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  <entry>
    <source releaseDate="2022-02-04">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
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      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>The structure of human liver fructose-1,6-bisphosphate aldolase.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="11679716" refType="primary-reference" refTypeAc="MI:0358"/>
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          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">The structure of human liver fructose-1,6-bisphosphate aldolase.</attribute>
            <attribute name="journal" nameAc="MI:0885">Acta crystallographica. Section D, Biological crystallography</attribute>
            <attribute name="publication year" nameAc="MI:0886">2001</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Dalby AR., Tolan DR., Littlechild JA.</attribute>
            <attribute name="contact-email" nameAc="MI:0634">j.a.littlechild@exeter.ac.uk</attribute>
            <attribute name="author-announcement">05-Jan-2021: Contacted by IntAct-Help.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
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        </bibref>
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        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="83333">
            <names>
              <shortLabel>ecoli</shortLabel>
              <fullName>Escherichia coli (strain K12)</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>x-ray diffraction</shortLabel>
            <fullName>x-ray crystallography</fullName>
            <alias type="go synonym" typeAc="MI:0303">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">x-ray diffraction</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
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          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
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          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Dalby AR., Tolan DR., Littlechild JA.</attribute>
          <attribute name="contact-email" nameAc="MI:0634">j.a.littlechild@exeter.ac.uk</attribute>
          <attribute name="accepted">Accepted 2020-NOV-30 AT 16:11 GMT AT 16:11 GMT by MGT</attribute>
          <attribute name="journal" nameAc="MI:0885">Acta crystallographica. Section D, Biological crystallography</attribute>
          <attribute name="publication year" nameAc="MI:0886">2001</attribute>
          <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
          <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>aldob_human</shortLabel>
          <fullName>Fructose-bisphosphate aldolase B</fullName>
          <alias type="gene name" typeAc="MI:0301">ALDOB</alias>
          <alias type="gene name synonym" typeAc="MI:0302">ALDB</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Liver-type aldolase</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P05062" version="SP_105" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5T7D6" version="SP_122" refType="secondary-ac" refTypeAc="MI:0360"/>
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          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q13742" version="SP_105" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000497731" version="SP_222" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000497767" version="SP_222" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000497990" version="SP_222" refType="identity" refTypeAc="MI:0356"/>
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          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_000026.2"/>
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          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000648758" version="SP_222" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004332" version="SP_222"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006116" version="SP_222"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008092" version="SP_222"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030388" version="SP_222"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0034451" version="SP_222"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" version="SP_222"/>
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          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013785" version="SP_222"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR029768" version="SP_222"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1QO5" version="SP_222"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1XDL" version="SP_222"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1XDM" version="SP_222"/>
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          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000136872" version="SP_222" refType="gene"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
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            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MAHRFPALTQEQKKELSEIAQSIVANGKGILAADESVGTMGNRLQRIKVENTEENRRQFREILFSVDSSINQSIGGVILFHETLYQKDSQGKLFRNILKEKGIVVGIKLDQGGAPLAGTNKETTIQGLDGLSERCAQYKKDGVDFGKWRAVLRIADQCPSSLAIQENANALARYASICQQNGLVPIVEPEVIPDGDHDLEHCQYVTEKVLAAVYKALNDHHVYLEGTLLKPNMVTAGHACTKKYTPEQVAMATVTALHRTVPAAVPGICFLSGGMSEEDATLNLNAINLCPLPKPWKLSFSYGRALQASALAAWGGKAANKEATQEAFMKRAMANCQAAKGQYVHTGSSGAASTQSLFTACYTY</sequence>
        <attributeList>
          <attribute name="crc64">DCE314E7AC5586CA</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="3" imexId="IM-28535-1">
        <names>
          <shortLabel>aldob-1</shortLabel>
        </names>
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          <primaryRef db="wwpdb" dbAc="MI:0805" id="1QO5" refType="identity" refTypeAc="MI:0356"/>
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          <secondaryRef db="imex" dbAc="MI:0670" id="IM-28535-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="4">
            <interactorRef>2</interactorRef>
            <participantIdentificationMethodList>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>structure determination</shortLabel>
                  <fullName>identification by structure determination</fullName>
                  <alias type="synonym" typeAc="MI:1041">identification by structure determination</alias>
                  <alias type="synonym" typeAc="MI:1041">structure determination</alias>
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              </participantIdentificationMethod>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>predetermined</shortLabel>
                  <fullName>predetermined participant</fullName>
                  <alias type="synonym" typeAc="MI:1041">predetermined</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
            </participantIdentificationMethodList>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>over-expressed</shortLabel>
                  <fullName>over expressed level</fullName>
                  <alias type="synonym" typeAc="MI:1041">over-expressed</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
              <experimentalPreparation>
                <names>
                  <shortLabel>purified</shortLabel>
                  <fullName>purified</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="83333">
                <names>
                  <shortLabel>ecoli</shortLabel>
                  <fullName>Escherichia coli (strain K12)</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
            <stoichiometry value="4"/>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">Table 1</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
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