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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>IntAct</shortLabel>
        <fullName>European Bioinformatics Institute</fullName>
        <alias type="synonym" typeAc="MI:1041">IntAct</alias>
        <alias type="synonym" typeAc="MI:1041">intact</alias>
      </names>
      <bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
      </bibref>
      <xref>
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      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
        <attribute name="search-url" nameAc="MI:0615">http://www.ebi.ac.uk/intact/query/${ac}</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
        <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
        <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Binding of human myeloperoxidase to red blood cells: Molecular targets and biophysical consequences at the plasma membrane level.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="26714302" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-25297915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-27606" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Binding of human myeloperoxidase to red blood cells: Molecular targets and biophysical consequences at the plasma membrane level.</attribute>
            <attribute name="journal" nameAc="MI:0885">Archives of biochemistry and biophysics</attribute>
            <attribute name="publication year" nameAc="MI:0886">2016</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Gorudko IV., Sokolov AV., Shamova EV., Grigorieva DV., Mironova EV., Kudryavtsev IV., Gusev SA., Gusev AA., Chekanov AV., Vasilyev VB., Cherenkevich SN., Panasenko OM., Timoshenko AV.</attribute>
            <attribute name="contact-email" nameAc="MI:0634">o-panas@mail.ru</attribute>
            <attribute name="author-announcement">04-05-20: Contacted by IntAct-Help.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="26714302" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-27606" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="-1">
            <names>
              <shortLabel>in vitro</shortLabel>
              <fullName>In vitro</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>far western blotting</shortLabel>
            <fullName>far western blotting</fullName>
            <alias type="go synonym" typeAc="MI:0303">Affinity blotting</alias>
            <alias type="synonym" typeAc="MI:1041">Affinity blotting</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0047" refType="identity" refTypeAc="MI:0356"/>
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          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>ms participant</shortLabel>
            <fullName>Identification by mass spectrometry</fullName>
            <alias type="synonym" typeAc="MI:1041">ms participant</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0427" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608794" refType="identity" refTypeAc="MI:0356"/>
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          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Gorudko IV., Sokolov AV., Shamova EV., Grigorieva DV., Mironova EV., Kudryavtsev IV., Gusev SA., Gusev AA., Chekanov AV., Vasilyev VB., Cherenkevich SN., Panasenko OM., Timoshenko AV.</attribute>
          <attribute name="remark-internal">I cannot see Supplementary info;if you can see it,  please check the IDs of the  RBC proteins.</attribute>
          <attribute name="contact-email" nameAc="MI:0634">o-panas@mail.ru</attribute>
          <attribute name="accepted">Accepted 2020-JAN-06 AT 11:48 GMT AT 11:48 GMT by KALPANAP</attribute>
          <attribute name="journal" nameAc="MI:0885">Archives of biochemistry and biophysics</attribute>
          <attribute name="publication year" nameAc="MI:0886">2016</attribute>
          <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
          <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>glpb_human</shortLabel>
          <fullName>Glycophorin-B</fullName>
          <alias type="gene name" typeAc="MI:0301">GYPB</alias>
          <alias type="gene name synonym" typeAc="MI:0302">GPB</alias>
          <alias type="gene name synonym" typeAc="MI:0302">PAS-3</alias>
          <alias type="gene name synonym" typeAc="MI:0302">SS-active sialoglycoprotein</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Sialoglycoprotein delta</alias>
        </names>
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        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
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          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MYGKIIFVLLLSEIVSISALSTTEVAMHTSTSSSVTKSYISSQTNGETGQLVHRFTVPAPVVIILIILCVMAGIIGTILLISYSIRRLIKA</sequence>
        <attributeList>
          <attribute name="crc64">EF15A64BAA929B7B</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>glpa_human</shortLabel>
          <fullName>Glycophorin-A</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">PAS-2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Sialoglycoprotein alpha</alias>
          <alias type="gene name synonym" typeAc="MI:0302">MN sialoglycoprotein</alias>
          <alias type="gene name" typeAc="MI:0301">GYPA</alias>
          <alias type="gene name synonym" typeAc="MI:0302">GPA</alias>
        </names>
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          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001195"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018938"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2KPE"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5EH4"/>
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          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001295119.1"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" version="SP_219"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
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            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MYGKIIFVLLLSEIVSISASSTTGVAMHTSTSSSVTKSYISSQTNDTHKRDTYAATPRAHEVSEISVRTVYPPEEETGERVQLAHHFSEPEITLIIFGVMAGVIGTILLISYGIRRLIKKSPSDVKPLPSPDTDVPLSSVEIENPETSDQ</sequence>
        <attributeList>
          <attribute name="crc64">48A5450E22FA99C9</attribute>
        </attributeList>
      </interactor>
      <interactor id="4">
        <names>
          <shortLabel>perm_human</shortLabel>
          <fullName>Myeloperoxidase</fullName>
          <alias type="gene name" typeAc="MI:0301">MPO</alias>
        </names>
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            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
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            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWREAS</sequence>
        <attributeList>
          <attribute name="crc64">348B1CE0A11038B4</attribute>
        </attributeList>
      </interactor>
      <interactor id="5">
        <names>
          <shortLabel>b3at_human</shortLabel>
          <fullName>Band 3 anion transport protein</fullName>
