall armyworm Cloned from the parent cell line, IPLB-SF-21-AE (SF-21) derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae cells are susceptible to Baculovirus infection direct interaction direct interaction Fig 1, Fig S2, Table S1 clock-arntl-18 2 5 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9WTL8-4:p.Trp427Ala W427A mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain W A Mon Jun 28 16:47:37 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'Q9WTL8-4:Trp427Ala' Q9WTL8-4:p.Val435Arg V435R mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain V R Mon Jun 28 17:41:47 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'Q9WTL8-4:Val435Arg' Q9WTL8-4:p.[Phe423Arg;Val435Arg] F423R;V435R mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain V R certain certain sequence position certain certain certain sequence position certain F R Q9WTL8-4:p.[Leu95Glu;Leu150Glu;Trp427Ala] L95E/L150E/W427A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain L E certain certain sequence position certain certain certain sequence position certain L E certain certain sequence position certain certain certain sequence position certain W A Q9WTL8-4:p.Leu115Glu L115E mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain L E Mon Jun 28 16:51:57 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'Q9WTL8-4:Leu115Glu' Q9WTL8-4:p.Leu150Glu L150E mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain L E Mon Jun 28 17:23:44 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'Q9WTL8-4:Leu150Glu' Q9WTL8-4:p.Ile317Asp I317D mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain I D Mon Jun 28 16:54:28 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'Q9WTL8-4:Ile317Asp' Q9WTL8-4:p.Phe423Arg F423R mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain F R Mon Jun 28 17:16:44 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'Q9WTL8-4:Phe423Arg' Q9WTL8-4:p.Leu95Glu L95E mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain L E Mon Jun 28 17:15:35 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'Q9WTL8-4:Leu95Glu' 6 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed FLAG tag FLAG tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined O08785:p.Trp284Ala p.[Trp284Ala] mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain W A Mon Jun 29 10:19:49 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Trp284Ala]' Tue Jun 30 20:13:16 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Trp284Ala' O08785:p.Val315Arg p.V315R mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain V R Thu Apr 22 12:49:41 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val315Arg' O08785:p.Leu74Glu p.L74E mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain L E Thu Apr 22 12:59:09 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu74Glu' O08785:p.Phe122Asp p.F122D mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain F D Thu Apr 22 13:09:37 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe122Asp' O08785:p.[Leu57Glu;Leu113Glu;Trp284Ala] p.[L57E;L113E;W284A] mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain L E certain certain sequence position certain certain certain sequence position certain L E certain certain sequence position certain certain certain sequence position certain W A Thu Apr 22 12:22:34 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Leu57Glu;Leu113Glu;Trp284Ala]' O08785:p.Leu57Glu p.L57E mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain L E Thu Apr 22 11:41:39 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu57Glu' O08785:p.Leu113Glu p.L113E mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain L E physical association physical association Fig 4D arntl-clock-23 1 5 unspecified role unspecified role neutral component neutral component purified purified Q9WTL8-4:p.Ile317Asp I317D mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain I D c-terminal region venus-n venus n-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range Q9WTL8-4:p.Leu150Glu L150E mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain L E Q9WTL8-4:p.Leu115Glu L115E mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain L E Q9WTL8-4:p.Phe423Arg F423R mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain F R Q9WTL8-4:p.Trp427Ala W427A mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain W A Mon Jun 28 17:46:11 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'Q9WTL8-4:p.Trp417Ala' Q9WTL8-4:p.Val435Arg V435R mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain V R Q9WTL8-4:p.[Phe423Arg;Val435Arg] F423R/V435R mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain V R certain certain sequence position certain certain certain sequence position certain F R Q9WTL8-4:p.[Leu95Glu;Leu150Glu;Trp427Ala] L95E/L150E/W427A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain L E certain certain sequence position certain certain certain sequence position certain W A certain certain sequence position certain certain certain sequence position certain L E binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain Q9WTL8-4:p.Leu95Glu L95E mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain L E spofr-sf_9 Spodoptera frugiperda insect cells Fall armyworm sf_9 insect cells Derived from pupal ovarian tissue of the fall armyworm Cloned from the parent cell line, IPLB-SF-21-AE (SF-21) derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae cells are susceptible to Baculovirus infection 6 unspecified role unspecified role neutral component neutral component purified purified O08785:p.