DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system. Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system. Science (New York, N.Y.) 2018 imex curation Segarra M., Aburto MR., Cop F., Llaó-Cid C., Härtl R., Damm M., Bethani I., Parrilla M., Husainie D., Schänzer A., Schlierbach H., Acker T., Mohr L., Torres-Masjoan L., Ritter M., Acker-Palmer A. acker-palmer@bio.uni-frankfurt.de 09-May-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-uvec Human Umbilical Vein Endothelial Cells (HUVEC) huvec umbilical_vein_endothelium Umbilical vein endothelial cell [Umbilical vein endothelium] anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Segarra M., Aburto MR., Cop F., Llaó-Cid C., Härtl R., Damm M., Bethani I., Parrilla M., Husainie D., Schänzer A., Schlierbach H., Acker T., Mohr L., Torres-Masjoan L., Ritter M., Acker-Palmer A. acker-palmer@bio.uni-frankfurt.de Accepted 2018-NOV-28 AT 09:44 GMT AT 09:44 GMT by ORCHARD Science (New York, N.Y.) 2018 imex curation Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system. Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system. Science (New York, N.Y.) 2018 imex curation Segarra M., Aburto MR., Cop F., Llaó-Cid C., Härtl R., Damm M., Bethani I., Parrilla M., Husainie D., Schänzer A., Schlierbach H., Acker T., Mohr L., Torres-Masjoan L., Ritter M., Acker-Palmer A. acker-palmer@bio.uni-frankfurt.de 09-May-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-uvec Human Umbilical Vein Endothelial Cells (HUVEC) huvec umbilical_vein_endothelium Umbilical vein endothelial cell [Umbilical vein endothelium] pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Segarra M., Aburto MR., Cop F., Llaó-Cid C., Härtl R., Damm M., Bethani I., Parrilla M., Husainie D., Schänzer A., Schlierbach H., Acker T., Mohr L., Torres-Masjoan L., Ritter M., Acker-Palmer A. acker-palmer@bio.uni-frankfurt.de Accepted 2018-NOV-28 AT 09:44 GMT AT 09:44 GMT by ORCHARD Science (New York, N.Y.) 2018 imex curation lrp8_human Low-density lipoprotein receptor-related protein 8 APOER2 Apolipoprotein E receptor 2 LRP8 protein protein human Homo sapiens Human MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDDGLP DIP protein Q14114 original sequence version: 140 DIP protein Q14114 original sequence version: 90 DIP protein Q14114 original sequence version: 97 B10DCF72F62DE71C vgfr2_human Vascular endothelial growth factor receptor 2 Kinase insert domain receptor Protein-tyrosine kinase receptor flk-1 KDR FLK1 Fetal liver kinase 1 VEGFR2 protein protein human Homo sapiens Human MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV DIP protein P35968 original sequence version: 81 DIP protein P35968 original sequence version: 146 DIP protein P35968 original sequence version: 117 DIP protein P35968 original sequence version: 121 59E7C44B05CFEBB3 kdr-lrp8-1 1 3 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level native native 4 unspecified role unspecified role bait bait physiological level physiological level endogenous level endogenous endogenous endogenous level native native physical association physical association Fig 2A kdr-lrp8-2 2 3 unspecified role unspecified role neutral component neutral component native native 4 unspecified role unspecified role neutral component neutral component native native proximity proximity close-contact colocalization neighbourhood interaction Fig S2B