          <alias type="gene name" typeAc="MI:0301">SLC4A1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">AE1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">DI</alias>
          <alias type="gene name synonym" typeAc="MI:0302">EPB3</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Anion exchange protein 1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Solute carrier family 4 member 1</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P02730" version="SP_119" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UDJ1" version="SP_154" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q1ZZ45" version="SP_145" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="G4V2I6" version="SP_185" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q4VB84" version="SP_119" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q4KKW9" version="SP_145" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P78487" version="SP_119" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="MINT-1344291" refType="intact-secondary"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UCY7" version="SP_145" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000262418" version="SP_262" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7576138" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_000333.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005257650.1"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000004939" version="SP_262" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000262418" version="SP_262" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007596" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005452" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006820" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006821" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006873" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008509" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009898" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0015106" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0015108" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0015301" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0015701" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016323" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0017121" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0022857" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030018" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030492" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030506" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030863" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035811" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042803" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043495" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045852" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048821" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050801" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051354" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051453" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0055085" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0072562" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0072659" version="SP_262"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1904539" version="SP_262"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001717" version="SP_262"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002977" version="SP_262"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003020" version="SP_262"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011531" version="SP_262"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013769" version="SP_262"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016152" version="SP_262"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018241" version="SP_262"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P02730" version="SP_262"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1BH7" version="SP_262"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1BNX" version="SP_262"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1BTQ" version="SP_262"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1BTR" version="SP_262"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1BTS" version="SP_262"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1BTT" version="SP_262"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1BZK" version="SP_262"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1HYN" version="SP_262"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2BTA" version="SP_262"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2BTB" version="SP_262"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3BTB" version="SP_262"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4KY9" version="SP_262"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4YZF" version="SP_262"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1237044" version="SP_262"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1247673" version="SP_262"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-425381" version="SP_262"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5619050" version="SP_262"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-42428N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MEELQDDYEDMMEENLEQEEYEDPDIPESQMEEPAAHDTEATATDYHTTSHPGTHKVYVELQELVMDEKNQELRWMEAARWVQLEENLGENGAWGRPHLSHLTFWSLLELRRVFTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSHAGELEALGGVKPAVLTRSGDPSQPLLPQHSSLETQLFCEQGDGGTEGHSPSGILEKIPPDSEATLVLVGRADFLEQPVLGFVRLQEAAELEAVELPVPIRFLFVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTDAPSEQALLSLVPVQRELLRRRYQSSPAKPDSSFYKGLDLNGGPDDPLQQTGQLFGGLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPAITFGGLLGEKTRNQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWIGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKTYNYNVLMVPKPQGPLPNTALLSLVLMAGTFFFAMMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPLGLRSEFPIWMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASTPGAAAQIQEVKEQRISGLLVAVLVGLSILMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKSTPASLALPFVLILTVPLRRVLLPLIFRNVELQCLDADDAKATFDEEEGRDEYDEVAMPV</sequence>
        <attributeList>
          <attribute name="function" nameAc="MI:0613">Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape</attribute>
          <attribute name="function" nameAc="MI:0613">Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis</attribute>
          <attribute name="function" nameAc="MI:0613">Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]</attribute>
          <attribute name="function" nameAc="MI:0613">Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
          <attribute name="function" nameAc="MI:0613">Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal</attribute>
          <attribute name="crc64">35EC3EE7AFF27D2F</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="6" imexId="IM-27606-1">
        <names>