[Leu57Glu;Leu113Glu;Trp284Ala] L57E;L113E;W284A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain L E certain certain sequence position certain certain certain sequence position certain L E certain certain sequence position certain certain certain sequence position certain W A O08785:p.Leu113Glu L113E mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain L E O08785:p.Phe122Asp F122D mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain F D O08785:p.Trp284Ala W284A mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain W A O08785:p.Val315Arg V315R mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain V R O08785:p.Leu57Glu L57E mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain L E O08785:p.Leu74Glu L74E mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain L E c-terminal region venus-c venus c-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr-sf_9 Spodoptera frugiperda insect cells Fall armyworm sf_9 insect cells Derived from pupal ovarian tissue of the fall armyworm Cloned from the parent cell line, IPLB-SF-21-AE (SF-21) derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae cells are susceptible to Baculovirus infection direct interaction direct interaction Fig S5 clock-arntl-4 2 5 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9WTL8-4:p.Leu150Glu L150E mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain L E Mon Jun 28 17:41:58 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'Q9WTL8-4:Leu150Glu' 6 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed FLAG tag FLAG tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined O08785:p.Phe122Asp p.F122D mutation mutation certain certain sequence position certain certain certain sequence position certain F D Thu Apr 22 13:09:37 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe122Asp' 60 63 physical association physical association Fig 4D clock-arntl-5 2 5 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9WTL8-4:p.Ile317Asp I317D mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain I D Mon Jun 28 17:05:26 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'Q9WTL8-4:Ile317Asp' 6 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed FLAG tag FLAG tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined O08785:p.Leu113Glu p.L113E mutation mutation certain certain sequence position certain certain certain sequence position certain L E 70 67 physical association physical association Fig 4D clock-arntl-19 2 5 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9WTL8-4:p.Trp427Ala W427A mutation mutation certain certain sequence position certain certain certain sequence position certain W A Mon Jun 28 17:47:04 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'Q9WTL8-4:Trp427Ala' 6 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed O08785:p.Trp284Ala p.[Trp284Ala] mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain W A Mon Jun 29 10:19:49 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Trp284Ala]' Tue Jun 30 20:13:16 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Trp284Ala' FLAG tag FLAG tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 74 76 physical association physical association Fig 4D arntl-clock-24 1 5 unspecified role unspecified role neutral component neutral component purified purified c-terminal region venus-n venus n-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range Q9WTL8-4:p.Leu150Glu L150E mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain L E binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr-sf_9 Spodoptera frugiperda insect cells Fall armyworm sf_9 insect cells Derived from pupal ovarian tissue of the fall armyworm Cloned from the parent cell line, IPLB-SF-21-AE (SF-21) derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae cells are susceptible to Baculovirus infection 6 unspecified role unspecified role neutral component neutral component purified purified O08785:p.Phe122Asp F122D mutation mutation certain certain sequence position certain certain certain sequence position certain F D c-terminal region venus-c venus c-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr-sf_9 Spodoptera frugiperda insect cells Fall armyworm sf_9 insect cells Derived from pupal ovarian tissue of the fall armyworm Cloned from the parent cell line, IPLB-SF-21-AE (SF-21) derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae cells are susceptible to Baculovirus infection 84 81 direct interaction direct interaction Fig S5 arntl-clock-25 1 5 unspecified role unspecified role neutral component neutral component purified purified Q9WTL8-4:p.Ile317Asp I317D mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain I D c-terminal region venus-n venus n-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr-sf_9 Spodoptera frugiperda insect cells Fall armyworm sf_9 insect cells Derived from pupal ovarian tissue of the fall armyworm Cloned from the parent cell line, IPLB-SF-21-AE (SF-21) derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae cells are susceptible to Baculovirus infection 6 unspecified role unspecified role neutral component neutral component purified purified O08785:p.Leu113Glu L113E mutation mutation certain certain sequence position certain certain certain sequence position certain L E c-terminal region venus-c venus c-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr-sf_9 Spodoptera frugiperda insect cells Fall armyworm sf_9 insect cells Derived from pupal ovarian tissue of the fall armyworm Cloned from the parent cell line, IPLB-SF-21-AE (SF-21) derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae cells are susceptible to Baculovirus infection 93 89 direct interaction direct interaction Fig S5 arntl-clock-26 1 5 unspecified role unspecified role neutral component neutral component purified purified c-terminal region venus-n venus n-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range Q9WTL8-4:p.Trp427Ala W427A mutation mutation certain certain sequence position certain certain certain sequence position certain W A Mon Jun 28 16:51:16 BST 2021 This feature has been corrected as a result of our quality control procedures. The original label was 'Q9WTL8-4:p.Trp417Ala' binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr-sf_9 Spodoptera frugiperda insect cells Fall armyworm sf_9 insect cells Derived from pupal ovarian tissue of the fall armyworm Cloned from the parent cell line, IPLB-SF-21-AE (SF-21) derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae cells are susceptible to Baculovirus infection 6 unspecified role unspecified role neutral component neutral component purified purified O08785:p.Trp284Ala W284A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain W A c-terminal region venus-c venus c-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr-sf_9 Spodoptera frugiperda insect cells Fall armyworm sf_9 insect cells Derived from pupal ovarian tissue of the fall armyworm Cloned from the parent cell line, IPLB-SF-21-AE (SF-21) derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae cells are susceptible to Baculovirus infection 102 99 direct interaction direct interaction Fig S5