          <shortLabel>mpo-slc4a1-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-25298065" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-27606-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="7">
            <interactorRef>5</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>cell lysate</shortLabel>
                  <fullName>cell lysate</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0344" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537757" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="9606">
                <names>
                  <shortLabel>human-erythrocyte</shortLabel>
                  <fullName>Homo sapiens</fullName>
                </names>
                <tissue>
                  <names>
                    <shortLabel>erythrocyte</shortLabel>
                    <fullName>Erythrocyte, Red blood cell; Corpuscle; RBC</fullName>
                  </names>
                  <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="IA:0222" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="brenda" dbAc="MI:0864" id="BTO:0000424" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="MINT-6762070" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-514781" refType="identity" refTypeAc="MI:0356"/>
                  </xref>
                </tissue>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="8">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>purified</shortLabel>
                  <fullName>purified</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="9606">
                <names>
                  <shortLabel>human-leukocyte</shortLabel>
                  <fullName>Homo sapiens</fullName>
                </names>
                <tissue>
                  <names>
                    <shortLabel>leukocyte</shortLabel>
                    <fullName>Leukocyte (white blood cell)</fullName>
                  </names>
                  <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="IA:0617" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="brenda" dbAc="MI:0864" id="BTO:0000751" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1225419" refType="identity" refTypeAc="MI:0356"/>
                  </xref>
                </tissue>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">1A-1</attribute>
        </attributeList>
      </interaction>
      <interaction id="9" imexId="IM-27606-3">
        <names>
          <shortLabel>mpo-slc4a1-2</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-25298070" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-27606-3" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="10">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>cell lysate</shortLabel>
                  <fullName>cell lysate</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0344" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537757" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="9606">
                <names>
                  <shortLabel>human-erythrocyte</shortLabel>
                  <fullName>Homo sapiens</fullName>
                </names>
                <tissue>
                  <names>
                    <shortLabel>erythrocyte</shortLabel>
                    <fullName>Erythrocyte, Red blood cell; Corpuscle; RBC</fullName>
                  </names>
                  <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="IA:0222" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="brenda" dbAc="MI:0864" id="BTO:0000424" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="MINT-6762070" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-514781" refType="identity" refTypeAc="MI:0356"/>
                  </xref>
                </tissue>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="11">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>purified</shortLabel>
                  <fullName>purified</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="9606">
                <names>
                  <shortLabel>human-leukocyte</shortLabel>
                  <fullName>Homo sapiens</fullName>
                </names>
                <tissue>
                  <names>
                    <shortLabel>leukocyte</shortLabel>
                    <fullName>Leukocyte (white blood cell)</fullName>
                  </names>
                  <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="IA:0617" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="brenda" dbAc="MI:0864" id="BTO:0000751" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1225419" refType="identity" refTypeAc="MI:0356"/>
                  </xref>
                </tissue>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">1A-2</attribute>
        </attributeList>
      </interaction>
      <interaction id="12" imexId="IM-27606-5">
        <names>
          <shortLabel>mpo-gypb-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-25298074" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-27606-5" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="13">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>cell lysate</shortLabel>
                  <fullName>cell lysate</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0344" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537757" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="9606">
                <names>
                  <shortLabel>human-erythrocyte</shortLabel>
                  <fullName>Homo sapiens</fullName>
                </names>
                <tissue>
                  <names>
                    <shortLabel>erythrocyte</shortLabel>
                    <fullName>Erythrocyte, Red blood cell; Corpuscle; RBC</fullName>
                  </names>
                  <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="IA:0222" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="brenda" dbAc="MI:0864" id="BTO:0000424" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="MINT-6762070" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-514781" refType="identity" refTypeAc="MI:0356"/>
                  </xref>
                </tissue>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="14">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>purified</shortLabel>
                  <fullName>purified</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="9606">
                <names>
                  <shortLabel>human-leukocyte</shortLabel>
                  <fullName>Homo sapiens</fullName>
                </names>
                <tissue>
                  <names>
                    <shortLabel>leukocyte</shortLabel>
                    <fullName>Leukocyte (white blood cell)</fullName>
                  </names>
                  <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="IA:0617" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="brenda" dbAc="MI:0864" id="BTO:0000751" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1225419" refType="identity" refTypeAc="MI:0356"/>
                  </xref>
                </tissue>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">1A-3</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>